EA200801008A1 - Гипохолестеринемические соединения - Google Patents

Гипохолестеринемические соединения

Info

Publication number
EA200801008A1
EA200801008A1 EA200801008A EA200801008A EA200801008A1 EA 200801008 A1 EA200801008 A1 EA 200801008A1 EA 200801008 A EA200801008 A EA 200801008A EA 200801008 A EA200801008 A EA 200801008A EA 200801008 A1 EA200801008 A1 EA 200801008A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hypocholesterynamic
connections
cholesterol
atherosclerosis
esters
Prior art date
Application number
EA200801008A
Other languages
English (en)
Inventor
Роберт Дж. Девита
Грегори Дж. Морриелло
Питер Лин
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA200801008A1 publication Critical patent/EA200801008A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к ингибиторам поглощения холестерина формулы I и к их фармацевтически приемлемым солям и сложным эфирам. Указанные соединения могут быть использованы для снижения уровней холестерина в плазме, а в частности, ЛНП-холестерина, и для лечения и предупреждения атеросклероза и атеросклеротических заболеваний.
EA200801008A 2005-10-05 2006-09-29 Гипохолестеринемические соединения EA200801008A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72378105P 2005-10-05 2005-10-05
PCT/US2006/038551 WO2007044318A2 (en) 2005-10-05 2006-09-29 Anti-hypercholesterolemic compounds

Publications (1)

Publication Number Publication Date
EA200801008A1 true EA200801008A1 (ru) 2009-02-27

Family

ID=37845278

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801008A EA200801008A1 (ru) 2005-10-05 2006-09-29 Гипохолестеринемические соединения

Country Status (25)

