IL312936A - 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo-[1,2-A] pyrido [3,4-E] pyrimidine-5(1H)-one, analogs and salts thereof, and methods of use for therapy - Google Patents

7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo-[1,2-A] pyrido [3,4-E] pyrimidine-5(1H)-one, analogs and salts thereof, and methods of use for therapy

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Publication number
IL312936A
IL312936A IL312936A IL31293624A IL312936A IL 312936 A IL312936 A IL 312936A IL 312936 A IL312936 A IL 312936A IL 31293624 A IL31293624 A IL 31293624A IL 312936 A IL312936 A IL 312936A
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IL
Israel
Prior art keywords
cancer
tumor
cell
leukemia
lymphoma
Prior art date
Application number
IL312936A
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English (en)
Hebrew (he)
Inventor
Martin Stogniew
Joshua E Allen
Richard S Pottorf
Bhaskara Rao Nallaganchu
Gary L Olson
Yanjun Sun
Original Assignee
Oncoceutics Inc
Martin Stogniew
Joshua E Allen
Richard S Pottorf
Bhaskara Rao Nallaganchu
Gary L Olson
Yanjun Sun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncoceutics Inc, Martin Stogniew, Joshua E Allen, Richard S Pottorf, Bhaskara Rao Nallaganchu, Gary L Olson, Yanjun Sun filed Critical Oncoceutics Inc
Publication of IL312936A publication Critical patent/IL312936A/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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IL312936A 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo-[1,2-A] pyrido [3,4-E] pyrimidine-5(1H)-one, analogs and salts thereof, and methods of use for therapy IL312936A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562109737P 2015-01-30 2015-01-30
US201562148844P 2015-04-17 2015-04-17
US201562233757P 2015-09-28 2015-09-28
PCT/US2016/015817 WO2016123571A1 (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy

Publications (1)

Publication Number Publication Date
IL312936A true IL312936A (en) 2024-07-01

Family

ID=56544438

Family Applications (5)

Application Number Title Priority Date Filing Date
IL312936A IL312936A (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo-[1,2-A] pyrido [3,4-E] pyrimidine-5(1H)-one, analogs and salts thereof, and methods of use for therapy
IL295286A IL295286B2 (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs thereof, and salts thereof and methods for their use in therapy
IL288525A IL288525B (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo-[1,2-a] pyrido [3,4-e] pyrimidine-5(1h)-one, analogs and salts thereof, and methods of use for therapy
IL253689A IL253689B (en) 2015-01-30 2017-07-27 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo-[1,2-a] pyrido [3,4-e] pyrimidine-5(1h)-one, analogs and salts thereof, and methods of use for therapy
IL274135A IL274135B (en) 2015-01-30 2020-04-22 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo-[1,2-a] pyrido [3,4-e] pyrimidine-5(1h)-one, analogs and salts thereof, and methods of use for therapy

Family Applications After (4)

Application Number Title Priority Date Filing Date
IL295286A IL295286B2 (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs thereof, and salts thereof and methods for their use in therapy
IL288525A IL288525B (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo-[1,2-a] pyrido [3,4-e] pyrimidine-5(1h)-one, analogs and salts thereof, and methods of use for therapy
IL253689A IL253689B (en) 2015-01-30 2017-07-27 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo-[1,2-a] pyrido [3,4-e] pyrimidine-5(1h)-one, analogs and salts thereof, and methods of use for therapy
IL274135A IL274135B (en) 2015-01-30 2020-04-22 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo-[1,2-a] pyrido [3,4-e] pyrimidine-5(1h)-one, analogs and salts thereof, and methods of use for therapy

Country Status (27)

Country Link
US (6) US9845324B2 (https=)
EP (4) EP4516359A3 (https=)
JP (4) JP6802172B2 (https=)
KR (3) KR20250134216A (https=)
CN (2) CN107427516B8 (https=)
AU (4) AU2016211243B2 (https=)
BR (1) BR112017016487B1 (https=)
CA (3) CA2975476C (https=)
CY (1) CY1123616T1 (https=)
DK (2) DK3805222T3 (https=)
EA (1) EA037552B1 (https=)
ES (2) ES2839401T3 (https=)
FI (1) FI3805222T3 (https=)
HR (2) HRP20201949T1 (https=)
HU (2) HUE070309T2 (https=)
IL (5) IL312936A (https=)
LT (2) LT3250208T (https=)
MA (2) MA41434B1 (https=)
MD (2) MD3805222T2 (https=)
MX (3) MX379425B (https=)
PL (2) PL3805222T3 (https=)
PT (2) PT3250208T (https=)
RS (2) RS66551B1 (https=)
SG (2) SG10201803508WA (https=)
SI (2) SI3250208T1 (https=)
SM (2) SMT202000696T1 (https=)
WO (1) WO2016123571A1 (https=)

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WO2016123571A1 (en) 2015-01-30 2016-08-04 Oncoceutics Inc. 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy
CN104860948B (zh) 2015-05-15 2017-09-26 南京盖特医药技术有限公司 咪唑并嘧啶酮类化合物及其制备方法和应用
PL3408298T3 (pl) * 2016-01-29 2025-03-31 Oncoceutics, Inc. Modulacja przez imiprydony receptora sprzężonego z białkiem g (gpcr)
WO2017151613A1 (en) 2016-03-01 2017-09-08 Corcept Therapeutics, Inc. The use of glucocorticoid receptor modulators to potentiate checkpoint inhibitors
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
WO2018031987A1 (en) 2016-08-12 2018-02-15 Nanjing Gator Meditech Company, Ltd. Protein kinase regulators
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