EA035098B1 - Способ лечения рецидивирующей и/или рефрактерной множественной миеломы - Google Patents
Способ лечения рецидивирующей и/или рефрактерной множественной миеломы Download PDFInfo
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- EA035098B1 EA035098B1 EA201690905A EA201690905A EA035098B1 EA 035098 B1 EA035098 B1 EA 035098B1 EA 201690905 A EA201690905 A EA 201690905A EA 201690905 A EA201690905 A EA 201690905A EA 035098 B1 EA035098 B1 EA 035098B1
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Classifications
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
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- Molecular Biology (AREA)
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- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Oncology (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| EP14306220 | 2014-07-31 | ||
| PCT/US2014/063380 WO2015066450A1 (en) | 2013-10-31 | 2014-10-31 | Specific anti-cd38 antibodies for treating human cancers |
Publications (2)
| Publication Number | Publication Date |
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| EA201690905A1 EA201690905A1 (ru) | 2016-08-31 |
| EA035098B1 true EA035098B1 (ru) | 2020-04-27 |
Family
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| EP (2) | EP3805266A1 (enExample) |
| JP (3) | JP2016536314A (enExample) |
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| BR (1) | BR112016009403A2 (enExample) |
| CA (1) | CA2927099A1 (enExample) |
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| EA (1) | EA035098B1 (enExample) |
| IL (1) | IL245196B (enExample) |
| MA (2) | MA39070A1 (enExample) |
| MX (1) | MX373301B (enExample) |
| NZ (1) | NZ719784A (enExample) |
| PL (1) | PL3063173T3 (enExample) |
| PT (1) | PT3063173T (enExample) |
| SG (2) | SG11201603088RA (enExample) |
| TN (1) | TN2016000142A1 (enExample) |
| TW (1) | TW201522378A (enExample) |
| WO (1) | WO2015066450A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA112170C2 (uk) | 2010-12-10 | 2016-08-10 | Санофі | Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб |
| JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| US10342869B2 (en) * | 2012-12-07 | 2019-07-09 | The Regents Of The University Of California | Compositions comprising anti-CD38 antibodies and lenalidomide |
| CN112043826A (zh) * | 2013-03-13 | 2020-12-08 | 赛诺菲 | 包含抗cd38抗体和卡非佐米的组合物 |
| US9732154B2 (en) | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
| US9603927B2 (en) | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
| MA40608A (fr) | 2014-09-09 | 2016-03-17 | Janssen Biotech Inc | Polythérapies avec des anticorps anti-cd38 |
| JP6802791B2 (ja) | 2014-12-04 | 2020-12-23 | ヤンセン バイオテツク，インコーポレーテツド | 急性骨髄性白血病の治療のための抗ｃｄ３８抗体 |
| HUE054271T2 (hu) * | 2015-05-13 | 2021-08-30 | Morphosys Ag | Mielóma Multiplex (MM) kezelése |
| EP4553157A3 (en) | 2015-05-20 | 2025-07-23 | Janssen Biotech, Inc. | Anti-cd38 antibodies for treatment of light chain amyloidosis and other cd38-positive hematological malignancies |
| EP3303373B1 (en) | 2015-05-30 | 2020-04-08 | Molecular Templates, Inc. | De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same |
| WO2016201337A1 (en) * | 2015-06-12 | 2016-12-15 | Immungene, Inc. | Engineered antibody-interferon fusion molecules for the treatment of glucose-regulated protein 94 (grp94) expressing cancers |
