EA036551B1 - Макроциклические ингибиторы mcl1 для лечения рака - Google Patents

Макроциклические ингибиторы mcl1 для лечения рака Download PDF

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Publication number
EA036551B1
EA036551B1 EA201892300A EA201892300A EA036551B1 EA 036551 B1 EA036551 B1 EA 036551B1 EA 201892300 A EA201892300 A EA 201892300A EA 201892300 A EA201892300 A EA 201892300A EA 036551 B1 EA036551 B1 EA 036551B1
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EA
Eurasian Patent Office
Prior art keywords
chloro
tridecaene
carboxylic acid
tetramethyl
dithia
Prior art date
Application number
EA201892300A
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English (en)
Russian (ru)
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EA201892300A1 (ru
Inventor
Александер Хирд
Меттью Алан Бельмонте
Вэньцчжань Ян
Джон Пол Секрист
Даниель Уилльям Роббинс
Стивен Ли Казмирски
Дэдун У
Бо Пэн
Джеффри Йоханнес
Мишель Лоре Лэм
Цин Е
Сяолань Чжен
Original Assignee
Астразенека Аб
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Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of EA201892300A1 publication Critical patent/EA201892300A1/ru
Publication of EA036551B1 publication Critical patent/EA036551B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D497/00Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/22Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201892300A 2016-04-22 2017-04-21 Макроциклические ингибиторы mcl1 для лечения рака EA036551B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662326156P 2016-04-22 2016-04-22
PCT/EP2017/059511 WO2017182625A1 (en) 2016-04-22 2017-04-21 Macrocyclic mcl1 inhibitors for treating cancer

Publications (2)

Publication Number Publication Date
EA201892300A1 EA201892300A1 (ru) 2019-05-31
EA036551B1 true EA036551B1 (ru) 2020-11-23

Family

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EA201892300A EA036551B1 (ru) 2016-04-22 2017-04-21 Макроциклические ингибиторы mcl1 для лечения рака

