EA030646B1 - Соединения и способы их применения - Google Patents

Info

Publication number

EA030646B1

EA030646B1 EA201590987A EA201590987A EA030646B1 EA 030646 B1 EA030646 B1 EA 030646B1 EA 201590987 A EA201590987 A EA 201590987A EA 201590987 A EA201590987 A EA 201590987A EA 030646 B1 EA030646 B1 EA 030646B1

Authority

EA

Eurasian Patent Office

Prior art keywords

compound

bis

diyl

pharmaceutically acceptable

acceptable salt

Prior art date

2012-11-22

Links

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• 150000001875 compounds Chemical class 0.000 title claims abstract description 257
• 238000000034 method Methods 0.000 title abstract description 224
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• 108010073324 Glutaminase Proteins 0.000 claims abstract description 28
• -1 -OH Chemical group 0.000 claims description 279
• 230000014509 gene expression Effects 0.000 claims description 88
• 229910052757 nitrogen Inorganic materials 0.000 claims description 84
• 125000000217 alkyl group Chemical group 0.000 claims description 46
• 108050007957 Cadherin Proteins 0.000 claims description 43
• 150000003839 salts Chemical class 0.000 claims description 41
• 102000000905 Cadherin Human genes 0.000 claims description 38
• 108010065472 Vimentin Proteins 0.000 claims description 36
• 108010053763 Pyruvate Carboxylase Proteins 0.000 claims description 35
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• 125000000623 heterocyclic group Chemical group 0.000 claims description 32
• 125000003118 aryl group Chemical group 0.000 claims description 30
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• 230000000694 effects Effects 0.000 claims description 22
• 125000001072 heteroaryl group Chemical group 0.000 claims description 22
• 125000005842 heteroatom Chemical group 0.000 claims description 22
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 21
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 21
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 20
• 125000003545 alkoxy group Chemical group 0.000 claims description 19
• 239000008194 pharmaceutical composition Substances 0.000 claims description 18
• 229910052717 sulfur Inorganic materials 0.000 claims description 17
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• 150000002367 halogens Chemical class 0.000 claims description 16
• 125000001424 substituent group Chemical group 0.000 claims description 16
• 229910052739 hydrogen Inorganic materials 0.000 claims description 15
• 239000001257 hydrogen Substances 0.000 claims description 15
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
• 125000002619 bicyclic group Chemical group 0.000 claims description 13
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 13
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• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 7
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• 125000003282 alkyl amino group Chemical group 0.000 claims description 4
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• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
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• 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
• 239000008186 active pharmaceutical agent Substances 0.000 claims description 2
• 125000006311 cyclobutyl amino group Chemical group [H]N(*)C1([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
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• 125000006302 indol-3-yl methyl group Chemical group [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])* 0.000 claims description 2
• 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 claims description 2
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• 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
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• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
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• 239000000243 solution Substances 0.000 description 91
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