EA017815B1 - Биомаркеры для прогнозирования чувствительности или отсутствия чувствительности к анти-фно агентам - Google Patents
Биомаркеры для прогнозирования чувствительности или отсутствия чувствительности к анти-фно агентам Download PDFInfo
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- EA017815B1 EA017815B1 EA200971131A EA200971131A EA017815B1 EA 017815 B1 EA017815 B1 EA 017815B1 EA 200971131 A EA200971131 A EA 200971131A EA 200971131 A EA200971131 A EA 200971131A EA 017815 B1 EA017815 B1 EA 017815B1
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2749247C1 (ru) * | 2020-09-28 | 2021-06-07 | федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) (ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Се | Способ прогнозирования эффективности лечения ревматоидного артрита препаратом олокизумаб на основе генотипирования |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090235713A1 (en) * | 2008-03-24 | 2009-09-24 | Hirotec America, Inc. | Magnetically actuated roller head |
| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
| EP2376091A4 (en) | 2008-12-12 | 2012-08-01 | Univ California | NEW TARGETS FOR THE TREATMENT OF HYPERCHOLESTERINMIA |
| JP4883117B2 (ja) * | 2009-03-23 | 2012-02-22 | コニカミノルタビジネステクノロジーズ株式会社 | 画像処理装置の課金装置、それを用いた画像処理装置、画像処理装置の課金装置の制御方法、及び画像処理装置の課金装置の制御プログラム |
| JP6078339B2 (ja) | 2009-05-07 | 2017-02-08 | ベラサイト インコーポレイテッド | 甲状腺状態の診断のための方法および組成物 |
| MX353186B (es) | 2009-09-03 | 2018-01-05 | Genentech Inc | Metodos para el tratamiento, diagnosis y monitoreo de artritis reumatoide. |
| WO2011104381A2 (en) | 2010-02-26 | 2011-09-01 | Novo Nordisk A/S | Stable antibody containing compositions |
| CN102918165A (zh) * | 2010-03-24 | 2013-02-06 | Tc园表达公司 | 患有炎症疾病的受试者对细胞因子靶向药物(CyTD)的早期反应或无反应预测的基因和基因组合 |
| CA2800188A1 (en) | 2010-05-28 | 2011-12-01 | Novo Nordisk A/S | Stable multi-dose compositions comprising an antibody and a preservative |
| CN103502472B (zh) | 2011-02-28 | 2017-06-06 | 弗·哈夫曼-拉罗切有限公司 | 生物标记物和用于预测对b‑细胞拮抗剂的响应的方法 |
| EP2812445A2 (en) | 2012-02-10 | 2014-12-17 | Novo Nordisk A/S | Methods related to treatment of inflammatory diseases and disorders |
| US9031292B2 (en) * | 2012-04-19 | 2015-05-12 | Chang Gung University | Method for the diagnosis of neurodegenerative disorder by using diffusion kurtosis imaging |
| US20130338027A1 (en) * | 2012-06-15 | 2013-12-19 | Nuclea Biotechnologies, Inc. | Predictive Markers For Cancer and Metabolic Syndrome |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| ES2524164B1 (es) * | 2013-05-03 | 2015-10-27 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | Pronóstico de respuesta al tratamiento con anti-tnfalfa en pacientes de artritis reumatoide |
| US12297505B2 (en) | 2014-07-14 | 2025-05-13 | Veracyte, Inc. | Algorithms for disease diagnostics |
| US20170306402A1 (en) * | 2014-09-12 | 2017-10-26 | Biogen Ma Inc. | Systems and methods for characterization of multiple sclerosis |
| EP3770274A1 (en) | 2014-11-05 | 2021-01-27 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
| US10098168B2 (en) * | 2014-12-08 | 2018-10-09 | Apple Inc. | Neighbor awareness networking datapath |
| GB2547406A (en) * | 2015-11-20 | 2017-08-23 | Folkersen Lasse | Apparatus and methods of using of biomarkers for predicting TNF-inhibitor response |
| CN114712497B (zh) * | 2015-12-03 | 2024-03-22 | 雷杰纳荣制药公司 | 抗vegf剂在制备用于治疗新生血管性年龄相关性黄斑变性患者的药物中的用途 |
| GB201521357D0 (en) * | 2015-12-03 | 2016-01-20 | Univ Liverpool | Methods for predicting response to anti-TNF therapy |
| CN106520771B (zh) * | 2016-12-20 | 2019-02-12 | 江苏省人民医院 | 一种长非编码rna及其在诊断/治疗子痫前期中的应用 |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| KR102094802B1 (ko) * | 2017-10-24 | 2020-03-31 | 고려대학교 산학협력단 | 소변 대사체 분석을 이용한 베체트병의 진단방법 |
