NO20075145L - Farmakokinetisk forbedrede forbindelser - Google Patents
Farmakokinetisk forbedrede forbindelserInfo
- Publication number
- NO20075145L NO20075145L NO20075145A NO20075145A NO20075145L NO 20075145 L NO20075145 L NO 20075145L NO 20075145 A NO20075145 A NO 20075145A NO 20075145 A NO20075145 A NO 20075145A NO 20075145 L NO20075145 L NO 20075145L
- Authority
- NO
- Norway
- Prior art keywords
- improved compounds
- pharmacokinetically improved
- pharmacokinetically
- compounds
- rock2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nanotechnology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- General Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Composite Materials (AREA)
- Physics & Mathematics (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
Abstract
Foreliggende oppfinnelse angår inhibitorer av ROCK1 og ROCK2 og metoder for å modulere de farmakokinetiske og/eller farmakodynamisk egenskapene til slike forbindelser. Også gitt er metoder for å inhibere ROCK1 og/eller ROCK2 som er anvendelig for behandling av sykdom. ?? ?? ?? ?? 1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66516505P | 2005-03-25 | 2005-03-25 | |
PCT/US2006/011271 WO2006105081A2 (en) | 2005-03-25 | 2006-03-27 | Pharmacokinetically improved compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20075145L true NO20075145L (no) | 2007-11-28 |
Family
ID=37054004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20075145A NO20075145L (no) | 2005-03-25 | 2007-10-10 | Farmakokinetisk forbedrede forbindelser |
Country Status (21)
Country | Link |
---|---|
US (6) | US8357693B2 (no) |
EP (1) | EP1865958B1 (no) |
JP (2) | JP2008534518A (no) |
KR (1) | KR20080081122A (no) |
CN (1) | CN101208094B (no) |
AU (1) | AU2006230159A1 (no) |
BR (1) | BRPI0622285A2 (no) |
CA (1) | CA2602254C (no) |
CR (1) | CR9465A (no) |
EA (1) | EA022875B1 (no) |
EC (1) | ECSP077836A (no) |
ES (1) | ES2549397T3 (no) |
GE (1) | GEP20105029B (no) |
IL (1) | IL186299A0 (no) |
MX (1) | MX2007011859A (no) |
NO (1) | NO20075145L (no) |
NZ (1) | NZ562083A (no) |
SG (1) | SG155163A1 (no) |
UA (1) | UA96126C2 (no) |
WO (1) | WO2006105081A2 (no) |
ZA (1) | ZA200708858B (no) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8093273B2 (en) | 2004-10-20 | 2012-01-10 | Resverlogix Corp. | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases |
CR9465A (es) * | 2005-03-25 | 2008-06-19 | Surface Logix Inc | Compuestos mejorados farmacocineticamente |
KR101431279B1 (ko) | 2005-07-29 | 2014-08-20 | 리스버로직스 코퍼레이션 | 복합 질환의 예방 및 치료용 약학적 조성물 및 삽입가능한의료 장치에 의한 이의 전달 |
US20090247519A1 (en) | 2006-04-26 | 2009-10-01 | Tony Michael Raynham | Amino-ethyl-amino-aryl (aeaa) compounds and their use |
JP2010501577A (ja) * | 2006-08-24 | 2010-01-21 | サーフェイス ロジックス,インコーポレイティド | 薬物動態が改善された化合物 |
WO2008069976A2 (en) | 2006-12-01 | 2008-06-12 | President And Fellows Of Harvard College | Compounds and methods for enzyme-mediated tumor imaging and therapy |
ES2454966T3 (es) | 2007-02-01 | 2014-04-14 | Resverlogix Corp. | Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares |
EP2132177B1 (en) * | 2007-03-01 | 2013-07-17 | Novartis AG | Pim kinase inhibitors and methods of their use |