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US (4) US9840518B2 (enExample)
EP (1) EP3445767B1 (enExample)
JP (1) JP6894449B2 (enExample)
KR (1) KR102388208B1 (enExample)
CN (1) CN109071566B (enExample)
AR (1) AR108301A1 (enExample)
AU (1) AU2017252222B2 (enExample)
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CA (1) CA3020378A1 (enExample)
CL (1) CL2018002410A1 (enExample)
CO (1) CO2018008759A2 (enExample)
CR (1) CR20180499A (enExample)
CY (1) CY1123186T1 (enExample)
DK (1) DK3445767T3 (enExample)
DO (1) DOP2018000222A (enExample)
EA (1) EA036551B1 (enExample)
ES (1) ES2791319T3 (enExample)
HR (1) HRP20200673T1 (enExample)
HU (1) HUE049591T2 (enExample)
IL (1) IL262237B (enExample)
LT (1) LT3445767T (enExample)
MA (1) MA44721B1 (enExample)
ME (1) ME03729B (enExample)
MX (1) MX386103B (enExample)
NI (1) NI201800093A (enExample)
PE (1) PE20181803A1 (enExample)
PH (1) PH12018502227A1 (enExample)
PL (1) PL3445767T3 (enExample)
PT (1) PT3445767T (enExample)
RS (1) RS60257B1 (enExample)
SG (1) SG11201805838UA (enExample)
SI (1) SI3445767T1 (enExample)
SM (1) SMT202000249T1 (enExample)
SV (1) SV2018005742A (enExample)
TN (1) TN2018000319A1 (enExample)
TW (1) TWI742074B (enExample)
WO (1) WO2017182625A1 (enExample)
ZA (1) ZA201807766B (enExample)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11066416B2 (en) 2016-02-04 2021-07-20 The Johns Hopkins University Rapafucin derivative compounds and methods of use thereof
MX380313B (es) 2016-02-04 2025-03-12 Univ Johns Hopkins Rapadocinas, inhibidores de transportador 1 de nucleósido equilibrador y usos de los mismos.
MX2018009408A (es) 2016-02-04 2018-11-09 Univ Johns Hopkins Rapaglutinas, nuevos inhibidores de transportadores de glucosa (glut) y uso de los mismos.
MX386103B (es) 2016-04-22 2025-03-18 Astrazeneca Ab Inhibidores de mcl-1 y metodos de uso de los mismos.
EP3458459B1 (en) 2016-05-19 2022-04-27 Bayer Aktiengesellschaft Macrocyclic indole derivatives
TWI781996B (zh) * 2017-03-31 2022-11-01 瑞典商阿斯特捷利康公司 合成mcl-1抑制劑之方法
TW201904976A (zh) * 2017-03-31 2019-02-01 瑞典商阿斯特捷利康公司 Mcl-1抑制劑及其使用方法
BR112020003163A2 (pt) * 2017-08-15 2020-09-15 AbbVie Deutschland GmbH & Co. KG inibidores macrocíclicos de mcl-1 e métodos de uso
SG10202106345VA (en) 2017-08-15 2021-07-29 Abbvie Inc Macrocyclic mcl-1 inhibitors and methods of use
WO2019096909A1 (en) 2017-11-17 2019-05-23 The Broad Institute, Inc. Macrocyclic fluorine substituted indole derivatives as mcl-1 inhibitors, for use in the treatment of cancer
WO2019096907A1 (en) * 2017-11-17 2019-05-23 Bayer Aktiengesellschaft Aryl annulated macrocyclic indole derivatives
AR113887A1 (es) * 2017-11-17 2020-06-24 Bayer Ag Derivados de indol macrocíclicos sustituidos con cloro
UY37973A (es) 2017-11-17 2019-06-28 Bayer Ag Derivados de indol macrocíclicos
EP3710450A1 (en) 2017-11-17 2020-09-23 Bayer Aktiengesellschaft Macrocyclic chlorine substituted indole derivatives
UY37971A (es) * 2017-11-17 2019-06-28 Bayer Ag Derivados de indol macrocíclicos sustituidos
TW202014184A (zh) 2018-04-30 2020-04-16 瑞典商阿斯特捷利康公司 用於治療癌症之組合
CN112533929B (zh) * 2018-09-30 2022-09-16 福建盛迪医药有限公司 吲哚类大环衍生物、其制备方法及其在医药上的应用
TWI810397B (zh) 2018-11-14 2023-08-01 瑞典商阿斯特捷利康公司 治療癌症之方法
CN111205309B (zh) * 2018-11-21 2023-04-07 江苏恒瑞医药股份有限公司 吲哚类大环衍生物、其制备方法及其在医药上的应用
US11691989B2 (en) 2018-11-22 2023-07-04 Ascentage Pharma (Suzhou) Co., Ltd. Macrocyclic indoles as Mcl-1 inhibitors
TWI760685B (zh) * 2019-01-23 2022-04-11 大陸商蘇州亞盛藥業有限公司 作為mcl-1抑制劑的大環稠合的吡唑
WO2020185606A1 (en) * 2019-03-08 2020-09-17 Zeno Management, Inc. Macrocyclic compounds
CN113574058B (zh) * 2019-04-30 2024-04-16 江苏恒瑞医药股份有限公司 吲哚类大环衍生物、其制备方法及其在医药上的应用
CA3139806A1 (en) 2019-05-10 2020-11-19 Janssen Biotech, Inc. Macrocyclic chelators and methods of use thereof
EP3969457B1 (en) 2019-05-17 2025-08-13 The Broad Institute Inc. Methods of preparing macrocyclic indoles
UY38700A (es) 2019-05-20 2020-12-31 Novartis Ag Conjugados de anticuerpo-fármaco inhibidores de mcl-1 y sus métodos de uso
JP7617861B2 (ja) * 2019-06-21 2025-01-20 ヤンセン ファーマシューティカ エヌ.ベー. Mcl-1の大環状阻害剤
ES2987630T3 (es) 2019-07-09 2024-11-15 Janssen Pharmaceutica Nv Derivados de espirociclos macrocíclicos como inhibidores de MCL-1
WO2021067405A1 (en) * 2019-10-01 2021-04-08 The Johns Hopkins University Neuroprotective compounds and methods of use thereof
WO2021092053A1 (en) * 2019-11-08 2021-05-14 Unity Biotechnology, Inc. Mcl-1 inhibitor macrocycle compounds for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
WO2021092061A1 (en) * 2019-11-08 2021-05-14 Unity Biotechnology, Inc. Combination treatment for senescence-associated diseases
JP2023502692A (ja) * 2019-11-21 2023-01-25 ヤンセン ファーマシューティカ エヌ.ベー. Mcl-1阻害剤としての大環状スルホニル誘導体