| EP3765634A4 (en) * | 2018-03-16 | 2021-12-01 | Scipher Medicine Corporation | METHODS AND SYSTEMS FOR PREDICTING THE RESPONSE TO ANTI-TNF THERAPIES |
| US11519020B2 (en) | 2018-05-25 | 2022-12-06 | Regeneron Pharmaceuticals, Inc. | Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF |
| CN110141578B (zh) * | 2019-06-10 | 2022-06-14 | 南通大学 | 环状RNA circ-Ankib1在制备促进神经再生和修复神经损伤药物中的应用 |
| GB2603294A (en) | 2019-06-27 | 2022-08-03 | Scipher Medicine Corp | Developing classifiers for stratifying patients |
| GB2616129A (en) * | 2020-09-01 | 2023-08-30 | Scipher Medicine Corp | Methods and systems for predicting response to anti-TNF therapies |
| US12379368B2 (en) * | 2020-09-11 | 2025-08-05 | Washington University | Methods for determining therapeutic responsiveness for inflammatory bowel disease therapy |
| CN112180082B (zh) * | 2020-09-27 | 2022-03-08 | 西安交通大学 | Tweak在制备红斑狼疮诊断试剂中的应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002046433A2 (en) * | 2000-12-08 | 2002-06-13 | Juan Saus | Tnf-inducible promotors and methods for using them |
| US20040009479A1 (en) * | 2001-06-08 | 2004-01-15 | Jay Wohlgemuth | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| WO2007025085A2 (en) * | 2005-08-24 | 2007-03-01 | Genizon Biosciences Inc. | Genemap of the human genes associated with crohn's disease |
| WO2007038501A2 (en) * | 2005-09-27 | 2007-04-05 | The Feinstein Institute For Medical Research | Rheumatoid arthritis markers |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4499052A (en) | 1982-08-30 | 1985-02-12 | Becton, Dickinson And Company | Apparatus for distinguishing multiple subpopulations of cells |
| US4582789A (en) | 1984-03-21 | 1986-04-15 | Cetus Corporation | Process for labeling nucleic acids using psoralen derivatives |
| US4563417A (en) | 1984-08-31 | 1986-01-07 | Miles Laboratories, Inc. | Nucleic acid hybridization assay employing antibodies to intercalation complexes |
| SE458968B (sv) | 1987-06-16 | 1989-05-22 | Wallac Oy | Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser |
| DK641487A (da) | 1987-12-07 | 1989-06-08 | Gluetech Aps | Fremgangsmaade til modificering af polymeroverflader |
| US5871928A (en) | 1989-06-07 | 1999-02-16 | Fodor; Stephen P. A. | Methods for nucleic acid analysis |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| DE69132905T2 (de) | 1990-12-06 | 2002-08-01 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Detektion von Nukleinsäuresequenzen |
| US5919452A (en) | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
| US5656272A (en) | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
| US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
| AU6852594A (en) | 1993-06-03 | 1995-01-03 | Therapeutic Antibodies Inc. | Production of antibody fragments |
| US6027880A (en) | 1995-08-02 | 2000-02-22 | Affymetrix, Inc. | Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis |
| US5888510A (en) | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
| FR2707882B1 (fr) | 1993-07-23 | 1997-08-01 | Immunotech Sa | Nouveaux kits thérapeutiques anti-médiateurs protéiques, procédé de préparation et compositions pharmaceutiques les renfermant. |
| US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| US8017121B2 (en) | 1994-06-30 | 2011-09-13 | Chugai Seiyaku Kabushika Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
| US5925351A (en) | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
| US5981180A (en) | 1995-10-11 | 1999-11-09 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
| AU3568897A (en) | 1996-06-07 | 1998-01-05 | Eos Biotechnology, Inc. | Immobilised linear oligonucleotide arrays |
