TR200100734T2 - İntegrin antagonistlerini kullanarak multipl miyeloma ve miyeloma tarafından uyarılan kemik rezorpsiyonunun iyileştirilmesi - Google Patents
İntegrin antagonistlerini kullanarak multipl miyeloma ve miyeloma tarafından uyarılan kemik rezorpsiyonunun iyileştirilmesiInfo
- Publication number
- TR200100734T2 TR200100734T2 TR2001/00734T TR200100734T TR200100734T2 TR 200100734 T2 TR200100734 T2 TR 200100734T2 TR 2001/00734 T TR2001/00734 T TR 2001/00734T TR 200100734 T TR200100734 T TR 200100734T TR 200100734 T2 TR200100734 T2 TR 200100734T2
- Authority
- TR
- Turkey
- Prior art keywords
- myeloma
- antagonists
- multiple myeloma
- bone resorption
- integrin antagonists
- Prior art date
Links
- 206010035226 Plasma cell myeloma Diseases 0.000 title abstract 5
- 239000005557 antagonist Substances 0.000 title abstract 5
- 208000034578 Multiple myelomas Diseases 0.000 title abstract 3
- 201000000050 myeloid neoplasm Diseases 0.000 title abstract 2
- 208000006386 Bone Resorption Diseases 0.000 title 1
- 230000024279 bone resorption Effects 0.000 title 1
- 102000006495 integrins Human genes 0.000 title 1
- 108010044426 integrins Proteins 0.000 title 1
- 210000000988 bone and bone Anatomy 0.000 abstract 3
- 108010041012 Integrin alpha4 Proteins 0.000 abstract 2
- 230000006378 damage Effects 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 1
- 210000001185 bone marrow Anatomy 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2836—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD106
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70542—CD106
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Photoreceptors In Electrophotography (AREA)
Abstract
Alfa4 integrin/alfa4 integrin ligand yapismasinin antagonistleri olup, bu antagonistler, bu yapismanin biyolojik etkilerini engellemektedir ve bu antagonistlerin kullanimi ayrintili olarak anlatirlmistir. Bu antagonistler multipl miyeloma ile görülen kemik tahribatinin bastirilmasinda yararli olmaktadir. Multipl miyeloma hücrelerinin kemik iliginde yuvalanmasi ve bu hüzcrelerin kemik rezorbe etme faktörlerinin alfa4 integrine bagli salinmasi, sonuçta miyelomasi olan hastalarda kemik tahribati engellenmektedir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10018298P | 1998-09-14 | 1998-09-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200100734T2 true TR200100734T2 (tr) | 2001-07-23 |
Family
ID=22278506
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/00734T TR200100734T2 (tr) | 1998-09-14 | 1999-09-13 | İntegrin antagonistlerini kullanarak multipl miyeloma ve miyeloma tarafından uyarılan kemik rezorpsiyonunun iyileştirilmesi |
Country Status (29)
Country | Link |
---|---|
US (1) | US7211252B2 (tr) |
EP (2) | EP1113810B1 (tr) |
JP (3) | JP2002524529A (tr) |
KR (1) | KR100628818B1 (tr) |
CN (1) | CN1236815C (tr) |
AT (1) | ATE418999T1 (tr) |
AU (1) | AU757873B2 (tr) |
BR (1) | BR9913705A (tr) |
CA (1) | CA2343579C (tr) |
CY (1) | CY1109413T1 (tr) |
CZ (1) | CZ302997B6 (tr) |
DE (1) | DE69940206D1 (tr) |
DK (1) | DK1113810T3 (tr) |
EA (1) | EA004270B1 (tr) |
EE (1) | EE05558B1 (tr) |
ES (1) | ES2319831T3 (tr) |
HK (1) | HK1038313A1 (tr) |
HU (1) | HU229038B1 (tr) |
IL (2) | IL141877A0 (tr) |
IS (1) | IS2631B (tr) |