EP2163258A1 (en) * | 2007-06-19 | 2010-03-17 | Takeda Pharmaceutical Company Limited | Preventive/remedy for cancer |
RU2520098C2 (ru) | 2008-06-26 | 2014-06-20 | Ресверлоджикс Корп. | Способы получения производных хиназолинона |
JP5412519B2 (ja) | 2008-09-02 | 2014-02-12 | ノバルティス アーゲー | キナーゼ阻害剤としてのピコリンアミド誘導体 |
WO2010079431A2 (en) | 2009-01-08 | 2010-07-15 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
EP2406236A4 (en) * | 2009-03-09 | 2013-07-24 | Surface Logix Inc | INHIBITORS OF RHO KINASE |
NZ595747A (en) | 2009-03-18 | 2015-06-26 | Resverlogix Corp | Novel quinazolinones and related compounds for use as anti-inflammatory agents |
KR20190091564A (ko) | 2009-04-22 | 2019-08-06 | 리스버로직스 코퍼레이션 | 신규한 소염제 |
US8658676B2 (en) * | 2010-10-12 | 2014-02-25 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
PT2773354T (pt) | 2011-11-01 | 2019-07-17 | Resverlogix Corp | Formulações orais de libertação imediata para quinazolinonas substituídas |
SG11201407546QA (en) | 2012-05-21 | 2014-12-30 | Novartis Ag | Novel ring-substituted n-pyridinyl amides as kinase inhibitors |
WO2013191244A1 (ja) * | 2012-06-21 | 2013-12-27 | 大正製薬株式会社 | ピリドピリミジン-4-オン誘導体 |
CN113620933A (zh) | 2012-10-05 | 2021-11-09 | 卡德门企业有限公司 | Rho激酶抑制剂 |
WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
WO2014096965A2 (en) | 2012-12-21 | 2014-06-26 | Rvx Therapeutics Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
CN105407894A (zh) | 2013-03-14 | 2016-03-16 | 康威基内有限公司 | 用于抑制含布罗莫结构域的蛋白质的方法和组合物 |
PL3035936T3 (pl) | 2013-08-23 | 2019-08-30 | Neupharma, Inc. | Pewne jednostki chemiczne, kompozycje i sposoby |
US10947201B2 (en) | 2015-02-17 | 2021-03-16 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
JO3789B1 (ar) | 2015-03-13 | 2021-01-31 | Resverlogix Corp | التراكيب والوسائل العلاجية المعتمدة لمعالجة الامراض المتعلقة بالمتممة |
JP6480025B2 (ja) * | 2015-06-24 | 2019-03-06 | 日東電工株式会社 | イオン性化合物及び組成物並びにその使用 |
US10508106B2 (en) | 2015-11-25 | 2019-12-17 | Convergene Llc | Bicyclic BET bromodomain inhibitors and uses thereof |
US10544106B2 (en) | 2016-08-15 | 2020-01-28 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US11071735B2 (en) | 2017-04-28 | 2021-07-27 | Kadmon Corporation, Llc | Treatment of inflammatory conditions and autoimmune diseases with glucose uptake inhibitors |
JP7039802B2 (ja) | 2017-06-30 | 2022-03-23 | ベイジン タイド ファーマシューティカル カンパニー リミテッド | Rho-関連プロテインキナーゼ阻害剤、rho-関連プロテインキナーゼ阻害剤を含む医薬組成物、当該医薬組成物の調製方法及び使用 |
WO2019000682A1 (zh) | 2017-06-30 | 2019-01-03 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
CA3063616A1 (en) | 2017-06-30 | 2019-12-06 | Beijing Tide Pharmaceutical Co., Ltd. | Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof |
US11548867B2 (en) | 2017-07-19 | 2023-01-10 | Idea Ya Biosciences, Inc. | Amido compounds as AhR modulators |
CA3073956A1 (en) | 2017-09-03 | 2019-03-07 | Angion Biomedica Corp. | Vinylheterocycles as rho-associated coiled-coil kinase (rock) inhibitors |
DK3749669T3 (da) | 2018-02-06 | 2023-06-06 | Ideaya Biosciences Inc | Ahr-modulatorer |
JP7187575B2 (ja) | 2018-04-18 | 2022-12-12 | メッドシャイン ディスカバリー インコーポレイテッド | Rhoキナーゼ阻害剤としてのベンゾピラゾール系化合物 |
CN112969694B (zh) * | 2018-11-09 | 2023-06-13 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其用途 |
