NO20082075L - Anti-hyperkolesterolemiske forbindelser - Google Patents

Anti-hyperkolesterolemiske forbindelser

Info

Publication number
NO20082075L
NO20082075L NO20082075A NO20082075A NO20082075L NO 20082075 L NO20082075 L NO 20082075L NO 20082075 A NO20082075 A NO 20082075A NO 20082075 A NO20082075 A NO 20082075A NO 20082075 L NO20082075 L NO 20082075L
Authority
NO
Norway
Prior art keywords
compounds
cholesterol
hypercholesterolemic compounds
hypercholesterolemic
esters
Prior art date
Application number
NO20082075A
Other languages
English (en)
Inventor
Robert J Devita
Gregori J Moriello
Peter Lin
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO20082075L publication Critical patent/NO20082075L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Denne oppfinnelsen tilveiebringer kolesterol-absorpsjonsinhibitorer med formel I og de farmasøytisk akseptable saltene og esterne derav. Forbindelsene er anvendbare til senking av plasmakolesterolnivåer, særlig LDL-kolesterol, og til behandling og forebyggelse av aterosklerose og aterosklerotiske sykdomstilfeller.
NO20082075A 2005-10-05 2008-05-02 Anti-hyperkolesterolemiske forbindelser NO20082075L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72378105P 2005-10-05 2005-10-05
PCT/US2006/038551 WO2007044318A2 (en) 2005-10-05 2006-09-29 Anti-hypercholesterolemic compounds

Publications (1)

Publication Number Publication Date
NO20082075L true NO20082075L (no) 2008-07-04

Family

ID=37845278

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082075A NO20082075L (no) 2005-10-05 2008-05-02 Anti-hyperkolesterolemiske forbindelser

Country Status (25)

