EA029990B1 - Способы лечения ингибиторами глюкозилцерамидсинтазы - Google Patents

Способы лечения ингибиторами глюкозилцерамидсинтазы Download PDF

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Publication number
EA029990B1
EA029990B1 EA201592195A EA201592195A EA029990B1 EA 029990 B1 EA029990 B1 EA 029990B1 EA 201592195 A EA201592195 A EA 201592195A EA 201592195 A EA201592195 A EA 201592195A EA 029990 B1 EA029990 B1 EA 029990B1
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EA
Eurasian Patent Office
Prior art keywords
compound
formula
hemitartrate
subject
administered
Prior art date
Application number
EA201592195A
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English (en)
Russian (ru)
Other versions
EA201592195A1 (ru
Inventor
Ханлан Лиу
Крис Уиллис
Рену Бардваж
Диане П. Коупланд
Абизер Харианавала
Джеффри Скелл
Джон Маршалл
Джианмеи Кочлинг
Джерард Палас
Джудит Петершмитт
Крейг Сигел
Сенг Ченг
Original Assignee
Джензим Корпорэйшн
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Application filed by Джензим Корпорэйшн filed Critical Джензим Корпорэйшн
Publication of EA201592195A1 publication Critical patent/EA201592195A1/ru
Publication of EA029990B1 publication Critical patent/EA029990B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)
  • Molecular Biology (AREA)
EA201592195A 2009-11-27 2010-11-24 Способы лечения ингибиторами глюкозилцерамидсинтазы EA029990B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26474809P 2009-11-27 2009-11-27

Publications (2)

Publication Number Publication Date
EA201592195A1 EA201592195A1 (ru) 2016-04-29
EA029990B1 true EA029990B1 (ru) 2018-06-29

Family

ID=43431870

Family Applications (3)

Application Number Title Priority Date Filing Date
EA201592195A EA029990B1 (ru) 2009-11-27 2010-11-24 Способы лечения ингибиторами глюкозилцерамидсинтазы
EA201270646A EA023923B1 (ru) 2009-11-27 2010-11-24 Ингибиторы глюкозилцерамидсинтазы
EA201890254A EA201890254A3 (ru) 2009-11-27 2010-11-24 Ингибиторы глюкозилцерамидсинтазы

Family Applications After (2)

Application Number Title Priority Date Filing Date
EA201270646A EA023923B1 (ru) 2009-11-27 2010-11-24 Ингибиторы глюкозилцерамидсинтазы
EA201890254A EA201890254A3 (ru) 2009-11-27 2010-11-24 Ингибиторы глюкозилцерамидсинтазы

Country Status (40)

Country Link
US (6) US11458119B2 (enExample)
EP (5) EP3896069A1 (enExample)
JP (6) JP2013512252A (enExample)
KR (6) KR20180049255A (enExample)
CN (5) CN112521366A (enExample)
AR (3) AR079152A1 (enExample)
AU (3) AU2010324810B2 (enExample)
BR (1) BR112012012947B8 (enExample)
CA (3) CA3140959A1 (enExample)
CL (2) CL2012001348A1 (enExample)
CR (1) CR20120277A (enExample)
CY (3) CY1115880T1 (enExample)
DK (3) DK2796457T3 (enExample)
DO (2) DOP2012000141A (enExample)
EA (3) EA029990B1 (enExample)
EC (2) ECSP12011926A (enExample)
ES (4) ES2586947T3 (enExample)
GT (1) GT201200161A (enExample)
HR (3) HRP20140780T4 (enExample)
HU (2) HUE029371T2 (enExample)
IL (4) IL310635A (enExample)
LT (2) LT2796457T (enExample)
MA (1) MA33838B1 (enExample)
ME (1) ME02477B (enExample)
MX (2) MX358345B (enExample)
MY (2) MY160542A (enExample)
NI (1) NI201200096A (enExample)
NZ (3) NZ625712A (enExample)
PE (2) PE20171255A1 (enExample)
PH (2) PH12015502514B1 (enExample)
PL (4) PL3133070T3 (enExample)
PT (4) PT2796457T (enExample)
RS (3) RS54978B1 (enExample)
SG (2) SG10201407881WA (enExample)
SI (3) SI3133070T1 (enExample)
SM (1) SMT201600273B (enExample)
TN (1) TN2012000237A1 (enExample)
TW (3) TWI586663B (enExample)
UA (1) UA113491C2 (enExample)
WO (1) WO2011066352A1 (enExample)

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