JP7252417B2 (ja) | 2019-10-18 | 2023-04-04 | メッドシャイン ディスカバリー インコーポレイテッド | Rhoキナーゼ阻害剤としてのベンゾピラゾール化合物の塩形、結晶形及びその製造方法 |
WO2021129589A1 (zh) * | 2019-12-27 | 2021-07-01 | 广东东阳光药业有限公司 | Kd-025的新晶型及其制备方法 |
CN116390918A (zh) * | 2020-07-22 | 2023-07-04 | 梯瓦制药国际有限责任公司 | Belumosudil和belumosudil盐的固态形式 |
WO2022042666A1 (zh) * | 2020-08-28 | 2022-03-03 | 杭州邦顺制药有限公司 | 选择性rock2激酶抑制剂 |
WO2022170864A1 (zh) * | 2021-02-09 | 2022-08-18 | 苏州科睿思制药有限公司 | Belumosudil甲磺酸盐的晶型及其制备方法和用途 |
CN114573566B (zh) * | 2021-03-04 | 2023-05-30 | 杭州邦顺制药有限公司 | 选择性rock2激酶抑制剂 |
EP4370205A1 (en) | 2021-07-16 | 2024-05-22 | Sandoz Ag | Solid-state forms of 2-(3-(4-(1h-indazol-5-ylamino)quinazolin-2-yl )phenoxy)-n- isopropylacetamide methane sulfonic acid salt |
WO2023205153A1 (en) | 2022-04-19 | 2023-10-26 | Kadmon Corporation, Llc | Belumosudil for treating chronic lung allograft dysfunction |
WO2024000060A1 (en) * | 2022-06-30 | 2024-01-04 | Apotex Inc | Salts of belumosudil, crystalline forms and pharmaceutical compositions thereof and their use in the treatment of chronic graft-versus-host disease |
CA3178077A1 (en) | 2022-07-14 | 2024-01-14 | Kadmon Corporation, Llc | Methods of administering belumosudil in combination with cyp3a inducers and/or proton pump inhibitors |
CA3178096A1 (en) | 2022-07-14 | 2024-01-14 | Kadmon Corporation, Llc | Methods of administering belumosudil for treatment of chronic graft versus host disease |
WO2024015068A1 (en) | 2022-07-14 | 2024-01-18 | Kadmon Corporation, Llc | Belumosudil metabolites and uses thereof in the treatment of chronic graft-versus-host disease |
CA3178086A1 (en) | 2022-07-14 | 2024-01-14 | Kadmon Corporation, Llc | Methods of administering belumosudil for treatment of chronic graft versus host disease in patient subpopulations |
CN115385899B (zh) * | 2022-09-08 | 2024-04-02 | 药康众拓(江苏)医药科技有限公司 | ROCK2抑制剂belumosudil的氘代药物及用途 |
WO2024063770A1 (en) | 2022-09-21 | 2024-03-28 | Kadmon Corporation, Llc | Liquid formulation of belumosudil |
WO2024100601A1 (en) | 2022-11-11 | 2024-05-16 | Assia Chemical Industries Ltd. | Solid state forms of belumosudil and processes for preparation thereof |
WO2024118556A1 (en) | 2022-11-29 | 2024-06-06 | Kadmon Corporation, Llc | Solid dispersion comprising amorphous 2-[3-[4-(lh-indazol-5- ylamino)quinazolin-2-yl]phenoxy]-n-propan-2-yl-acetamide |
WO2024124084A1 (en) | 2022-12-09 | 2024-06-13 | Kadmon Corporation, Llc | Methods of administering belumosudil for treatment of multiple myeloma |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT836605E (pt) * | 1995-07-06 | 2002-07-31 | Novartis Ag | Pirrolopirimidinas e processos para a sua preparacao |
ATE359822T1 (de) | 1996-08-12 | 2007-05-15 | Mitsubishi Pharma Corp | Medikamente enthaltend rho-kinase inhibitoren |
TWI284642B (en) * | 1999-01-18 | 2007-08-01 | Hoffmann La Roche | Novel heterocyclic sulfonamides |
SI1270570T1 (sl) * | 2000-03-16 | 2006-10-31 | Mitsubishi Pharma Corp | Amidne spojine in njihova uporaba |
EP1270577B1 (en) * | 2000-03-23 | 2006-12-06 | Takeda Pharmaceutical Company Limited | Furoisoquinoline derivatives, process for producing the same and use thereof |
