DZ2977A1 - 4-Amino-azépam-3-ones inhibitrices de protéases, et compositions pharmaceutiques les contenant. - Google Patents
4-Amino-azépam-3-ones inhibitrices de protéases, et compositions pharmaceutiques les contenant.Info
- Publication number
- DZ2977A1 DZ2977A1 DZ990277A DZ990277A DZ2977A1 DZ 2977 A1 DZ2977 A1 DZ 2977A1 DZ 990277 A DZ990277 A DZ 990277A DZ 990277 A DZ990277 A DZ 990277A DZ 2977 A1 DZ2977 A1 DZ 2977A1
- Authority
- DZ
- Algeria
- Prior art keywords
- amino
- pharmaceutical compositions
- disease
- azepam
- ones
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11363698P | 1998-12-23 | 1998-12-23 | |
US16458199P | 1999-11-10 | 1999-11-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
DZ2977A1 true DZ2977A1 (fr) | 2004-03-15 |
Family
ID=26811293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DZ990277A DZ2977A1 (fr) | 1998-12-23 | 1999-12-22 | 4-Amino-azépam-3-ones inhibitrices de protéases, et compositions pharmaceutiques les contenant. |
Country Status (24)
Country | Link |
---|---|
US (2) | US20020147188A1 (tr) |
EP (1) | EP1158986A4 (tr) |
JP (1) | JP2002533397A (tr) |
KR (1) | KR100630986B1 (tr) |
CN (1) | CN1253441C (tr) |
AT (1) | ATE411294T1 (tr) |
AU (1) | AU768565B2 (tr) |
BR (1) | BR9916488A (tr) |
CA (1) | CA2356671A1 (tr) |
CZ (1) | CZ20012277A3 (tr) |
DE (1) | DE69939752D1 (tr) |
DZ (1) | DZ2977A1 (tr) |
ES (1) | ES2315456T3 (tr) |
GC (1) | GC0000178A (tr) |
HK (1) | HK1043536A1 (tr) |
HU (1) | HUP0104768A3 (tr) |
IL (2) | IL143142A0 (tr) |
NO (1) | NO318910B1 (tr) |
NZ (1) | NZ511710A (tr) |
PE (1) | PE20001340A1 (tr) |
PL (1) | PL350132A1 (tr) |
TR (1) | TR200101869T2 (tr) |
UY (1) | UY25874A1 (tr) |
WO (1) | WO2000038687A1 (tr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030144175A1 (en) | 1998-12-23 | 2003-07-31 | Smithkline Beecham Corporation | Protease inhibitors |
EP1229912A4 (en) * | 1999-11-10 | 2003-05-07 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
EP1229911A4 (en) * | 1999-11-10 | 2003-05-07 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
WO2001034157A1 (en) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
US6583137B1 (en) | 1999-11-10 | 2003-06-24 | Smithkline Beecham Corporation | Protease inhibitors |
EP1351930A4 (en) * | 1999-11-10 | 2004-09-15 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
AU1474601A (en) * | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
EP1229915A4 (en) * | 1999-11-10 | 2003-05-14 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
WO2001034565A2 (en) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
EP1231922A4 (en) * | 1999-11-10 | 2004-06-23 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
JP2003513924A (ja) * | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテア−ゼ阻害剤 |
WO2001034158A1 (en) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
WO2001034599A1 (en) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
CN1416346A (zh) * | 2000-03-21 | 2003-05-07 | 史密丝克莱恩比彻姆公司 | 蛋白酶抑制剂 |
CO5280093A1 (es) * | 2000-04-18 | 2003-05-30 | Smithkline Beecham Corp | Metodos de tratamiento |
CO5280088A1 (es) * | 2000-04-18 | 2003-05-30 | Smithkline Beecham Corp | Inhibidores de proteasa |
SK17592002A3 (sk) * | 2000-06-14 | 2003-05-02 | Smithkline Beecham Corporation | 4-Amino-azepán-3-ónové zlúčeniny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty |
WO2002017924A1 (en) * | 2000-09-01 | 2002-03-07 | Smithkline Beecham Corporation | Method of treatment |
CN1635903A (zh) * | 2000-11-22 | 2005-07-06 | 史密丝克莱恩比彻姆公司 | 蛋白酶抑制剂 |
SI1370260T1 (sl) | 2001-02-20 | 2011-02-28 | Chugai Pharmaceutical Co Ltd | Azoli kot inhibitorji malonil-CoA dekarboksilaze, uporabni kot metabolični modulatorji |
US7709510B2 (en) | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
