HUE039267T2 - GIP-receptor aktivitást mutató glukagon-analógok - Google Patents

GIP-receptor aktivitást mutató glukagon-analógok

Info

Publication number
HUE039267T2
HUE039267T2 HUE13731246A HUE13731246A HUE039267T2 HU E039267 T2 HUE039267 T2 HU E039267T2 HU E13731246 A HUE13731246 A HU E13731246A HU E13731246 A HUE13731246 A HU E13731246A HU E039267 T2 HUE039267 T2 HU E039267T2
Authority
HU
Hungary
Prior art keywords
analogs
receptor activity
gip receptor
glucagon
exhibiting gip
Prior art date
Application number
HUE13731246A
Other languages
English (en)
Inventor
Richard D Dimarchi
David L Smiley
Konrad H Bleicher
Eric A Kitas
Original Assignee
Univ Indiana Res & Tech Corp
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Indiana Res & Tech Corp, Novo Nordisk As filed Critical Univ Indiana Res & Tech Corp
Publication of HUE039267T2 publication Critical patent/HUE039267T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HUE13731246A 2012-06-21 2013-06-18 GIP-receptor aktivitást mutató glukagon-analógok HUE039267T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261662874P 2012-06-21 2012-06-21
US201361787973P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
HUE039267T2 true HUE039267T2 (hu) 2018-12-28

Family

ID=48692696

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE13731246A HUE039267T2 (hu) 2012-06-21 2013-06-18 GIP-receptor aktivitást mutató glukagon-analógok

Country Status (30)

Country Link
US (2) US9868772B2 (hu)
EP (1) EP2864350B1 (hu)
JP (1) JP6300239B2 (hu)
KR (1) KR20150039748A (hu)
CN (1) CN104583233B (hu)
AR (1) AR091478A1 (hu)
AU (1) AU2013277372B2 (hu)
BR (1) BR112014031671A2 (hu)
CA (1) CA2877127A1 (hu)
CL (1) CL2014003421A1 (hu)
CO (1) CO7170125A2 (hu)
CR (1) CR20150015A (hu)
DK (1) DK2864350T3 (hu)
EA (1) EA029025B1 (hu)
ES (1) ES2674946T3 (hu)
HR (1) HRP20180936T1 (hu)
HU (1) HUE039267T2 (hu)
IL (1) IL236386B (hu)
MX (1) MX356000B (hu)
MY (1) MY185217A (hu)
PE (1) PE20150863A1 (hu)
PH (1) PH12014502857A1 (hu)
PL (1) PL2864350T3 (hu)
PT (1) PT2864350T (hu)
RS (1) RS57347B1 (hu)
SG (1) SG11201408491SA (hu)
SI (1) SI2864350T1 (hu)
TR (1) TR201808818T4 (hu)
TW (1) TWI644920B (hu)
WO (1) WO2013192130A1 (hu)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3243826T1 (sl) 2012-04-26 2020-03-31 Bristol-Myers Squibb Company Derivati imidazotiadiazola in imidazopirazina kot proteazno aktivirani receptor 4 (PAR4) inhibitorji za zdravljenje agregacije trombocitov
SG11201408491SA (en) * 2012-06-21 2015-01-29 Univ Indiana Res & Tech Corp Analogs of glucagon exhibiting gip receptor activity
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
UA116553C2 (uk) 2012-12-21 2018-04-10 Санофі Пептидна сполука - агоніст рецептора glp-1 i glp
UA118558C2 (uk) 2013-05-28 2019-02-11 Такеда Фармасьютікал Компані Лімітед Пептидна сполука
TW201609795A (zh) 2013-12-13 2016-03-16 賽諾菲公司 作為雙重ｇｌｐ－１／ｇｉｐ受體促效劑的艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物
WO2015086730A1 (en) 2013-12-13 2015-06-18 Sanofi Non-acylated exendin-4 peptide analogues
TW201609799A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重ｇｌｐ－１／ｇｉｐ受體促效劑
TW201609797A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重ｇｌｐ－１／升糖素受體促效劑
JP2017504598A (ja) 2013-12-20 2017-02-09 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション 脂質化インクレチン受容体リガンドヒト免疫グロブリンｆｃ−領域融合ポリペプチド
TW201625668A (zh) * 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
TW201625669A (zh) * 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
MA55068A (fr) 2014-10-24 2022-01-05 Merck Sharp & Dohme Co-agonistes des récepteurs du glucagon et du glp-1
CA2972748A1 (en) 2014-12-30 2016-07-07 Hanmi Pharm. Co., Ltd. Glucagon derivative having improved stability
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
KR102005456B1 (ko) 2015-06-30 2019-07-30 한미약품 주식회사 신규 글루카곤 유도체 및 이의 지속형 결합체를 포함하는 조성물
AR105284A1 (es) 2015-07-10 2017-09-20 Sanofi Sa Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
TWI622596B (zh) 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
DK3393496T3 (en) 2015-12-23 2023-11-13 Univ Johns Hopkins Long-acting glp-1r agonist as a therapy of neurological and neurodegenerative conditions
JP6712323B2 (ja) * 2015-12-31 2020-06-17 ハンミ ファーマシューティカル カンパニー リミテッド グルカゴン、ｇｌｐ−１及びｇｉｐ受容体のすべてに活性を有する三重活性体
CA3024962A1 (en) 2016-05-24 2017-11-30 Takeda Pharmaceutical Company Limited Peptide compound
BR112018077457A2 (pt) 2016-06-29 2019-04-02 Hanmi Pharm. Co., Ltd. composição farmacêutica para evitar ou tratar hiperinsulinismo congênito e seu método, hipoglicemia e seu método, síndrome metabólica e seu método e peptídeo isolado
TW201833132A (zh) 2016-12-02 2018-09-16 法商賽諾菲公司 作為肽類ｇｌｐ１／升糖素／ｇｉｐ三重受體激動劑之新穎化合物
AR110301A1 (es) 2016-12-02 2019-03-13 Sanofi Sa Compuestos como agonistas peptídicos de receptores de glp1 / glucagón / gip
JOP20180028A1 (ar) 2017-03-31 2019-01-30 Takeda Pharmaceuticals Co مركب ببتيد
CN115304666A (zh) * 2017-11-24 2022-11-08 浙江道尔生物科技有限公司 一种治疗代谢疾病的胰高血糖素类似物
KR20200142032A (ko) 2018-04-10 2020-12-21 사노피-아벤티스 도이칠란트 게엠베하 캡핑을 사용한 릭시세나티드 합성
KR20200142033A (ko) 2018-04-10 2020-12-21 사노피-아벤티스 도이칠란트 게엠베하 고체상으로부터 고체상-결합된 펩타이드를 절단하는 방법
CA3097939A1 (en) * 2018-05-04 2019-11-07 Novo Nordisk A/S Gip derivatives and uses thereof
UY38249A (es) 2018-05-30 2019-12-31 Sanofi Sa Productos conjugados que comprenden un agonista del receptor triple de glp-1/glucagón/gip, un conector y ácido hialurónico
US11166910B2 (en) * 2019-01-25 2021-11-09 Nordiccan A/S Cannabinoid chewing gum with sugar alcohols
WO2021169512A1 (zh) * 2020-02-24 2021-09-02 中山大学 多肽化合物及其在预防或治疗糖尿病或糖尿病并发症中的应用
CN113493503B (zh) * 2020-04-08 2022-08-05 浙江道尔生物科技有限公司 一种肠促胰岛素类似物及其制备方法和用途
KR102446310B1 (ko) 2020-07-22 2022-09-23 노보 노르디스크 에이/에스 경구 전달에 적합한 glp-1 및 gip 수용체에서의 공-작용제
EP4249505A1 (en) 2020-12-23 2023-09-27 Zhejiang Doer Biologics Co., Ltd. Long-acting glucagon derivative
WO2022156189A1 (zh) * 2021-01-22 2022-07-28 深圳市图微安创科技开发有限公司 多肽化合物在预防或治疗炎症性肠病及其相关的肠纤维化中的应用
TW202330584A (zh) 2022-01-20 2023-08-01 丹麥商諾佛 儂迪克股份有限公司 前藥及其用途
CN115536739B (zh) * 2022-07-04 2023-04-14 北京惠之衡生物科技有限公司 一种glp-1受体和gcg受体共激动多肽衍生物的制备方法
JP7402574B1 (ja) 2023-03-15 2023-12-21 株式会社合同資源 α－ヨード置換カルボン酸

