US7695735B2 - Fast disintegrating tablet - Google Patents
Fast disintegrating tablet Download PDFInfo
- Publication number
- US7695735B2 US7695735B2 US11/368,767 US36876706A US7695735B2 US 7695735 B2 US7695735 B2 US 7695735B2 US 36876706 A US36876706 A US 36876706A US 7695735 B2 US7695735 B2 US 7695735B2
- Authority
- US
- United States
- Prior art keywords
- weight
- tablet
- group
- agent
- mixtures
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related, expires
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
Definitions
- the invention relates to a rapidly disintegratable tablet of the type which disintegrates in the mouth in less than 40 seconds, said tablet comprising particles of coated active principle which have intrinsic compression characteristics, and a mixture of excipients.
- Ibuprofen, paracetamol and aspirin may be mentioned as examples of active principles which can be used to produce the tablets according to the invention.
- U.S. Pat. No. 5,215,755 describes chewing tablets in which the ibuprofen is present in the form of granules having a coating based on hydroxyethyl cellulose or a hydroxyethyl cellulose/hydroxypropyl methyl cellulose mixture.
- This coating was chosen to overcome the observed deficiencies of the coatings of the prior art based on ethyl cellulose only.
- the object of the invention is to provide tablets obtained with the aid of particles of coated active principle which not only disintegrate rapidly in the mouth in less than 40 seconds, but also have a pleasant palatability, together with satisfactory hardness characteristics enabling them to be manufactured industrially, and which keep sufficiently well under normal storage conditions to enable them to be handled by the patient, these tablets also optimizing the bioavailability of the active principle.
- the tablet according to the invention is characterized in that it is based on particles of coated active principle which have intrinsic compression characteristics, and on a mixture of excipients, the ratio of excipient mixture to coated active principle being 0.4 to 6 parts by weight, preferably 1 to 4 parts by weight, the mixture of excipients comprising:
- the soluble diluent agent with binding properties consists of a polyol having less than 13 carbon atoms and being either in the form of the directly compressible product with an average particle diameter of between 100 to 500 micrometers, or in the form of a powder with an average particle diameter of less than 100 micrometers, this polyol preferably being selected from the group comprising mannitol, xylitol, sorbitol and maltitol, it being impossible to use sorbitol alone.
- soluble diluent agents with binding properties are used, one is present in the form of the directly compressible product and the other, which can consist of the same polyol, is present in the form of a powder in which the average diameter of the constituent particles is less than 100 micrometers, the ratio of directly compressible polyol to powder polyol being 99/1 to 20/80, preferably 80/20 to 20/80.
- the disintegration agent is selected from the group comprising especially crosslinked sodium carboxymethyl cellulose (known in the profession as croscarmellose), crospovidone and mixtures thereof.
- croscarmellose crosslinked sodium carboxymethyl cellulose
- crospovidone crosslinked sodium carboxymethyl cellulose
- the tablet retains an acceptable hardness for normal handling conditions when tablets are kept in leaktight packaging up to temperatures of at least 30° C.
- the chosen proportions of disintegration agent and soluble agent for constituting the excipient are 1 to 15% by weight and 30 to 90% by weight, respectively, based in each case on the weight of the tablet.
- the lubricant preferably used in this mixture of excipients is selected from the group comprising magnesium stearate, sodium stearyl fumarate, stearic acid, micronized polyoxyethylene glycol (micronized Macrogol 6000) and mixtures thereof. It can be used in a proportion of 0.05 to 2%, based on the total weight of the tablet.
- the permeabilizing agent used is a compound selected from the group comprising especially silicas with a high affinity for aqueous solvents, such as the precipitated silica better known by the trade mark Sylo ⁇ d®, maltodextrins, ⁇ -cyclodextrins and mixtures thereof.
- the permeabilizing agent allows the creation of a hydrophilic network which facilitates the penetration of the saliva and hence assists the disintegration of the tablet.
- the permeabilizing agent is the precipitated silica better known by the trade mark Sylo ⁇ d® FP244.
- this silica not only assists the disintegration of the tablets, but also, through its properties as a flow promoter, favours the rearrangements of the particles during compression, and it makes it possible on the one hand to reduce the amount of hydrophobic lubricant needed to ensure optimum manufacturing conditions, and on the other hand to reduce the intensity of the compression force needed to produce a tablet which can be handled under these industrial conditions.
- the proportion of permeabilizing agent is between 0.5 and 5% by weight, based on the weight of the tablet.
- a sweetener and optionally a flavouring and a colour are also included in the mixture of excipients forming part of the composition of the tablets according to the invention.
- the sweetener can be selected from the group comprising especially aspartame, potassium acesulfame, sodium saccharinate, neohesperidin dihydrochalcone and mixtures thereof.
- flavourings and colouring are those conventionally used in pharmacy for the preparation of tablets.
