DOP2011000386A - Antagonistas de la trayectoria hedgehog de ftalazina disustituida - Google Patents
Antagonistas de la trayectoria hedgehog de ftalazina disustituidaInfo
- Publication number
- DOP2011000386A DOP2011000386A DO2011000386A DO2011000386A DOP2011000386A DO P2011000386 A DOP2011000386 A DO P2011000386A DO 2011000386 A DO2011000386 A DO 2011000386A DO 2011000386 A DO2011000386 A DO 2011000386A DO P2011000386 A DOP2011000386 A DO P2011000386A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- antagonists
- hedgehog
- ftalazina
- disttituted
- trajectory
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 241000027355 Ferocactus setispinus Species 0.000 title 1
- -1 1,4-disubstituted phthalazine Chemical class 0.000 abstract 1
- 241000289669 Erinaceus europaeus Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21862809P | 2009-06-19 | 2009-06-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2011000386A true DOP2011000386A (es) | 2012-02-29 |
Family
ID=42332981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2011000386A DOP2011000386A (es) | 2009-06-19 | 2011-12-13 | Antagonistas de la trayectoria hedgehog de ftalazina disustituida |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US8273742B2 (OSRAM) |
| EP (1) | EP2443104B1 (OSRAM) |
| JP (1) | JP5596139B2 (OSRAM) |
| KR (1) | KR101389165B1 (OSRAM) |
| CN (1) | CN102459233B (OSRAM) |
| AR (1) | AR077014A1 (OSRAM) |
| AU (1) | AU2010260244B2 (OSRAM) |
| BR (1) | BRPI1011601A2 (OSRAM) |
| CA (1) | CA2764542C (OSRAM) |
| CL (1) | CL2011003147A1 (OSRAM) |
| CO (1) | CO6480932A2 (OSRAM) |
| CR (1) | CR20110658A (OSRAM) |
| DK (1) | DK2443104T3 (OSRAM) |
| DO (1) | DOP2011000386A (OSRAM) |
| EA (1) | EA019059B1 (OSRAM) |
| EC (1) | ECSP11011541A (OSRAM) |
| ES (1) | ES2409054T3 (OSRAM) |
| HN (1) | HN2011003139A (OSRAM) |
| HR (1) | HRP20130408T1 (OSRAM) |
| IL (1) | IL216599A (OSRAM) |
| JO (1) | JO2931B1 (OSRAM) |
| MA (1) | MA33363B1 (OSRAM) |
| MX (1) | MX2011014029A (OSRAM) |
| MY (1) | MY156667A (OSRAM) |
| NZ (1) | NZ596882A (OSRAM) |
| PE (1) | PE20121050A1 (OSRAM) |
| PL (1) | PL2443104T3 (OSRAM) |
| PT (1) | PT2443104E (OSRAM) |
| SG (1) | SG177289A1 (OSRAM) |
| SI (1) | SI2443104T1 (OSRAM) |
| TN (1) | TN2011000627A1 (OSRAM) |
| TW (1) | TWI385165B (OSRAM) |
| UA (1) | UA106755C2 (OSRAM) |
| WO (1) | WO2010147917A1 (OSRAM) |
| ZA (1) | ZA201108587B (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5442717B2 (ja) * | 2008-04-29 | 2014-03-12 | イーライ リリー アンド カンパニー | 二置換フタラジンヘッジホッグ経路アンタゴニスト |
| PE20110433A1 (es) * | 2008-11-03 | 2011-07-09 | Lilly Co Eli | Antagonistas de la via hedgehog de ftalazina disustituida |
| HRP20120762T1 (hr) | 2008-11-17 | 2012-10-31 | Eli Lilly And Company | Tetrasupstituirani piridazini kao inhibitori hedgehog puta |
| EP2358703B1 (en) * | 2008-11-17 | 2013-12-25 | Eli Lilly and Company | Tetrasubstituted pyridazines hedgehog pathway antagonists |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
| US9464079B2 (en) | 2011-03-23 | 2016-10-11 | Semorex Technologies Ltd. | Treatment of proliferative disorders with a chemiluminescent agent |
| GB201309508D0 (en) * | 2013-05-28 | 2013-07-10 | Redx Pharma Ltd | Compounds |
| GB201311953D0 (en) * | 2013-07-03 | 2013-08-14 | Redx Pharma Ltd | Compounds |
| WO2015073691A1 (en) | 2013-11-14 | 2015-05-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating cancer by activation of bmp signaling |
| CN105017140B (zh) * | 2014-04-28 | 2017-12-29 | 复旦大学 | 邻氨基苯甲酰胺化合物及其制备方法和用途 |