NO (2) | NO327855B1 (tr) |
NZ (1) | NZ511062A (tr) |
PL (1) | PL203114B1 (tr) |
PT (1) | PT1113810E (tr) |
SI (1) | SI1113810T1 (tr) |
SK (1) | SK287601B6 (tr) |
TR (1) | TR200100734T2 (tr) |
WO (1) | WO2000015247A2 (tr) |
ZA (1) | ZA200102032B (tr) |
Families Citing this family (23)
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US7618630B2 (en) | 1998-09-14 | 2009-11-17 | Board Of Regents, The University Of Texas System | Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists |
WO2001019396A1 (en) * | 1999-09-14 | 2001-03-22 | Biogen, Inc. | Therapies for chronic renal failure using one or more integrin antagonists |
US20010046496A1 (en) * | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
AU2002356180A1 (en) | 2001-08-06 | 2003-03-10 | The Regents Of The University Of California | Methods for inhibiting angiogenesis |
MXPA06008746A (es) * | 2004-02-06 | 2007-01-23 | Elan Pharm Inc | Metodos y composiciones para tratamiento de tumores y enfermedad metastatica. |
WO2007092471A2 (en) * | 2006-02-03 | 2007-08-16 | The Regents Of The University Of California | Methods for inhibition of lymphangiogenesis and tumor metastasis |
EP3042668B1 (en) * | 2006-06-07 | 2018-09-19 | The Board of Trustees of the Leland Stanford Junior University | Anti-leukocyte recruitment therapy for the treatment of seizures and epilepsy |
US8574577B2 (en) | 2008-01-03 | 2013-11-05 | The Scripps Research Institute | VEGF antibodies comprising modular recognition domains |
US8557243B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | EFGR antibodies comprising modular recognition domains |
SG10201605629VA (en) * | 2008-01-03 | 2016-08-30 | Scripps Research Inst | Antibody targeting through a modular recognition domain |
US8557242B2 (en) | 2008-01-03 | 2013-10-15 | The Scripps Research Institute | ERBB2 antibodies comprising modular recognition domains |
US8454960B2 (en) | 2008-01-03 | 2013-06-04 | The Scripps Research Institute | Multispecific antibody targeting and multivalency through modular recognition domains |
KR101238061B1 (ko) * | 2009-03-31 | 2013-02-27 | 한화케미칼 주식회사 | Vcam-1에 특이적으로 결합하는 인간 단일클론항체 및 그를 포함하는 염증성 질환 또는 암의 치료용 조성물 |
PT3202789T (pt) * | 2010-04-16 | 2020-06-16 | Biogen Ma Inc | Anticorpos anti-vla-4 |
US20120100166A1 (en) | 2010-07-15 | 2012-04-26 | Zyngenia, Inc. | Ang-2 Binding Complexes and Uses Thereof |
CN103857699B (zh) | 2011-05-24 | 2016-08-31 | 泽恩格尼亚股份有限公司 | 多价和单价多特异性复合物及其用途 |
EP2727937A4 (en) * | 2011-06-30 | 2015-03-18 | Immuno Biological Lab Co Ltd | SOLUBLE MUTANT OF INEGRINE ALPHA-4 |
CA2907181C (en) | 2013-03-15 | 2023-10-17 | Viktor Roschke | Multivalent and monovalent multispecific complexes and their uses |
CN103215223B (zh) * | 2013-03-18 | 2014-10-29 | 中国人民解放军第四军医大学 | 人椎间盘髓核细胞和免疫细胞相互作用的体外模型构建方法 |
CN103838980A (zh) * | 2014-03-27 | 2014-06-04 | 山东大学 | 对多发性骨髓瘤骨病治疗方法的疗效进行模拟评测的方法 |
CN105688185B (zh) * | 2016-03-13 | 2019-03-19 | 浙江药苑生物科技有限公司 | 一种用于治疗骨髓增生、骨癌的药物组合物及其用途 |
WO2017205560A1 (en) * | 2016-05-27 | 2017-11-30 | Albert Einstein College Of Medicine, Inc. | Methods for treating cancer by targeting vcam1 and maea |
US11560433B2 (en) | 2016-05-27 | 2023-01-24 | Albert Einstein College Of Medicine | Methods of treatment by targeting VCAM1 and MAEA |
