UA96126C2 - Соединение для ингибирования активности rho киназы, фармацевтическая композиция, которая содержит такое соединение, и способ ингибирования активности rho киназы - Google Patents

Соединение для ингибирования активности rho киназы, фармацевтическая композиция, которая содержит такое соединение, и способ ингибирования активности rho киназы

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Publication number
UA96126C2
UA96126C2 UAA200711701A UAA200711701A UA96126C2 UA 96126 C2 UA96126 C2 UA 96126C2 UA A200711701 A UAA200711701 A UA A200711701A UA A200711701 A UAA200711701 A UA A200711701A UA 96126 C2 UA96126 C2 UA 96126C2
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UA
Ukraine
Prior art keywords
rhokinase
activity
compound
inhibiting
inhibition
Prior art date
Application number
UAA200711701A
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English (en)
Ukrainian (uk)
Inventor
Алессандра Бартолоцци
Стюарт Кемпбелл
Хоуп Фудулакис
Брайян Кирк
Сия Рам
Пол Свитнем
Хемалатха Сешадри
Original Assignee
Сьёрфейс Лоджикс, Инк.
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Application filed by Сьёрфейс Лоджикс, Инк. filed Critical Сьёрфейс Лоджикс, Инк.
Publication of UA96126C2 publication Critical patent/UA96126C2/ru

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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Данное изобретение касается ингибиторов ROCK1 и ROCK2 и способов модуляции фармакокинетических и/или фармакодинамических свойств таких соединений.Также описаны способы ингибирования ROCK1 и или ROCK2, которые применяются для лечения заболевания.
UAA200711701A 2005-03-25 2006-03-27 Соединение для ингибирования активности rho киназы, фармацевтическая композиция, которая содержит такое соединение, и способ ингибирования активности rho киназы UA96126C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66516505P 2005-03-25 2005-03-25

Publications (1)

Publication Number Publication Date
UA96126C2 true UA96126C2 (ru) 2011-10-10

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UAA200711701A UA96126C2 (ru) 2005-03-25 2006-03-27 Соединение для ингибирования активности rho киназы, фармацевтическая композиция, которая содержит такое соединение, и способ ингибирования активности rho киназы

Country Status (21)