- the tablets according to the invention have an improved palatability and particularly an improved taste and texture, and can allow a reduction in the ratio of tablet weight to active principal dose.
- hardnesses which satisfy these conditions are generally between 20 and 70 Newtons.
- the tablets according to the invention can be prepared in the following manner or by any other appropriate process. Particles of coated active principle which have intrinsic compression characteristics are added to a mixture of excipients containing a disintegration agent, a soluble diluent agent with binding properties, a permeabilizing agent and advantageously a lubricant, sweeteners, flavourings and colours, in the proportions indicated above.
- the mixture obtained in this way is homogenized in a dry mixer and then subjected to a compression force which gives the resulting tablet a satisfactory hardness, enabling it to be manufactured industrially and handled under normal conditions without special operating precautions; by way of indication, it is pointed out that hardnesses which satisfy these conditions are generally between 20 and 70 Newtons.
- Table I shows the unit formula and the centesimal formula of this tablet.
- This tablet is prepared as indicated below.
- excipients identified in Table I are sieved on a grid with a mesh size of 1000 ⁇ m.
- the different constituents are weighed in separate containers of appropriate capacity.
- coated ibuprofen particles having the formulation given in Table II below
- the granulated mannitol, the pulverulent mannitol, the croscarmellose, the aspartame, the potassium acesulfame, the precipitated silica and the flavorings are introduced into a rotating mixer.
- the homogeneous mixture is prepared.
- the mixer is stopped, the magnesium stearate is added and the mixing operation is continued for 1 to 5 min, according to the weight of the mixture.
- This disintegration time corresponds to the time between the moment when the tablet is placed in contact with the saliva in the mouth and the moment when the suspension resulting from the disintegration of the tablet in contact with the saliva is swallowed.
- Table III shows the unit formula and the centesimal formulation of this tablet.
- the tablets are prepared in the same way as in Example 1 with the aid of coated granules having the formula given in Table IV below.
- Table V shows the unit formula and the centesimal formula of this tablet.
- the tablets are prepared in the same way as in Example 1 with the aid of coated granules having the formula given in Table VI below.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Detergent Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
Description
-
- a disintegration agent;
- a soluble diluent agent with binding properties which consists of a polyol having less than 13 carbon atoms and being either in the form of the directly compressible product with an average particle diameter of 100 to 500 μm, or in the form of a powder with an average particle diameter of less than 100 μm, this polyol preferably being selected from the group comprising mannitol, xylitol, sorbitol and maltitol, it being understood that sorbitol cannot be used alone and that, in the case where there is only one soluble diluent agent with binding properties, it is used in the form of the directly compressible product, whereas in the case where there are at least two soluble diluent agents with binding properties, one is present in the directly compressible form and the other is present in powder form, it then being possible for the polyols to be the same, the ratio of directly compressible polyol to powder polyol being 99/1 to 20/80, preferably 80/20 to 20/80;
- a lubricant;
- a permeabilizing agent; and
- advantageously sweeteners, flavourings and colours,
the proportion of disintegrating agent being 1 to 15% by weight, preferably 2 to 7% by weight, and the proportion of soluble agent being 30 to 90% by weight, preferably 40 to 70% by weight, based in each case on the weight of the tablet.
TABLE I | ||
Constituents | Unit formula | Centesimal formula |
Coated ibuprofen granules | 261.70 | 37.24 | |
Granulated mannitol | 186.65 | 26.71 | |
Pulverulent mannitol | 186.65 | 26.76 | |
Croscarmellose | 21.00 | 3.00 | |
Precipitated silica | 7.00 | 1.00 | |
Aspartame | 9.60 | 1.37 | |
Potassium acesulfame | 6.40 | 0.91 | |
Lemon flavoring | 16.00 | 2.29 | |
Mint flavoring | 2.00 | 0.29 | |
Magnesium stearate | 3.00 | 0.43 | |
700.00 | mg | 100.00 | |
-
- average weight of between 665 mg and 735 mg;
- breaking strength of between 20 and 50 N; and
- average disintegration time in the mouth of less than 40 seconds.
