EA200001047A1 - Кристаллические формы (1s)-[1-альфа-(2s*, 3r*)-9-альфа]-6,10-диоксо-n-(2-этокси-5-оксотетрагидро-3-фуранил)-9-[[(1-изохинолил) карбонил] амино]-октагидро-6h-пиридазино[1,2-a][1,2] диазепин-1-карбоксамида - Google Patents

Кристаллические формы (1s)-[1-альфа-(2s*, 3r*)-9-альфа]-6,10-диоксо-n-(2-этокси-5-оксотетрагидро-3-фуранил)-9-[[(1-изохинолил) карбонил] амино]-октагидро-6h-пиридазино[1,2-a][1,2] диазепин-1-карбоксамида

Info

Publication number
EA200001047A1
EA200001047A1 EA200001047A EA200001047A EA200001047A1 EA 200001047 A1 EA200001047 A1 EA 200001047A1 EA 200001047 A EA200001047 A EA 200001047A EA 200001047 A EA200001047 A EA 200001047A EA 200001047 A1 EA200001047 A1 EA 200001047A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alpha
pyridazino
diazepin
dioxo
carboxamide
Prior art date
Application number
EA200001047A
Other languages
English (en)
Other versions
EA002761B1 (ru
Inventor
Жан-Ив Годар
Валери Роньон
Original Assignee
Хехст Марион Руссель
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хехст Марион Руссель filed Critical Хехст Марион Руссель
Publication of EA200001047A1 publication Critical patent/EA200001047A1/ru
Publication of EA002761B1 publication Critical patent/EA002761B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Предметом изобретения являются новые кристаллические (безводная (форма A) и гидратированная (форма B)) формы (1S)-[1-альфа-(2S*,3R*)-9-альфа]-6,10-диоксо-N-(2-этокси-5-оксотетрагидро-3-фуранил)-9-[[(1-изохинолил)карбонил]амино]октагидро-6H-пиридазино[1,2-a][1,2]диазепин-1-карбоксамида, способ их получения, их применение в качестве лекарственного средства и содержащие их фармацевтические композиции.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200001047A 1998-04-08 1999-04-07 Кристаллические формы (1s)-[1-альфа-(2s*, 3r*)-9-альфа]-6, 10-диоксо-n-(2-этокси-5-оксотетрагидро-3-фуранил)-9-[[(1-изохинолил) карбонил] амино]-октагидро-6h-пиридазино[1,2-а][1,2] диазепин-1-карбоксамида EA002761B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9804367A FR2777279B1 (fr) 1998-04-08 1998-04-08 Nouvelles formes cristallines du 1s-[1alpha(2s*,3r*), 9 alpha] 6,10-dioxo-n-(2-ethoxy-5-oxo-tetrahydro-3-furanyl) -9[[(1-isoquinolyl)carbonyl]amino]octohydro-6h-pyridazino [1,2-a][1,2]diazepine-1-carboxamide
PCT/FR1999/000799 WO1999052935A1 (fr) 1998-04-08 1999-04-07 Formes cristallines du 1s-[1alpha (2s*,3r*),9alpha]-6, 10-dioxo-n- (2-ethoxy-5 -oxo-tetrahydro-3 -furanyl) -9-[[(1-isoquinolyl) carbonyl]-amino] octahydro-6h -piridazino[1, 2-a][1,2] diazepine-1- carboxamide

Publications (2)

Publication Number Publication Date
EA200001047A1 true EA200001047A1 (ru) 2001-04-23
EA002761B1 EA002761B1 (ru) 2002-08-29

Family

ID=9524993

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200001047A EA002761B1 (ru) 1998-04-08 1999-04-07 Кристаллические формы (1s)-[1-альфа-(2s*, 3r*)-9-альфа]-6, 10-диоксо-n-(2-этокси-5-оксотетрагидро-3-фуранил)-9-[[(1-изохинолил) карбонил] амино]-октагидро-6h-пиридазино[1,2-а][1,2] диазепин-1-карбоксамида

Country Status (38)