WO2002092563A2 (en) * | 2001-05-17 | 2002-11-21 | Smithkline Beecham Corporation | Protease inhibitors |
US6982263B2 (en) | 2001-06-08 | 2006-01-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitriles useful as reversible inhibitors of cysteine proteases |
AU2003263738A1 (en) * | 2002-05-22 | 2003-12-02 | Smithkline Beecham Corporation | Protease inhibitors |
US20050256105A1 (en) * | 2002-05-22 | 2005-11-17 | Jeong Jae U | Protease inhibitors |
KR100962972B1 (ko) * | 2002-07-26 | 2010-06-09 | 주식회사유한양행 | 1-페닐피페리딘-3-온 유도체 및 그의 제조방법 |
AU2003273697A1 (en) * | 2002-10-08 | 2004-05-04 | Merck Frosst Canada Ltd | 4-amino-azepan-3-one compounds as cathepsin k inhibitors useful in the treatment of osteoporosis |
SI3549936T1 (sl) | 2003-04-11 | 2021-09-30 | Ptc Therapeutics, Inc. | Spojina 1,2,4-oksadiazol benzojske kisline in njena uporaba za supresijo nesmiselne mutacije in zdravljenje bolezni |
CA2533747C (en) * | 2003-08-01 | 2012-11-13 | Chugai Seiyaku Kabushiki Kaisha | Heterocyclic compounds useful as malonyl-coa decarboxylase inhibitors |
ES2314491T3 (es) | 2003-08-01 | 2009-03-16 | Chugai Seiyaku Kabushiki Kaisha | Compuestos azol basados en cianoguanidina utiles como inhibidores de la manonil-coa descaraboxilasa. |
CA2533749C (en) | 2003-08-01 | 2012-07-10 | Chugai Seiyaku Kabushiki Kaisha | Piperidine compounds useful as malonyl-coa decarboxylase inhibitors |
CA2552726A1 (en) * | 2004-01-08 | 2005-07-21 | Merck Frosst Canada Ltd. | Cathepsin cysteine protease inhibitors |
EP1796793A4 (en) * | 2004-09-07 | 2009-08-05 | Smithkline Beecham Corp | NEW CONNECTIONS |
WO2007012180A1 (en) * | 2005-07-26 | 2007-02-01 | Merck Frosst Canada Ltd. | Papain family cysteine protease inhibitors for the treatment of parasitic diseases |
RU2462246C2 (ru) | 2006-03-30 | 2012-09-27 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы получения функционального белка из днк, имеющей нонсенс-мутацию, и лечения нарушений, ассоциированных с ней |
BR112013029672A2 (pt) | 2011-05-16 | 2017-01-17 | Bayer Ip Gmbh | uso de inibição da catepsina k para o tratamento e/ou profilaxia da hipertensão pulmonar e/ou insuficiência cardíaca |
CN103275070A (zh) * | 2013-05-10 | 2013-09-04 | 郑彪 | 调节单核细胞增殖的四环化合物及其应用 |
TWI636978B (zh) | 2014-03-06 | 2018-10-01 | 美商Ptc治療公司 | 1,2,4-二唑苯甲酸之鹽及醫藥組合物 |
US10517853B2 (en) | 2015-10-30 | 2019-12-31 | Ptc Therapeutics, Inc. | Methods for treating epilepsy |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1195287B (it) * | 1981-11-05 | 1988-10-12 | Ausonia Farma Srl | Derivato tiazolico,procedimento per la sua preparazione e relative composizioni farmaceutiche |
JPH05140063A (ja) * | 1991-11-19 | 1993-06-08 | Suntory Ltd | ジペプチド誘導体及びそれを有効成分とする骨疾患の予防及び治療剤 |
ATE171171T1 (de) * | 1992-12-25 | 1998-10-15 | Mitsubishi Chem Corp | Alpha-aminoketon derivate |
CA2111930A1 (en) * | 1992-12-25 | 1994-06-26 | Ryoichi Ando | Aminoketone derivatives |
JPH06199850A (ja) * | 1992-12-28 | 1994-07-19 | Tanabe Seiyaku Co Ltd | インドール含有ペプチド及びその製法 |
EP0808839B1 (en) * | 1995-12-12 | 2001-05-23 | Taiho Pharmaceutical Co., Ltd. | Epoxysuccinamide derivatives or salts thereof, and drugs containing the same |
US5902882A (en) * | 1996-04-17 | 1999-05-11 | Hoffmann-La Roche Inc. | Assymetric synthesis of azepines |
DZ2285A1 (fr) * | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
US6107291A (en) * | 1997-12-19 | 2000-08-22 | Amgen Inc. | Azepine or larger medium ring derivatives and methods of use |
EP1229915A4 (en) * | 1999-11-10 | 2003-05-14 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
WO2001034158A1 (en) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
EP1229912A4 (en) * | 1999-11-10 | 2003-05-07 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