TABLE II |
Formula of coated ibuprofen granules |
Ibuprofen | 200.00 | |||
Ethyl cellulose | 40.00 | |||
Precipitated silica | 13.70 | |||
Hydroxypropyl methyl cellulose | 8.0 | |||
261.70 | mg | |||
TABLE III | ||||
Constituents | Unit formula | Centesimal formula | ||
Coated aspirin granules | 564.00 | 40.26 | |||
Granulated mannitol | 333.00 | 23.77 | |||
Pulverulent mannitol | 333.00 | 23.77 | |||
Crospovidone | 120.00 | 8.57 | |||
Precipitated silica | 14.00 | 1.00 | |||
Aspartame | 14.40 | 1.03 | |||
Potassium acesulfame | 9.60 | 0.69 | |||
Lemon flavoring | 5.00 | 0.36 | |||
Sodium stearyl fumarate | 7.00 | 0.50 | |||
1400.00 | mg | 99.928622 | |||
TABLE IV |
Formula of coated aspirin granules |
Aspirin | 500.0 | |||
Ethyl cellulose | 50.0 | |||
Hydroxypropyl methyl cellulose | 10.0 | |||
Colloidal silica | 4.0 | |||
564.0 | mg | |||
TABLE V | ||
Constituents | Unit formula | Centesimal formula |
Coated paracetamol granules | 566.50 | 40.44 | |
Granulated mannitol | 331.30 | 23.65 | |
Pulverulent mannitol | 331.30 | 23.65 | |
Crospovidone | 120.00 | 8.57 | |
Precipitated silica | 14.00 | 1.00 | |
Aspartame | 19.20 | 1.37 | |
Potassium acesulfame | 12.80 | 0.91 | |
Blackcurrant flavoring | 5.00 | 0.36 | |
Magnesium stearate | 0.90 | 0.06 | |
1401.00 | mg | 100.00 | |
TABLE VI |
Formula of coated paracetamol granules |
Paracetamol | 500.00 | |||
30% dispersion of poly(ethyl acrylate/ | ||||
methyl methacrylate) | 17.0 | |||
Aminoalkyl methacrylate copolymer | 33.0 | |||
Precipitated silica | 16.5 | |||
566.5 | mg | |||
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/368,767 US7695735B2 (en) | 1998-11-06 | 2006-03-06 | Fast disintegrating tablet |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9814034 | 1998-11-06 | ||
FR98/14034 | 1998-11-06 | ||
FR9814034A FR2785538B1 (en) | 1998-11-06 | 1998-11-06 | PERFECTED QUICK DELIVERY TABLET |
PCT/FR1999/002681 WO2000027357A1 (en) | 1998-11-06 | 1999-11-03 | Improved fast disintegrating tablet |
US09/830,946 US7067149B1 (en) | 1998-11-06 | 1999-11-03 | Fast disintegrating tablet |
US11/368,767 US7695735B2 (en) | 1998-11-06 | 2006-03-06 | Fast disintegrating tablet |
Related Parent Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09830946 Continuation | 1999-11-03 | ||
US09/830,946 Continuation US7067149B1 (en) | 1998-11-06 | 1999-11-03 | Fast disintegrating tablet |
PCT/FR1999/002681 Continuation WO2000027357A1 (en) | 1998-11-06 | 1999-11-03 | Improved fast disintegrating tablet |
Publications (2)
Publication Number | Publication Date |
---|---|
US20060177508A1 US20060177508A1 (en) | 2006-08-10 |
US7695735B2 true US7695735B2 (en) | 2010-04-13 |
Family
ID=9532493
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/830,946 Expired - Lifetime US7067149B1 (en) | 1998-11-06 | 1999-11-03 | Fast disintegrating tablet |
US11/368,767 Expired - Fee Related US7695735B2 (en) | 1998-11-06 | 2006-03-06 | Fast disintegrating tablet |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/830,946 Expired - Lifetime US7067149B1 (en) | 1998-11-06 | 1999-11-03 | Fast disintegrating tablet |
Country Status (28)
Country | Link |
---|---|
US (2) | US7067149B1 (en) |
EP (1) | EP1126821B1 (en) |
JP (2) | JP2002529392A (en) |
KR (1) | KR100630465B1 (en) |
CN (1) | CN1154476C (en) |
AT (1) | ATE293954T1 (en) |
AU (1) | AU767703B2 (en) |
BG (1) | BG65011B1 (en) |
BR (1) | BR9915110A (en) |
CA (1) | CA2350054C (en) |
CZ (1) | CZ301589B6 (en) |
DE (1) | DE69925016T2 (en) |
DK (1) | DK1126821T3 (en) |
EA (1) | EA004239B1 (en) |
ES (1) | ES2241334T3 (en) |
FR (1) | FR2785538B1 (en) |
HK (1) | HK1039891B (en) |
HU (1) | HU226590B1 (en) |
IL (1) | IL142788A (en) |
MX (1) | MXPA01004518A (en) |
NZ (1) | NZ511480A (en) |
PL (1) | PL194526B1 (en) |
PT (1) | PT1126821E (en) |
SI (1) | SI1126821T1 (en) |
SK (1) | SK284645B6 (en) |
TR (1) | TR200101224T2 (en) |
WO (1) | WO2000027357A1 (en) |
ZA (1) | ZA200103629B (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070197480A1 (en) * | 2003-12-18 | 2007-08-23 | Srz Properties, Inc. | (S)-2-N-Propylamino-5-Hydroxytetralin As A D3-Agonist |