| GB2528298A (en) * | 2014-07-16 | 2016-01-20 | Redx Pharma Plc | Compounds |
| CN105985319B (zh) * | 2015-02-11 | 2019-02-26 | 复旦大学 | 芳基酞嗪化合物及其制备方法和用途 |
| CN105985320B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 苄基酞嗪化合物及其制备方法和用途 |
| CN105985321B (zh) * | 2015-02-11 | 2018-10-26 | 复旦大学 | 吡唑酞嗪化合物及其制备方法和用途 |
| BR112017026103B1 (pt) | 2015-06-04 | 2023-10-03 | Sol-Gel Technologies Ltd | Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos |
| US10464897B2 (en) | 2015-06-05 | 2019-11-05 | Dana-Farber Cancer Institute, Inc. | Compounds and methods for treating cancer |
| SG10201913331VA (en) | 2016-03-15 | 2020-03-30 | Oryzon Genomics Sa | Combinations of lsd1 inhibitors for use in the treatment of solid tumors |
| CN106279114B (zh) * | 2016-08-04 | 2019-01-29 | 东南大学 | 一种Taladegib的合成方法 |
| US10548908B2 (en) | 2016-09-15 | 2020-02-04 | Nostopharma, LLC | Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification |
| CN106831718B (zh) * | 2016-12-30 | 2019-05-07 | 上海科技大学 | 平滑受体配体及其应用 |
| US11389434B2 (en) | 2017-05-18 | 2022-07-19 | Inserm | Methods and pharmaceutical compositions for the treatment of mast cell diseases |
| EP4173639A4 (en) | 2020-06-26 | 2024-03-13 | RaQualia Pharma Inc. | Method for selecting cancer patient for which combination therapy of retinoid and cancer treatment agent will be effective, and combined drug of retinoid and cancer treatment agent |
| WO2022081661A1 (en) * | 2020-10-13 | 2022-04-21 | Endeavor Biomedicines, Inc. | Methods of treating fibrosis |
| US12447148B2 (en) | 2024-03-05 | 2025-10-21 | Endeavor Biomedicines, Inc. | Methods of improving lung function |
| WO2025189041A1 (en) * | 2024-03-07 | 2025-09-12 | Endeavor Biomedicines, Inc. | Methods of treating fibrosis |
| WO2025242197A1 (zh) * | 2024-05-24 | 2025-11-27 | 成都思倍博医药科技有限公司 | 氘代的Hedgehog通路SMO受体抑制剂 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN148482B (OSRAM) * | 1977-06-03 | 1981-03-07 | Pfizer | |
| CN1104430C (zh) | 1996-01-15 | 2003-04-02 | 詹森药业有限公司 | 抑制血管生成的哒嗪胺 |
| WO1999052534A1 (en) | 1998-04-09 | 1999-10-21 | Johns Hopkins University School Of Medicine | Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways |
| ES2233383T3 (es) | 1999-06-08 | 2005-06-16 | Lorantis Limited | Utilizacion terapeutica de un ihibidor de la via de señalizacion hedgehog. |
| MXPA04000803A (es) * | 2001-07-27 | 2004-05-21 | Curis Inc | Mediadores de rutas de senalizacion de hedgehog, composiciones y usos relacionados a los mismos. |
| US7655674B2 (en) * | 2002-04-22 | 2010-02-02 | The Johns Hopkins University | Modulators of hedgehog signaling pathways, compositions and uses related thereto |
| WO2004020599A2 (en) | 2002-08-29 | 2004-03-11 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
| US8067608B2 (en) | 2003-09-29 | 2011-11-29 | The Johns Hopkins University | Hedgehog pathway antagonists |
| WO2005080378A1 (ja) | 2004-02-24 | 2005-09-01 | Mitsubishi Pharma Corporation | 縮合ピリダジン誘導体 |
| CA2564996A1 (en) | 2004-05-08 | 2006-01-12 | Taeyoung Yoon | 3-aryl-5,6-disubstituted pyridazines |
| PT1789390E (pt) | 2004-09-02 | 2012-02-08 | Genentech Inc | Inibidores de piridilo da sinalização de hedgehog |
| EP1900731A1 (de) * | 2006-09-07 | 2008-03-19 | Bayer Schering Pharma Aktiengesellschaft | N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren |
| BRPI0809193A2 (pt) * | 2007-03-15 | 2014-09-23 | Novartis Ag | Compostos orgânicos e seus usos |
| AU2008269128B2 (en) * | 2007-06-25 | 2012-08-02 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
