EA200100362A1 - Способы лечения множественной миеломы и индуцированной миеломой резорбции костей с помощью антагонистов интегрина - Google Patents

Способы лечения множественной миеломы и индуцированной миеломой резорбции костей с помощью антагонистов интегрина

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Publication number
EA200100362A1
EA200100362A1 EA200100362A EA200100362A EA200100362A1 EA 200100362 A1 EA200100362 A1 EA 200100362A1 EA 200100362 A EA200100362 A EA 200100362A EA 200100362 A EA200100362 A EA 200100362A EA 200100362 A1 EA200100362 A1 EA 200100362A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antagonists
multiple myeloma
methods
myelous
integrines
Prior art date
Application number
EA200100362A
Other languages
English (en)
Other versions
EA004270B1 (ru
Inventor
Грегори Р. Манди
Тосиюки Йонеда
Original Assignee
Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем filed Critical Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем
Publication of EA200100362A1 publication Critical patent/EA200100362A1/ru
Publication of EA004270B1 publication Critical patent/EA004270B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2836—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD106
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70542—CD106
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Описаны антагонисты адгезии альфа4 интегрин/лиганд альфа4 интегрина, которые ингибируют биологические эффекты такой адгезии, а также подробно представлены способы их применения. Указанные антагонисты пригодны для подавления деструкции костей, связанной со множественной миеломой. Заселение костного мозга клетками множественной миеломы и альфа4 интегринзависимое высвобождение ими факторов резорбции костей, приводящее к деструкции костей, ингибируются.Отчет о международном поиске был опубликован 2000.05.25.
EA200100362A 1998-09-14 1999-09-13 Способы лечения множественной миеломы и индуцированной миеломой резорбции костей с помощью антагонистов интегрина EA004270B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10018298P 1998-09-14 1998-09-14
PCT/US1999/021170 WO2000015247A2 (en) 1998-09-14 1999-09-13 Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists

Publications (2)

Publication Number Publication Date
EA200100362A1 true EA200100362A1 (ru) 2001-12-24
EA004270B1 EA004270B1 (ru) 2004-02-26

Family

ID=22278506

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100362A EA004270B1 (ru) 1998-09-14 1999-09-13 Способы лечения множественной миеломы и индуцированной миеломой резорбции костей с помощью антагонистов интегрина

Country Status (29)

Country Link
US (1) US7211252B2 (ru)
EP (2) EP1113810B1 (ru)
JP (3) JP2002524529A (ru)
KR (1) KR100628818B1 (ru)
CN (1) CN1236815C (ru)
AT (1) ATE418999T1 (ru)
AU (1) AU757873B2 (ru)
BR (1) BR9913705A (ru)
CA (1) CA2343579C (ru)
CY (1) CY1109413T1 (ru)
CZ (1) CZ302997B6 (ru)
DE (1) DE69940206D1 (ru)
DK (1) DK1113810T3 (ru)
EA (1) EA004270B1 (ru)
EE (1) EE05558B1 (ru)
ES (1) ES2319831T3 (ru)
HK (1) HK1038313A1 (ru)
HU (1) HU229038B1 (ru)
IL (2) IL141877A0 (ru)
IS (1) IS2631B (ru)
NO (2) NO327855B1 (ru)
NZ (1) NZ511062A (ru)
PL (1) PL203114B1 (ru)
PT (1) PT1113810E (ru)
SI (1) SI1113810T1 (ru)
SK (1) SK287601B6 (ru)
TR (1) TR200100734T2 (ru)
WO (1) WO2000015247A2 (ru)
ZA (1) ZA200102032B (ru)

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Also Published As

Publication number Publication date
SK287601B6 (sk) 2011-03-04
HUP0103630A3 (en) 2004-03-01
KR100628818B1 (ko) 2006-09-27
NO20011244D0 (no) 2001-03-12
EE05558B1 (et) 2012-08-15
IS5856A (is) 2001-02-23
CZ2001916A3 (cs) 2001-08-15
NO20011283D0 (no) 2001-03-14
CA2343579C (en) 2012-05-29
EP2065050A1 (en) 2009-06-03
CZ302997B6 (cs) 2012-02-15
CN1236815C (zh) 2006-01-18
CA2343579A1 (en) 2000-03-23
SI1113810T1 (sl) 2009-04-30
CY1109413T1 (el) 2014-08-13
ZA200102032B (en) 2002-11-07
EP1113810A2 (en) 2001-07-11
IL141877A0 (en) 2002-03-10
EA004270B1 (ru) 2004-02-26
PL347128A1 (en) 2002-03-25
AU6248699A (en) 2000-04-03
NO20011244L (no) 2001-05-14
KR20010085793A (ko) 2001-09-07
DK1113810T3 (da) 2009-04-06
BR9913705A (pt) 2001-06-05
NO327855B1 (no) 2009-10-05
HK1038313A1 (en) 2002-03-15
IL197686A0 (en) 2011-07-31
WO2000015247A3 (en) 2000-05-25
WO2000015247A8 (en) 2009-12-23
EE200100146A (et) 2002-06-17
DE69940206D1 (de) 2009-02-12
NZ511062A (en) 2003-04-29
HUP0103630A2 (hu) 2002-01-28
ES2319831T3 (es) 2009-05-12
CN1321091A (zh) 2001-11-07
WO2000015247A2 (en) 2000-03-23
SK6052001A3 (en) 2001-12-03
JP5378303B2 (ja) 2013-12-25
US20020022028A1 (en) 2002-02-21
US7211252B2 (en) 2007-05-01
JP2010235620A (ja) 2010-10-21
JP2013241441A (ja) 2013-12-05
PL203114B1 (pl) 2009-08-31
ATE418999T1 (de) 2009-01-15
AU757873B2 (en) 2003-03-06
TR200100734T2 (tr) 2001-07-23
HU229038B1 (hu) 2013-07-29
PT1113810E (pt) 2009-03-10
JP2002524529A (ja) 2002-08-06
EP1113810B1 (en) 2008-12-31
IS2631B (is) 2010-06-15

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