US20100259603A1 (en) * | 2009-04-14 | 2010-10-14 | Kazuhiro Mihara | Video display apparatus, video viewing glasses, and system comprising the display apparatus and the glasses |
US8613950B2 (en) | 2005-03-01 | 2013-12-24 | Bayer Intellectual Property Gmbh | Pharmaceutical forms with improved pharmacokinetic properties |
US8841446B2 (en) | 2002-07-16 | 2014-09-23 | Bayer Intellectual Property Gmbh | Medicaments containing vardenafil hydrochloride trihydrate |
US9011911B2 (en) | 2002-04-23 | 2015-04-21 | Novartis Ag | High drug load tablet |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2790387B1 (en) | 1999-03-01 | 2001-05-18 | Prographarm Laboratoires | ORODISPERSIBLE TABLET HAVING LOW FRIABILITY AND PROCESS FOR THE PREPARATION THEREOF |
DE10041478A1 (en) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | New pharmaceutical composition |
FR2824477B1 (en) * | 2001-05-09 | 2005-09-09 | Ethypharm Lab Prod Ethiques | ENVELOPED GRANULES BASED ON INHIBITOR OF THE ANFIOTENSIN CONVERTING ENZYME, PROCESS FOR THEIR PREPARATION AND ORODISPERSIBLE TABLETS CONTAINING COATED GRANULES |
ATE346590T1 (en) * | 2001-07-26 | 2006-12-15 | Ethypharm Sa | COATED ALLYLAMINES OR BENZYLAMINES CONTAINING GRANULES, METHOD FOR THE PRODUCTION AND ORAL DISPERSIBLE TABLETS CONTAINING THE COATED GRANULES |
GB0123400D0 (en) | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
US6723348B2 (en) * | 2001-11-16 | 2004-04-20 | Ethypharm | Orodispersible tablets containing fexofenadine |
JP2005298338A (en) * | 2002-02-27 | 2005-10-27 | Eisai Co Ltd | Quickly disintegrating compression-molded preparation |
DE10232020A1 (en) | 2002-07-04 | 2004-02-26 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Neuroreceptor-active heteroarenecarboxamides |
CN100337628C (en) * | 2002-08-07 | 2007-09-19 | 王登之 | Nimodipine oral disintegrant tablet for curing dementia and its preparation method |
JP5062871B2 (en) * | 2003-05-13 | 2012-10-31 | 東和薬品株式会社 | Orally disintegrating tablets with reduced bitterness |
FR2855756B1 (en) * | 2003-06-06 | 2005-08-26 | Ethypharm Sa | MULTILAYER ORODISPERSIBLE TABLET |
MXPA05013202A (en) * | 2003-06-06 | 2006-03-09 | Ethypharm Sa | Orally-dispersible multilayer tablet. |
CN100450470C (en) * | 2003-06-28 | 2009-01-14 | 南昌弘益科技有限公司 | Rapid disintegrate tablet in oral and its preparation method |
JP5062872B2 (en) * | 2003-08-13 | 2012-10-31 | 東和薬品株式会社 | Orally disintegrating tablets with reduced unpleasant taste |
US8349361B2 (en) | 2003-10-15 | 2013-01-08 | Fuji Chemical Industry Co., Ltd. | Composition for rapid disintegrating tablet in oral cavity |
JP3841804B2 (en) | 2003-10-15 | 2006-11-08 | 富士化学工業株式会社 | Composition for intraorally rapidly disintegrating tablets |
CN100438914C (en) * | 2003-10-15 | 2008-12-03 | 富士化学工业株式会社 | Tablet quickly disintegrating in oral cavity |
EP1621187A1 (en) * | 2004-07-26 | 2006-02-01 | AstraZeneca AB | Pharmaceutical multiparticulate tablet formulations and process for their preparation |
CN1303989C (en) * | 2004-10-25 | 2007-03-14 | 北京科信必成医药科技发展有限公司 | Zinc gluconate oral disintegrating tablet and its preparation process |
TWI358407B (en) * | 2005-06-22 | 2012-02-21 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersibl |
JPWO2007072840A1 (en) * | 2005-12-20 | 2009-05-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Oral rapidly disintegrating tablets containing fat-soluble drugs |
US20090291136A1 (en) * | 2006-07-11 | 2009-11-26 | Lek Pharmaceuticals D.D. | Multiple Unit Tablets |
EA017832B1 (en) | 2006-08-04 | 2013-03-29 | Этифарм | Granule and orally disintegrating tablet comprising oxycodone |
AU2007280471B2 (en) | 2006-08-04 | 2012-10-18 | Ethypharm | Multilayer orally disintegrating tablet |
FR2910319B1 (en) | 2006-12-20 | 2011-06-03 | Substipharm Dev | DISPERSIBLE PHARMACEUTICAL FORMULATIONS CONTAINING FLUOXETINE |