| US7060667B1 (en) | 1998-01-30 | 2006-06-13 | Biogen Idec Ma, Inc. | Treatment of follicular lymphomas using inhibitors of the LT pathway |
| US6197599B1 (en) | 1998-07-30 | 2001-03-06 | Guorong Chin | Method to detect proteins |
| US7473528B2 (en) * | 1999-01-06 | 2009-01-06 | Genenews Inc. | Method for the detection of Chagas disease related gene transcripts in blood |
| US6410231B1 (en) | 1999-02-26 | 2002-06-25 | Incyte Genomics, Inc. | SNP detection |
| ATE412184T1 (de) | 1999-08-17 | 2008-11-15 | Luminex Corp | Verfahren zur analyse einer mehrzahl von proben verschiedenen ursprungs auf einen analyten |
| JP2003515149A (ja) | 1999-11-26 | 2003-04-22 | キュラジェン コーポレイション | 核酸プローブアレイ |
| EP1283722A1 (en) | 2000-03-31 | 2003-02-19 | Idec Pharmaceuticals Corporation | Combined use of anti-cytokine antibodies or antagonists and anti-cd20 for the treatment of b cell lymphoma |
| CA2439402A1 (en) | 2001-03-02 | 2002-09-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pcr method |
| EP1379545A2 (de) | 2001-04-19 | 2004-01-14 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Verfahren zur herstellung stabiler, regenerierbarer antikörper-arrays |
| US6812341B1 (en) | 2001-05-11 | 2004-11-02 | Ambion, Inc. | High efficiency mRNA isolation methods and compositions |
| US20030013208A1 (en) | 2001-07-13 | 2003-01-16 | Milagen, Inc. | Information enhanced antibody arrays |
| AU2003212822A1 (en) * | 2002-01-22 | 2003-09-02 | Trustees Of The University Of Pennsylvania | Methods for determining drug responsiveness |
| CA2496296A1 (en) | 2002-08-20 | 2004-03-04 | Cyvera Corporation | Diffraction grating-based encoded micro-particles for multiplexed experiments |
| US7252976B2 (en) | 2002-08-28 | 2007-08-07 | Board Of Regents The University Of Texas System | Quantitative RT-PCR to AC133 to diagnose cancer and monitor angiogenic activity in a cell sample |
| AU2003261787B2 (en) | 2002-08-30 | 2008-11-06 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Human antihuman interleukin-6 antibody and fragment of the antibody |
| WO2004024328A1 (en) | 2002-09-12 | 2004-03-25 | Cyvera Corporation | Method and apparatus for aligning elongated microbeads in order to interrogate the same |
| EP1540590A1 (en) | 2002-09-12 | 2005-06-15 | Cyvera Corporation | Assay stick comprising coded microbeads |
| WO2004025562A1 (en) | 2002-09-12 | 2004-03-25 | Cyvera Corp. | Method and apparatus for labelling using diffraction grating-based encoded optical identification elements |
| CA2499046A1 (en) | 2002-09-12 | 2004-03-25 | Cyvera Corporation | Diffraction grating-based encoded micro-particles for multiplexed experiments |
| US7092160B2 (en) | 2002-09-12 | 2006-08-15 | Illumina, Inc. | Method of manufacturing of diffraction grating-based optical identification element |
| CA2498916A1 (en) | 2002-09-12 | 2004-03-25 | Cyvera Corporation | Chemical synthesis using diffraction grating-based encoded optical elements |
| GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| JP4685369B2 (ja) * | 2004-04-30 | 2011-05-18 | 独立行政法人科学技術振興機構 | 関節リウマチ診断用試薬 |
| US20060008823A1 (en) | 2004-05-12 | 2006-01-12 | Kemp Jennifer T | DNA profiling and SNP detection utilizing microarrays |
| GB0422417D0 (en) * | 2004-10-08 | 2004-11-10 | Ihg Diagnostics | Improvements in induced heteroduplex generators |
| TW200630106A (en) * | 2004-10-08 | 2006-09-01 | Wyeth Corp | Immunotherapy of autoimmune disorders |
| WO2006074399A2 (en) | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
| JO3058B1 (ar) | 2005-04-29 | 2017-03-15 | Applied Molecular Evolution Inc | الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها |