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450150A (en) 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
WO1987005330A1 (en) 1986-03-07 1987-09-11 Michel Louis Eugene Bergh Method for enhancing glycoprotein stability
IN165717B (hu) 1986-08-07 1989-12-23 Battelle Memorial Institute
JP3266311B2 (ja) 1991-05-02 2002-03-18 生化学工業株式会社 新規ポリペプチドおよびこれを用いる抗ｈｉｖ剤
CN1296417A (zh) 1998-02-10 2001-05-23 卫福有限公司 控释制剂
GB2344287A (en) 1998-12-03 2000-06-07 Ferring Bv Controlled release pharmaceutical formulation
ATE458534T1 (de) 2002-10-04 2010-03-15 Microchips Inc Medizinische vorrichtung zur gesteuerten arzneimittelverabreichung sowie herzüberwachung und/oder herzstimulation
SE0302312D0 (sv) * 2002-10-04 2003-08-27 Forskarpatent I Syd Ab Peptide-based passive immunization therapy for treatment of atherosclerosis
JP2006524039A (ja) 2003-01-09 2006-10-26 マクロジェニクス，インコーポレーテッド 変異型Ｆｃ領域を含む抗体の同定および作製ならびにその利用法
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
US7846445B2 (en) 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
MX2008014418A (es) 2006-05-15 2008-11-27 Wisconsin Alumni Res Found Administracion pulmonar de la 1 alfa, 25-dihidroxivitamina d3 y co-administracion de la homona paratiroidea o calcitonina.
FR2902092B1 (fr) 2006-06-07 2008-09-05 Sapelem Soc Par Actions Simpli Appareil de manutention de charge
EA017849B1 (ru) * 2007-02-15 2013-03-29 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Соагонисты глюкагоновых/glp-1-рецепторов
JP5302952B2 (ja) 2007-04-19 2013-10-02 ドン・ア・ファーム・カンパニー・リミテッド 糖調節ペプチドの制御放出に適した生分解性マイクロスフェア組成物及びその製造方法
EP2185701A4 (en) 2007-08-15 2011-03-02 Amunix Operating Inc COMPOSITIONS AND METHODS FOR ENHANCING THE PRODUCTION OF RECOMBINANT POLYPEPTIDES
ES2650038T3 (es) * 2008-06-17 2018-01-16 Indiana University Research And Technology Corporation Agonistas mixtos a base de GIP para el tratamiento de trastornos metabólicos y obesidad
ES2579502T3 (es) * 2008-06-17 2016-08-11 Indiana University Research And Technology Corporation Coagonistas de receptores de glucagón/GLP-1
SG172291A1 (en) 2008-12-19 2011-07-28 Univ Indiana Res & Tech Corp Amide based glucagon superfamily peptide prodrugs
JP5887265B2 (ja) * 2009-06-16 2016-03-16 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション Ｇｉｐ受容体活性グルカゴン化合物
RU2012136450A (ru) 2010-01-27 2014-03-10 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Конъюгаты антагонист глюкагона - агонист gip и композиции для лечения метаболических расстройств и ожирения
CA2797095A1 (en) * 2010-05-13 2011-11-17 Indiana University Research And Technology Corporation Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
KR20130102470A (ko) * 2010-06-24 2013-09-17 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 아미드계 글루카곤 슈퍼패밀리 펩티드 프로드러그
US9309301B2 (en) * 2011-06-22 2016-04-12 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
GEP20176629B (en) * 2011-06-22 2017-02-27 Indiana Unversity Research And Tech Corporation Glucagon/glp-1 receptor co-agonists
SG11201408491SA (en) * 2012-06-21 2015-01-29 Univ Indiana Res & Tech Corp Analogs of glucagon exhibiting gip receptor activity
CN108271356A (zh) * 2014-09-24 2018-07-10 印第安纳大学研究及科技有限公司 肠降血糖素-胰岛素缀合物