AR058580A1 (en) | 2006-12-20 | 2008-02-13 | Makuc Ruben Antonio | COMPRIMIBLE SOLID PARTICLES, PROCEDURES FOR OBTAINING THEM AND PROCEDURES TO USE SOLID PARTICLES IN TABLETS OR COMPRESSED FOR BODY HYGIENE |
WO2008089773A1 (en) * | 2007-01-22 | 2008-07-31 | Crd Saidal | Formulation of a rapidly disintegrating matrix |
WO2008089772A1 (en) * | 2007-01-22 | 2008-07-31 | Crd Saidal | Formulation of an orodispersible coated tablet containing acetylsalicylic acid |
WO2008094877A2 (en) * | 2007-01-30 | 2008-08-07 | Drugtech Corporation | Compositions for oral delivery of pharmaceuticals |
CA2617688C (en) * | 2007-02-22 | 2015-08-18 | Alpex Pharma S.A. | Solid dosage formulations containing weight-loss drugs |
KR20090119993A (en) * | 2007-03-13 | 2009-11-23 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | Oral disintegrating tablet |
JP5766899B2 (en) * | 2007-04-11 | 2015-08-19 | ニプロ株式会社 | Oral disintegrant and method for producing the same |
KR101109633B1 (en) * | 2007-08-03 | 2012-01-31 | 제이더블유중외제약 주식회사 | Composition for manufacturing orally disintegrating dosage forms, for protecting the coating of active substance |
FR2920311B1 (en) * | 2007-08-31 | 2010-06-18 | Galenix Innovations | SOLID COMPOSITION, ORODISPERSIBLE AND / OR DISPERSIBLE, WITHOUT A KNOWLEDGE EXCIPIENT AND PROCESS FOR PREPARING THE SAME |
JP2009114113A (en) * | 2007-11-06 | 2009-05-28 | Nipro Corp | Intraorally disintegrable tablet and method for producing the same |
DE102008014237A1 (en) * | 2008-03-14 | 2009-09-17 | J. Rettenmaier & Söhne Gmbh + Co. Kg | Directly compressible tableting aid |
US20090269403A1 (en) * | 2008-04-24 | 2009-10-29 | Shaked Ze Ev | Oral contraceptive dosage forms and methods of making such dosage forms |
WO2010077878A1 (en) * | 2008-12-15 | 2010-07-08 | Fleming And Company, Pharmaceuticals | Rapidly dissolving vitamin formulation and methods of using the same |
ES2422281T3 (en) | 2009-04-09 | 2013-09-10 | E Pharma Trento Spa | Granules for the formulation of orodispersible tablets |
FR2962331B1 (en) | 2010-07-06 | 2020-04-24 | Ethypharm | PHARMACEUTICAL FORM FOR COMBATING CHEMICAL SUBMISSION, METHOD USING THE SAME |
FR2962550B1 (en) | 2010-07-06 | 2013-06-14 | Ethypharm Sa | METHOD FOR CONTROLLING CHEMICAL SUBMISSION, USE OF COLORING AGENT FOR COMBATING CHEMICAL SUBMISSION AND PHARMACEUTICAL COMPOSITION FOR THE IMPLEMENTATION OF THE METHOD |
CN102440971A (en) * | 2010-10-15 | 2012-05-09 | 重庆市力扬医药开发有限公司 | Iloperidone orally disintegrating tablet |
KR20160010595A (en) | 2013-05-21 | 2016-01-27 | 다케다 야쿠힌 고교 가부시키가이샤 | Orally disintegrable tablet |
JP6128160B2 (en) * | 2015-05-07 | 2017-05-17 | ニプロ株式会社 | Method for producing orally disintegrating tablets |
CN106389339B (en) * | 2015-08-12 | 2020-08-04 | 北京科信必成医药科技发展有限公司 | Aspirin taste-masking granule capable of being swallowed without water and preparation method thereof |
FR3055800B1 (en) * | 2016-09-15 | 2020-06-26 | Unither Pharmaceuticals | SOLID COMPOSITION WITH FAST INGESTION AND EASY SWALLOWING, IN THE FORM OF NON-AGGLOMERATED SOLID PARTICLES, COMPRISING TWO DIFFERENT TYPES OF PARTICLES |
US10543205B2 (en) | 2016-11-18 | 2020-01-28 | Fertin Pharma A/S | Oral delivery vehicle containing nicotine |
US10632076B2 (en) | 2016-11-18 | 2020-04-28 | Fertin Pharma A/S | Tablet comprising separate binder and erythritol |
US20180296486A1 (en) * | 2017-04-18 | 2018-10-18 | Kashiv Pharma, Llc | Food independent immediate release drug formulation with abuse deterrence and overdose protection |
US11090263B2 (en) | 2018-05-22 | 2021-08-17 | Fertin Pharma A/S | Tableted chewing gum suitable for active pharmaceutical ingredients |
US20190350858A1 (en) | 2018-05-17 | 2019-11-21 | Fertin Pharma A/S | Oral tablet for delivery of active ingredients to the gastrointestinal tract |
US11096896B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Tablet dosage form for buccal absorption of active ingredients |
US11052047B2 (en) | 2018-05-17 | 2021-07-06 | Fertin Pharma A/S | Oral tablet suitable for fast release of active pharmaceutical ingredients |
