EA014832B1 - Производные хинолина в качестве антибактериальных средств - Google Patents

Производные хинолина в качестве антибактериальных средств Download PDF

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Publication number
EA014832B1
EA014832B1 EA200800501A EA200800501A EA014832B1 EA 014832 B1 EA014832 B1 EA 014832B1 EA 200800501 A EA200800501 A EA 200800501A EA 200800501 A EA200800501 A EA 200800501A EA 014832 B1 EA014832 B1 EA 014832B1
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EA
Eurasian Patent Office
Prior art keywords
alkyl
formula
compound
phenyl
use according
Prior art date
Application number
EA200800501A
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English (en)
Russian (ru)
Other versions
EA200800501A1 (ru
Inventor
Кунрад Йозеф Лодевейк Марсель Андрис
Анил Коул
Жером Эмиль Жорж Гийемон
Элизабет Тереза Жанна Паскье
Давид Франсис Ален Лансуа
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35768940&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA014832(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200800501A1 publication Critical patent/EA200800501A1/ru
Publication of EA014832B1 publication Critical patent/EA014832B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EA200800501A 2005-08-03 2006-07-31 Производные хинолина в качестве антибактериальных средств EA014832B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05107159 2005-08-03
PCT/EP2006/064856 WO2007014940A2 (en) 2005-08-03 2006-07-31 Quinoline derivatives as antibacterical agents

Publications (2)

Publication Number Publication Date
EA200800501A1 EA200800501A1 (ru) 2008-10-30
EA014832B1 true EA014832B1 (ru) 2011-02-28

Family

ID=35768940

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800501A EA014832B1 (ru) 2005-08-03 2006-07-31 Производные хинолина в качестве антибактериальных средств

Country Status (28)

Country Link
US (1) US8017606B2 (https=)
EP (1) EP1912647B1 (https=)
JP (1) JP5410753B2 (https=)
KR (1) KR101337237B1 (https=)
CN (1) CN101277695B (https=)
AR (1) AR054889A1 (https=)
AU (1) AU2006274879B2 (https=)
BR (1) BRPI0614524B8 (https=)
CA (1) CA2615901C (https=)
CY (1) CY1114908T1 (https=)
DK (1) DK1912647T3 (https=)
EA (1) EA014832B1 (https=)
ES (1) ES2437575T3 (https=)
HR (1) HRP20131116T1 (https=)
IL (1) IL189141A (https=)
JO (1) JO2952B1 (https=)
MX (1) MX2008001602A (https=)
MY (1) MY148241A (https=)
NO (1) NO341247B1 (https=)
NZ (1) NZ565283A (https=)
PL (1) PL1912647T3 (https=)
PT (1) PT1912647E (https=)
RS (1) RS53065B (https=)
SI (1) SI1912647T1 (https=)
TW (1) TWI381839B (https=)
UA (1) UA95916C2 (https=)
WO (1) WO2007014940A2 (https=)
ZA (1) ZA200801108B (https=)

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JP2512364B2 (ja) 1992-03-02 1996-07-03 共栄電工株式会社 筒状の被加工物の内面研磨方法および装置
EA011277B1 (ru) * 2004-01-23 2009-02-27 Янссен Фармацевтика Н.В. Производные хинолина и их применение в качестве ингибиторов микобактерий
JO2952B1 (en) 2005-08-03 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO3271B1 (ar) * 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
CA2711912A1 (en) * 2008-01-14 2009-07-23 Jyoti Chattopadhyaya Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivates as anti-mycobacterial agents
JP5246715B2 (ja) * 2009-01-27 2013-07-24 独立行政法人科学技術振興機構 蛋白質架橋阻害剤およびその用途
WO2010144102A1 (en) * 2009-06-09 2010-12-16 The United States Of America, As Represented By The Secretary Of The Army, On Behalf Of U.S. Army Medical Research And Material Command Pentafluorosulfanyl analogs of mefloquine
CN104254527B (zh) 2012-04-27 2017-05-31 詹森药业有限公司 抗菌的喹啉衍生物
ES2607879T3 (es) 2012-04-27 2017-04-04 Janssen Pharmaceutica N.V. Derivados de quinolina antibacterianos
ES2619610T3 (es) 2012-10-16 2017-06-26 Janssen Pharmaceutica Nv Moduladores de ROR-gamma-t de quinolinilo enlazado con heteroarilo
CA2888485C (en) 2012-10-16 2021-01-26 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of ror.gamma.t
MY189505A (en) 2012-10-16 2022-02-16 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of roryt
US9642858B2 (en) 2012-10-30 2017-05-09 University of Pittsburgh—of the Commonwealth System of Higher Education Use of resazurin, or analogs thereof, for antibacterial therapy
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
KR20160068948A (ko) 2013-10-15 2016-06-15 얀센 파마슈티카 엔.브이. RORyt의 이차 알코올 퀴놀리닐 조절제
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
BR112016008215A2 (pt) 2013-10-15 2017-09-26 Janssen Pharmaceutica Nv moduladores de quinolinila ligados por alquila de roryt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
ES2742843T3 (es) 2013-10-15 2020-02-17 Janssen Pharmaceutica Nv Moduladores de quinolinilo de ROR(gamma)t
GB201904796D0 (en) * 2019-04-04 2019-05-22 Univ Sheffield Antimicrobial agent
AR121682A1 (es) * 2020-03-31 2022-06-29 Takeda Pharmaceuticals Co Derivados de n-(heterociclil y heterociclilalquil)-3-bencilpiridin-2-amina como agonistas de sstr4
AR121683A1 (es) * 2020-03-31 2022-06-29 Takeda Pharmaceuticals Co Derivados de n-heteroarilalquil-2-(heterociclil y heterociclilmetil)acetamida como agonistas de sstr4

