HRP20130688T1 - Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha - Google Patents

Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha

Info

Publication number
HRP20130688T1
HRP20130688T1 HRP20130688AT HRP20130688T HRP20130688T1 HR P20130688 T1 HRP20130688 T1 HR P20130688T1 HR P20130688A T HRP20130688A T HR P20130688AT HR P20130688 T HRP20130688 T HR P20130688T HR P20130688 T1 HRP20130688 T1 HR P20130688T1
Authority
HR
Croatia
Prior art keywords
methods
treating cancer
pi3k alpha
pyridopyrimidinone
inhibitors
Prior art date
Application number
HRP20130688AT
Other languages
English (en)
Inventor
Peter Lamb
David Matthews
Original Assignee
Exelixis Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc. filed Critical Exelixis Inc.
Publication of HRP20130688T1 publication Critical patent/HRP20130688T1/hr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • A61K31/282Platinum compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HRP20130688AT 2007-04-10 2013-07-22 Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha HRP20130688T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92289907P 2007-04-10 2007-04-10
PCT/US2008/004573 WO2008124161A1 (en) 2007-04-10 2008-04-09 Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha

Publications (1)

Publication Number Publication Date
HRP20130688T1 true HRP20130688T1 (en) 2013-09-30

Family

ID=39627802

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20130688AT HRP20130688T1 (en) 2007-04-10 2013-07-22 Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha

Country Status (32)

Country Link
US (1) US8513266B2 (hr)
EP (1) EP2139484B9 (hr)
JP (3) JP2010523670A (hr)
KR (1) KR101626435B1 (hr)
CN (2) CN101715345A (hr)
AU (1) AU2008236562B2 (hr)
BR (1) BRPI0810206A2 (hr)
CA (1) CA2683641C (hr)
CO (1) CO6251254A2 (hr)
CR (1) CR11100A (hr)
DK (1) DK2139484T3 (hr)
DO (1) DOP2009000243A (hr)
EA (1) EA020022B1 (hr)
EC (1) ECSP099724A (hr)
ES (1) ES2430614T3 (hr)
HK (1) HK1139863A1 (hr)
HN (1) HN2009003002A (hr)
HR (1) HRP20130688T1 (hr)
IL (1) IL201284A (hr)
MA (1) MA31358B1 (hr)
ME (1) ME00936B (hr)
MX (1) MX2009010930A (hr)
MY (1) MY150697A (hr)
NZ (1) NZ580110A (hr)
PL (1) PL2139484T3 (hr)
PT (1) PT2139484E (hr)
RS (1) RS52939B (hr)
SI (1) SI2139484T1 (hr)
TN (1) TN2009000400A1 (hr)
UA (1) UA100979C2 (hr)
WO (1) WO2008124161A1 (hr)
ZA (1) ZA200906764B (hr)

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US8470834B2 (en) 2008-08-20 2013-06-25 Merck Sharp & Dohme Corp. AZO-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
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EP2326626B1 (en) * 2008-08-20 2013-10-16 Merck Sharp & Dohme Corp. Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
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WO2013071264A1 (en) * 2011-11-11 2013-05-16 Intellikine, Llc Combination of kinase inhibitors and uses thereof
US20150010545A1 (en) 2011-12-27 2015-01-08 Kadmon Corporation, Llc Methods for treatment of breast cancer nonresponsive to trastuzumab
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
MX367055B (es) 2012-06-26 2019-08-02 Del Mar Pharmaceuticals El uso de una composición que comprende dianhidrogalactitol, diacetildianhidrogalactitol, y dibromodulcitol, y análogos o derivados de cada uno para el tratamiento de malignidades resistentes a inhibidores de tirosina cinasa.
US8980259B2 (en) * 2012-07-20 2015-03-17 Novartis Ag Combination therapy
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US11491154B2 (en) 2013-04-08 2022-11-08 Dennis M. Brown Therapeutic benefit of suboptimally administered chemical compounds
US9950194B2 (en) 2014-09-09 2018-04-24 Mevion Medical Systems, Inc. Patient positioning system
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CR20190062A (es) * 2016-08-15 2019-05-22 Pfizer Inhibidores de cdk2/4/6
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Also Published As

Publication number Publication date
IL201284A0 (en) 2010-05-31
TN2009000400A1 (en) 2010-12-31
HN2009003002A (es) 2014-03-24
HK1139863A1 (en) 2010-09-30
PL2139484T3 (pl) 2013-12-31
EA200970932A1 (ru) 2010-04-30
CN102727498A (zh) 2012-10-17
ECSP099724A (es) 2010-03-31
DOP2009000243A (es) 2010-10-31
CN101715345A (zh) 2010-05-26
EP2139484B1 (en) 2013-07-17
MX2009010930A (es) 2010-01-20
UA100979C2 (ru) 2013-02-25
EP2139484B9 (en) 2014-06-11
BRPI0810206A2 (pt) 2014-10-21
KR20100016354A (ko) 2010-02-12
NZ580110A (en) 2012-06-29
CA2683641C (en) 2016-08-16
CR11100A (es) 2010-01-19
SI2139484T1 (sl) 2013-10-30
AU2008236562B2 (en) 2013-11-07
ES2430614T3 (es) 2013-11-21
EP2139484B8 (en) 2013-08-21
AU2008236562A1 (en) 2008-10-16
EA020022B1 (ru) 2014-08-29
JP2014034576A (ja) 2014-02-24
CN102727498B (zh) 2016-08-03
ZA200906764B (en) 2010-08-25
CO6251254A2 (es) 2011-02-21
DK2139484T3 (da) 2013-10-21
CA2683641A1 (en) 2008-10-16
RS52939B (en) 2014-02-28
PT2139484E (pt) 2013-10-31
US20100209420A1 (en) 2010-08-19
ME00936B (me) 2012-06-20
JP2010523670A (ja) 2010-07-15
JP2014139217A (ja) 2014-07-31
EP2139484A1 (en) 2010-01-06
WO2008124161A1 (en) 2008-10-16
MA31358B1 (fr) 2010-05-03
IL201284A (en) 2016-06-30
MY150697A (en) 2014-02-28
KR101626435B1 (ko) 2016-06-01
US8513266B2 (en) 2013-08-20

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