US11135157B2 (en) | 2018-05-17 | 2021-10-05 | Fertin Pharma A/S | Oral tablet for delivery of active ingredients to the throat |
US11096894B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Oral tablet for induced saliva generation |
US11058641B2 (en) | 2018-05-17 | 2021-07-13 | Fertin Pharma A/S | Oral tablet for taste masking of active ingredients |
US11096895B2 (en) | 2018-05-17 | 2021-08-24 | Fertin Pharma A/S | Oral tablet suitable for active pharmaceutical ingredients |
US11058633B2 (en) * | 2018-05-17 | 2021-07-13 | Fertin Pharma A/S | Disintegrating oral tablet suitable for active pharmaceutical ingredients |
US10925853B2 (en) | 2019-04-17 | 2021-02-23 | Nordiccan A/S | Oral cannabinoid tablet |
FR3099881B1 (en) * | 2019-08-13 | 2022-08-26 | Ethypharm Sa | Low dosage opioid orodispersible tablet and process for its preparation. |
FR3095762A1 (en) * | 2020-05-07 | 2020-11-13 | Unither Pharmaceuticals | Solid composition for rapid ingestion and easy swallowing, in the form of non-agglomerated solid particles, comprising two different types of particles |
CN111759849B (en) * | 2020-08-04 | 2021-10-01 | 重庆康刻尔制药股份有限公司 | Anti-angina pectoris pharmaceutical composition and preparation method and application thereof |
Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989002266A1 (en) | 1987-09-17 | 1989-03-23 | Mallinckrodt, Inc. | A free-flowing granular composition containing ibuprofen and a method for its preparation |
US4832956A (en) | 1985-09-25 | 1989-05-23 | Gerhard Gergely | Disintegrating tablet and process for its preparation |
WO1991015194A1 (en) | 1990-04-11 | 1991-10-17 | The Upjohn Company | Taste masking of ibuprofen by fluid bed coating |
US5064656A (en) | 1989-11-14 | 1991-11-12 | Dr. Gergely & Co. | Uncoated pharmaceutical reaction tablet |
US5084278A (en) | 1989-06-02 | 1992-01-28 | Nortec Development Associates, Inc. | Taste-masked pharmaceutical compositions |
WO1993001805A1 (en) | 1991-07-22 | 1993-02-04 | Laboratoires Prographarm | Rapidly disintegratable multiparticulate tablet |
US5215755A (en) | 1989-08-04 | 1993-06-01 | Mcneil-Ppc, Inc. | Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets |
US5320848A (en) | 1991-05-28 | 1994-06-14 | Affinity Biotech, Inc. | Chewable drug-delivery composition |
US5567439A (en) | 1994-06-14 | 1996-10-22 | Fuisz Technologies Ltd. | Delivery of controlled-release systems(s) |
EP0745382A1 (en) | 1994-01-31 | 1996-12-04 | Yamanouchi Pharmaceutical Co. Ltd. | Intraorally soluble compressed molding and process for producing the same |
US5814332A (en) | 1993-08-13 | 1998-09-29 | Eurand America, Inc. | Procedure for encapsulating ibuprofen |
US5869098A (en) * | 1997-08-20 | 1999-02-09 | Fuisz Technologies Ltd. | Fast-dissolving comestible units formed under high-speed/high-pressure conditions |
US5876759A (en) * | 1993-07-27 | 1999-03-02 | Mcneil-Ppc, Inc. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
US5958453A (en) * | 1996-10-31 | 1999-09-28 | Takeda Chemical Industries, Ltd. | Solid pharmaceutical preparation with improved buccal disintegrability and/or dissolubility |
US5994348A (en) | 1995-06-07 | 1999-11-30 | Sanofi | Pharmaceutical compositions containing irbesartan |
US6099865A (en) | 1998-07-08 | 2000-08-08 | Fmc Corporation | Croscarmellose taste masking |
US6106861A (en) | 1997-07-21 | 2000-08-22 | Laboratoires Prographarm | Multiparticulate tablet disintegrating in less than 40 seconds in the mouth |
US6465009B1 (en) | 1998-03-18 | 2002-10-15 | Yamanouchi Pharmaceutical Co., Ltd. | Water soluble polymer-based rapidly dissolving tablets and production processes thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5324848A (en) * | 1993-03-11 | 1994-06-28 | Nec Research Institute, Inc. | Vanadium phosphate materials |
JPH10167958A (en) * | 1996-12-09 | 1998-06-23 | Sankyo Co Ltd | Loxoprofen sodium-containing oral cavity promptly soluble preparation and its production |
-
1998
- 1998-11-06 FR FR9814034A patent/FR2785538B1/en not_active Expired - Lifetime