| CA2607697C (en) | 2005-05-10 | 2015-01-06 | Biogen Idec Ma Inc. | Treating and evaluating inflammatory disorders |
| WO2006138275A2 (en) * | 2005-06-13 | 2006-12-28 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| CN100338228C (zh) * | 2005-06-30 | 2007-09-19 | 卫生部北京医院 | 一种预测2型糖尿病易感性的试剂 |
| EP1857559A1 (en) * | 2006-05-16 | 2007-11-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for predicting responsiveness to TNF alpha blocking agents |
| WO2008028031A2 (en) * | 2006-08-30 | 2008-03-06 | Centocor, Inc. | Markers and methods for assessing and treating ulcerative colitis and related disorders using a 43 gene panel |
| WO2008132176A2 (en) * | 2007-04-27 | 2008-11-06 | Universite Catholique De Louvain | Method for evaluating the response of an individual to tnf blocking therapy |
-
2008
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- 2008-06-06 US US12/663,335 patent/US20100303813A1/en not_active Abandoned
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- 2012-12-04 IL IL223419A patent/IL223419A0/en unknown
-
2013
- 2013-10-31 JP JP2013226708A patent/JP2014033676A/ja not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002046433A2 (en) * | 2000-12-08 | 2002-06-13 | Juan Saus | Tnf-inducible promotors and methods for using them |
| US20040009479A1 (en) * | 2001-06-08 | 2004-01-15 | Jay Wohlgemuth | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
| WO2007025085A2 (en) * | 2005-08-24 | 2007-03-01 | Genizon Biosciences Inc. | Genemap of the human genes associated with crohn's disease |
| WO2007038501A2 (en) * | 2005-09-27 | 2007-04-05 | The Feinstein Institute For Medical Research | Rheumatoid arthritis markers |
Non-Patent Citations (2)
| Title |
|---|
| BATLIWALLA Franak M. et al. "Microarray analyses of peripheral blood cells identifies unique gene expression signature in psoriatic arthritis", Molecular medicine. 2005, v. 11, n. 1-12, p. 21-29, особенно табл. 2 * |
| WESOLY Joanna et al. "Genetic markers of treatment response in rheumatoid arthritis", Current rheumatology reports. 2006, v. 8, p. 369-377, особенно p. 371-374 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2749247C1 (ru) * | 2020-09-28 | 2021-06-07 | федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) (ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Се | Способ прогнозирования эффективности лечения ревматоидного артрита препаратом олокизумаб на основе генотипирования |
| WO2022066032A1 (ru) * | 2020-09-28 | 2022-03-31 | федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) | Способ прогнозирования эффективности лечения ревматоидного артрита препаратом олокизумаб |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103710458A (zh) | 2014-04-09 |
| JP2010529464A (ja) | 2010-08-26 |
| EP2617837A2 (en) | 2013-07-24 |
| EA200971131A1 (ru) | 2010-06-30 |
| AU2008261869A1 (en) | 2008-12-18 |
| US20100303813A1 (en) | 2010-12-02 |
| WO2008154423A2 (en) | 2008-12-18 |
| AU2008261869B2 (en) | 2014-12-18 |
| CA2690898A1 (en) | 2008-12-18 |
| EP2167687B1 (en) | 2013-03-27 |
| CN101796197B (zh) | 2014-02-12 |
| WO2008154423A3 (en) | 2009-02-05 |
| IL202562A0 (en) | 2011-08-01 |
| JP5719591B2 (ja) | 2015-05-20 |
| NZ581742A (en) | 2012-09-28 |
| EP2617837A3 (en) | 2013-10-23 |
| MX2009013410A (es) | 2010-03-22 |
| EP2167687A2 (en) | 2010-03-31 |
| SG182183A1 (en) | 2012-07-30 |
| NO20093488L (no) | 2010-01-08 |
| EP2167687A4 (en) | 2010-10-13 |
| KR20100037590A (ko) | 2010-04-09 |
| CN101796197A (zh) | 2010-08-04 |
| JP2014033676A (ja) | 2014-02-24 |
| IL223419A0 (en) | 2013-02-03 |
| BRPI0812461A2 (pt) | 2017-06-13 |
| ZA200909215B (en) | 2010-09-29 |
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