| UA125115C2 (uk) | 2015-06-22 | 2022-01-12 | Янссен Байотек, Інк. | Спосіб лікування суб'єкта, який має множинну мієлому (мм) |
| US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
| US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
| JP7027321B2 (ja) | 2015-11-03 | 2022-03-01 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｃｄ３８抗体の皮下製剤及びその使用 |
| JP7362250B2 (ja) | 2016-03-04 | 2023-10-17 | モルフォシス・アーゲー | 多発性骨髄腫におけるｍタンパク質反応の臨床評価 |
| WO2017223111A1 (en) | 2016-06-21 | 2017-12-28 | Teneobio, Inc. | Cd3 binding antibodies |
| JP7316930B2 (ja) | 2016-07-15 | 2023-07-28 | 武田薬品工業株式会社 | 形質芽細胞及び形質細胞枯渇療法に対する応答を評価するための方法及び材料 |
| HRP20240767T1 (hr) | 2016-09-14 | 2024-09-13 | Teneoone, Inc. | Cd3 vezujuća antitijela |
| NZ754713A (en) | 2016-12-21 | 2025-11-28 | Teneobio Inc | Anti-bcma heavy chain-only antibodies |
| CN117567624A (zh) | 2017-06-20 | 2024-02-20 | 特纳奥尼股份有限公司 | 仅有重链的抗bcma抗体 |
| CN117866097A (zh) | 2017-06-20 | 2024-04-12 | 特尼奥生物股份有限公司 | 仅有重链的抗bcma抗体 |
| JPWO2019031444A1 (ja) * | 2017-08-07 | 2020-08-27 | 国立大学法人九州大学 | 細胞集団における特異的結合物質の占有率を測定する方法 |
| WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
| CN111133007A (zh) * | 2017-09-13 | 2020-05-08 | 特尼奥生物股份有限公司 | 与胞外酶结合的重链抗体 |
| JP2021502961A (ja) | 2017-10-31 | 2021-02-04 | ヤンセン バイオテツク，インコーポレーテツド | 高リスク多発性骨髄腫の治療方法 |
| CN111542545A (zh) | 2017-11-03 | 2020-08-14 | 索伦托治疗有限公司 | Cd38定向嵌合抗原受体构建体 |
| CN112739715A (zh) | 2018-01-12 | 2021-04-30 | 武田药品工业株式会社 | 抗cd38抗体的皮下给药 |
| MX2020010144A (es) * | 2018-03-28 | 2020-12-07 | Takeda Pharmaceuticals Co | Dosificación subcutánea de anticuerpos anti grupo de diferenciación 38 (cd38). |
| BR112021000065A2 (pt) * | 2018-07-10 | 2021-04-06 | Sanofi | Terapias de combinação contra câncer direcionando cd38 e tgf-beta |
| MX2021007047A (es) | 2018-12-14 | 2021-10-26 | Morphosys Ag | Formulaciones de anticuerpos. |
| CN113853204A (zh) * | 2019-03-21 | 2021-12-28 | 盖米达细胞有限公司 | 适用于移植组合疗法的扩增nk细胞组分的扩增及其用途 |
| MX2021012205A (es) | 2019-04-05 | 2022-02-21 | Teneobio Inc | Anticuerpos de cadena pesada que se unen al psma. |
| US11655302B2 (en) | 2019-06-10 | 2023-05-23 | Sanofi | Anti-CD38 antibodies and formulations |
| TWI872082B (zh) | 2019-06-14 | 2025-02-11 | 美商泰尼歐生物公司 | 與ｃ ｄ ２ ２ 及ｃ ｄ ３ 結合之多特異性重鏈抗體 |
| CN112876563B (zh) * | 2019-11-29 | 2022-08-16 | 康诺亚生物医药科技（成都）有限公司 | 药物组合物及其制备方法和应用 |
| KR20220159947A (ko) | 2019-12-05 | 2022-12-05 | 사노피-아벤티스 유.에스. 엘엘씨 | 피하 투여를 위한 항-cd38 항체의 제형 |
| EP4069740A1 (en) * | 2019-12-06 | 2022-10-12 | Sanofi-Aventis U.S. LLC | Use of isatuximab for the treatment of relapsed and/or refractory multiple myeloma |
| WO2021259227A1 (zh) * | 2020-06-23 | 2021-12-30 | 江苏康缘药业股份有限公司 | 抗cd38抗体及其用途 |
| JP2024508207A (ja) | 2020-12-02 | 2024-02-26 | ブイアイビー ブイゼットダブリュ | がんに対する組み合わせ治療におけるｌｔｂｒアゴニスト |
| US20250382378A1 (en) * | 2022-10-31 | 2025-12-18 | Genmab A/S | Cd38 antibodies and uses thereof |
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| WO2013059885A2 (en) * | 2011-10-28 | 2013-05-02 | Cephalon Australia Pty Ltd | Polypeptide constructs and uses thereof |
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| MX2007011064A (es) | 2005-03-23 | 2008-02-19 | Genmab As | Anticuerpos contra cd38 para tratamiento de mieloma multiple. |
| US20090123950A1 (en) * | 2005-05-24 | 2009-05-14 | Morphosys Ag | Generation And Profiling Of Fully Human Hucal Gold®-Derived Therapeutic Antibodies Specific For Human CD38 |
