EA200100492A1 - Улучшенная быстро диспергируемая таблетка - Google Patents
Улучшенная быстро диспергируемая таблеткаInfo
- Publication number
- EA200100492A1 EA200100492A1 EA200100492A EA200100492A EA200100492A1 EA 200100492 A1 EA200100492 A1 EA 200100492A1 EA 200100492 A EA200100492 A EA 200100492A EA 200100492 A EA200100492 A EA 200100492A EA 200100492 A1 EA200100492 A1 EA 200100492A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- fillers
- particles
- mixture
- tablet
- coated
- Prior art date
Links
- 239000000945 filler Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000000314 lubricant Substances 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000003086 colorant Substances 0.000 abstract 1
- 230000006835 compression Effects 0.000 abstract 1
- 238000007906 compression Methods 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000007884 disintegrant Substances 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000003094 microcapsule Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 210000003296 saliva Anatomy 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
Abstract
В заявке описана улучшенная таблетка, состоящая из микрокапсул, которая диспергируется во рту при контакте со слюной менее чем за 40 с. Изобретение характеризуется тем, что оно основано на использовании частиц действующего вещества, покрытых оболочкой, причем указанные частицы обладают свойством внутреннего сжатия, и смеси наполнителей, соотношение смеси наполнителей и частиц действующего вещества, покрытых оболочкой, составляет от 0,4 до 6 вес.ч., смесь наполнителей, включающая разрыхлитель, растворимый разбавитель со свойствами связующего, смазывающее вещество, агент, повышающий впитывание жидкости, и дополнительные смазывающие вещества, подслащивающие вещества, ароматизаторы и красители, причем содержание разрыхлителя и растворимого агента в пересчете на массу таблетки составляет от 1 до 15 мас.% для первого и от 30 до 90 мас.% для второго.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9814034A FR2785538B1 (fr) | 1998-11-06 | 1998-11-06 | Comprime a delitement rapide perfectionne |
PCT/FR1999/002681 WO2000027357A1 (fr) | 1998-11-06 | 1999-11-03 | Comprime a delitement rapide perfectionne |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200100492A1 true EA200100492A1 (ru) | 2001-12-24 |
EA004239B1 EA004239B1 (ru) | 2004-02-26 |
Family
ID=9532493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200100492A EA004239B1 (ru) | 1998-11-06 | 1999-11-03 | Улучшенная быстро диспергируемая таблетка |
Country Status (28)
Country | Link |
---|---|
US (2) | US7067149B1 (ru) |
EP (1) | EP1126821B1 (ru) |
JP (2) | JP2002529392A (ru) |
KR (1) | KR100630465B1 (ru) |
CN (1) | CN1154476C (ru) |
AT (1) | ATE293954T1 (ru) |
AU (1) | AU767703B2 (ru) |
BG (1) | BG65011B1 (ru) |
BR (1) | BR9915110A (ru) |
CA (1) | CA2350054C (ru) |
CZ (1) | CZ301589B6 (ru) |
DE (1) | DE69925016T2 (ru) |
DK (1) | DK1126821T3 (ru) |
EA (1) | EA004239B1 (ru) |
ES (1) | ES2241334T3 (ru) |
FR (1) | FR2785538B1 (ru) |
HK (1) | HK1039891B (ru) |
HU (1) | HU226590B1 (ru) |