Also Published As

Publication number Publication date
PL2864350T3 (pl) 2019-01-31
RS57347B1 (sr) 2018-08-31
US20150368310A1 (en) 2015-12-24
SI2864350T1 (en) 2018-08-31
JP2015528795A (ja) 2015-10-01
JP6300239B2 (ja) 2018-03-28
KR20150039748A (ko) 2015-04-13
EP2864350A1 (en) 2015-04-29
PH12014502857A1 (en) 2015-02-23
PE20150863A1 (es) 2015-06-11
EA029025B1 (ru) 2018-01-31
CL2014003421A1 (es) 2015-05-22
DK2864350T3 (en) 2018-05-28
PT2864350T (pt) 2018-05-14
CN104583233B (zh) 2018-10-23
AU2013277372A1 (en) 2014-12-11
EA201590065A1 (ru) 2015-07-30
MY185217A (en) 2021-04-30
BR112014031671A2 (pt) 2018-08-07
US20180105569A1 (en) 2018-04-19
HRP20180936T1 (hr) 2018-12-14
CA2877127A1 (en) 2013-12-27
WO2013192130A1 (en) 2013-12-27
CR20150015A (es) 2015-04-24
CO7170125A2 (es) 2015-01-28
IL236386A0 (en) 2015-02-26
TWI644920B (zh) 2018-12-21
EP2864350B1 (en) 2018-03-28
MX2014015556A (es) 2015-03-05
TW201402603A (zh) 2014-01-16
AU2013277372B2 (en) 2018-03-29
IL236386B (en) 2019-09-26
ES2674946T3 (es) 2018-07-05
US9868772B2 (en) 2018-01-16
SG11201408491SA (en) 2015-01-29
AR091478A1 (es) 2015-02-04
MX356000B (es) 2018-05-08
CN104583233A (zh) 2015-04-29
TR201808818T4 (tr) 2018-07-23

Similar Documents

Publication Publication Date Title
HRP20180936T1 (hr) Analozi glukagona koji pokazuju aktivnost prema receptoru za gip
HK1209764A1 (en) Glucagon analogs exhibiting gip receptor activity gip
ZA201702364B (en) Glucagon analogues
HK1217946A1 (zh) 司普力西歐他汀類似物
HK1206757A1 (en) Glucagon analogues
BR112014015681A2 (pt) análogos de glucagon
IL231199A0 (en) New analogs of glucagon
BR112013024076A2 (pt) análogos de glucagon
HRP20181596T1 (hr) Tiazolopirimidinoni kao modulatori aktivnosti nmda receptora
IL238080A0 (en) Somatostatin-dopamine chimeric analogs
EP2939081A4 (en) ORIENTATION OF PERIODIC ACTIVITIES
EP2928469A4 (en) POLYMORPHIC FORMS OF DESAZADESFERRITHIOCIN ANALOGS
TWM433525U (en) Structure of calorifier
HUE049152T2 (hu) Hosszantartó hatású GLP-1 peptidek alkalmazása