EA020022B1 - Способы лечения с применением пиридопиримидиноновых ингибиторов pi3k-альфа - Google Patents

Info

Publication number

EA020022B1

EA020022B1 EA200970932A EA200970932A EA020022B1 EA 020022 B1 EA020022 B1 EA 020022B1 EA 200970932 A EA200970932 A EA 200970932A EA 200970932 A EA200970932 A EA 200970932A EA 020022 B1 EA020022 B1 EA 020022B1

Authority

EA

Eurasian Patent Office

Prior art keywords

methyl

compound

cancer

treatment

formula

Prior art date

2007-04-10

Links

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• 206010028980 Neoplasm Diseases 0.000 title claims abstract description 124
• 201000011510 cancer Diseases 0.000 title claims abstract description 118
• 239000003112 inhibitor Substances 0.000 title claims description 69
• 238000000034 method Methods 0.000 title description 521
• IAAQUOVTPAMQCR-UHFFFAOYSA-N 1h-pyrido[3,2-d]pyrimidin-2-one Chemical compound C1=CC=C2NC(=O)N=CC2=N1 IAAQUOVTPAMQCR-UHFFFAOYSA-N 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 343
• 238000011282 treatment Methods 0.000 claims abstract description 304
• 150000003839 salts Chemical class 0.000 claims abstract description 75
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims abstract description 31
• 229960004562 carboplatin Drugs 0.000 claims abstract description 25
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims abstract description 25
• 229960002930 sirolimus Drugs 0.000 claims abstract description 25
• AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims abstract description 21
• 239000005551 L01XE03 - Erlotinib Substances 0.000 claims abstract description 20
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• 239000003795 chemical substances by application Substances 0.000 claims description 30
• VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims description 25
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• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 58
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• 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 description 51
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 51
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 42
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 39
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 38
• 125000001424 substituent group Chemical group 0.000 description 38
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 34
• 229910052739 hydrogen Inorganic materials 0.000 description 33
• 239000001257 hydrogen Substances 0.000 description 32
• 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 32
• 239000012453 solvate Substances 0.000 description 32
• ANTISGAVDLDNTA-UHFFFAOYSA-N 2-methoxyquinazolin-4-amine Chemical compound C1=CC=CC2=NC(OC)=NC(N)=C21 ANTISGAVDLDNTA-UHFFFAOYSA-N 0.000 description 31
• 125000003118 aryl group Chemical group 0.000 description 29
• 125000004432 carbon atom Chemical group C* 0.000 description 29
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 28
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