EA033830B1 - Производные аденина в качестве активаторов толл-подобных рецепторов tlr7 - Google Patents
Производные аденина в качестве активаторов толл-подобных рецепторов tlr7 Download PDFInfo
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- EA033830B1 EA033830B1 EA201490947A EA201490947A EA033830B1 EA 033830 B1 EA033830 B1 EA 033830B1 EA 201490947 A EA201490947 A EA 201490947A EA 201490947 A EA201490947 A EA 201490947A EA 033830 B1 EA033830 B1 EA 033830B1
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11188511 | 2011-11-09 | ||
| PCT/EP2012/072090 WO2013068438A1 (en) | 2011-11-09 | 2012-11-08 | Purine derivatives for the treatment of viral infections |
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| EA201490947A1 EA201490947A1 (ru) | 2014-08-29 |
| EA033830B1 true EA033830B1 (ru) | 2019-11-29 |
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| EA201991767A EA036645B1 (ru) | 2011-11-09 | 2012-11-08 | Производные пурина для лечения вирусных инфекций |
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| US8367670B2 (en) | 2008-12-09 | 2013-02-05 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
| SI2694484T1 (sl) | 2011-04-08 | 2018-10-30 | Janssen Sciences Ireland Uc | Derivati pirimidina za zdravljenje virusnih okužb |
| EA033830B1 (ru) * | 2011-11-09 | 2019-11-29 | Janssen Sciences Ireland Uc | Производные аденина в качестве активаторов толл-подобных рецепторов tlr7 |
| AU2013288600B2 (en) | 2012-07-13 | 2017-06-29 | Janssen Sciences Ireland Uc | Macrocyclic purines for the treatment of viral infections |
| NZ705589A (en) | 2012-10-10 | 2019-05-31 | Janssen Sciences Ireland Uc | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases |
| EA035431B1 (ru) | 2012-11-16 | 2020-06-15 | Янссен Сайенсиз Айрлэнд Юси | Гетероциклические замещенные производные 2-амино-хиназолина в качестве модуляторов tlr7 и/или tlr8 для лечения вирусных инфекций |
| KR102300861B1 (ko) | 2013-02-21 | 2021-09-10 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염의 치료를 위한 2-아미노피리미딘 유도체 |
| SG11201508078XA (en) | 2013-03-29 | 2015-11-27 | Janssen Sciences Ireland Uc | Macrocyclic deaza-purinones for the treatment of viral infections |
| WO2014187932A1 (en) | 2013-05-24 | 2014-11-27 | Janssen R&D Ireland | Pyridone derivatives for the treatment of viral infections and further diseases |
| ES2645950T3 (es) | 2013-06-27 | 2017-12-11 | Janssen Sciences Ireland Uc | Derivados de pirrolo[3,2-d]pirimidina para el tratamiento de infecciones víricas y otras enfermedades |
| UA117253C2 (uk) * | 2013-07-30 | 2018-07-10 | ЯНССЕН САЙЄНСЕЗ АЙРЛЕНД ЮСі | ПОХІДНІ ТІЄНО[3,2-d]ПІРИМІДИНІВ ДЛЯ ЛІКУВАННЯ ВІРУСНИХ ІНФЕКЦІЙ |
| GB201321737D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
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- 2012-11-08 CN CN201610878913.2A patent/CN107011346B/zh active Active
- 2012-11-08 AU AU2012334127A patent/AU2012334127B2/en not_active Ceased
- 2012-11-08 EP EP12784574.1A patent/EP2776439B1/en active Active
- 2012-11-08 US US14/357,495 patent/US9556176B2/en not_active Expired - Fee Related
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2014
- 2014-04-10 IL IL232046A patent/IL232046A/en active IP Right Grant
- 2014-05-08 CL CL2014001205A patent/CL2014001205A1/es unknown
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2017
- 2017-01-30 US US15/420,045 patent/US10280167B2/en active Active
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2018
- 2018-10-03 CY CY20181101018T patent/CY1121452T1/el unknown
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2019
- 2019-05-06 US US16/404,601 patent/US11104678B2/en active Active
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2021
- 2021-08-30 US US17/460,922 patent/US20220235052A1/en not_active Abandoned
Patent Citations (8)
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|---|---|---|---|---|
| US6028076A (en) * | 1996-07-03 | 2000-02-22 | Japan Energy Corporation | Purine derivative |
| US6376501B1 (en) * | 1997-12-22 | 2002-04-23 | Japan Energy Corporation | Type 2 helper T cell-selective immune response suppressors |
| US20070225303A1 (en) * | 2004-03-26 | 2007-09-27 | Haruhisa Ogita | 8-Oxoadenine Compound |
| EP1939198A1 (en) * | 2005-09-22 | 2008-07-02 | Dainippon Sumitomo Pharma Co., Ltd. | Novel adenine compound |
| WO2008114008A1 (en) * | 2007-03-19 | 2008-09-25 | Astrazeneca Ab | 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7 ) modulators |
| EP2138497A1 (en) * | 2007-03-20 | 2009-12-30 | Dainippon Sumitomo Pharma Co., Ltd. | Novel adenine compound |
| WO2009005687A1 (en) * | 2007-06-29 | 2009-01-08 | Gilead Sciences, Inc. | Purine derivatives and their use as modulators of toll-like receptor 7 |
| WO2011049825A1 (en) * | 2009-10-22 | 2011-04-28 | Gilead Sciences, Inc. | Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections |
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