-
1999
- 1999-11-03 SI SI9930794T patent/SI1126821T1/en unknown
- 1999-11-03 PL PL99347550A patent/PL194526B1/en unknown
- 1999-11-03 CA CA2350054A patent/CA2350054C/en not_active Expired - Lifetime
- 1999-11-03 DE DE69925016T patent/DE69925016T2/en not_active Expired - Lifetime
- 1999-11-03 JP JP2000580588A patent/JP2002529392A/en active Pending
- 1999-11-03 WO PCT/FR1999/002681 patent/WO2000027357A1/en active IP Right Grant
- 1999-11-03 AU AU10507/00A patent/AU767703B2/en not_active Expired
- 1999-11-03 EP EP99954046A patent/EP1126821B1/en not_active Expired - Lifetime
- 1999-11-03 CZ CZ20011433A patent/CZ301589B6/en not_active IP Right Cessation
- 1999-11-03 ES ES99954046T patent/ES2241334T3/en not_active Expired - Lifetime
- 1999-11-03 KR KR1020017005750A patent/KR100630465B1/en active IP Right Grant
- 1999-11-03 US US09/830,946 patent/US7067149B1/en not_active Expired - Lifetime
- 1999-11-03 BR BR9915110-3A patent/BR9915110A/en not_active Application Discontinuation
- 1999-11-03 CN CNB998138010A patent/CN1154476C/en not_active Expired - Lifetime
- 1999-11-03 SK SK567-2001A patent/SK284645B6/en not_active IP Right Cessation
- 1999-11-03 DK DK99954046T patent/DK1126821T3/en active
- 1999-11-03 MX MXPA01004518A patent/MXPA01004518A/en active IP Right Grant
- 1999-11-03 AT AT99954046T patent/ATE293954T1/en active
- 1999-11-03 EA EA200100492A patent/EA004239B1/en not_active IP Right Cessation
- 1999-11-03 PT PT99954046T patent/PT1126821E/en unknown
- 1999-11-03 TR TR2001/01224T patent/TR200101224T2/en unknown
- 1999-11-03 HU HU0104393A patent/HU226590B1/en unknown
- 1999-11-03 NZ NZ511480A patent/NZ511480A/en not_active IP Right Cessation
-
2001
- 2001-04-24 IL IL142788A patent/IL142788A/en not_active IP Right Cessation
- 2001-04-25 BG BG105475A patent/BG65011B1/en unknown
- 2001-05-04 ZA ZA200103629A patent/ZA200103629B/en unknown
-
2002
- 2002-02-01 HK HK02100788.4A patent/HK1039891B/en not_active IP Right Cessation
-
2006
- 2006-03-06 US US11/368,767 patent/US7695735B2/en not_active Expired - Fee Related
-
2011
- 2011-09-12 JP JP2011198153A patent/JP2012001557A/en active Pending
Patent Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4832956A (en) | 1985-09-25 | 1989-05-23 | Gerhard Gergely | Disintegrating tablet and process for its preparation |
WO1989002266A1 (en) | 1987-09-17 | 1989-03-23 | Mallinckrodt, Inc. | A free-flowing granular composition containing ibuprofen and a method for its preparation |
US5084278A (en) | 1989-06-02 | 1992-01-28 | Nortec Development Associates, Inc. | Taste-masked pharmaceutical compositions |
US5215755A (en) | 1989-08-04 | 1993-06-01 | Mcneil-Ppc, Inc. | Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets |
US5064656A (en) | 1989-11-14 | 1991-11-12 | Dr. Gergely & Co. | Uncoated pharmaceutical reaction tablet |
WO1991015194A1 (en) | 1990-04-11 | 1991-10-17 | The Upjohn Company | Taste masking of ibuprofen by fluid bed coating |
US5320848A (en) | 1991-05-28 | 1994-06-14 | Affinity Biotech, Inc. | Chewable drug-delivery composition |
WO1993001805A1 (en) | 1991-07-22 | 1993-02-04 | Laboratoires Prographarm | Rapidly disintegratable multiparticulate tablet |
US5876759A (en) * | 1993-07-27 | 1999-03-02 | Mcneil-Ppc, Inc. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
US5814332A (en) | 1993-08-13 | 1998-09-29 | Eurand America, Inc. | Procedure for encapsulating ibuprofen |
EP0745382A1 (en) | 1994-01-31 | 1996-12-04 | Yamanouchi Pharmaceutical Co. Ltd. | Intraorally soluble compressed molding and process for producing the same |
US5567439A (en) | 1994-06-14 | 1996-10-22 | Fuisz Technologies Ltd. | Delivery of controlled-release systems(s) |
US5994348A (en) | 1995-06-07 | 1999-11-30 | Sanofi | Pharmaceutical compositions containing irbesartan |
US5958453A (en) * | 1996-10-31 | 1999-09-28 | Takeda Chemical Industries, Ltd. | Solid pharmaceutical preparation with improved buccal disintegrability and/or dissolubility |
