EA029025B1 - Аналоги глюкагона, проявляющие активность на рецепторе gip - Google Patents

Аналоги глюкагона, проявляющие активность на рецепторе gip Download PDF

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Publication number
EA029025B1
EA029025B1 EA201590065A EA201590065A EA029025B1 EA 029025 B1 EA029025 B1 EA 029025B1 EA 201590065 A EA201590065 A EA 201590065A EA 201590065 A EA201590065 A EA 201590065A EA 029025 B1 EA029025 B1 EA 029025B1
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EA
Eurasian Patent Office
Prior art keywords
amino acid
present
alkyl
peptide
glucagon
Prior art date
Application number
EA201590065A
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English (en)
Russian (ru)
Other versions
EA201590065A1 (ru
Inventor
Ричард Д. Димарчи
Дэвид Л. СМАЙЛИ
Конрад Х. Блайхер
Эрик А. Китас
Original Assignee
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн
Ф. Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн, Ф. Хоффманн-Ля Рош Аг filed Critical Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн
Publication of EA201590065A1 publication Critical patent/EA201590065A1/ru
Publication of EA029025B1 publication Critical patent/EA029025B1/ru

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
EA201590065A 2012-06-21 2013-06-18 Аналоги глюкагона, проявляющие активность на рецепторе gip EA029025B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261662874P 2012-06-21 2012-06-21
US201361787973P 2013-03-15 2013-03-15
PCT/US2013/046229 WO2013192130A1 (en) 2012-06-21 2013-06-18 Analogs of glucagon exhibiting gip receptor activity

Publications (2)

Publication Number Publication Date
EA201590065A1 EA201590065A1 (ru) 2015-07-30
EA029025B1 true EA029025B1 (ru) 2018-01-31

Family

ID=48692696

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590065A EA029025B1 (ru) 2012-06-21 2013-06-18 Аналоги глюкагона, проявляющие активность на рецепторе gip

Country Status (30)

Country Link
US (2) US9868772B2 (https=)
EP (1) EP2864350B1 (https=)
JP (1) JP6300239B2 (https=)
KR (1) KR20150039748A (https=)
CN (1) CN104583233B (https=)
AR (1) AR091478A1 (https=)
AU (1) AU2013277372B2 (https=)
BR (1) BR112014031671A2 (https=)
CA (1) CA2877127A1 (https=)
CL (1) CL2014003421A1 (https=)
CO (1) CO7170125A2 (https=)
CR (1) CR20150015A (https=)
DK (1) DK2864350T3 (https=)
EA (1) EA029025B1 (https=)
ES (1) ES2674946T3 (https=)
HR (1) HRP20180936T1 (https=)
HU (1) HUE039267T2 (https=)
IL (1) IL236386B (https=)
MX (1) MX356000B (https=)
MY (1) MY185217A (https=)
PE (1) PE20150863A1 (https=)
PH (1) PH12014502857A1 (https=)
PL (1) PL2864350T3 (https=)
PT (1) PT2864350T (https=)
RS (1) RS57347B1 (https=)
SG (1) SG11201408491SA (https=)
SI (1) SI2864350T1 (https=)
TR (1) TR201808818T4 (https=)
TW (1) TWI644920B (https=)
WO (1) WO2013192130A1 (https=)

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US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
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KR20240051304A (ko) * 2018-07-23 2024-04-19 일라이 릴리 앤드 캄파니 Gip/glp1 공효능제 화합물
US11166910B2 (en) 2019-01-25 2021-11-09 Nordiccan A/S Cannabinoid chewing gum with sugar alcohols
CN114945589B (zh) * 2020-02-24 2024-05-24 深圳市图微安创科技开发有限公司 多肽化合物及其在预防或治疗糖尿病或糖尿病并发症中的应用
CN115335395A (zh) * 2020-03-25 2022-11-11 武田药品工业株式会社 Gip受体激动剂肽化合物的qd给药及其用途
CN113493503B (zh) * 2020-04-08 2022-08-05 浙江道尔生物科技有限公司 一种肠促胰岛素类似物及其制备方法和用途
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CN114621327B (zh) * 2020-12-10 2023-08-18 江苏中新医药有限公司 GLP-1、GIP和Gcg多重受体激动蛋白质
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TW202330584A (zh) 2022-01-20 2023-08-01 丹麥商諾佛 儂迪克股份有限公司 前藥及其用途
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US9868772B2 (en) 2018-01-16
MY185217A (en) 2021-04-30
SG11201408491SA (en) 2015-01-29
EP2864350A1 (en) 2015-04-29
PH12014502857A1 (en) 2015-02-23
BR112014031671A2 (pt) 2018-08-07
CN104583233A (zh) 2015-04-29
TR201808818T4 (tr) 2018-07-23
MX2014015556A (es) 2015-03-05
CA2877127A1 (en) 2013-12-27
AR091478A1 (es) 2015-02-04
CN104583233B (zh) 2018-10-23
IL236386A0 (en) 2015-02-26
KR20150039748A (ko) 2015-04-13
MX356000B (es) 2018-05-08
AU2013277372A1 (en) 2014-12-11
DK2864350T3 (en) 2018-05-28
TWI644920B (zh) 2018-12-21
EA201590065A1 (ru) 2015-07-30
WO2013192130A1 (en) 2013-12-27
HRP20180936T1 (hr) 2018-12-14
CO7170125A2 (es) 2015-01-28
CL2014003421A1 (es) 2015-05-22
PL2864350T3 (pl) 2019-01-31
IL236386B (en) 2019-09-26
ES2674946T3 (es) 2018-07-05
SI2864350T1 (en) 2018-08-31
HUE039267T2 (hu) 2018-12-28
RS57347B1 (sr) 2018-08-31
JP2015528795A (ja) 2015-10-01
CR20150015A (es) 2015-04-24
AU2013277372B2 (en) 2018-03-29
PT2864350T (pt) 2018-05-14
US20150368310A1 (en) 2015-12-24
TW201402603A (zh) 2014-01-16
US20180105569A1 (en) 2018-04-19
JP6300239B2 (ja) 2018-03-28
EP2864350B1 (en) 2018-03-28
PE20150863A1 (es) 2015-06-11

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