IL (1) | IL142788A (ru) |
MX (1) | MXPA01004518A (ru) |
NZ (1) | NZ511480A (ru) |
PL (1) | PL194526B1 (ru) |
PT (1) | PT1126821E (ru) |
SI (1) | SI1126821T1 (ru) |
SK (1) | SK284645B6 (ru) |
TR (1) | TR200101224T2 (ru) |
WO (1) | WO2000027357A1 (ru) |
ZA (1) | ZA200103629B (ru) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2790387B1 (fr) | 1999-03-01 | 2001-05-18 | Prographarm Laboratoires | Comprime orodispersible presentant une faible friabilite et son procede de preparation |
DE10041478A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
FR2824477B1 (fr) * | 2001-05-09 | 2005-09-09 | Ethypharm Lab Prod Ethiques | Granules enrobes a base d'inhibiteur de l'enzyme de conversion de l'anfiotensine, leur procede de preparation et comprimes orodispersibles contenant les granules enrobes |
EP1279402B1 (en) * | 2001-07-26 | 2006-11-29 | Ethypharm | Coated granules of allylamine-or benzylamine-anti-mycotics, process for preparation thereof and orodispersible tablets containing said coated granules |
GB0123400D0 (en) | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
US6723348B2 (en) * | 2001-11-16 | 2004-04-20 | Ethypharm | Orodispersible tablets containing fexofenadine |
JP2005298338A (ja) * | 2002-02-27 | 2005-10-27 | Eisai Co Ltd | 速崩壊性圧縮成形製剤 |
GB0209265D0 (en) | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
DE10232020A1 (de) | 2002-07-04 | 2004-02-26 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Neurorezeptoraktive Heteroarencarboxamide |
DE10232113A1 (de) | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
CN100337628C (zh) * | 2002-08-07 | 2007-09-19 | 王登之 | 治疗痴呆症的尼莫地平口腔崩解片及其制备方法 |
JP5062871B2 (ja) * | 2003-05-13 | 2012-10-31 | 東和薬品株式会社 | 苦味を低減した口腔内崩壊錠剤 |
KR101125268B1 (ko) | 2003-06-06 | 2012-04-23 | 에띠팜 | 구강 분산성 다중층 정제 |
FR2855756B1 (fr) * | 2003-06-06 | 2005-08-26 | Ethypharm Sa | Comprime orodispersible multicouche |
CN100450470C (zh) * | 2003-06-28 | 2009-01-14 | 南昌弘益科技有限公司 | 口腔内快速崩解片剂及其制备方法 |
JP5062872B2 (ja) * | 2003-08-13 | 2012-10-31 | 東和薬品株式会社 | 不快な味を低減した口腔内崩壊錠剤 |
JP3841804B2 (ja) | 2003-10-15 | 2006-11-08 | 富士化学工業株式会社 | 口腔内速崩壊性錠剤用の組成物 |
US8349361B2 (en) | 2003-10-15 | 2013-01-08 | Fuji Chemical Industry Co., Ltd. | Composition for rapid disintegrating tablet in oral cavity |
CN100438914C (zh) * | 2003-10-15 | 2008-12-03 | 富士化学工业株式会社 | 用于口腔内快速崩解的片剂的组合物 |
DE10359528A1 (de) * | 2003-12-18 | 2005-07-28 | Schwarz Pharma Ag | (S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum |
EP1621187A1 (en) * | 2004-07-26 | 2006-02-01 | AstraZeneca AB | Pharmaceutical multiparticulate tablet formulations and process for their preparation |
CN1303989C (zh) * | 2004-10-25 | 2007-03-14 | 北京科信必成医药科技发展有限公司 | 葡萄糖酸锌口腔崩解片及其制备工艺 |
DE102005009240A1 (de) | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften |
TWI347942B (en) * | 2005-06-22 | 2011-09-01 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
WO2007072840A1 (ja) * | 2005-12-20 | 2007-06-28 | Eisai R & D Management Co., Ltd. | 脂溶性薬物を含有する口腔内速崩錠 |
WO2008006534A2 (en) * | 2006-07-11 | 2008-01-17 | Lek Pharmaceuticals D.D. | Multiple unit tablets |
