EA035134B1 - Иммуномодуляторы - Google Patents

Иммуномодуляторы Download PDF

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Publication number
EA035134B1
EA035134B1 EA201891879A EA201891879A EA035134B1 EA 035134 B1 EA035134 B1 EA 035134B1 EA 201891879 A EA201891879 A EA 201891879A EA 201891879 A EA201891879 A EA 201891879A EA 035134 B1 EA035134 B1 EA 035134B1
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EA
Eurasian Patent Office
Prior art keywords
dmf
resin
frit
solution
fmoc
Prior art date
Application number
EA201891879A
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English (en)
Russian (ru)
Other versions
EA201891879A1 (ru
Inventor
Мартин Патрик Аллен
Эрик П. Гиллис
Дэвид Р. Лэнгли
Майкл Мэттью Миллер
Эрик Мулл
Ли-Цян Сунь
Кап-Сунь Йеун
Кэтерин А. Грант-Янг
Николас А. Минвелл
Пол Майкл Скола
Original Assignee
Бристол-Майерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201891879A1 publication Critical patent/EA201891879A1/ru
Publication of EA035134B1 publication Critical patent/EA035134B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55516Proteins; Peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA201891879A 2016-03-04 2017-03-02 Иммуномодуляторы EA035134B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662303673P 2016-03-04 2016-03-04
PCT/US2017/020304 WO2017151830A1 (en) 2016-03-04 2017-03-02 Immunomodulators

Publications (2)

Publication Number Publication Date
EA201891879A1 EA201891879A1 (ru) 2019-02-28
EA035134B1 true EA035134B1 (ru) 2020-04-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891879A EA035134B1 (ru) 2016-03-04 2017-03-02 Иммуномодуляторы

Country Status (19)

Country Link
US (1) US10143746B2 (OSRAM)
EP (1) EP3423470B1 (OSRAM)
JP (1) JP6976263B2 (OSRAM)
KR (1) KR102409246B1 (OSRAM)
CN (1) CN109153703B (OSRAM)
AR (1) AR107802A1 (OSRAM)
AU (1) AU2017227777B2 (OSRAM)
BR (1) BR112018017114A2 (OSRAM)
CA (1) CA3016024A1 (OSRAM)
CL (1) CL2018002506A1 (OSRAM)
CO (1) CO2018010316A2 (OSRAM)
EA (1) EA035134B1 (OSRAM)
ES (1) ES2886635T3 (OSRAM)
IL (1) IL261408B (OSRAM)
MX (1) MX379487B (OSRAM)
SG (1) SG11201807426WA (OSRAM)
TW (1) TW201734022A (OSRAM)
UY (1) UY37143A (OSRAM)
WO (1) WO2017151830A1 (OSRAM)

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TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
EA038019B1 (ru) 2016-05-19 2021-06-23 Бристол-Маерс Сквибб Компани Иммуномодуляторы для пэт-визуализации
WO2018085750A2 (en) * 2016-11-07 2018-05-11 Bristol-Myers Squibb Company Immunomodulators
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WO2022120179A1 (en) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Multi-tumor gene signatures and uses thereof
JP2024514245A (ja) 2021-03-29 2024-03-29 ジュノー セラピューティクス インコーポレイテッド チェックポイント阻害剤療法とcar t細胞療法との組合せを用いた投薬および処置のための方法
CN118176214A (zh) 2021-10-29 2024-06-11 百时美施贵宝公司 血液癌症的lag-3拮抗剂疗法
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Also Published As

Publication number Publication date
CO2018010316A2 (es) 2018-10-22
CN109153703B (zh) 2022-09-23
KR102409246B1 (ko) 2022-06-14
CL2018002506A1 (es) 2018-11-09
EP3423470B1 (en) 2021-08-18
WO2017151830A1 (en) 2017-09-08
UY37143A (es) 2017-08-31
IL261408A (en) 2018-10-31
EP3423470A1 (en) 2019-01-09
ES2886635T3 (es) 2021-12-20
AU2017227777A1 (en) 2018-10-25
CN109153703A (zh) 2019-01-04
KR20180118724A (ko) 2018-10-31
JP6976263B2 (ja) 2021-12-08
TW201734022A (zh) 2017-10-01
MX2018010414A (es) 2018-11-09
EA201891879A1 (ru) 2019-02-28
AR107802A1 (es) 2018-06-06
MX379487B (es) 2025-03-11
US20170252432A1 (en) 2017-09-07
IL261408B (en) 2022-01-01
US10143746B2 (en) 2018-12-04
SG11201807426WA (en) 2018-09-27
AU2017227777B2 (en) 2021-07-01
CA3016024A1 (en) 2017-09-08
BR112018017114A2 (pt) 2018-12-26
JP2019512478A (ja) 2019-05-16

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