EA200100069A1 - Новые 19-норстероиды, галогенированные в положении 17, способ их получения и их применение, промежуточные продукты и фармацевтические композиции, их содержащие - Google Patents
Новые 19-норстероиды, галогенированные в положении 17, способ их получения и их применение, промежуточные продукты и фармацевтические композиции, их содержащиеInfo
- Publication number
- EA200100069A1 EA200100069A1 EA200100069A EA200100069A EA200100069A1 EA 200100069 A1 EA200100069 A1 EA 200100069A1 EA 200100069 A EA200100069 A EA 200100069A EA 200100069 A EA200100069 A EA 200100069A EA 200100069 A1 EA200100069 A1 EA 200100069A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical compositions
- intermediate products
- norsteroid
- halogenated
- reception
- Prior art date
Links
- 239000013067 intermediate product Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- -1 Y = simple bond Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Предметом изобретения являются соединения общей формулы (I), в которой, в частности, X = галоген, Y = простая связь, O, NH, S, SO или SO; Z = водород или галоген; n, R, R, Rи Rтакие, как определенные в описании, способ их получения и промежуточные продукты, их применение в качестве лекарств и фармацевтические композиции, их содержащие.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9807898A FR2780060B1 (fr) | 1998-06-23 | 1998-06-23 | Nouveaux 19-nor steroides 17-halogenes, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant |
| PCT/FR1999/001491 WO1999067274A1 (fr) | 1998-06-23 | 1999-06-22 | Nouveaux 19-nor steroides 17-halogenes, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200100069A1 true EA200100069A1 (ru) | 2001-06-25 |
| EA003325B1 EA003325B1 (ru) | 2003-04-24 |
Family
ID=9527717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200100069A EA003325B1 (ru) | 1998-06-23 | 1999-06-22 | 19-норстероиды, галогенированные в положении 17, способы их получения и их применение, промежуточные продукты и фармацевтические композиции, их содержащие |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US6423700B1 (ru) |
| EP (1) | EP1090027B1 (ru) |
| JP (1) | JP4509380B2 (ru) |
| KR (1) | KR20010034919A (ru) |
| CN (1) | CN1313862A (ru) |
| AP (1) | AP1579A (ru) |
| AR (1) | AR018916A1 (ru) |
| AT (1) | ATE237628T1 (ru) |
| AU (1) | AU771369B2 (ru) |
| BR (1) | BR9912206A (ru) |
| CA (1) | CA2336167A1 (ru) |
| CZ (1) | CZ296246B6 (ru) |
| DE (1) | DE69906972T2 (ru) |
| DK (1) | DK1090027T3 (ru) |
| DZ (1) | DZ2827A1 (ru) |
| EA (1) | EA003325B1 (ru) |
| ES (1) | ES2196879T3 (ru) |
| FR (1) | FR2780060B1 (ru) |
| HK (1) | HK1039945A1 (ru) |
| HR (1) | HRP20000893A2 (ru) |
| HU (1) | HUP0103194A3 (ru) |
| ID (1) | ID27410A (ru) |
| IL (1) | IL140416A (ru) |
| MA (1) | MA26656A1 (ru) |
| MY (1) | MY118101A (ru) |
| NO (1) | NO318381B1 (ru) |
| NZ (1) | NZ508535A (ru) |
| PL (1) | PL345073A1 (ru) |
| PT (1) | PT1090027E (ru) |
| SK (1) | SK19492000A3 (ru) |
| TN (1) | TNSN99130A1 (ru) |
| TR (1) | TR200003857T2 (ru) |
| TW (1) | TW550077B (ru) |
| UA (1) | UA66867C2 (ru) |
| WO (1) | WO1999067274A1 (ru) |
| YU (1) | YU80700A (ru) |
| ZA (1) | ZA200007355B (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3922104B2 (ja) * | 2002-06-07 | 2007-05-30 | 富士通株式会社 | ポイント管理装置、ポイント管理システム、ポイント管理方法、およびポイント管理プログラム |