| TR201910145T4 (tr) * | 2006-09-26 | 2019-08-21 | Genmab As | Tümörlerin tedavi edilmesine yönelik anti-CD38 artı kortikosteroidler artı bir kortikosteroid-olmayan kemoterapötik. |
| EP1914242A1 (en) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
| EP2191843A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cyclophosphamide |
| EP2191841A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine |
| EP2191842A1 (en) | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine |
| EP2191840A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan |
| UA112170C2 (uk) * | 2010-12-10 | 2016-08-10 | Санофі | Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб |
| JOP20210044A1 (ar) * | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| US10342869B2 (en) * | 2012-12-07 | 2019-07-09 | The Regents Of The University Of California | Compositions comprising anti-CD38 antibodies and lenalidomide |
| CN112043826A (zh) * | 2013-03-13 | 2020-12-08 | 赛诺菲 | 包含抗cd38抗体和卡非佐米的组合物 |
-
2014
- 2014-10-31 TN TN2016000142A patent/TN2016000142A1/en unknown
- 2014-10-31 PL PL14799089T patent/PL3063173T3/pl unknown
- 2014-10-31 TW TW103137932A patent/TW201522378A/zh unknown
- 2014-10-31 WO PCT/US2014/063380 patent/WO2015066450A1/en not_active Ceased
- 2014-10-31 MA MA39070A patent/MA39070A1/fr unknown
- 2014-10-31 JP JP2016527374A patent/JP2016536314A/ja active Pending
- 2014-10-31 SG SG11201603088RA patent/SG11201603088RA/en unknown
- 2014-10-31 CA CA2927099A patent/CA2927099A1/en not_active Abandoned
- 2014-10-31 BR BR112016009403A patent/BR112016009403A2/pt not_active Application Discontinuation
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- 2014-10-31 EP EP20188077.0A patent/EP3805266A1/en not_active Withdrawn
- 2014-10-31 EP EP14799089.9A patent/EP3063173B1/en active Active
- 2014-10-31 MA MA44560A patent/MA44560B2/fr unknown
- 2014-10-31 NZ NZ719784A patent/NZ719784A/en unknown
- 2014-10-31 PT PT147990899T patent/PT3063173T/pt unknown
- 2014-10-31 KR KR1020167013974A patent/KR20160077155A/ko not_active Ceased
- 2014-10-31 AU AU2014342103A patent/AU2014342103B2/en active Active
- 2014-10-31 EA EA201690905A patent/EA035098B1/ru not_active IP Right Cessation
- 2014-10-31 CN CN201480071448.0A patent/CN106103481A/zh active Pending
- 2014-10-31 SG SG10201803288RA patent/SG10201803288RA/en unknown
- 2014-10-31 US US14/529,719 patent/US20150118251A1/en not_active Abandoned
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2016
- 2016-04-19 IL IL245196A patent/IL245196B/en active IP Right Grant
- 2016-04-21 CR CR20160186A patent/CR20160186A/es unknown
-
2017
- 2017-04-05 US US15/479,500 patent/US20180022814A1/en not_active Abandoned
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2023
- 2023-05-24 JP JP2023085105A patent/JP2023109927A/ja active Pending
-
2025
- 2025-05-07 JP JP2025077126A patent/JP2025139586A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2013059885A2 (en) * | 2011-10-28 | 2013-05-02 | Cephalon Australia Pty Ltd | Polypeptide constructs and uses thereof |
Non-Patent Citations (6)