US8465776B2 (en) | 2006-08-04 | 2013-06-18 | Ethypharm | Granule and orally disintegrating tablet comprising oxycodone |
WO2008015221A2 (en) | 2006-08-04 | 2008-02-07 | Ethypharm | Multilayer orally disintegrating tablet |
FR2910319B1 (fr) * | 2006-12-20 | 2011-06-03 | Substipharm Dev | Formulations pharmaceutiques dispersibles contenant de la fluoxetine |
AR058580A1 (es) | 2006-12-20 | 2008-02-13 | Makuc Ruben Antonio | Particulas solidas comprimibles , procedimientos para obtenerlas y procedimientos para utilizar las particulas solidas en tabletas o comprimidos para la higiene corporal |
WO2008089773A1 (fr) * | 2007-01-22 | 2008-07-31 | Crd Saidal | Formulation d'une matrice a desintegration rapide |
WO2008089772A1 (fr) * | 2007-01-22 | 2008-07-31 | Crd Saidal | Formulation d'un comprime orodispersible a base d'acide acetylsalicylique enrobe |
US20080181932A1 (en) * | 2007-01-30 | 2008-07-31 | Drugtech Corporation | Compositions for oral delivery of pharmaceuticals |
CA2617688C (en) * | 2007-02-22 | 2015-08-18 | Alpex Pharma S.A. | Solid dosage formulations containing weight-loss drugs |
BRPI0808889A2 (pt) * | 2007-03-13 | 2014-11-11 | Dainippon Sumitomo Pharma Co | Comprimido desintegrante oral |
JP5766899B2 (ja) * | 2007-04-11 | 2015-08-19 | ニプロ株式会社 | 口腔内崩壊剤及びその製造方法 |
KR101109633B1 (ko) * | 2007-08-03 | 2012-01-31 | 제이더블유중외제약 주식회사 | 활성성분의 코팅막이 보호되는 구강내붕해제형을 제조하기위한 조성물 |
FR2920311B1 (fr) * | 2007-08-31 | 2010-06-18 | Galenix Innovations | Composition solide, orodispersible et/ou dispersible, sans excipient a effet notoire et son procede de preparation |
JP2009114113A (ja) * | 2007-11-06 | 2009-05-28 | Nipro Corp | 口腔内崩壊錠及びその製造方法 |
DE102008014237A1 (de) * | 2008-03-14 | 2009-09-17 | J. Rettenmaier & Söhne Gmbh + Co. Kg | Direktverpressbares Tablettierhilfsmittel |
CA2725578A1 (en) * | 2008-04-24 | 2009-10-29 | Evestra, Inc. | Oral contraceptive dosage forms comprising a progestogen dispersed in an enteric polymer and further comprising an estrogen |
CA2750216A1 (en) * | 2008-12-15 | 2010-07-08 | Fleming And Company, Pharmaceuticals | Rapidly dissolving vitamin formulation and methods of using the same |
DK2238974T3 (da) | 2009-04-09 | 2013-08-26 | E Pharma Trento Spa | Granulat til formulering af smeltetabletter |
JPWO2010119490A1 (ja) * | 2009-04-14 | 2012-10-18 | パナソニック株式会社 | 立体映像表示装置 |
FR2962550B1 (fr) | 2010-07-06 | 2013-06-14 | Ethypharm Sa | Methode pour lutter contre la soumission chimique, utilisation d'agent colorant pour lutter contre la soumission chimique et composition pharmaceutique permettant la mise en oeuvre de la methode |
FR2962331B1 (fr) | 2010-07-06 | 2020-04-24 | Ethypharm | Forme pharmaceutique pour lutter contre la soumission chimique, methode la mettant en oeuvre |
CN102440971A (zh) * | 2010-10-15 | 2012-05-09 | 重庆市力扬医药开发有限公司 | 伊潘立酮口腔崩解片 |
WO2014189034A1 (ja) | 2013-05-21 | 2014-11-27 | 武田薬品工業株式会社 | 口腔内崩壊錠 |
JP6128160B2 (ja) * | 2015-05-07 | 2017-05-17 | ニプロ株式会社 | 口腔内崩壊錠の製造方法 |
CN106389339B (zh) * | 2015-08-12 | 2020-08-04 | 北京科信必成医药科技发展有限公司 | 一种阿司匹林无水吞服掩味颗粒及其制备方法 |