| AU2008300019A1 (en) | 2007-09-07 | 2009-03-19 | Amgen Inc. | Annelated pyridazines for the treatment of tumors driven by inappropriate hedgehog signalling |
| CN101896472A (zh) * | 2007-12-13 | 2010-11-24 | 锡耶纳生物技术股份公司 | Hedgehog途径拮抗剂及其治疗应用 |
| JP5442717B2 (ja) * | 2008-04-29 | 2014-03-12 | イーライ リリー アンド カンパニー | 二置換フタラジンヘッジホッグ経路アンタゴニスト |
| US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
| US20110301162A1 (en) * | 2008-08-04 | 2011-12-08 | Amgen Inc. | Aurora kinase modulators and methods of use |
| PE20110433A1 (es) | 2008-11-03 | 2011-07-09 | Lilly Co Eli | Antagonistas de la via hedgehog de ftalazina disustituida |
| EP2358703B1 (en) | 2008-11-17 | 2013-12-25 | Eli Lilly and Company | Tetrasubstituted pyridazines hedgehog pathway antagonists |
| HRP20120762T1 (hr) | 2008-11-17 | 2012-10-31 | Eli Lilly And Company | Tetrasupstituirani piridazini kao inhibitori hedgehog puta |
| AR077014A1 (es) | 2009-06-19 | 2011-07-27 | Lilly Co Eli | Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer |
-
2010
- 2010-06-08 AR ARP100102003A patent/AR077014A1/es active IP Right Grant
- 2010-06-10 JO JO2010188A patent/JO2931B1/en active
- 2010-06-11 TW TW099119158A patent/TWI385165B/zh not_active IP Right Cessation
- 2010-06-15 CA CA2764542A patent/CA2764542C/en not_active Expired - Fee Related
- 2010-06-15 CN CN201080027189.3A patent/CN102459233B/zh active Active
- 2010-06-15 EP EP10726756.9A patent/EP2443104B1/en active Active
- 2010-06-15 NZ NZ596882A patent/NZ596882A/xx not_active IP Right Cessation
- 2010-06-15 MX MX2011014029A patent/MX2011014029A/es active IP Right Grant
- 2010-06-15 ES ES10726756T patent/ES2409054T3/es active Active
- 2010-06-15 PT PT107267569T patent/PT2443104E/pt unknown
- 2010-06-15 EA EA201270049A patent/EA019059B1/ru not_active IP Right Cessation
- 2010-06-15 MY MYPI2011006137A patent/MY156667A/en unknown
- 2010-06-15 UA UAA201114996A patent/UA106755C2/uk unknown
- 2010-06-15 SG SG2011094190A patent/SG177289A1/en unknown
- 2010-06-15 HR HRP20130408AT patent/HRP20130408T1/hr unknown
- 2010-06-15 JP JP2012516178A patent/JP5596139B2/ja active Active
- 2010-06-15 AU AU2010260244A patent/AU2010260244B2/en not_active Ceased
- 2010-06-15 BR BRPI1011601A patent/BRPI1011601A2/pt not_active Application Discontinuation
- 2010-06-15 PE PE2011002119A patent/PE20121050A1/es active IP Right Grant
- 2010-06-15 WO PCT/US2010/038568 patent/WO2010147917A1/en not_active Ceased
- 2010-06-15 KR KR1020117030157A patent/KR101389165B1/ko not_active Expired - Fee Related
- 2010-06-15 MA MA34455A patent/MA33363B1/fr unknown
- 2010-06-15 SI SI201030200T patent/SI2443104T1/sl unknown
- 2010-06-15 DK DK10726756.9T patent/DK2443104T3/da active
- 2010-06-15 US US12/815,439 patent/US8273742B2/en active Active
- 2010-06-15 PL PL10726756T patent/PL2443104T3/pl unknown
-
2011
- 2011-11-22 ZA ZA2011/08587A patent/ZA201108587B/en unknown
- 2011-11-24 IL IL216599A patent/IL216599A/en not_active IP Right Cessation
- 2011-11-29 HN HN2011003139A patent/HN2011003139A/es unknown
- 2011-12-07 TN TNP2011000627A patent/TN2011000627A1/en unknown
- 2011-12-08 CR CR20110658A patent/CR20110658A/es unknown
- 2011-12-13 DO DO2011000386A patent/DOP2011000386A/es unknown
- 2011-12-14 CL CL2011003147A patent/CL2011003147A1/es unknown
- 2011-12-16 EC EC2011011541A patent/ECSP11011541A/es unknown
- 2011-12-22 CO CO11177210A patent/CO6480932A2/es not_active Application Discontinuation
-
2012
- 2012-08-21 US US13/590,481 patent/US9000023B2/en active Active
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