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006047A1 (en) * 1993-08-23 1995-03-02 Fujisawa Pharmaceutical Co., Ltd. Antimicrobial quinolinyl-(1h-1,2,4-triazol-1-yl)alkanol derivatives
WO2000078748A1 (en) * 1999-06-21 2000-12-28 Smithkline Beecham P.L.C. Quinoline derivatives as antibacterials
WO2001007432A2 (en) * 1999-07-23 2001-02-01 Smithkline Beecham P.L.C. Aminopiperidine derivatives as antibacterials
WO2004011436A1 (en) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors
WO2004035569A2 (de) * 2002-10-10 2004-04-29 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue verbindungen mit antibakterieller aktivität
WO2004089947A2 (de) * 2003-04-08 2004-10-21 Morphochem Ag Neue verbindungen mit antibakterieller aktivität
WO2005070430A1 (en) * 2004-01-23 2005-08-04 Janssen Pharmaceutica N.V. Quinoline derivatives and use thereof as mycobacterial inhibitors

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US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6376670B1 (en) * 1997-06-19 2002-04-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
GB0101577D0 (en) * 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
EA011211B1 (ru) * 2003-11-20 2009-02-27 Янссен Фармацевтика Н. В. 7-фенилалкилзамещённые 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза)полимеразы
AU2004295059B2 (en) * 2003-12-05 2010-12-16 Janssen Pharmaceutica N.V. 6-substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
JO2952B1 (en) 2005-08-03 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006047A1 (en) * 1993-08-23 1995-03-02 Fujisawa Pharmaceutical Co., Ltd. Antimicrobial quinolinyl-(1h-1,2,4-triazol-1-yl)alkanol derivatives
WO2000078748A1 (en) * 1999-06-21 2000-12-28 Smithkline Beecham P.L.C. Quinoline derivatives as antibacterials
WO2001007432A2 (en) * 1999-07-23 2001-02-01 Smithkline Beecham P.L.C. Aminopiperidine derivatives as antibacterials
WO2004011436A1 (en) * 2002-07-25 2004-02-05 Janssen Pharmaceutica N.V. Quinoline derivatives and their use as mycobacterial inhibitors
WO2004035569A2 (de) * 2002-10-10 2004-04-29 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue verbindungen mit antibakterieller aktivität
WO2004089947A2 (de) * 2003-04-08 2004-10-21 Morphochem Ag Neue verbindungen mit antibakterieller aktivität
WO2005070430A1 (en) * 2004-01-23 2005-08-04 Janssen Pharmaceutica N.V. Quinoline derivatives and use thereof as mycobacterial inhibitors

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ANDRIES K. ET AL.: "A DIARYLQUINOLINE DRUG ACTIVE ON THE ATP SYNTHASE OF MYCOBACTERIUM TUBERCULOSIS" SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 307, 14 January 2005 (2005-01-14), pages 223-227, XP002358962 ISSN: 0036-8075 cited in the application page 224, left-hand column *
GENTHER C. S. ET AL.: "Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chiorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli." JOURNAL OF MEDICINAL CHEMISTRY FEB 1977, vol. 20, no. 2, February 1977 (1977-02), pages 237-243, XP002414938 ISSN: 0022-2623 page 242; compound 37 *
WOMMACK J. B. ET AL.:"POTENTIAL ANTIMALARIALS. 6. SOME 2-PHENYL-6- AND 8-QUINOLINEMETHANOLS1.2 AND 8-PHENYL-4-QUINOLINEMETHANOLS" JOURNAL OF MEDICINAL AND PHARMACEUTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 14, no.12, 1962, pages 1218-1220, XP000915126 page 1218, right-hand column *

Also Published As

Publication number Publication date
MY148241A (en) 2013-03-29
IL189141A (en) 2015-10-29
RS53065B (sr) 2014-04-30
EP1912647B1 (en) 2013-09-11
KR101337237B1 (ko) 2013-12-06
CN101277695B (zh) 2011-12-14
CN101277695A (zh) 2008-10-01
AR054889A1 (es) 2007-07-25
DK1912647T3 (da) 2013-12-02
ZA200801108B (en) 2009-05-27
MX2008001602A (es) 2008-02-19
BRPI0614524B8 (pt) 2021-05-25
CA2615901C (en) 2014-06-03
PL1912647T3 (pl) 2014-02-28
PT1912647E (pt) 2013-12-05
WO2007014940A2 (en) 2007-02-08
WO2007014940A3 (en) 2007-03-29
NO341247B1 (no) 2017-09-25
WO2007014940A8 (en) 2007-07-05
IL189141A0 (en) 2008-08-07
NZ565283A (en) 2011-07-29
CA2615901A1 (en) 2007-02-08
ES2437575T3 (es) 2014-01-13
CY1114908T1 (el) 2016-12-14
EP1912647A2 (en) 2008-04-23
JP2009503024A (ja) 2009-01-29
JO2952B1 (en) 2016-03-15
AU2006274879A1 (en) 2007-02-08
NO20080955L (no) 2008-02-25
TW200744594A (en) 2007-12-16
UA95916C2 (ru) 2011-09-26
KR20080038380A (ko) 2008-05-06
US8017606B2 (en) 2011-09-13
TWI381839B (zh) 2013-01-11
EA200800501A1 (ru) 2008-10-30
JP5410753B2 (ja) 2014-02-05
HK1124233A1 (en) 2009-07-10
SI1912647T1 (sl) 2014-01-31
US20080255116A1 (en) 2008-10-16
AU2006274879B2 (en) 2013-01-10
BRPI0614524A2 (pt) 2011-04-05
BRPI0614524B1 (pt) 2020-05-19
HRP20131116T1 (hr) 2013-12-20

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