EA029069B1 - C17-гетероарильные производные олеаноловой кислоты и способы их применения - Google Patents

C17-гетероарильные производные олеаноловой кислоты и способы их применения Download PDF

Info

Publication number
EA029069B1
EA029069B1 EA201590539A EA201590539A EA029069B1 EA 029069 B1 EA029069 B1 EA 029069B1 EA 201590539 A EA201590539 A EA 201590539A EA 201590539 A EA201590539 A EA 201590539A EA 029069 B1 EA029069 B1 EA 029069B1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound according
disease
compound
pharmaceutically acceptable
groups
Prior art date
Application number
EA201590539A
Other languages
English (en)
Russian (ru)
Other versions
EA201590539A1 (ru
Inventor
Синь Цзян
Кристофер Ф. Бендер
Мелеэн Висник
Original Assignee
Рита Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рита Фармасьютикалз, Инк. filed Critical Рита Фармасьютикалз, Инк.
Publication of EA201590539A1 publication Critical patent/EA201590539A1/ru
Publication of EA029069B1 publication Critical patent/EA029069B1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/101,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J63/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008Expansion of ring D by one atom, e.g. D homo steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Lubricants (AREA)
  • Steroid Compounds (AREA)
  • Epidemiology (AREA)
EA201590539A 2012-09-10 2013-09-10 C17-гетероарильные производные олеаноловой кислоты и способы их применения EA029069B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261699199P 2012-09-10 2012-09-10
PCT/US2013/059015 WO2014040056A1 (en) 2012-09-10 2013-09-10 C17-heteroaryl derivatives of oleanolic acid and methods of use thereof

Publications (2)

Publication Number Publication Date
EA201590539A1 EA201590539A1 (ru) 2015-08-31
EA029069B1 true EA029069B1 (ru) 2018-02-28

Family

ID=49253401

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590539A EA029069B1 (ru) 2012-09-10 2013-09-10 C17-гетероарильные производные олеаноловой кислоты и способы их применения

Country Status (28)

Country Link
US (1) US20140088163A1 (cg-RX-API-DMAC7.html)
EP (1) EP2892911B1 (cg-RX-API-DMAC7.html)
JP (1) JP6272870B2 (cg-RX-API-DMAC7.html)
KR (1) KR102237364B1 (cg-RX-API-DMAC7.html)
CN (1) CN104768965B (cg-RX-API-DMAC7.html)
AU (1) AU2013312102B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015005200B1 (cg-RX-API-DMAC7.html)
CA (1) CA2882417C (cg-RX-API-DMAC7.html)
CY (1) CY1119762T1 (cg-RX-API-DMAC7.html)
DK (1) DK2892911T3 (cg-RX-API-DMAC7.html)
EA (1) EA029069B1 (cg-RX-API-DMAC7.html)
ES (1) ES2644615T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20171565T1 (cg-RX-API-DMAC7.html)
HU (1) HUE036797T2 (cg-RX-API-DMAC7.html)
IL (1) IL237638B (cg-RX-API-DMAC7.html)
IN (1) IN2015DN01547A (cg-RX-API-DMAC7.html)
LT (1) LT2892911T (cg-RX-API-DMAC7.html)
ME (1) ME02911B (cg-RX-API-DMAC7.html)
MX (1) MX366954B (cg-RX-API-DMAC7.html)
NZ (1) NZ705213A (cg-RX-API-DMAC7.html)
PL (1) PL2892911T3 (cg-RX-API-DMAC7.html)
PT (1) PT2892911T (cg-RX-API-DMAC7.html)
RS (1) RS56563B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201501800UA (cg-RX-API-DMAC7.html)
SI (1) SI2892911T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201700501T1 (cg-RX-API-DMAC7.html)
WO (1) WO2014040056A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201501203B (cg-RX-API-DMAC7.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3492077A1 (en) 2008-01-11 2019-06-05 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
AU2009251437B2 (en) 2008-04-18 2014-10-30 Reata Pharmaceuticals, Inc. Compounds including an anti-inflammatory pharmacore and methods of use
WO2009129546A1 (en) 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17
EA025568B1 (ru) 2010-12-17 2017-01-30 Рита Фармасьютикалз, Инк. Пиразолильные и пиримидинильные трициклические еноны в качестве антиоксидантных модуляторов воспаления
MX357060B (es) 2012-04-27 2018-06-25 Reata Pharmaceuticals Inc Derivados de 2,2-difluoropropionamida de bardoxolon metilo, formas polimorficas y metodo para su uso de los mismos.
WO2013188818A1 (en) 2012-06-15 2013-12-19 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
UY35023A (es) 2012-09-10 2014-03-31 Reata Pharmaceuticals Inc Derivados c17-alcandiilo y alquendiilo del ácido oleanólico y sus métodos de uso
UY39092A (es) 2013-04-24 2021-03-26 Abbvie Inc Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso
AU2016219109B2 (en) 2015-02-12 2020-05-14 Reata Pharmaceuticals, Inc. Imidazolyl tricyclic enones as antioxidant iflammation modulators
CA2998681C (en) 2015-09-23 2024-02-06 Reata Pharmaceuticals, Inc. C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses
BR112019009256A2 (pt) 2016-11-08 2019-07-16 Reata Pharmaceuticals Inc métodos para tratar síndrome de alport usando bardoxolona metil ou análogos do mesmo
CN106632574B (zh) * 2016-12-07 2018-05-29 广东天键生物科技有限公司 一种化合物、其制备方法及用途
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制RORγ及其他用途的嘧啶三環烯酮衍生物
MX2020002883A (es) 2017-09-14 2020-10-05 Phoenix Biotechnology Inc Método y composiciones para tratar la infección viral.
AU2018334467B2 (en) 2017-09-14 2022-10-20 Phoenix Biotechnology, Inc. Method and improved neuroprotective composition for treating neurological conditions
IL322405A (en) 2018-06-15 2025-09-01 Reata Pharmaceuticals Inc Decahydro-2h-naphth[1,2-d]imidazole compounds for inhibition of IL-17 and ROR-gamma
US12060340B2 (en) 2018-06-20 2024-08-13 Reata Pharmaceuticals, Inc Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith
JP2022501445A (ja) * 2018-09-28 2022-01-06 スーチョワン ハイスコ ファーマスーティカル カンパニー リミテッドSichuan Haisco Pharmaceutical Co., Ltd. テルペノイド誘導体及びその用途
CN114641483B (zh) * 2019-07-19 2024-12-06 里亚塔医药公司 C17极性的-取代的杂芳族合成三萜类化合物及其使用方法
EP4295854A3 (en) 2020-03-31 2024-04-03 Phoenix Biotechnology, Inc. Method and compositions for treating coronavirus infection
RU2020130238A (ru) 2020-03-31 2022-03-14 Феникс Байотекнолоджи, Инк. Способ и композиции для лечения коронавирусной инфекции
JP7214696B2 (ja) * 2020-10-01 2023-01-30 一般財団法人 化学物質評価研究機構 新規in vitro皮膚感作性試験法
WO2022126129A1 (en) 2020-12-11 2022-06-16 Reata Pharmaceuticals, Inc. Synthetic triterpenoids for use in therapy
AU2022208727A1 (en) 2021-01-18 2023-08-03 Reata Pharmaceuticals, Inc. Synthetic ursolic acid derivatives and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009129545A1 (en) * 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
WO2009129548A1 (en) * 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives
WO2012125488A1 (en) * 2011-03-11 2012-09-20 Reata Pharmaceuticals, Inc. C4-monomethyl triterpenoid derivatives and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326507B1 (en) * 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
CA2485565A1 (en) * 2002-05-13 2004-08-05 Trustees Of Dartmouth College Inhibitors and methods of use thereof
EP3492077A1 (en) 2008-01-11 2019-06-05 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
WO2009129546A1 (en) * 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17
TW201004627A (en) 2008-04-18 2010-02-01 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: novel derivatives of oleanolic acid
WO2013188818A1 (en) * 2012-06-15 2013-12-19 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009129545A1 (en) * 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
WO2009129548A1 (en) * 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives
WO2012125488A1 (en) * 2011-03-11 2012-09-20 Reata Pharmaceuticals, Inc. C4-monomethyl triterpenoid derivatives and methods of use thereof

