DOP2013000267A - Hidroximetil pirrolidinas como agonistas del receptor adrenérgico beta 3 - Google Patents
Hidroximetil pirrolidinas como agonistas del receptor adrenérgico beta 3Info
- Publication number
- DOP2013000267A DOP2013000267A DO2013000267A DO2013000267A DOP2013000267A DO P2013000267 A DOP2013000267 A DO P2013000267A DO 2013000267 A DO2013000267 A DO 2013000267A DO 2013000267 A DO2013000267 A DO 2013000267A DO P2013000267 A DOP2013000267 A DO P2013000267A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- pirrolidins
- adreneral
- hydroximethyl
- agonists
- beta
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title 1
- 108060003345 Adrenergic Receptor Proteins 0.000 abstract 1
- 102000017910 Adrenergic receptor Human genes 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente invención proporciona compuestos de Fórmula (Ia), composiciones farmacéuticas de los mismos, y un procedimiento de uso de los mismos en el tratamiento o prevención de enfermedades mediadas por la activación del adrenoceptor B3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12306308P | 2008-04-04 | 2008-04-04 | |
| US20604309P | 2009-01-27 | 2009-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2013000267A true DOP2013000267A (es) | 2014-01-31 |
Family
ID=40671093
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2010000294A DOP2010000294A (es) | 2008-04-04 | 2010-10-01 | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
| DO2013000267A DOP2013000267A (es) | 2008-04-04 | 2013-11-15 | Hidroximetil pirrolidinas como agonistas del receptor adrenérgico beta 3 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2010000294A DOP2010000294A (es) | 2008-04-04 | 2010-10-01 | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
Country Status (38)
| Country | Link |
|---|---|
| US (3) | US8247415B2 (es) |
| EP (1) | EP2276756B9 (es) |
| JP (3) | JP4783867B2 (es) |
| KR (3) | KR20120118086A (es) |
| CN (2) | CN102391255B (es) |
| AR (1) | AR072043A1 (es) |
| AT (1) | ATE535521T1 (es) |
| AU (1) | AU2009231714B2 (es) |
| BR (1) | BRPI0909768B1 (es) |
| CA (1) | CA2719876C (es) |
| CL (1) | CL2009000815A1 (es) |
| CO (1) | CO6331440A2 (es) |
| CR (2) | CR11751A (es) |
| CY (1) | CY1112552T1 (es) |
| DO (2) | DOP2010000294A (es) |
| EA (1) | EA020135B1 (es) |
| EC (1) | ECSP10010518A (es) |
| ES (1) | ES2376278T3 (es) |
| GE (1) | GEP20125666B (es) |
| HK (1) | HK1147099A1 (es) |
| HN (1) | HN2010002030A (es) |
| HR (1) | HRP20120129T2 (es) |
| IL (1) | IL208215A (es) |
| MA (1) | MA32257B1 (es) |
| ME (1) | ME01988B (es) |
| MX (1) | MX2010010929A (es) |
| NI (1) | NI201000164A (es) |
| NZ (1) | NZ588266A (es) |
| PE (1) | PE20091825A1 (es) |
| PL (1) | PL2276756T3 (es) |
| PT (1) | PT2276756E (es) |
| RS (1) | RS52175B (es) |
| SG (1) | SG188883A1 (es) |
| SI (1) | SI2276756T1 (es) |
| SV (1) | SV2010003687A (es) |
| TW (1) | TWI378098B (es) |
| WO (2) | WO2009124166A1 (es) |
| ZA (1) | ZA201006720B (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20091825A1 (es) * | 2008-04-04 | 2009-12-04 | Merck & Co Inc | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
| MX2012002366A (es) * | 2009-08-27 | 2012-03-29 | Merck Sharp & Dohme | Agonistas novedosos de receptores beta 3 andrenergicos derivados de pirrolidina. |
| RU2012118668A (ru) * | 2009-10-07 | 2013-11-20 | Мерк Шарп Энд Домэ Корп. | Комбинированная терапия с использованием агониста бета 3 адренергического рецептора и антимускаринового средства |