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| CHILLEMI A, ZACCARELLO G, QUARONA V, FERRACIN M, GHIMENTI C, MASSAIA M, HORENSTEIN AL, MALAVASI F.: "Anti-CD38 antibody therapy: windows of opportunity yielded by the functional characteristics of the target molecule.", MOLECULAR MEDICINE, FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, WASHINGTON, DC; US, vol. 19, no. 1, 1 May 2013 (2013-05-01), WASHINGTON, DC; US, pages 99 - 108, XP002735274, ISSN: 1076-1551, DOI: 10.2119/molmed.2013.00009 * |
| MARTIN T , BAZ R, BENSON D, LENDVAI N, VIJ R, CHARPENTIER E, HSU K: "A PHASE IB DOSE ESCALATION TRIAL OF SAR650984 (ANTI-CD-38 MAB) IN COMBINATION WITH LENALIDOMIDE AND DEXAMETHASONE IN RELAPSED/REFRACTORY MULTIPLE MYELOMA", HAEMATOLOGICA, FONDAZIONE FERRATA STORTI, IT, vol. 99, no. Suppl. 1, P373, 1 June 2014 (2014-06-01), IT, pages 114, XP002735276, ISSN: 0390-6078 * |
| P RICHARDSON, H LOKHORST, A PALUMBO, H NAHI, J LAUBACH, PETER GIMSING, S LISBY, A CAKANA, N C BRUN, TORBEN PLESNER: "Daratumumab. Anti-CD38 monoclonal antibody, treatment of multiple myeloma", DRUGS OF THE FUTURE, PROUS SCIENCE, ES, vol. 38, no. 8, 1 August 2013 (2013-08-01), ES, pages 545 - 554, XP002735278, ISSN: 0377-8282, DOI: 10.1358/dof.2013.038.08.2025424 * |
| Sanofi: "Dose Escalation Study of Anti-CD38 Monoclonal Antibody in Patients With Selected CD38+ Hematological Malignancies", ClinicalTrials.gov arhivve, 15 October 2013 (2013-10-15), XP002735279, Retrieved from the Internet: URL:https://clinicaltrials.gov/archive/NCT01084252/2013_10_15 [retrieved on 2015-01-30] the whole document * |
| SATHISH GOPALAKRISHNAN, DARYL TAN: "Daratumumab improves the anti-myeloma effect of newly emerging multidrug therapies", BLOOD AND LYMPHATIC CANCER: TARGETS AND THERAPY, DOVE MEDICAL PRESS LTD., GB, vol. 2013, no. 3, 18 April 2013 (2013-04-18), GB, pages 19 - 24, XP002735277, ISSN: 1179-9889, DOI: 10.2147/BLCTT.S29567 * |
| THOMAS G MARTIN , STEPHEN A. STRICKLAND, MARTHA GLENN, WEI ZHENG, NIKKI DASKALAKIS, JOSEPH R. MIKHAEL: "SAR650984, a CD38 Monoclonal Antibody In Patients With Selected CD38+ Hematological Malignancies- Data From a Dose-Escalation Phase I Study", BLOOD, THE AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 122, no. 21, 284, 15 November 2013 (2013-11-15), US, pages 284, XP002735275, ISSN: 0006-4971 * |
Also Published As
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|---|---|
| US20180022814A1 (en) | 2018-01-25 |
| SG10201803288RA (en) | 2018-05-30 |
| AU2014342103A1 (en) | 2016-05-26 |
| CA2927099A1 (en) | 2015-05-07 |
| TW201522378A (zh) | 2015-06-16 |
| EP3805266A1 (en) | 2021-04-14 |
| MX373301B (es) | 2020-04-24 |
| JP2023109927A (ja) | 2023-08-08 |
| CR20160186A (es) | 2016-06-13 |
| EP3063173A1 (en) | 2016-09-07 |
| PL3063173T3 (pl) | 2021-01-11 |
| IL245196A0 (en) | 2016-06-30 |
| BR112016009403A2 (pt) | 2017-09-19 |
| MA44560A1 (fr) | 2019-09-30 |
| EP3063173B1 (en) | 2020-07-29 |
| EA201690905A1 (ru) | 2016-08-31 |
| JP2025139586A (ja) | 2025-09-26 |
| WO2015066450A1 (en) | 2015-05-07 |
| MA44560B1 (fr) | 2020-06-30 |
| US20150118251A1 (en) | 2015-04-30 |
| PT3063173T (pt) | 2020-10-20 |
| MX2016005666A (es) | 2016-07-14 |
| CN106103481A (zh) | 2016-11-09 |
| KR20160077155A (ko) | 2016-07-01 |
| MA44560B2 (fr) | 2021-01-29 |
| NZ719784A (en) | 2022-02-25 |
| AU2014342103B2 (en) | 2020-06-04 |
| SG11201603088RA (en) | 2016-05-30 |
| IL245196B (en) | 2021-04-29 |
| JP2016536314A (ja) | 2016-11-24 |
| MA39070A1 (fr) | 2017-11-30 |
| TN2016000142A1 (en) | 2017-10-06 |
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