Country Link
US (2) US20090137546A1 (no)
EP (1) EP1934175B1 (no)
JP (1) JP4879991B2 (no)
KR (1) KR20080050610A (no)
CN (1) CN101277930A (no)
AR (1) AR058068A1 (no)
AT (1) ATE488495T1 (no)
AU (1) AU2006302584B2 (no)
BR (1) BRPI0616834A2 (no)
CA (1) CA2624481C (no)
CR (1) CR9903A (no)
DE (1) DE602006018341D1 (no)
DO (1) DOP2006000211A (no)
EA (1) EA200801008A1 (no)
ES (1) ES2354460T3 (no)
GT (1) GT200600444A (no)
IL (1) IL190434A0 (no)
MA (1) MA30006B1 (no)
NO (1) NO20082075L (no)
PE (1) PE20070493A1 (no)
SV (1) SV2009002863A (no)
TN (1) TNSN08153A1 (no)
TW (1) TW200806623A (no)
WO (1) WO2007044318A2 (no)
ZA (1) ZA200802587B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176193B2 (en) * 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
GB0215579D0 (en) * 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
WO2005061452A1 (en) * 2003-12-23 2005-07-07 Astrazeneca Ab Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
GB0329778D0 (en) * 2003-12-23 2004-01-28 Astrazeneca Ab Chemical compounds
WO2005062824A2 (en) * 2003-12-23 2005-07-14 Merck & Co., Inc. Anti-hypercholesterolemic compounds
UY29607A1 (es) * 2005-06-20 2007-01-31 Astrazeneca Ab Compuestos quimicos
AR057072A1 (es) * 2005-06-22 2007-11-14 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto
AR054482A1 (es) * 2005-06-22 2007-06-27 Astrazeneca Ab Derivados de azetidinona para el tratamiento de hiperlipidemias
AR057383A1 (es) * 2005-06-22 2007-12-05 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto
AR057380A1 (es) * 2005-06-22 2007-11-28 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona y uso terapeutico de los mismos
SA06270191B1 (ar) * 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
TW200806623A (en) * 2005-10-05 2008-02-01 Merck & Co Inc Anti-hypercholesterolemic compounds
DE102005055726A1 (de) * 2005-11-23 2007-08-30 Sanofi-Aventis Deutschland Gmbh Hydroxy-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
TW200811098A (en) * 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
WO2008085300A1 (en) * 2006-12-20 2008-07-17 Merck & Co., Inc. Anti-hypercholesterolemic compounds
US8029405B2 (en) 2008-05-30 2011-10-04 Hyundai Motor Company Gear train of automatic transmission for vehicles
WO2010056788A1 (en) * 2008-11-17 2010-05-20 Merck Sharp & Dohme Corp. Anti-hypercholesterolemic compounds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2107548T3 (es) * 1991-07-23 1997-12-01 Schering Corp Compuestos de beta-lactama sustituidos utiles como agentes hipocolesterolemicos y procedimientos para su preparacion.
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
CA2191455A1 (en) * 1994-06-20 1995-12-28 Wayne Vaccaro Substituted azetidinone compounds useful as hypocholesterolemic agents
US5624920A (en) * 1994-11-18 1997-04-29 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
BR0116325A (pt) * 2000-12-21 2003-10-14 Aventis Pharma Gmbh 1,2-difenilazetidinonas, processos para a sua preparação, medicamentos contendo estes compostos e sua aplicação para o tratamento de distúrbios do metabolismo de lipìdios
TWI291957B (en) * 2001-02-23 2008-01-01 Kotobuki Pharmaceutical Co Ltd Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
US7176193B2 (en) * 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US7176194B2 (en) * 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
ES2311806T3 (es) * 2003-03-07 2009-02-16 Schering Corporation Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
JP2005015434A (ja) * 2003-06-27 2005-01-20 Kotobuki Seiyaku Kk 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
WO2005062824A2 (en) * 2003-12-23 2005-07-14 Merck & Co., Inc. Anti-hypercholesterolemic compounds
EP1851197A2 (en) * 2005-02-09 2007-11-07 Microbia, Inc. Phenylazetidinone derivatives
JP2008543837A (ja) * 2005-06-15 2008-12-04 メルク エンド カムパニー インコーポレーテッド 抗高コレステロール血症化合物
TW200806623A (en) * 2005-10-05 2008-02-01 Merck & Co Inc Anti-hypercholesterolemic compounds
DE102005055726A1 (de) * 2005-11-23 2007-08-30 Sanofi-Aventis Deutschland Gmbh Hydroxy-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
CA2668094A1 (en) * 2006-11-02 2008-05-08 Sanofi-Aventis Deutschland Gmbh Novel diphenylazetidinone substituted by piperazine-1-sulfonic acid and having improved pharmacological properties

Also Published As

Publication number Publication date
GT200600444A (es) 2007-05-04
TW200806623A (en) 2008-02-01
WO2007044318A3 (en) 2007-07-12
CR9903A (es) 2008-07-29
CA2624481C (en) 2012-04-03
AU2006302584B2 (en) 2011-10-13
BRPI0616834A2 (pt) 2016-08-23
SV2009002863A (es) 2009-02-19
TNSN08153A1 (en) 2009-10-30
US20070078098A1 (en) 2007-04-05
US20090137546A1 (en) 2009-05-28
WO2007044318A2 (en) 2007-04-19
KR20080050610A (ko) 2008-06-09
JP2009511475A (ja) 2009-03-19
DE602006018341D1 (de) 2010-12-30
AR058068A1 (es) 2008-01-23
ES2354460T3 (es) 2011-03-15
IL190434A0 (en) 2008-11-03
ZA200802587B (en) 2009-06-24
AU2006302584A1 (en) 2007-04-19
JP4879991B2 (ja) 2012-02-22
ATE488495T1 (de) 2010-12-15
DOP2006000211A (es) 2007-05-31
PE20070493A1 (es) 2007-06-13
EP1934175A2 (en) 2008-06-25
CN101277930A (zh) 2008-10-01
US7704988B2 (en) 2010-04-27
MA30006B1 (fr) 2008-12-01
EA200801008A1 (ru) 2009-02-27
EP1934175B1 (en) 2010-11-17
CA2624481A1 (en) 2007-04-19

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application