| JP5812500B2 (ja) * | 2010-04-30 | 2015-11-17 | メルク・シャープ・エンド・ドーム・コーポレイション | 新規なβ３アドレナリン作動性受容体アゴニスト |
| EP2595483B1 (en) * | 2010-07-23 | 2017-03-22 | Merck Sharp & Dohme Corp. | Novel pyrrolidine derived beta 3 adrenergic receptor agonists |
| EA030145B1 (ru) * | 2010-08-03 | 2018-06-29 | Велисепт Терапьютикс, Инк. | Комбинации агонистов бета-3-адренергических рецепторов и антагонистов мускариновых рецепторов для лечения гиперактивности мочевого пузыря |
| US9907767B2 (en) | 2010-08-03 | 2018-03-06 | Velicept Therapeutics, Inc. | Pharmaceutical compositions and the treatment of overactive bladder |
| US9522129B2 (en) | 2010-08-03 | 2016-12-20 | Velicept Therapeutics, Inc. | Pharmaceutical Combination |
| GB2484713A (en) | 2010-10-21 | 2012-04-25 | Optovate Ltd | Illumination apparatus |
| CA2855948C (en) * | 2011-08-11 | 2020-07-28 | Bayer Cropscience Ag | 1,2,4-triazolyl-substituted keto-enols |
| US20150087832A1 (en) | 2011-10-27 | 2015-03-26 | Merck Sharp & Dohme, Corp. | Process for making beta 3 agonists and intermediates |
| ES2584427T3 (es) | 2011-10-27 | 2016-09-27 | Merck Sharp & Dohme Corp. | Proceso para la preparación de agonistas beta 3 y productos intermedios |
| CN104053771B (zh) | 2011-11-18 | 2016-11-09 | 科德克希思公司 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
| KR20150020160A (ko) * | 2012-02-09 | 2015-02-25 | 앨씨알엑스, 인크. | 과민성 방광의 치료를 위한 무스카린 수용체 길항제 및 베타―3 아드레날린 수용체 작용제의 조합물 |
| JP2015178458A (ja) * | 2012-07-25 | 2015-10-08 | 杏林製薬株式会社 | ベンゼン環縮合含窒素５員複素環式化合物、またはその薬理学的に許容される塩 |
| WO2014108449A1 (en) | 2013-01-08 | 2014-07-17 | Atrogi Ab | A screening method, a kit, a method of treatment and a compound for use in a method of treatment |
| US9783529B2 (en) * | 2013-03-13 | 2017-10-10 | Flatley Discovery Lab, Llc | Pyridazinone compounds and methods for the treatment of cystic fibrosis |
| JP6383403B2 (ja) | 2013-03-15 | 2018-08-29 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | β−３作動薬および中間体の製造方法 |
| CN103232352B (zh) * | 2013-05-11 | 2015-12-23 | 苏州永健生物医药有限公司 | (r)-4-(2-(2-羟基-2-苯乙胺基)乙基)苯胺基甲酸叔丁基酯 |
| CN103760286A (zh) * | 2014-01-14 | 2014-04-30 | 北京万全德众医药生物技术有限公司 | 一种用高效液相色谱法测定琥珀酸索非那新中间体光学纯度的方法 |
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| KR20170086659A (ko) | 2014-12-03 | 2017-07-26 | 벨리셉트 테라퓨틱스, 인크. | 하부 요로 증상을 위한 변형 방출형 솔라베그론을 이용한 조성물 및 방법 |
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| CN110869022A (zh) | 2017-06-06 | 2020-03-06 | 乌洛万特科学有限公司 | 使用维贝隆以治疗膀胱过度活动症 |
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| GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
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| EP3730141A4 (en) * | 2017-12-21 | 2021-10-13 | Kyorin Pharmaceutical Co., Ltd. | THERAPEUTIC FOR NIGHTLY POLLAKISURIA |
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| MX2021003980A (es) * | 2018-12-05 | 2021-07-21 | Urovant Sciences Gmbh | Vibegrón para el tratamiento de los síntomas de la vejiga hiperactiva. |
| CN109503500A (zh) * | 2018-12-17 | 2019-03-22 | 天津药明康德新药开发有限公司 | 一种2-(2-氧代吡嗪-1(2h)-基)乙酸的合成方法 |
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| CN113840607A (zh) | 2019-03-18 | 2021-12-24 | 尤偌万科学有限公司 | 维贝格龙治疗膀胱过度活动症的用途 |
| TW202102883A (zh) | 2019-07-02 | 2021-01-16 | 美商瑞爾Ｄ斯帕克有限責任公司 | 定向顯示設備 |
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| CN114631046A (zh) | 2019-09-11 | 2022-06-14 | 瑞尔D斯帕克有限责任公司 | 可切换照明设备和防窥显示器 |
