EA037552B1 - 7-бензил-4-(2-метилбензил)-2,4,6,7,8,9-гексагидроимидазо[1,2-а]пиридо[3,4-е]пиримидин-5(1н)-он, его аналоги и соли и способы их применения в терапии - Google Patents

7-бензил-4-(2-метилбензил)-2,4,6,7,8,9-гексагидроимидазо[1,2-а]пиридо[3,4-е]пиримидин-5(1н)-он, его аналоги и соли и способы их применения в терапии Download PDF

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EA037552B1
EA037552B1 EA201791727A EA201791727A EA037552B1 EA 037552 B1 EA037552 B1 EA 037552B1 EA 201791727 A EA201791727 A EA 201791727A EA 201791727 A EA201791727 A EA 201791727A EA 037552 B1 EA037552 B1 EA 037552B1
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cancer
compound
subject
treatment
present
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EA201791727A
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English (en)
Russian (ru)
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EA201791727A1 (ru
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Мартин Стогниев
Джошуа Э. Аллен
Ричард С. Потторф
Бхаскара Рао Наллаганчу
Гэри Л. Олсон
Яньцзюнь Сунь
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Онкосьютикс, Инк.
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Publication of EA037552B1 publication Critical patent/EA037552B1/ru

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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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EA201791727A 2015-01-30 2016-01-29 7-бензил-4-(2-метилбензил)-2,4,6,7,8,9-гексагидроимидазо[1,2-а]пиридо[3,4-е]пиримидин-5(1н)-он, его аналоги и соли и способы их применения в терапии EA037552B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562109737P 2015-01-30 2015-01-30
US201562148844P 2015-04-17 2015-04-17
US201562233757P 2015-09-28 2015-09-28
PCT/US2016/015817 WO2016123571A1 (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy

Publications (2)

Publication Number Publication Date
EA201791727A1 EA201791727A1 (ru) 2018-01-31
EA037552B1 true EA037552B1 (ru) 2021-04-13

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EA201791727A EA037552B1 (ru) 2015-01-30 2016-01-29 7-бензил-4-(2-метилбензил)-2,4,6,7,8,9-гексагидроимидазо[1,2-а]пиридо[3,4-е]пиримидин-5(1н)-он, его аналоги и соли и способы их применения в терапии

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US (6) US9845324B2 (https=)
EP (4) EP4516359A3 (https=)
JP (4) JP6802172B2 (https=)
KR (3) KR20250134216A (https=)
CN (2) CN107427516B8 (https=)
AU (4) AU2016211243B2 (https=)
BR (1) BR112017016487B1 (https=)
CA (3) CA2975476C (https=)
CY (1) CY1123616T1 (https=)
DK (2) DK3805222T3 (https=)
EA (1) EA037552B1 (https=)
ES (2) ES2839401T3 (https=)
FI (1) FI3805222T3 (https=)
HR (2) HRP20201949T1 (https=)
HU (2) HUE070309T2 (https=)
IL (5) IL312936A (https=)
LT (2) LT3250208T (https=)
MA (2) MA41434B1 (https=)
MD (2) MD3805222T2 (https=)
MX (3) MX379425B (https=)
PL (2) PL3805222T3 (https=)
PT (2) PT3250208T (https=)
RS (2) RS66551B1 (https=)
SG (2) SG10201803508WA (https=)
SI (2) SI3250208T1 (https=)
SM (2) SMT202000696T1 (https=)
WO (1) WO2016123571A1 (https=)

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WO2016123571A1 (en) 2015-01-30 2016-08-04 Oncoceutics Inc. 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy
CN104860948B (zh) 2015-05-15 2017-09-26 南京盖特医药技术有限公司 咪唑并嘧啶酮类化合物及其制备方法和应用
PL3408298T3 (pl) * 2016-01-29 2025-03-31 Oncoceutics, Inc. Modulacja przez imiprydony receptora sprzężonego z białkiem g (gpcr)
WO2017151613A1 (en) 2016-03-01 2017-09-08 Corcept Therapeutics, Inc. The use of glucocorticoid receptor modulators to potentiate checkpoint inhibitors
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
WO2018031987A1 (en) 2016-08-12 2018-02-15 Nanjing Gator Meditech Company, Ltd. Protein kinase regulators
US10172862B2 (en) * 2017-01-30 2019-01-08 Oncoceutics, Inc. Imipridones for gliomas
US20200129596A1 (en) * 2017-03-13 2020-04-30 City Of Hope m6A mRNA MODIFICATION IN CANCER TREATMENT
EP3589745A1 (en) * 2018-04-11 2020-01-08 Chemestmed Ltd. A method of modulating the rna methylation
CN113631192B (zh) 2019-03-26 2023-07-21 富士胶片株式会社 抑制乙型肝炎病毒蛋白产生的医药组合物、用于处置乙型肝炎的医药组合物及筛选方法
BR112022015011A2 (pt) * 2020-01-29 2022-09-20 Corcept Therapeutics Inc Método para tratar um sujeito que sofre de tumor de carcinoma adrenocortical e tendo excesso de cortisol, e, composição farmacêutica para tratar carcinoma adrenocortical
MX2023001576A (es) * 2020-08-06 2023-05-09 Eoetvoes Lorand Tudomanyegyetem Síntesis de nuevos derivados de imipridona y su evaluación de su actividad anticáncerigena.
EP4223876A4 (en) 2020-09-30 2025-12-10 Fujifilm Corp DOUBLE-STRANDED RNA THAT INHIBITS THE PRODUCTION OF A HEPATITIS B VIRUS PROTEIN, AND PHARMACEUTICAL COMPOSITION
KR20230118855A (ko) * 2020-11-13 2023-08-14 더 리전츠 오브 더 유니버시티 오브 캘리포니아 IRE1α 억제제 및 이의 용도
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