EA028595B1 - Селективные ингибиторы cdk8/cdk19 и их применение в качестве противометастатических и химиопрофилактических агентов для лечения рака - Google Patents

Селективные ингибиторы cdk8/cdk19 и их применение в качестве противометастатических и химиопрофилактических агентов для лечения рака Download PDF

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EA028595B1
EA028595B1 EA201491399A EA201491399A EA028595B1 EA 028595 B1 EA028595 B1 EA 028595B1 EA 201491399 A EA201491399 A EA 201491399A EA 201491399 A EA201491399 A EA 201491399A EA 028595 B1 EA028595 B1 EA 028595B1
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molecular weight
low molecular
cancer
patient
weight compound
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EA201491399A
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English (en)
Russian (ru)
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EA201491399A1 (ru
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Игорь Ронинсон
Дональд Си. Портер
Марк Пи. Уэнтланд
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Сенекс Биотекнолоджи Инк.
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Publication of EA201491399A1 publication Critical patent/EA201491399A1/ru
Publication of EA028595B1 publication Critical patent/EA028595B1/ru

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57515—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the breast
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EA201491399A 2012-02-02 2013-02-01 Селективные ингибиторы cdk8/cdk19 и их применение в качестве противометастатических и химиопрофилактических агентов для лечения рака EA028595B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261594023P 2012-02-02 2012-02-02
US61/594,023 2012-02-02
US201261673419P 2012-07-19 2012-07-19
US61/673,419 2012-07-19
PCT/US2013/024515 WO2013116786A1 (en) 2012-02-02 2013-02-01 Cdk8/cdk19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer

Publications (2)

Publication Number Publication Date
EA201491399A1 EA201491399A1 (ru) 2015-04-30
EA028595B1 true EA028595B1 (ru) 2017-12-29

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Application Number Title Priority Date Filing Date
EA201491399A EA028595B1 (ru) 2012-02-02 2013-02-01 Селективные ингибиторы cdk8/cdk19 и их применение в качестве противометастатических и химиопрофилактических агентов для лечения рака
EA201791284A EA032429B1 (ru) 2012-02-02 2013-02-01 Селективные низкомолекулярные ингибиторы cdk8/cdk19 и их применение в качестве агентов для лечения рака

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EA201791284A EA032429B1 (ru) 2012-02-02 2013-02-01 Селективные низкомолекулярные ингибиторы cdk8/cdk19 и их применение в качестве агентов для лечения рака

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US (2) US9321737B2 (OSRAM)
EP (2) EP3431087A1 (OSRAM)
JP (1) JP6193268B2 (OSRAM)
KR (1) KR20150023223A (OSRAM)
CN (1) CN104363913B (OSRAM)
AU (1) AU2013214783B2 (OSRAM)
BR (1) BR112014019052A8 (OSRAM)
CL (1) CL2014002062A1 (OSRAM)
CO (1) CO7151516A2 (OSRAM)
EA (2) EA028595B1 (OSRAM)
GE (2) GEP201706688B (OSRAM)
MY (1) MY165446A (OSRAM)
PH (1) PH12014501862A1 (OSRAM)
SG (1) SG11201404596UA (OSRAM)
UA (1) UA117342C2 (OSRAM)
WO (1) WO2013116786A1 (OSRAM)

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WO2016182932A1 (en) 2015-05-08 2016-11-17 President And Fellows Of Harvard College Cortistatin analogues, syntheses, and uses thereof
WO2017004411A1 (en) 2015-07-01 2017-01-05 President And Fellows Of Harvard College Cortistatin analogues and syntheses and uses thereof
JP6977238B2 (ja) 2015-11-03 2021-12-08 エルユー ライセンス エービーLu License Ab 低増殖性障害の治療のための化合物
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US10993945B2 (en) 2021-05-04
US20140038958A1 (en) 2014-02-06
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US9321737B2 (en) 2016-04-26
PH12014501862A1 (en) 2014-11-24
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AU2013214783A1 (en) 2014-08-28
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