US6699665B1 (en) | 2000-11-08 | 2004-03-02 | Surface Logix, Inc. | Multiple array system for integrating bioarrays |
DK1370552T3 (da) * | 2001-03-23 | 2007-05-07 | Bayer Pharmaceuticals Corp | Rho-kinase-inhibitorer |
CA2441492C (en) * | 2001-03-23 | 2011-08-09 | Bayer Corporation | Rho-kinase inhibitors |
AU2002327385A1 (en) | 2001-07-27 | 2003-02-17 | Surface Logix, Inc. | Resealable and sealable devices for biochemical assays |
EP1560939A4 (en) | 2001-08-27 | 2007-04-25 | Surface Logix Inc | IMMOBILIZATION OF BIOLOGICAL MOLECULES ON SURFACES COATED WITH MONOSLAYS |
JP2003221386A (ja) * | 2001-11-26 | 2003-08-05 | Takeda Chem Ind Ltd | 二環性誘導体、その製造法およびその用途 |
DE10162435A1 (de) | 2001-12-19 | 2003-07-17 | Joerg Lahann | Verfahren zur Erzeugung von Oberflächenbeschichtungen, die die Adsorption von Proteinen bzw. die Adhäsion von Bakterien und/oder Zellen vermindern |
GB0206860D0 (en) * | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
US7645878B2 (en) | 2002-03-22 | 2010-01-12 | Bayer Healthcare Llc | Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof |
AU2003298611A1 (en) * | 2002-11-21 | 2004-06-18 | Eli Lilly And Company | Mixed lineage kinase modulators |
GB0301016D0 (en) * | 2003-01-16 | 2003-02-19 | Univ London | Treatment of benign prostatic hyperplasia |
US20050014783A1 (en) * | 2003-05-29 | 2005-01-20 | Schering Aktiengesellschaft | Use of Rho-kinase inhibitors in the treatment of aneurysm and cardiac hypertrophy |
EP1644003A1 (en) * | 2003-06-04 | 2006-04-12 | Vernalis (Cambridge) Limited | Triazolo ´1,5-a!pyrimidines and their use in medicine |
EP1663204B1 (en) * | 2003-08-29 | 2014-05-07 | Exelixis, Inc. | C-kit modulators and methods of use |
ATE525377T1 (de) * | 2003-10-15 | 2011-10-15 | Osi Pharm Inc | Imidazoä1,5-aüpyrazine als inhibitoren von tyrosinkinase |
EP1848437A4 (en) * | 2005-02-18 | 2012-04-25 | Surface Logix Inc | METHOD FOR PRODUCING PHARMACOKINETIC IMPROVED COMPOUNDS WITH FUNCTIONAL RESTORATIONS OR GROUPS AND PHARMACEUTICAL COMPOSITIONS WITH THESE COMPOUNDS |
CN102351862A (zh) * | 2005-02-18 | 2012-02-15 | 表面线段公司 | 药动学改善的化合物 |
CR9465A (es) * | 2005-03-25 | 2008-06-19 | Surface Logix Inc | Compuestos mejorados farmacocineticamente |
JP2010501577A (ja) * | 2006-08-24 | 2010-01-21 | サーフェイス ロジックス,インコーポレイティド | 薬物動態が改善された化合物 |
-
2001
- 2001-10-23 CR CR9465A patent/CR9465A/es not_active Application Discontinuation
-
2006
- 2006-03-27 EA EA200702048A patent/EA022875B1/ru active IP Right Revival
- 2006-03-27 ES ES06748799.1T patent/ES2549397T3/es active Active
- 2006-03-27 GE GEAP200610335A patent/GEP20105029B/en unknown
- 2006-03-27 CA CA2602254A patent/CA2602254C/en active Active
- 2006-03-27 CN CN200680018211.1A patent/CN101208094B/zh active Active
- 2006-03-27 AU AU2006230159A patent/AU2006230159A1/en not_active Abandoned
- 2006-03-27 KR KR1020077024624A patent/KR20080081122A/ko not_active Application Discontinuation
- 2006-03-27 ZA ZA200708858A patent/ZA200708858B/xx unknown
- 2006-03-27 NZ NZ562083A patent/NZ562083A/en not_active IP Right Cessation
- 2006-03-27 MX MX2007011859A patent/MX2007011859A/es not_active Application Discontinuation
- 2006-03-27 SG SG200905004-8A patent/SG155163A1/en unknown
- 2006-03-27 BR BRPI0622285-4A patent/BRPI0622285A2/pt not_active IP Right Cessation