Country Link
US (6) US8357693B2 (ru)
EP (1) EP1865958B1 (ru)
JP (2) JP2008534518A (ru)
KR (1) KR20080081122A (ru)
CN (1) CN101208094B (ru)
AU (1) AU2006230159A1 (ru)
BR (1) BRPI0622285A2 (ru)
CA (1) CA2602254C (ru)
CR (1) CR9465A (ru)
EA (1) EA022875B1 (ru)
EC (1) ECSP077836A (ru)
ES (1) ES2549397T3 (ru)
GE (1) GEP20105029B (ru)
IL (1) IL186299A0 (ru)
MX (1) MX2007011859A (ru)
NO (1) NO20075145L (ru)
NZ (1) NZ562083A (ru)
SG (1) SG155163A1 (ru)
UA (1) UA96126C2 (ru)
WO (1) WO2006105081A2 (ru)
ZA (1) ZA200708858B (ru)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006045096A2 (en) 2004-10-20 2006-04-27 Resverlogix Corp. Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
CR9465A (es) * 2005-03-25 2008-06-19 Surface Logix Inc Compuestos mejorados farmacocineticamente
NZ566180A (en) 2005-07-29 2011-04-29 Resverlogix Corp Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
JP2009534458A (ja) 2006-04-26 2009-09-24 キャンサー・リサーチ・テクノロジー・リミテッド アミノ−エチル−アミノ−アリール（ａｅａａ）化合物およびそれらの使用
EP2705753A1 (en) * 2006-08-24 2014-03-12 Surface Logix, Inc. 2-Phenyl-imidazolotriazinone compounds as PDE5 inhibitors
AU2007328336B2 (en) 2006-12-01 2014-04-17 President And Fellows Of Harvard College Compounds and methods for enzyme-mediated tumor imaging and therapy
PT2118074E (pt) 2007-02-01 2014-03-20 Resverlogix Corp Compostos para a prevenção e tratamento de doenças cardiovasculares
BRPI0808523A2 (pt) * 2007-03-01 2014-08-19 Novartis Vaccines & Diagnostic Inibidores de pim cinase e métodos de seu uso
US20100183604A1 (en) * 2007-06-19 2010-07-22 Takeda Pharmaceutical Company Limited Preventive/remedy for cancer
CA2711103C (en) 2008-06-26 2016-08-09 Resverlogix Corp. Methods of preparing quinazolinone derivatives
PT2344474E (pt) 2008-09-02 2015-12-28 Novartis Ag Derivados de picolinamida como inibidores de cinase
WO2010079431A2 (en) 2009-01-08 2010-07-15 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
AU2010222848A1 (en) * 2009-03-09 2011-10-20 Surface Logix, Inc. Rho kinase inhibitors
EP2408454A2 (en) 2009-03-18 2012-01-25 Resverlogix Corp. Novel anti-inflammatory agents
KR101892987B1 (ko) 2009-04-22 2018-08-30 리스버로직스 코퍼레이션 신규한 소염제
US8658676B2 (en) * 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
JP5992049B2 (ja) 2011-11-01 2016-09-14 レスバーロジックス コーポレイション 置換されたキナゾリノンのための経口速放性製剤
WO2013175388A1 (en) 2012-05-21 2013-11-28 Novartis Ag Novel ring-substituted n-pyridinyl amides as kinase inhibitors
JP6187460B2 (ja) * 2012-06-21 2017-08-30 大正製薬株式会社 ピリドピリミジン−４−オン誘導体
US9815820B2 (en) * 2012-10-05 2017-11-14 Kadmon Corporation, Llc Rho kinase inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
JP2016507496A (ja) 2012-12-21 2016-03-10 ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． ブロモドメイン阻害剤としての新規複素環式化合物
CN105407894A (zh) 2013-03-14 2016-03-16 康威基内有限公司 用于抑制含布罗莫结构域的蛋白质的方法和组合物
HUE043465T2 (hu) 2013-08-23 2019-08-28 Neupharma Inc Kémiai anyagok, készítmények és módszerek
AU2016220219B2 (en) 2015-02-17 2020-05-14 Neupharma, Inc. Certain chemical entities, compositions, and methods
CN107530356A (zh) 2015-03-13 2018-01-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法
PT3313449T (pt) * 2015-06-24 2020-10-30 Nitto Denko Corp Compostos ionizáveis e composições e suas utilizações
ES2918589T3 (es) 2015-11-25 2022-07-19 Convergene Llc Inhibidores de bromodomios BET bicíclicos y usos de los mismos
AU2017312561B2 (en) 2016-08-15 2022-06-30 Neupharma, Inc. Certain chemical entities, compositions, and methods
WO2018201006A1 (en) * 2017-04-28 2018-11-01 Kadmon Corporation, Llc Treatment of inflammatory conditions and autoimmune diseases with glucose uptake inhibitors
CN117343049A (zh) * 2017-06-30 2024-01-05 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途
JP7039802B2 (ja) 2017-06-30 2022-03-23 ベイジン タイド ファーマシューティカル カンパニー リミテッド Ｒｈｏ－関連プロテインキナーゼ阻害剤、ｒｈｏ－関連プロテインキナーゼ阻害剤を含む医薬組成物、当該医薬組成物の調製方法及び使用
WO2019000682A1 (zh) 2017-06-30 2019-01-03 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途
US11548867B2 (en) 2017-07-19 2023-01-10 Idea Ya Biosciences, Inc. Amido compounds as AhR modulators
WO2019046795A1 (en) 2017-09-03 2019-03-07 Angion Biomedica Corp. VINYL HETEROCYCLES AS INHIBITORS OF RHO (ROCK) ASSOCIATED BISPIRALIZED KINASE
EP3749669B1 (en) 2018-02-06 2023-03-08 Ideaya Biosciences, Inc. Ahr modulators
US11345678B2 (en) 2018-04-18 2022-05-31 Medshine Discovery Inc. Benzopyrazole compound used as RHO kinase inhibitor
CN112969694B (zh) * 2018-11-09 2023-06-13 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其用途
WO2021073592A1 (zh) 2019-10-18 2021-04-22 南京明德新药研发有限公司 作为rho激酶抑制剂的苯并吡唑类化合物的盐型、晶型及其制备方法
WO2021129589A1 (zh) * 2019-12-27 2021-07-01 广东东阳光药业有限公司 Kd-025的新晶型及其制备方法
WO2022020850A1 (en) 2020-07-22 2022-01-27 Teva Pharmaceuticals International Gmbh Solid state forms of belumosudil and belumosudil salts
WO2022170864A1 (zh) * 2021-02-09 2022-08-18 苏州科睿思制药有限公司 Belumosudil甲磺酸盐的晶型及其制备方法和用途
CN114573566B (zh) * 2021-03-04 2023-05-30 杭州邦顺制药有限公司 选择性rock2激酶抑制剂
WO2023285706A1 (en) 2021-07-16 2023-01-19 Sandoz Ag Solid-state forms of 2-(3-(4-(1h-indazol-5-ylamino)quinazolin-2-yl )phenoxy)-n- isopropylacetamide methane sulfonic acid salt
WO2023205153A1 (en) 2022-04-19 2023-10-26 Kadmon Corporation, Llc Belumosudil for treating chronic lung allograft dysfunction
WO2024000060A1 (en) * 2022-06-30 2024-01-04 Apotex Inc Salts of belumosudil, crystalline forms and pharmaceutical compositions thereof and their use in the treatment of chronic graft-versus-host disease
CA3178096A1 (en) 2022-07-14 2024-01-14 Kadmon Corporation, Llc Methods of administering belumosudil for treatment of chronic graft versus host disease
CA3178086A1 (en) 2022-07-14 2024-01-14 Kadmon Corporation, Llc Methods of administering belumosudil for treatment of chronic graft versus host disease in patient subpopulations
WO2024015068A1 (en) 2022-07-14 2024-01-18 Kadmon Corporation, Llc Belumosudil metabolites and uses thereof in the treatment of chronic graft-versus-host disease
CA3178077A1 (en) 2022-07-14 2024-01-14 Kadmon Corporation, Llc Methods of administering belumosudil in combination with cyp3a inducers and/or proton pump inhibitors
CN115385899B (zh) * 2022-09-08 2024-04-02 药康众拓(江苏)医药科技有限公司 ROCK2抑制剂belumosudil的氘代药物及用途
WO2024063770A1 (en) 2022-09-21 2024-03-28 Kadmon Corporation, Llc Liquid formulation of belumosudil