| FR2854402B1 (fr) * | 2003-04-29 | 2008-07-04 | Aventis Pharma Sa | Nouveau procede et intermediaires de preparation de composes 19-nor-steroides |
| FR2854403B1 (fr) | 2003-04-29 | 2008-07-11 | Aventis Pharma Sa | Nouveau procede et intermediaires de preparation de composes 19-nor-steroides 17-halogenes |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3079408A (en) * | 1963-02-26 | Ig-bisoxygenated iy-haloestra- | ||
| US3264327A (en) * | 1962-07-27 | 1966-08-02 | Syntex Corp | 17alpha-fluoro-, 17beta-chlorofluoroacetoxy- and 17beta-methyl-delta4-and delta5-androstene derivatives |
| US3413321A (en) * | 1966-06-03 | 1968-11-26 | Du Pont | Selected 17-fluoro-delta16 steroids |
| FR2528434B1 (fr) * | 1982-06-11 | 1985-07-19 | Roussel Uclaf | Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament |
| FR2640977A2 (en) * | 1982-06-11 | 1990-06-29 | Roussel Uclaf | New position-11 substituted 19-norsteroids and their application as medicinal products. |
| FR2685332A1 (fr) * | 1991-12-20 | 1993-06-25 | Roussel Uclaf | Nouveaux 19-nor sterouides ayant en position 11beta une chaine thiocarbonee, leur procede de preparation et les intermediaires et leur application a titre de medicaments. |
| FR2757519B1 (fr) * | 1996-12-23 | 1999-06-11 | Hoechst Marion Roussel Inc | Steroides substitues en position 11, leur procede de preparation, leur application comme medicament et les compositions pharmaceutiques les renfermant |
| FR2761992B1 (fr) * | 1997-04-09 | 1999-06-11 | Hoechst Marion Roussel Inc | Nouveaux steroides 4-halogenes, leur procede et intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| FR2771096B1 (fr) * | 1997-11-17 | 2000-08-11 | Hoechst Marion Roussel Inc | Nouveaux 19-nor steroides, substitues en position 11beta, procede et intermediaires de preparation, application comme medicaments et compositions pharmaceutiques les renfermant |
-
1998
- 1998-06-23 FR FR9807898A patent/FR2780060B1/fr not_active Expired - Lifetime
-
1999
- 1999-06-07 TW TW088109436A patent/TW550077B/zh not_active IP Right Cessation
- 1999-06-21 MA MA25638A patent/MA26656A1/fr unknown
- 1999-06-21 MY MYPI99002542A patent/MY118101A/en unknown
- 1999-06-22 CN CN99809983A patent/CN1313862A/zh active Pending
- 1999-06-22 JP JP2000555925A patent/JP4509380B2/ja not_active Expired - Lifetime
- 1999-06-22 WO PCT/FR1999/001491 patent/WO1999067274A1/fr not_active Application Discontinuation
- 1999-06-22 UA UA2001010468A patent/UA66867C2/ru unknown
- 1999-06-22 EP EP99957166A patent/EP1090027B1/fr not_active Expired - Lifetime
- 1999-06-22 US US09/720,565 patent/US6423700B1/en not_active Expired - Lifetime
- 1999-06-22 AU AU42705/99A patent/AU771369B2/en not_active Ceased
- 1999-06-22 BR BR9912206-5A patent/BR9912206A/pt not_active IP Right Cessation
- 1999-06-22 CZ CZ20004834A patent/CZ296246B6/cs not_active IP Right Cessation
- 1999-06-22 AT AT99957166T patent/ATE237628T1/de not_active IP Right Cessation
- 1999-06-22 DE DE69906972T patent/DE69906972T2/de not_active Expired - Lifetime
- 1999-06-22 TN TNTNSN99130A patent/TNSN99130A1/fr unknown
- 1999-06-22 EA EA200100069A patent/EA003325B1/ru unknown
- 1999-06-22 SK SK1949-2000A patent/SK19492000A3/sk unknown
- 1999-06-22 ES ES99957166T patent/ES2196879T3/es not_active Expired - Lifetime
- 1999-06-22 PL PL99345073A patent/PL345073A1/xx not_active Application Discontinuation
- 1999-06-22 KR KR1020007014649A patent/KR20010034919A/ko not_active Application Discontinuation