Country Link
US (2) US6544977B1 (ru)
EP (1) EP1070083B1 (ru)
JP (1) JP2002511485A (ru)
KR (1) KR100582981B1 (ru)
CN (1) CN1202123C (ru)
AP (1) AP1734A (ru)
AR (1) AR018328A1 (ru)
AT (1) ATE315044T1 (ru)
AU (1) AU758042B2 (ru)
BG (1) BG64736B1 (ru)
BR (1) BR9909549A (ru)
CA (1) CA2325629C (ru)
CU (1) CU23055A3 (ru)
CZ (1) CZ299744B6 (ru)
DE (1) DE69929315T2 (ru)
DK (1) DK1070083T3 (ru)
EA (1) EA002761B1 (ru)
EE (1) EE04467B1 (ru)
ES (1) ES2253880T3 (ru)
FR (1) FR2777279B1 (ru)
GE (1) GEP20032974B (ru)
HK (1) HK1038575B (ru)
HR (1) HRP20000665B1 (ru)
HU (1) HU227561B1 (ru)
ID (1) ID26290A (ru)
IL (2) IL138818A (ru)
ME (1) ME01627B (ru)
NO (1) NO327995B1 (ru)
NZ (1) NZ507199A (ru)
PL (1) PL197016B1 (ru)
RS (1) RS49916B (ru)
SI (1) SI1070083T1 (ru)
SK (1) SK286267B6 (ru)
TR (1) TR200002914T2 (ru)
TW (1) TW522152B (ru)
UA (1) UA71563C2 (ru)
WO (1) WO1999052935A1 (ru)
ZA (1) ZA200005438B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101402398B1 (ko) * 2006-06-30 2014-06-03 노파르티스 아게 퀴놀리논 유도체 및 이의 제약 조성물
AU2014277867B2 (en) * 2007-12-04 2016-11-03 Arbutus Biopharma Corporation Targeting lipids

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5552400A (en) * 1994-06-08 1996-09-03 Sterling Winthrop Inc. Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors

Also Published As

Publication number Publication date
WO1999052935A1 (fr) 1999-10-21
CU23055A3 (es) 2005-06-24
EE200000586A (et) 2002-02-15
BG64736B1 (bg) 2006-01-31
UA71563C2 (ru) 2004-12-15
EA002761B1 (ru) 2002-08-29
DE69929315D1 (de) 2006-03-30
FR2777279A1 (fr) 1999-10-15
CA2325629A1 (fr) 1999-10-21
KR100582981B1 (ko) 2006-05-24
DK1070083T3 (da) 2006-05-15
ME01627B (me) 2008-09-29
HK1038575B (zh) 2006-01-06
GEP20032974B (en) 2003-05-27
FR2777279B1 (fr) 2004-08-13
NO20005060D0 (no) 2000-10-06
CZ299744B6 (cs) 2008-11-12
DE69929315T2 (de) 2006-08-17
NO20005060L (no) 2000-10-06
NZ507199A (en) 2002-12-20
AP1734A (en) 2007-03-22
HRP20000665A2 (en) 2001-08-31
HUP0101586A2 (hu) 2001-11-28
AU758042B2 (en) 2003-03-13
RS49916B (sr) 2008-09-29
NO327995B1 (no) 2009-11-02
CZ20003678A3 (cs) 2001-02-14
ES2253880T3 (es) 2006-06-01
BR9909549A (pt) 2000-12-12
CN1305491A (zh) 2001-07-25
YU60800A (sh) 2002-11-15
HRP20000665B1 (en) 2008-01-31
EP1070083B1 (fr) 2006-01-04
JP2002511485A (ja) 2002-04-16
SK14882000A3 (sk) 2001-04-09
AU3041699A (en) 1999-11-01
TR200002914T2 (tr) 2001-02-21
HU227561B1 (en) 2011-08-29
IL168047A (en) 2011-10-31
ID26290A (id) 2000-12-14
AP2000001939A0 (en) 2000-12-31
TW522152B (en) 2003-03-01
HUP0101586A3 (en) 2002-11-28
ZA200005438B (en) 2002-01-07
PL197016B1 (pl) 2008-02-29
CN1202123C (zh) 2005-05-18
EP1070083A1 (fr) 2001-01-24
SK286267B6 (sk) 2008-06-06
IL138818A (en) 2008-11-26
PL343350A1 (en) 2001-08-13
HK1038575A1 (en) 2002-03-22
US6946459B2 (en) 2005-09-20
CA2325629C (fr) 2013-01-22
AR018328A1 (es) 2001-11-14
SI1070083T1 (sl) 2006-04-30
KR20010034759A (ko) 2001-04-25
BG104829A (en) 2001-05-31
EE04467B1 (et) 2005-04-15
US20030171365A1 (en) 2003-09-11
US6544977B1 (en) 2003-04-08
ATE315044T1 (de) 2006-02-15

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MK4A Patent expired

Designated state(s): RU