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9620103A (sl) * 1995-07-06 1998-10-31 Novartis Ag Pirolopirimidini in postopki za njihovo pripravo
SI0956865T2 (sl) 1996-08-12 2011-04-29 Mitsubishi Pharma Corp Zdravila, ki obsegajo inhibitor Rho-kinaze
TWI284642B (en) * 1999-01-18 2007-08-01 Hoffmann La Roche Novel heterocyclic sulfonamides
ATE327993T1 (de) * 2000-03-16 2006-06-15 Mitsubishi Pharma Corp Amid-verbindung und deren verwendung
ATE347557T1 (de) * 2000-03-23 2006-12-15 Takeda Pharmaceutical Fluorisochinolinderivate, verfahren zu ihrer herstellung und ihre anwendung
US6699665B1 (en) 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
AU2002245709A1 (en) * 2001-03-23 2002-10-08 Bayer Corporation Rho-kinase inhibitors
AR035791A1 (es) * 2001-03-23 2004-07-14 Bayer Corp Compuesto n,n-diheterociclico de amina, inhibidor de la rho-quinasa, su uso para la fabricacion de un medicamento y proceso para la preparacion del compuesto
WO2003012392A2 (en) 2001-07-27 2003-02-13 Surface Logix, Inc. Resealable and sealable devices for biochemical assays
CA2458844A1 (en) 2001-08-27 2003-03-06 Surface Logix, Inc. Immobilization of biological molecules onto surfaces coated with monolayers
JP2003221386A (ja) * 2001-11-26 2003-08-05 Takeda Chem Ind Ltd 二環性誘導体、その製造法およびその用途
DE10162435A1 (de) 2001-12-19 2003-07-17 Joerg Lahann Verfahren zur Erzeugung von Oberflächenbeschichtungen, die die Adsorption von Proteinen bzw. die Adhäsion von Bakterien und/oder Zellen vermindern
GB0206860D0 (en) * 2002-03-22 2002-05-01 Glaxo Group Ltd Compounds
US7645878B2 (en) * 2002-03-22 2010-01-12 Bayer Healthcare Llc Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof
WO2004048383A1 (en) * 2002-11-21 2004-06-10 Eli Lilly And Company Mixed lineage kinase modulators
GB0301016D0 (en) * 2003-01-16 2003-02-19 Univ London Treatment of benign prostatic hyperplasia
WO2004105757A2 (en) * 2003-05-29 2004-12-09 Schering Aktiengesellschaft Use of rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy
WO2004108136A1 (en) * 2003-06-04 2004-12-16 Vernalis (Cambridge) Limited Triazolo `1 , 5-a!pyrimidines and their use in medicine
WO2005020921A2 (en) * 2003-08-29 2005-03-10 Exelixis, Inc. C-kit modulators and methods of use
JP4916883B2 (ja) * 2003-10-15 2012-04-18 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド イミダゾピラジンチロシンキナーゼ阻害剤
CN101287468A (zh) * 2005-02-18 2008-10-15 表面线段公司 制备包含官能性残基或基团的药动学改善的化合物的方法以及包含所述化合物的药用组合物
KR20080016531A (ko) * 2005-02-18 2008-02-21 서피스 로직스, 인크. 약동학적으로 개선된 화합물
CR9465A (es) * 2005-03-25 2008-06-19 Surface Logix Inc Compuestos mejorados farmacocineticamente
EP2705753A1 (en) * 2006-08-24 2014-03-12 Surface Logix, Inc. 2-Phenyl-imidazolotriazinone compounds as PDE5 inhibitors

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EA200702048A1 (ru) 2008-04-28
US8916576B2 (en) 2014-12-23
US8357693B2 (en) 2013-01-22
CN101208094B (zh) 2014-10-15
ES2549397T3 (es) 2015-10-27
MX2007011859A (es) 2008-04-04
CA2602254A1 (en) 2006-10-05
CA2602254C (en) 2015-03-24
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