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NZ215865A (en) | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
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IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
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PT923941E (pt) | 1996-06-27 | 2006-09-29 | Chugai Pharmaceutical Co Ltd | Medicamentos para mieloma a serem utilizados com agentes antitumorais de mostarda nitrogenada |
NZ509199A (en) * | 1998-05-28 | 2003-10-31 | Biogen Inc | A VLA-4 inhibitor: oMePUPA-V |
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1999
- 1999-09-13 JP JP2000569831A patent/JP2002524529A/ja active Pending
- 1999-09-13 CZ CZ20010916A patent/CZ302997B6/cs not_active IP Right Cessation
- 1999-09-13 WO PCT/US1999/021170 patent/WO2000015247A2/en active Application Filing
- 1999-09-13 EP EP99949656A patent/EP1113810B1/en not_active Expired - Lifetime
- 1999-09-13 EA EA200100362A patent/EA004270B1/ru not_active IP Right Cessation
- 1999-09-13 IL IL14187799A patent/IL141877A0/xx not_active IP Right Cessation
- 1999-09-13 DE DE69940206T patent/DE69940206D1/de not_active Expired - Lifetime
- 1999-09-13 BR BR9913705-4A patent/BR9913705A/pt not_active Application Discontinuation
- 1999-09-13 AU AU62486/99A patent/AU757873B2/en not_active Ceased
- 1999-09-13 AT AT99949656T patent/ATE418999T1/de active
- 1999-09-13 ES ES99949656T patent/ES2319831T3/es not_active Expired - Lifetime
- 1999-09-13 CA CA2343579A patent/CA2343579C/en not_active Expired - Fee Related
- 1999-09-13 EE EEP200100146A patent/EE05558B1/xx not_active IP Right Cessation
- 1999-09-13 SK SK605-2001A patent/SK287601B6/sk not_active IP Right Cessation
- 1999-09-13 PL PL347128A patent/PL203114B1/pl unknown
- 1999-09-13 NZ NZ511062A patent/NZ511062A/xx not_active IP Right Cessation
- 1999-09-13 TR TR2001/00734T patent/TR200100734T2/tr unknown
- 1999-09-13 CN CNB998109045A patent/CN1236815C/zh not_active Expired - Fee Related
- 1999-09-13 DK DK99949656T patent/DK1113810T3/da active
- 1999-09-13 PT PT99949656T patent/PT1113810E/pt unknown
- 1999-09-13 SI SI9931028T patent/SI1113810T1/sl unknown
- 1999-09-13 EP EP08016882A patent/EP2065050A1/en not_active Withdrawn
- 1999-09-13 HU HU0103630A patent/HU229038B1/hu not_active IP Right Cessation
- 1999-09-13 KR KR1020017003274A patent/KR100628818B1/ko not_active IP Right Cessation
-
2001
- 2001-02-23 IS IS5856A patent/IS2631B/is unknown
- 2001-03-12 ZA ZA200102032A patent/ZA200102032B/en unknown
- 2001-03-12 NO NO20011244A patent/NO327855B1/no not_active IP Right Cessation
- 2001-03-13 US US09/805,840 patent/US7211252B2/en not_active Expired - Lifetime
- 2001-03-14 NO NO20011283A patent/NO20011283D0/no unknown
- 2001-12-24 HK HK01109049.1A patent/HK1038313A1/xx not_active IP Right Cessation
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2009
- 2009-03-19 IL IL197686A patent/IL197686A0/en unknown
- 2009-03-23 CY CY20091100320T patent/CY1109413T1/el unknown
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2010
- 2010-06-09 JP JP2010132110A patent/JP5378303B2/ja not_active Expired - Fee Related
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2013
- 2013-07-25 JP JP2013154324A patent/JP2013241441A/ja active Pending
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