AU2020388114A1 (en) * 2019-11-21 2022-07-14 Janssen Pharmaceutica Nv Macrocyclic indole derivatives as MCL-1 inhibitors
WO2021126316A1 (en) * 2019-12-18 2021-06-24 Zeno Management, Inc. Macrocyclic compounds
EP4107161A1 (en) * 2020-02-21 2022-12-28 Janssen Pharmaceutica NV Macrocyclic indole derivatives as inhibitors of mcl-1
WO2021197295A1 (zh) * 2020-03-30 2021-10-07 江苏恒瑞医药股份有限公司 一种吲哚类大环衍生物的结晶形式及其制备方法
AU2021278292A1 (en) 2020-05-29 2023-02-09 Janssen Pharmaceutica Nv Macrocyclic 7-pyrazol-5-YL-indole derivatives as inhibitors of MCL-1
ES2994690T3 (en) 2020-06-19 2025-01-30 Janssen Pharmaceutica Nv N-linked macrocyclic 4-(pyrazol-5-yl)-indole derivatives as inhibitors of mcl-1
JP2023530985A (ja) 2020-06-19 2023-07-20 ヤンセン ファーマシューティカ エヌ.ベー. Mcl-1の阻害剤としてのn結合大環状7-(ピラゾール-5-イル)-インドール誘導体
EP4178677A1 (en) 2020-07-08 2023-05-17 JANSSEN Pharmaceutica NV Macrocyclic ether containing indole derivatives as inhibitors of mcl-1
WO2022032284A1 (en) * 2020-08-07 2022-02-10 Zeno Management, Inc. Macrocyclic compounds
US20240042051A1 (en) 2020-11-24 2024-02-08 Francesca Rocchetti Mcl-1 inhibitor antibody-drug conjugates and methods of use
EP4008324A1 (en) 2020-12-07 2022-06-08 Cellestia Biotech AG Combinations comprising an inhibitor of an anti-apoptotic protein, such as bcl-2, bcl-xl, bclw or mcl-1, and a notch signaling pathway inhibitor for treating cancer
ES3018757T3 (en) 2020-12-17 2025-05-19 Janssen Pharmaceutica Nv Branched macrocyclic 4-(pyrazol-5-yl)-indole derivatives as inhibitors of mcl-1
US20240190893A1 (en) 2021-02-12 2024-06-13 Janssen Pharmaceutica Nv Macrocyclic 1,3-bridged 6-chloro-7-pyrazol-4-yl-1 h-indole-2-carboxylate and 6-chloro-7-pyrimidin-5-yl-1h-indole-2-carboxylate derivatives as mcl-1 inhibitors for the treatment of cancer
WO2022251247A1 (en) * 2021-05-28 2022-12-01 Zeno Management, Inc. Macrocyclic compounds
CN117651554A (zh) 2021-06-11 2024-03-05 吉利德科学公司 Mcl-1抑制剂与抗癌剂的组合
WO2022261310A1 (en) 2021-06-11 2022-12-15 Gilead Sciences, Inc. Combination mcl-1 inhibitors with anti-body drug conjugates
CN115490708B (zh) * 2021-06-18 2025-01-24 苏州亚盛药业有限公司 磺酰胺类大环衍生物及其制备方法和用途
WO2023057484A1 (en) 2021-10-06 2023-04-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting and improving the efficacy of mcl-1 inhibitor therapy
WO2023225359A1 (en) 2022-05-20 2023-11-23 Novartis Ag Antibody-drug conjugates of antineoplastic compounds and methods of use thereof
WO2025111450A1 (en) 2023-11-22 2025-05-30 Les Laboratoires Servier Anti-cd74 antibody-drug conjugates and methods of use thereof
WO2025111431A1 (en) 2023-11-22 2025-05-30 Les Laboratoires Servier Anti-cd7 antibody-drug conjugates and methods of use thereof
TW202530255A (zh) 2023-12-15 2025-08-01 法商亞維西亞有限公司 抗il-1rap結合結構域及其抗體-藥物偶聯物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008131000A2 (en) * 2007-04-16 2008-10-30 Abbott Laboratories 7-substituted indole mcl-1 inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2951295C (en) 2007-04-16 2020-04-28 Abbvie Inc. 7-nonsubstituted indole mcl-1 inhibitors
RU2512396C2 (ru) * 2008-12-22 2014-04-10 Кьюбист Фармасьютикалз, Инк. Новые противобактериальные средства для лечения грамположительных инфекций
PH12012501280A1 (en) * 2009-12-23 2013-02-04 Ironwood Pharmaceuticals Inc Crth2 modulators
CA2872979C (en) * 2011-05-19 2020-02-18 Joaquin Pastor Fernandez Macrocyclic compounds as protein kinase inhibitors
WO2014047427A2 (en) 2012-09-21 2014-03-27 Vanderbilt University Substituted benzofuran, benzothiophene and indole mcl-1 inhibitors
US10005728B2 (en) 2013-08-28 2018-06-26 Vanderbilt University Substituted indole Mcl-1 inhibitors
US9944656B2 (en) * 2014-02-12 2018-04-17 VIIV Healthcare UK (No.5) Limited Benzothiazole macrocycles as inhibitors of human immunodeficiency virus replication
CA2943815C (en) 2014-03-27 2023-04-04 Vanderbilt University Substituted indole mcl-1 inhibitors
CR20160471A (es) * 2014-04-11 2016-12-21 Bayer Pharma AG Compuestos novedosos macrocíclicos
US9949965B2 (en) 2014-10-17 2018-04-24 Vanderbilt University Tricyclic indole Mcl-1 inhibitors and uses thereof
MX386103B (es) 2016-04-22 2025-03-18 Astrazeneca Ab Inhibidores de mcl-1 y metodos de uso de los mismos.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008131000A2 (en) * 2007-04-16 2008-10-30 Abbott Laboratories 7-substituted indole mcl-1 inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MILAN BRUNCKO, LE WANG, GEORGE S. SHEPPARD, DARREN C. PHILLIPS, STEPHEN K. TAHIR, JOHN XUE, SCOTT ERICKSON, STEVE FIDANZE, ELIZABE: "Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 58, no. 5, 12 March 2015 (2015-03-12), pages 2180 - 2194, XP055376701, ISSN: 0022-2623, DOI: 10.1021/jm501258m *