- 1999-06-22 AP APAP/P/2000/002007A patent/AP1579A/en active
- 1999-06-22 PT PT99957166T patent/PT1090027E/pt unknown
- 1999-06-22 NZ NZ508535A patent/NZ508535A/xx unknown
- 1999-06-22 DZ DZ990127A patent/DZ2827A1/xx active
- 1999-06-22 CA CA002336167A patent/CA2336167A1/fr not_active Abandoned
- 1999-06-22 YU YU80700A patent/YU80700A/sh unknown
- 1999-06-22 IL IL14041699A patent/IL140416A/xx not_active IP Right Cessation
- 1999-06-22 ID IDW20002721A patent/ID27410A/id unknown
- 1999-06-22 AR ARP990102991A patent/AR018916A1/es not_active Application Discontinuation
- 1999-06-22 HU HU0103194A patent/HUP0103194A3/hu unknown
- 1999-06-22 TR TR2000/03857T patent/TR200003857T2/xx unknown
- 1999-06-22 DK DK99957166T patent/DK1090027T3/da active
-
2000
- 2000-12-11 ZA ZA200007355A patent/ZA200007355B/en unknown
- 2000-12-21 HR HR20000893A patent/HRP20000893A2/hr not_active Application Discontinuation
- 2000-12-21 NO NO20006573A patent/NO318381B1/no unknown
-
2002
- 2002-02-28 HK HK02101559.9A patent/HK1039945A1/zh unknown
- 2002-06-18 US US10/173,914 patent/US6566542B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200400432A1 (ru) | Производные мочевины | |
| PL366198A1 (en) | Novel compounds | |
| DE60204452D1 (de) | Pyrazolo[1,5]pyridinderivate | |
| HK1048990A1 (en) | Novel compounds. | |
| YU149791A (sh) | Mometason, furoat monohidrat i postupak za njegovo dobijanje | |
| ATE286500T1 (de) | 1,2,3,4-tetrahydroisochinolin-derivate | |
| IL94915A0 (en) | Substituted quinazolinones and pharmaceutical compositions containing them | |
| EA200201179A1 (ru) | Производные 2-аминокарбонил-9h-пурина | |
| AU2003228770A8 (en) | Substituted pyrazolopyrimidines | |
| IL135536A0 (en) | Ortho-anthranilamide derivatives and pharmaceutical compositions containing the same | |
| CA2338600A1 (en) | Novel thiazolopyrimidine compounds | |
| PL306084A1 (en) | Novel compound and method of obtaining them as well as pharmaceutic agent containing such compounds | |
| EA200200479A1 (ru) | Новые олигосахариды, их получение и содержащие их фармацевтические композиции | |
| CR6540A (es) | Trifluorobutenos nematicidas | |
| ATE332301T1 (de) | Antivirale pyrazolopyridin verbindungen | |
| EA199900621A1 (ru) | Лечение рассеянного склероза путем приема внутрь или ингаляции сополимера-1 | |
| EA200100516A1 (ru) | Производные 3,3-биарилпиперидина и 2,2-биарилморфолина | |
| SE0101038D0 (sv) | Novel compounds | |
| PT1427417E (pt) | Derivados de 6, 7-di-hidroxitetra-hidroisoquinolina substituída em 3 para utilização como agentes antibacterianos | |
| SE9802574D0 (sv) | Novel compounds | |
| DE60201074D1 (en) | Pyrazolopyridinderivate | |
| SE9904128D0 (sv) | Novel compounds | |
| EA199700223A1 (ru) | Бициклические антагонисты тахикининов, их получение и применение в фармацевтической композиции | |
| EA200100069A1 (ru) | Новые 19-норстероиды, галогенированные в положении 17, способ их получения и их применение, промежуточные продукты и фармацевтические композиции, их содержащие | |
| EA200000530A1 (ru) | НОВЫЕ 19-НОРСТЕРОИДЫ, ЗАМЕЩЕННЫЕ В ПОЛОЖЕНИИ 11β, СПОСОБ И ПРОМЕЖУТОЧНЫЕ ПРОДУКТЫ ДЛЯ ИХ ПОЛУЧЕНИЯ, ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ И СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD4A | Registration of transfer of a eurasian patent in accordance with the succession in title |