Also Published As

Publication number Publication date
CN104768965A (zh) 2015-07-08
US20140088163A1 (en) 2014-03-27
WO2014040056A1 (en) 2014-03-13
CN104768965B (zh) 2018-05-11
AU2013312102A1 (en) 2015-03-12
IL237638A0 (en) 2015-04-30
SMT201700501T1 (it) 2017-11-15
KR20150053982A (ko) 2015-05-19
CA2882417C (en) 2021-04-20
IN2015DN01547A (cg-RX-API-DMAC7.html) 2015-07-03
ES2644615T3 (es) 2017-11-29
NZ705213A (en) 2018-07-27
JP2015529227A (ja) 2015-10-05
ZA201501203B (en) 2021-08-25
ME02911B (me) 2018-10-20
CY1119762T1 (el) 2018-06-27
DK2892911T3 (en) 2017-10-23
EA201590539A1 (ru) 2015-08-31
HUE036797T2 (hu) 2018-07-30
MX2015003078A (es) 2015-07-14
BR112015005200A2 (cg-RX-API-DMAC7.html) 2017-08-15
BR112015005200B1 (pt) 2022-07-05
CA2882417A1 (en) 2014-03-13
SI2892911T1 (sl) 2017-12-29
PT2892911T (pt) 2017-11-02
KR102237364B1 (ko) 2021-04-06
HRP20171565T1 (hr) 2017-12-15
JP6272870B2 (ja) 2018-01-31
PL2892911T3 (pl) 2018-03-30
AU2013312102B2 (en) 2018-03-08
IL237638B (en) 2020-04-30
HK1211295A1 (en) 2016-05-20
SG11201501800UA (en) 2015-04-29
EP2892911A1 (en) 2015-07-15
LT2892911T (lt) 2017-11-10
EP2892911B1 (en) 2017-08-30
MX366954B (es) 2019-07-31
RS56563B1 (sr) 2018-02-28

Similar Documents

Publication Publication Date Title
EA029069B1 (ru) C17-гетероарильные производные олеаноловой кислоты и способы их применения
US10898499B2 (en) C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
EA029174B1 (ru) C17-алкандиильные и алкендиильные производные олеаноловой кислоты и способы их применения
US9278912B2 (en) C13-hydroxy derivatives of oleanolic acid and methods of use thereof
ES2729405T3 (es) Derivados triterpenoides de C4-monometilo y métodos de uso de los mismos
US11059792B2 (en) Imidazolyl tricyclic enones as antioxidant inflammation modulators
HK1211295B (en) C17-heteroaryl derivatives of oleanolic acid and methods of use thereof