FR3055800B1 (fr) * | 2016-09-15 | 2020-06-26 | Unither Pharmaceuticals | Composition solide a ingestion rapide et deglutition facilitee, sous forme de particules solides non agglomerees, comprenant deux differents types de particules |
US10632076B2 (en) | 2016-11-18 | 2020-04-28 | Fertin Pharma A/S | Tablet comprising separate binder and erythritol |
US10543205B2 (en) | 2016-11-18 | 2020-01-28 | Fertin Pharma A/S | Oral delivery vehicle containing nicotine |
CA3002181C (en) * | 2017-04-18 | 2020-05-05 | Kashiv Pharma Llc | Food independent immediate release drug formulation with abuse deterrence and overdose protection |
US11096894B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Oral tablet for induced saliva generation |
US11135157B2 (en) | 2018-05-17 | 2021-10-05 | Fertin Pharma A/S | Oral tablet for delivery of active ingredients to the throat |
US11058641B2 (en) | 2018-05-17 | 2021-07-13 | Fertin Pharma A/S | Oral tablet for taste masking of active ingredients |
US20190350858A1 (en) | 2018-05-17 | 2019-11-21 | Fertin Pharma A/S | Oral tablet for delivery of active ingredients to the gastrointestinal tract |
US11052047B2 (en) | 2018-05-17 | 2021-07-06 | Fertin Pharma A/S | Oral tablet suitable for fast release of active pharmaceutical ingredients |
US11096896B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Tablet dosage form for buccal absorption of active ingredients |
US11090263B2 (en) | 2018-05-22 | 2021-08-17 | Fertin Pharma A/S | Tableted chewing gum suitable for active pharmaceutical ingredients |
US11058633B2 (en) * | 2018-05-17 | 2021-07-13 | Fertin Pharma A/S | Disintegrating oral tablet suitable for active pharmaceutical ingredients |
US11096895B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Oral tablet suitable for active pharmaceutical ingredients |
US10925853B2 (en) | 2019-04-17 | 2021-02-23 | Nordiccan A/S | Oral cannabinoid tablet |
FR3099881B1 (fr) * | 2019-08-13 | 2022-08-26 | Ethypharm Sa | Comprimé orodispersible d’opioide à faible dosage et son procédé de préparation. |
FR3095762A1 (fr) * | 2020-05-07 | 2020-11-13 | Unither Pharmaceuticals | Composition solide à ingestion rapide et déglutition facilitée, sous forme de particules solides non agglomérées, comprenant deux différents types de particules |
CN111759849B (zh) * | 2020-08-04 | 2021-10-01 | 重庆康刻尔制药股份有限公司 | 一种抗心绞痛的药物组合物及其制备方法和应用 |
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EP0272265B1 (de) * | 1985-09-25 | 1991-05-22 | Gergely, Gerhard, Dr. | Zerfallstablette und verfahren zu ihrer herstellung |
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EP0587744B1 (en) * | 1991-05-28 | 2003-07-16 | McNEIL-PPC, Inc. | Chewable drug-delivery composition |
FR2679451B1 (fr) * | 1991-07-22 | 1994-09-09 | Prographarm Laboratoires | Comprime multiparticulaire a delitement rapide. |
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CA2128820A1 (en) * | 1993-07-27 | 1995-01-28 | Walter G. Gowan, Jr. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
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CA2179382C (en) * | 1994-01-31 | 2009-11-10 | Takao Mizumoto | Intrabuccally dissolving compressed moldings and production process thereof |