US6106861A (en) | 1997-07-21 | 2000-08-22 | Laboratoires Prographarm | Multiparticulate tablet disintegrating in less than 40 seconds in the mouth |
US5869098A (en) * | 1997-08-20 | 1999-02-09 | Fuisz Technologies Ltd. | Fast-dissolving comestible units formed under high-speed/high-pressure conditions |
US6465009B1 (en) | 1998-03-18 | 2002-10-15 | Yamanouchi Pharmaceutical Co., Ltd. | Water soluble polymer-based rapidly dissolving tablets and production processes thereof |
US6099865A (en) | 1998-07-08 | 2000-08-08 | Fmc Corporation | Croscarmellose taste masking |
Non-Patent Citations (1)
Title |
---|
Khattab, et al., "Effect of Mode of Incorporation of Disintegrants on the Characteristics of Fluid-bed Wet-granulated Tablets", J. Pharm. Pharmacol., vol. 45, pp. 687-691 (1993). |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9011911B2 (en) | 2002-04-23 | 2015-04-21 | Novartis Ag | High drug load tablet |
US8841446B2 (en) | 2002-07-16 | 2014-09-23 | Bayer Intellectual Property Gmbh | Medicaments containing vardenafil hydrochloride trihydrate |
US20070197480A1 (en) * | 2003-12-18 | 2007-08-23 | Srz Properties, Inc. | (S)-2-N-Propylamino-5-Hydroxytetralin As A D3-Agonist |
US8609641B2 (en) | 2003-12-18 | 2013-12-17 | Ucb Pharma Gmbh | (S)-2-N-propylamino-5-hydroxytetralin as a D3-agonist |
US9108900B2 (en) | 2003-12-18 | 2015-08-18 | Ucb Pharma Gmbh | Method of treating diseases that respond to therapy by dopamine or dopamine agonists |
US8613950B2 (en) | 2005-03-01 | 2013-12-24 | Bayer Intellectual Property Gmbh | Pharmaceutical forms with improved pharmacokinetic properties |
US20100259603A1 (en) * | 2009-04-14 | 2010-10-14 | Kazuhiro Mihara | Video display apparatus, video viewing glasses, and system comprising the display apparatus and the glasses |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7695735B2 (en) | Fast disintegrating tablet | |
EP1058538B2 (en) | Fast disintegrating tablets | |
JP6764959B2 (en) | Pharmaceutical composition | |
JP4947833B2 (en) | Process for producing granules suitable for the production of fast disintegrating oral dissolving tablets | |
EP1145711B1 (en) | Flash-melt oral dosage formulation | |
US8377472B1 (en) | Orally dispersible tablet with low friability and method for preparing same | |
WO2007050631A2 (en) | Dosage form with coated active | |
JP4719899B2 (en) | Orally rapidly disintegrating tablets | |
WO2004089343A1 (en) | Water soluble tablets | |
US20220296507A1 (en) | Low-dosage orodispersible opioid tablet and method for preparing same | |
SI9200080A (en) | Pharmaceutical preparations containing compressed medicaments granules |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: ETHYPHARM,FRANCE Free format text: CHANGE OF NAME;ASSIGNOR:LABORATOIRES DES PRODUITS ETHIQUES ETHYPHARM;REEL/FRAME:018536/0214 Effective date: 20010711 Owner name: LABORATOIRES DES PRODUITS ETHIQUES ETHYPHARM S.A., Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:CHAUVEAU, CHARLES;ZUCCARELLI, JEAN-MARC;NOURI, NOURREDINE;AND OTHERS;REEL/FRAME:018536/0182 Effective date: 20010419 Owner name: ETHYPHARM, FRANCE Free format text: CHANGE OF NAME;ASSIGNOR:LABORATOIRES DES PRODUITS ETHIQUES ETHYPHARM;REEL/FRAME:018536/0214 Effective date: 20010711 |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
FPAY | Fee payment |
Year of fee payment: 4 |
|
MAFP | Maintenance fee payment |
Free format text: PAYMENT OF MAINTENANCE FEE, 8TH YEAR, LARGE ENTITY (ORIGINAL EVENT CODE: M1552) Year of fee payment: 8 |
|
FEPP | Fee payment procedure |
Free format text: MAINTENANCE FEE REMINDER MAILED (ORIGINAL EVENT CODE: REM.); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
LAPS | Lapse for failure to pay maintenance fees |
Free format text: PATENT EXPIRED FOR FAILURE TO PAY MAINTENANCE FEES (ORIGINAL EVENT CODE: EXP.); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
STCH | Information on status: patent discontinuation |
Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
|
FP | Lapsed due to failure to pay maintenance fee |
Effective date: 20220413 |