| US11016341B2 (en) | 2019-09-11 | 2021-05-25 | Reald Spark, Llc | Directional illumination apparatus and privacy display |
| JP2022550540A (ja) | 2019-10-03 | 2022-12-02 | リアルディー スパーク エルエルシー | 受動光学ナノ構造を備える照明装置 |
| EP4038313A4 (en) | 2019-10-03 | 2023-11-22 | RealD Spark, LLC | LIGHTING APPARATUS COMPRISING PASSIVE OPTICAL NANOSTRUCTURES |
| WO2021168090A1 (en) | 2020-02-20 | 2021-08-26 | Reald Spark, Llc | Illumination and display apparatus |
| TW202239412A (zh) | 2020-12-22 | 2022-10-16 | 瑞士商優洛凡特科學公司 | 使用維貝格隆（ｖｉｂｅｇｒｏｎ）並監測地高辛（ｄｉｇｏｘｉｎ）以治療膀胱過動症的方法 |
| WO2022175848A1 (en) | 2021-02-16 | 2022-08-25 | Urovant Sciences Gmbh | Methods of treating heart failure with vibegron |
| GB202113588D0 (en) | 2021-09-23 | 2021-11-10 | Atrogi Ab | New compounds and methods |
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| WO2024086240A1 (en) * | 2022-10-18 | 2024-04-25 | Bonafide Health, Llc | Beta-adrenergic agonist and muscarinic antagonist compositions and methods of using |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6525202B2 (en) * | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
| DOP2003000587A (es) | 2002-02-27 | 2003-08-30 | Pfizer Prod Inc | AGONISTAS DEL RECEPTOR ß3-ADRENERGICO |
| MXPA05004925A (es) * | 2002-11-07 | 2005-08-18 | Yamanouchi Pharma Co Ltd | Remedio para vejiga hiperactiva que incluye derivado de anilida de acido acetico como el ingrediente activo. |
| FR2874011B1 (fr) * | 2004-08-03 | 2007-06-15 | Sanofi Synthelabo | Derives de sulfonamides, leur preparation et leur application en therapeutique |
| PE20091825A1 (es) * | 2008-04-04 | 2009-12-04 | Merck & Co Inc | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
-
2009
- 2009-03-27 PE PE2009000460A patent/PE20091825A1/es active IP Right Grant
- 2009-03-30 AR ARP090101127A patent/AR072043A1/es active IP Right Grant
- 2009-04-02 RS RS20120042A patent/RS52175B/en unknown
- 2009-04-02 NZ NZ588266A patent/NZ588266A/en unknown
- 2009-04-02 KR KR1020127026256A patent/KR20120118086A/ko not_active Application Discontinuation
- 2009-04-02 KR KR1020107024750A patent/KR101331771B1/ko active Protection Beyond IP Right Term
- 2009-04-02 CN CN201110265670.2A patent/CN102391255B/zh active Active
- 2009-04-02 MX MX2010010929A patent/MX2010010929A/es active IP Right Grant
- 2009-04-02 ES ES09726601T patent/ES2376278T3/es active Active
- 2009-04-02 US US12/417,239 patent/US8247415B2/en active Active
- 2009-04-02 BR BRPI0909768A patent/BRPI0909768B1/pt active IP Right Grant
- 2009-04-02 JP JP2010543320A patent/JP4783867B2/ja active Active
- 2009-04-02 PT PT09726601T patent/PT2276756E/pt unknown
- 2009-04-02 CN CN200980121149.2A patent/CN102056917B/zh active Active
- 2009-04-02 EP EP09726601A patent/EP2276756B9/en active Active
- 2009-04-02 WO PCT/US2009/039249 patent/WO2009124166A1/en active Application Filing
- 2009-04-02 CA CA2719876A patent/CA2719876C/en active Active
- 2009-04-02 GE GEAP200911992A patent/GEP20125666B/en unknown
- 2009-04-02 WO PCT/US2009/039253 patent/WO2009124167A1/en active Application Filing
- 2009-04-02 ME MEP-2012-549A patent/ME01988B/me unknown
- 2009-04-02 KR KR1020127015876A patent/KR101288798B1/ko not_active IP Right Cessation
- 2009-04-02 SG SG2013017736A patent/SG188883A1/en unknown
- 2009-04-02 AT AT09726601T patent/ATE535521T1/de active
- 2009-04-02 US US12/936,221 patent/US8399480B2/en active Active
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