US5567439A (en) * | 1994-06-14 | 1996-10-22 | Fuisz Technologies Ltd. | Delivery of controlled-release systems(s) |
US5994348A (en) * | 1995-06-07 | 1999-11-30 | Sanofi | Pharmaceutical compositions containing irbesartan |
EP0839526A3 (en) * | 1996-10-31 | 1999-01-07 | Takeda Chemical Industries, Ltd. | Solid pharmaceutical preparation with fast buccal disintegration or dissolution |
JPH10167958A (ja) * | 1996-12-09 | 1998-06-23 | Sankyo Co Ltd | ロキソプロフェンナトリウム類を含有する口腔内速溶性製剤及びその製造方法 |
FR2766089B1 (fr) | 1997-07-21 | 2000-06-02 | Prographarm Lab | Comprime multiparticulaire perfectionne a delitement rapide |
US5869098A (en) * | 1997-08-20 | 1999-02-09 | Fuisz Technologies Ltd. | Fast-dissolving comestible units formed under high-speed/high-pressure conditions |
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-
1998
- 1998-11-06 FR FR9814034A patent/FR2785538B1/fr not_active Expired - Lifetime
-
1999
- 1999-11-03 PL PL99347550A patent/PL194526B1/pl unknown
- 1999-11-03 CZ CZ20011433A patent/CZ301589B6/cs not_active IP Right Cessation
- 1999-11-03 PT PT99954046T patent/PT1126821E/pt unknown
- 1999-11-03 EP EP99954046A patent/EP1126821B1/fr not_active Expired - Lifetime
- 1999-11-03 JP JP2000580588A patent/JP2002529392A/ja active Pending
- 1999-11-03 AT AT99954046T patent/ATE293954T1/de active
- 1999-11-03 SK SK567-2001A patent/SK284645B6/sk not_active IP Right Cessation
- 1999-11-03 DE DE69925016T patent/DE69925016T2/de not_active Expired - Lifetime
- 1999-11-03 EA EA200100492A patent/EA004239B1/ru not_active IP Right Cessation
- 1999-11-03 MX MXPA01004518A patent/MXPA01004518A/es active IP Right Grant
- 1999-11-03 AU AU10507/00A patent/AU767703B2/en not_active Expired
- 1999-11-03 TR TR2001/01224T patent/TR200101224T2/xx unknown
- 1999-11-03 CA CA2350054A patent/CA2350054C/fr not_active Expired - Lifetime
- 1999-11-03 US US09/830,946 patent/US7067149B1/en not_active Expired - Lifetime
- 1999-11-03 DK DK99954046T patent/DK1126821T3/da active
- 1999-11-03 HU HU0104393A patent/HU226590B1/hu unknown
- 1999-11-03 CN CNB998138010A patent/CN1154476C/zh not_active Expired - Lifetime
- 1999-11-03 NZ NZ511480A patent/NZ511480A/en not_active IP Right Cessation
- 1999-11-03 SI SI9930794T patent/SI1126821T1/xx unknown
- 1999-11-03 BR BR9915110-3A patent/BR9915110A/pt not_active Application Discontinuation
- 1999-11-03 KR KR1020017005750A patent/KR100630465B1/ko active IP Right Grant
- 1999-11-03 WO PCT/FR1999/002681 patent/WO2000027357A1/fr active IP Right Grant
- 1999-11-03 ES ES99954046T patent/ES2241334T3/es not_active Expired - Lifetime
-
2001
- 2001-04-24 IL IL142788A patent/IL142788A/en not_active IP Right Cessation
- 2001-04-25 BG BG105475A patent/BG65011B1/bg unknown
- 2001-05-04 ZA ZA200103629A patent/ZA200103629B/xx unknown
-
2002
- 2002-02-01 HK HK02100788.4A patent/HK1039891B/zh not_active IP Right Cessation
-
2006
- 2006-03-06 US US11/368,767 patent/US7695735B2/en not_active Expired - Fee Related
-
2011
- 2011-09-12 JP JP2011198153A patent/JP2012001557A/ja active Pending
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