EP1351930A4 (en) * | 1999-11-10 | 2004-09-15 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
AU1474601A (en) * | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
WO2001034599A1 (en) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
WO2001034565A2 (en) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
US6583137B1 (en) * | 1999-11-10 | 2003-06-24 | Smithkline Beecham Corporation | Protease inhibitors |
JP2003513924A (ja) * | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテア−ゼ阻害剤 |
EP1229911A4 (en) * | 1999-11-10 | 2003-05-07 | Smithkline Beecham Corp | PROTEASE INHIBITORS |
NL1013996C2 (nl) * | 1999-12-30 | 2001-07-03 | Innas Free Piston Bv | Vrijezuiger aggregaat voor opwekken van hydraulische energie. |
-
1999
- 1999-12-21 CN CNB998150932A patent/CN1253441C/zh not_active Expired - Fee Related
- 1999-12-21 CA CA002356671A patent/CA2356671A1/en not_active Abandoned
- 1999-12-21 PL PL99350132A patent/PL350132A1/xx not_active Application Discontinuation
- 1999-12-21 DE DE69939752T patent/DE69939752D1/de not_active Expired - Lifetime
- 1999-12-21 AU AU19411/00A patent/AU768565B2/en not_active Ceased
- 1999-12-21 AT AT03076211T patent/ATE411294T1/de not_active IP Right Cessation
- 1999-12-21 BR BR9916488-4A patent/BR9916488A/pt not_active IP Right Cessation
- 1999-12-21 JP JP2000590640A patent/JP2002533397A/ja active Pending
- 1999-12-21 ES ES03076211T patent/ES2315456T3/es not_active Expired - Lifetime
- 1999-12-21 CZ CZ20012277A patent/CZ20012277A3/cs unknown
- 1999-12-21 TR TR2001/01869T patent/TR200101869T2/tr unknown
- 1999-12-21 EP EP99963112A patent/EP1158986A4/en not_active Withdrawn
- 1999-12-21 IL IL14314299A patent/IL143142A0/xx active IP Right Grant
- 1999-12-21 WO PCT/US1999/030730 patent/WO2000038687A1/en active IP Right Grant
- 1999-12-21 KR KR1020017007989A patent/KR100630986B1/ko not_active IP Right Cessation
- 1999-12-21 NZ NZ511710A patent/NZ511710A/en unknown
- 1999-12-21 HU HU0104768A patent/HUP0104768A3/hu unknown
- 1999-12-22 DZ DZ990277A patent/DZ2977A1/xx active
- 1999-12-22 GC GCP1999461 patent/GC0000178A/en active
- 1999-12-22 UY UY25874A patent/UY25874A1/es not_active Application Discontinuation
- 1999-12-23 PE PE1999001312A patent/PE20001340A1/es not_active Application Discontinuation
-
2001
- 2001-05-14 IL IL143142A patent/IL143142A/en not_active IP Right Cessation
- 2001-06-22 NO NO20013124A patent/NO318910B1/no unknown
-
2002
- 2002-02-13 US US10/074,940 patent/US20020147188A1/en not_active Abandoned
- 2002-05-13 HK HK02103610.2A patent/HK1043536A1/zh unknown
-
2003
- 2003-04-01 US US10/404,142 patent/US20030225061A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2356671A1 (en) | 2000-07-06 |
EP1158986A4 (en) | 2002-03-27 |
DE69939752D1 (de) | 2008-11-27 |
US20020147188A1 (en) | 2002-10-10 |
NO20013124D0 (no) | 2001-06-22 |
JP2002533397A (ja) | 2002-10-08 |
ATE411294T1 (de) | 2008-10-15 |
PE20001340A1 (es) | 2001-01-28 |
KR100630986B1 (ko) | 2006-10-09 |
BR9916488A (pt) | 2001-10-09 |
ES2315456T3 (es) | 2009-04-01 |
NO318910B1 (no) | 2005-05-23 |
CN1350458A (zh) | 2002-05-22 |
PL350132A1 (en) | 2002-11-04 |
NO20013124L (no) | 2001-06-22 |
CN1253441C (zh) | 2006-04-26 |
AU768565B2 (en) | 2003-12-18 |
UY25874A1 (es) | 2001-08-27 |
IL143142A (en) | 2006-08-20 |
HUP0104768A2 (hu) | 2002-04-29 |
AU1941100A (en) | 2000-07-31 |
HK1043536A1 (zh) | 2002-09-20 |
HUP0104768A3 (en) | 2002-05-28 |
NZ511710A (en) | 2003-12-19 |
US20030225061A1 (en) | 2003-12-04 |
GC0000178A (en) | 2006-03-29 |
EP1158986A1 (en) | 2001-12-05 |
KR20010089677A (ko) | 2001-10-08 |
CZ20012277A3 (cs) | 2001-11-14 |
WO2000038687A1 (en) | 2000-07-06 |
IL143142A0 (en) | 2002-04-21 |
TR200101869T2 (tr) | 2002-01-21 |
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