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BR112018070677A2 (pt) 2019-02-05
CL2018002410A1 (es) 2018-12-07
US20190185485A1 (en) 2019-06-20
ES2791319T3 (es) 2020-11-03
CY1123186T1 (el) 2021-10-29
PE20181803A1 (es) 2018-11-19
SI3445767T1 (sl) 2020-07-31
DOP2018000222A (es) 2018-10-31
US20180155362A1 (en) 2018-06-07
SG11201805838UA (en) 2018-11-29
NZ748173A (en) 2025-05-02
PH12018502227A1 (en) 2019-07-29
ME03729B (me) 2021-01-20
CO2018008759A2 (es) 2018-09-20
DK3445767T3 (da) 2020-05-18
WO2017182625A1 (en) 2017-10-26
PT3445767T (pt) 2020-05-13
CA3020378A1 (en) 2017-10-26
US9840518B2 (en) 2017-12-12
AU2017252222B2 (en) 2019-11-07
SV2018005742A (es) 2019-03-25
IL262237A (en) 2018-11-29
AU2017252222A1 (en) 2018-11-29
AR108301A1 (es) 2018-08-08
CN109071566A (zh) 2018-12-21
TN2018000319A1 (en) 2020-01-16
TWI742074B (zh) 2021-10-11
KR102388208B1 (ko) 2022-04-18
TW201803879A (zh) 2018-02-01
HRP20200673T1 (hr) 2020-07-10
US11472816B2 (en) 2022-10-18
NI201800093A (es) 2019-03-14
PL3445767T3 (pl) 2020-07-13
JP6894449B2 (ja) 2021-06-30
IL262237B (en) 2021-08-31
MA44721A (fr) 2019-02-27
HUE049591T2 (hu) 2020-09-28
RS60257B1 (sr) 2020-06-30
EP3445767A1 (en) 2019-02-27
JP2019514863A (ja) 2019-06-06
CR20180499A (es) 2019-01-25
US20170305926A1 (en) 2017-10-26
US20210230184A1 (en) 2021-07-29
EP3445767B1 (en) 2020-02-19
US10889594B2 (en) 2021-01-12
MX386103B (es) 2025-03-18
MX2018012711A (es) 2019-05-30
EA201892300A1 (ru) 2019-05-31
KR20180135030A (ko) 2018-12-19
SMT202000249T1 (it) 2020-07-08
US10196404B2 (en) 2019-02-05
BR112018070677B1 (pt) 2024-02-06
LT3445767T (lt) 2020-05-25
ZA201807766B (en) 2021-09-29
CN109071566B (zh) 2021-08-31
MA44721B1 (fr) 2020-05-29

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