EA019156B1 - Производные оксима в качестве ингибиторов hsp90 - Google Patents

Производные оксима в качестве ингибиторов hsp90 Download PDF

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Publication number
EA019156B1
EA019156B1 EA201070912A EA201070912A EA019156B1 EA 019156 B1 EA019156 B1 EA 019156B1 EA 201070912 A EA201070912 A EA 201070912A EA 201070912 A EA201070912 A EA 201070912A EA 019156 B1 EA019156 B1 EA 019156B1
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EA
Eurasian Patent Office
Prior art keywords
methyl
amino
compound
phenyl
fluoro
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EA201070912A
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English (en)
Russian (ru)
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EA201070912A1 (ru
Inventor
Юн К. Чэнь
Эрик Ван Ко
Прасуна Гунтупалли
Джон Дэвид Лосон
Вольфганг Райнхард Людвиг Нотц
Джеффри А. Стаффорд
Хуонг-Тху Тон-Ну
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Такеда Фармасьютикал Компани Лимитед
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Publication of EA201070912A1 publication Critical patent/EA201070912A1/ru
Publication of EA019156B1 publication Critical patent/EA019156B1/ru

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EA201070912A 2008-02-01 2009-01-30 Производные оксима в качестве ингибиторов hsp90 EA019156B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2572508P 2008-02-01 2008-02-01
US10159508P 2008-09-30 2008-09-30
PCT/US2009/032728 WO2009097578A1 (en) 2008-02-01 2009-01-30 Oxim derivatives as hsp90 inhibitors

Publications (2)

Publication Number Publication Date
EA201070912A1 EA201070912A1 (ru) 2011-08-30
EA019156B1 true EA019156B1 (ru) 2014-01-30

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US (4) US20110053873A1 (ja)
EP (1) EP2252595B1 (ja)
JP (1) JP5524084B2 (ja)
KR (1) KR20100116206A (ja)
CN (1) CN101983191B (ja)
AR (1) AR071452A1 (ja)
AU (1) AU2009208947B2 (ja)
BR (1) BRPI0906598A2 (ja)
CA (1) CA2713658C (ja)
CL (1) CL2009000228A1 (ja)
CR (1) CR11659A (ja)
DO (1) DOP2010000236A (ja)
EA (1) EA019156B1 (ja)
EC (1) ECSP10010434A (ja)
ES (1) ES2475206T3 (ja)
GE (1) GEP20125718B (ja)
IL (1) IL207227A0 (ja)
MA (1) MA32104B1 (ja)
MX (1) MX2010008269A (ja)
MY (1) MY150596A (ja)
NZ (1) NZ587207A (ja)
PE (1) PE20091371A1 (ja)
SG (1) SG187502A1 (ja)
TW (1) TW200946531A (ja)
WO (1) WO2009097578A1 (ja)
ZA (1) ZA201005435B (ja)

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JP5383483B2 (ja) 2007-04-24 2014-01-08 塩野義製薬株式会社 アルツハイマー症治療用医薬組成物
GB2449293A (en) * 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
CN101983191B (zh) * 2008-02-01 2013-11-20 武田药品工业株式会社 作为hsp90抑制剂的肟衍生物
ES2738123T3 (es) 2008-06-13 2020-01-20 Shionogi & Co Derivado heterocíclico que contiene azufre que tiene actividad inhibitoria de ß-secretasa
JPWO2010047372A1 (ja) 2008-10-22 2012-03-22 塩野義製薬株式会社 Ｂａｃｅ１阻害活性を有する２−アミノピリミジン−４−オンおよび２−アミノピリジン誘導体
BR112012013854A2 (pt) 2009-12-11 2019-09-24 Shionogi & Co derivados de oxazina.
JP5766198B2 (ja) 2010-10-29 2015-08-19 塩野義製薬株式会社 縮合アミノジヒドロピリミジン誘導体
US8927721B2 (en) 2010-10-29 2015-01-06 Shionogi & Co., Ltd. Naphthyridine derivative
US8883779B2 (en) 2011-04-26 2014-11-11 Shinogi & Co., Ltd. Oxazine derivatives and a pharmaceutical composition for inhibiting BACE1 containing them
ITTO20111013A1 (it) 2011-11-03 2013-05-04 Dac Srl Composti farmaceutici
WO2014065434A1 (en) 2012-10-24 2014-05-01 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity
US20150320723A1 (en) * 2013-01-07 2015-11-12 St. Jude Children's Research Hospital Use of Small Molecule Unfolder Protein Response Modulators to Treat Tumors With Active Sonic Hedgehog (SSH) Signaling Due To Smoothened (SMO) Mutation
WO2014144715A1 (en) 2013-03-15 2014-09-18 Memorial Sloan-Kettering Cancer Center Hsp90-targeted cardiac imaging and therapy
WO2015023593A1 (en) 2013-08-12 2015-02-19 Emory University Progesterone phosphate analogs and uses related thereto
US10617772B2 (en) 2014-09-17 2020-04-14 Memorial Sloan Kettering Cancer Center Hsp9O-targeted inflammation and infection imaging and therapy
WO2016044120A1 (en) * 2014-09-19 2016-03-24 Merck Sharp & Dohme Corp. Diazine-fused amidine compounds as bace inhibitors, compositions, and their use
NZ745957A (en) 2016-04-07 2020-07-31 Glaxosmithkline Ip Dev Ltd Heterocyclic amides useful as protein modulators
CA3061185A1 (en) * 2017-04-24 2018-11-01 Samus Therapeutics, Inc. Hsp90 inhibitor oral formulations and related methods
CN111163839B (zh) 2017-05-26 2024-05-28 癌症研究科技有限公司 苯并咪唑酮衍生的bcl6抑制剂
JP2020534283A (ja) * 2017-09-15 2020-11-26 アンパサンド バイオファーマシューティカルズ インコーポレイテッドＡｍｐｅｒｓａｎｄ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． システインプロテアーゼのタンパク質阻害剤を介した自然転移の阻害
CN112544621B (zh) * 2020-04-13 2021-10-15 辽宁先达农业科学有限公司 一种制备2-(4-氯苯氧基)-丙氧胺的方法
CN111671749A (zh) * 2020-06-12 2020-09-18 重庆医科大学 双香豆素在制备HBx蛋白稳定性抑制剂中的用途
CN112661668B (zh) * 2020-12-31 2023-07-28 辽宁先达农业科学有限公司 一种n-取代酰胺类化合物及其制备方法
CN114259564B (zh) * 2021-11-30 2023-03-14 清华大学 Hsp90抑制剂阻碍stat3线粒体转运和治疗哮喘的新应用
CN115073458A (zh) * 2022-07-04 2022-09-20 山东致泰医药技术有限公司 一种阿维巴坦钠的制备方法
CN115381816A (zh) * 2022-08-04 2022-11-25 武汉市金银潭医院(武汉市传染病医院) Ver50589在制备抗肠道病毒71型药物中的应用
CN117907491B (zh) * 2024-03-12 2024-06-04 中国人民解放军军事科学院军事医学研究院 基于双衍生化技术的脱碱基位点lc-ms/ms分析方法

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