Country Link
US (2) US20090137546A1 (ru)
EP (1) EP1934175B1 (ru)
JP (1) JP4879991B2 (ru)
KR (1) KR20080050610A (ru)
CN (1) CN101277930A (ru)
AR (1) AR058068A1 (ru)
AT (1) ATE488495T1 (ru)
AU (1) AU2006302584B2 (ru)
BR (1) BRPI0616834A2 (ru)
CA (1) CA2624481C (ru)
CR (1) CR9903A (ru)
DE (1) DE602006018341D1 (ru)
DO (1) DOP2006000211A (ru)
EA (1) EA200801008A1 (ru)
ES (1) ES2354460T3 (ru)
GT (1) GT200600444A (ru)
IL (1) IL190434A0 (ru)
MA (1) MA30006B1 (ru)
NO (1) NO20082075L (ru)
PE (1) PE20070493A1 (ru)
SV (1) SV2009002863A (ru)
TN (1) TNSN08153A1 (ru)
TW (1) TW200806623A (ru)
WO (1) WO2007044318A2 (ru)
ZA (1) ZA200802587B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7176193B2 (en) * 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
GB0215579D0 (en) * 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
EP1699759B1 (en) * 2003-12-23 2010-10-20 AstraZeneca AB Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
GB0329778D0 (en) * 2003-12-23 2004-01-28 Astrazeneca Ab Chemical compounds
AU2004308332B2 (en) * 2003-12-23 2008-04-10 Merck Sharp & Dohme Corp. Anti-hypercholesterolemic compounds
UY29607A1 (es) * 2005-06-20 2007-01-31 Astrazeneca Ab Compuestos quimicos
SA06270191B1 (ar) * 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
AR057383A1 (es) * 2005-06-22 2007-12-05 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto
AR054482A1 (es) * 2005-06-22 2007-06-27 Astrazeneca Ab Derivados de azetidinona para el tratamiento de hiperlipidemias
AR057072A1 (es) * 2005-06-22 2007-11-14 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto
AR057380A1 (es) * 2005-06-22 2007-11-28 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona y uso terapeutico de los mismos
TW200806623A (en) * 2005-10-05 2008-02-01 Merck & Co Inc Anti-hypercholesterolemic compounds
DE102005055726A1 (de) * 2005-11-23 2007-08-30 Sanofi-Aventis Deutschland Gmbh Hydroxy-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
AR060623A1 (es) * 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
EP2124549A4 (en) * 2006-12-20 2010-01-20 Merck & Co Inc ANTIHYPERCHOLESTERINAMIC COMPOUNDS
DE102009023046B4 (de) 2008-05-30 2016-10-13 Hyundai Motor Company Automatisch schaltbares Getriebe eines Kraftfahrzeuges
WO2010056788A1 (en) * 2008-11-17 2010-05-20 Merck Sharp & Dohme Corp. Anti-hypercholesterolemic compounds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT67341A (en) * 1991-07-23 1995-03-28 Schering Corp Substituted beta-lactam compounds useful as hypocholesterolemic agents, pharmaceutical compositions containing the same and process for the production thereof
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
JPH10501811A (ja) * 1994-06-20 1998-02-17 シェーリング コーポレイション 低コレステロール化剤として有用な置換アゼチジノン化合物
US5624920A (en) * 1994-11-18 1997-04-29 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
DE50111751D1 (de) * 2000-12-21 2007-02-08 Sanofi Aventis Deutschland Neue diphenzylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung zur behandlung von lipidstoffwechselstörungen
TWI291957B (en) * 2001-02-23 2008-01-01 Kotobuki Pharmaceutical Co Ltd Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same
US7176194B2 (en) * 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
US7176193B2 (en) * 2002-06-19 2007-02-13 Sanofi-Aventis Deutschland Gmbh Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
ATE406364T1 (de) * 2003-03-07 2008-09-15 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
JP2005015434A (ja) * 2003-06-27 2005-01-20 Kotobuki Seiyaku Kk 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤
AU2004308332B2 (en) * 2003-12-23 2008-04-10 Merck Sharp & Dohme Corp. Anti-hypercholesterolemic compounds
WO2006086562A2 (en) * 2005-02-09 2006-08-17 Microbia, Inc. Phenylazetidinone derivatives
CN101198338A (zh) * 2005-06-15 2008-06-11 默克公司 抗高胆固醇血化合物
TW200806623A (en) * 2005-10-05 2008-02-01 Merck & Co Inc Anti-hypercholesterolemic compounds
DE102005055726A1 (de) * 2005-11-23 2007-08-30 Sanofi-Aventis Deutschland Gmbh Hydroxy-substituierte Diphenylazetidinone, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
CN101535249A (zh) * 2006-11-02 2009-09-16 塞诺菲-安万特德国有限公司 具有改善的药理性质的新的哌嗪-1-磺酸取代的二苯基氮杂环丁酮

Also Published As

Publication number Publication date
CR9903A (es) 2008-07-29
NO20082075L (no) 2008-07-04
DE602006018341D1 (de) 2010-12-30
EP1934175A2 (en) 2008-06-25
ZA200802587B (en) 2009-06-24
TNSN08153A1 (en) 2009-10-30
KR20080050610A (ko) 2008-06-09
AU2006302584B2 (en) 2011-10-13
BRPI0616834A2 (pt) 2016-08-23
SV2009002863A (es) 2009-02-19
WO2007044318A2 (en) 2007-04-19
GT200600444A (es) 2007-05-04
US20090137546A1 (en) 2009-05-28
WO2007044318A3 (en) 2007-07-12
AU2006302584A1 (en) 2007-04-19
AR058068A1 (es) 2008-01-23
PE20070493A1 (es) 2007-06-13
ES2354460T3 (es) 2011-03-15
JP4879991B2 (ja) 2012-02-22
US7704988B2 (en) 2010-04-27
TW200806623A (en) 2008-02-01
IL190434A0 (en) 2008-11-03
JP2009511475A (ja) 2009-03-19
CA2624481C (en) 2012-04-03
MA30006B1 (fr) 2008-12-01
EP1934175B1 (en) 2010-11-17
ATE488495T1 (de) 2010-12-15
US20070078098A1 (en) 2007-04-05
CN101277930A (zh) 2008-10-01
CA2624481A1 (en) 2007-04-19
DOP2006000211A (es) 2007-05-31

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