- 2006-03-27 UA UAA200711701A patent/UA96126C2/ru unknown
- 2006-03-27 JP JP2008503293A patent/JP2008534518A/ja not_active Withdrawn
- 2006-03-27 WO PCT/US2006/011271 patent/WO2006105081A2/en active Application Filing
- 2006-03-27 US US11/887,218 patent/US8357693B2/en active Active
- 2006-03-27 EP EP06748799.1A patent/EP1865958B1/en active Active
-
2007
- 2007-09-25 IL IL186299A patent/IL186299A0/en unknown
- 2007-10-10 NO NO20075145A patent/NO20075145L/no not_active Application Discontinuation
- 2007-10-23 EC EC2007007836A patent/ECSP077836A/es unknown
-
2012
- 2012-12-14 US US13/715,644 patent/US8916576B2/en active Active
-
2014
- 2014-12-23 US US14/581,746 patent/US9440961B2/en active Active
-
2015
- 2015-07-03 JP JP2015134574A patent/JP5956661B2/ja active Active
-
2017
- 2017-04-24 US US15/495,019 patent/US20180072710A1/en not_active Abandoned
-
2018
- 2018-07-19 US US16/040,245 patent/US10570123B2/en active Active
-
2020
- 2020-02-24 US US16/799,076 patent/US20210017166A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20075145L (no) | Farmakokinetisk forbedrede forbindelser | |
DK1877390T3 (da) | Benzisoxazol-piperazin-forbindelser og fremgangsmåder til anvendelse deraf | |
LTC1934174I2 (lt) | Azetinidai kaip MEK inhibitoriai, skirti proliferacinių ligų gydymui | |
NO20072567L (no) | Triazoler nyttige som proteinkinase-inhibitorer | |
UA86591C2 (ru) | Пирролодигидроизохинолины как ингибиторы pde10, фармацевтическая композиция на их основе | |
ATE548374T1 (de) | 2'-fluor-2'-desoxytetrahydrouridine als cytidindeaminaseinhibitoren | |
NO20075099L (no) | Alkynyl-pyrrolopyrmidiner og relaterte analoger som HSP90-inhibitorer | |
NO20076401L (no) | Diarylhydantoinforbindelser | |
NO20081636L (no) | FAP - inhibitorer | |
NO20080963L (no) | Piperidinyl-substiuerte isokinolinderivater som Rho-kinaseinhibitorer | |
WO2009073153A3 (en) | Small molecule myristate inhibitors of bcr-abl and methods of use | |
NO20052888L (no) | Diamintriazoler anvendelige som inhibitorer av proteinkinaser | |
MX354402B (es) | Inhibidores de molecula pequeña del dominio de homologia de pleckstrin y metodos para usar los mismos. | |
WO2007081740A3 (en) | Micrornarna-based methods and compositions for the diagnosis and treatment of solid cancers | |
NO20080141L (no) | Indanderivater som modulatorer av ionekanaler | |
MX2007010272A (es) | Inhibidores de moleculas pequenas de mdm2 y usos de los mismos. | |
DE602006015793D1 (de) | Proteolipidmembran und lipidmembranen-biosensor | |
UA83875C2 (ru) | Производные хинолина для применения в качестве микобактериальных ингибиторов | |
DE602006013191D1 (de) | Substituierte 1h-benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren | |
TW200621721A (en) | Methods of preparing indazole compounds | |
NO20072223L (no) | Glykogenfosforylaseinhibitor forbindelser med farmsoytiske preparater av disse | |
WO2007059008A3 (en) | N-substituted indenoisoquinolines and syntheses thereof | |
CY1113443T1 (el) | Παραγωγα πυριδαζινονης | |
NO20075849L (no) | Fremgangsmater og preparater til behandling eller forebygging av kreft | |
NO20076515L (no) | Hydantoinforbindelser |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |