DOP2006000088A - Compuestos utiles en terapia - Google Patents
Compuestos utiles en terapiaInfo
- Publication number
- DOP2006000088A DOP2006000088A DO2006000088A DO2006000088A DOP2006000088A DO P2006000088 A DOP2006000088 A DO P2006000088A DO 2006000088 A DO2006000088 A DO 2006000088A DO 2006000088 A DO2006000088 A DO 2006000088A DO P2006000088 A DOP2006000088 A DO P2006000088A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- alkyl
- optionally substituted
- halo
- cycloalkyl
- het
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/28—Two oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos de formula (I), o derivadosfarmacéuticamente aceptables de los mismos, en la que: R1 representa H, alquilo C1_6, alquil C1-6-oxi, cicloalquilo C3_8 o halo; R2 representa H, alquilo C1_6 (opcionalmente sustituido con R3), fenilo (opcionalmente sustituido con CN) o Het; R3 representa OH, CN, Het; -R4-alquilo C1-6 o CONR5R6; R4 representa -CO2- o -0-; R5 y R6 representan independientemente H, alquilo C1-6 (opcionalmente sustituido con OR7) o cicloalquilo C3_8; R7 representa H o alquilo C1-6; Het representa un grupo heterocíclico aromático de cinco o seis miembros que contiene (i) de uno a cuatro heteroátomo(s) de nitrógeno o (ii) uno o dos heteroátomo(s) de nitrógeno y un heteroátomo de oxígeno o uno de azufre o (iii) uno o dos heteroátomos(s) de oxígeno o azufre, estando dicho grupo heterocíclico opcionalmente sustituido con uno o más grupos seleccionados entre CN y alquilo C1_6; R8 representa alquilo C1_6, alquil C1_6-oxi, cicloalquilo C3_8 o halo; R9 y R10 representan independientemente H, alquilo C1_6, alquil C1_6-oxi, CN, CF3 o halo; pueden ser útiles para tratar endometriosis, fibroides uterinos (leiomiomata), menorragia, adenomiosis, dismenorrea primaria y secundaria
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67354405P | 2005-04-20 | 2005-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2006000088A true DOP2006000088A (es) | 2006-10-31 |
Family
ID=35044974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2006000088A DOP2006000088A (es) | 2005-04-20 | 2006-04-11 | Compuestos utiles en terapia |
Country Status (12)
Country | Link |
---|---|
US (2) | US7482375B2 (es) |
EP (1) | EP1874732A1 (es) |
JP (1) | JP2008536910A (es) |
AR (1) | AR053587A1 (es) |
CA (1) | CA2604218A1 (es) |
DO (1) | DOP2006000088A (es) |
GT (1) | GT200600155A (es) |
NL (1) | NL1031626C2 (es) |
PE (1) | PE20061316A1 (es) |
TW (1) | TW200716609A (es) |
UY (1) | UY29486A1 (es) |
WO (1) | WO2006111856A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998003167A1 (en) | 1996-07-24 | 1998-01-29 | Warner-Lambert Company | Isobutylgaba and its derivatives for the treatment of pain |
US20100087407A1 (en) * | 2006-08-04 | 2010-04-08 | James Symons | use of aromatase inhibitors |
US20080096950A1 (en) * | 2006-10-19 | 2008-04-24 | Karl Richard Gibson | Compounds Useful In Therapy |
PE20081803A1 (es) * | 2007-03-09 | 2008-12-11 | Wyeth Corp | Sintesis y caracterizacion de la forma ii polimorfica de 4-(2-(4,4-dimetil-2-oxooxazolidin-3-il)tiazol-4-il)benzonitrilo |
WO2008135824A1 (en) * | 2007-05-02 | 2008-11-13 | Pfizer Limited | Oxyalkylpyrazole compounds useful in therapy |
US20100292150A1 (en) * | 2007-12-10 | 2010-11-18 | Meditrina Pharmaceuticals, Inc. | Treatment of Menorrhagia with Aromatase Inhibitor |
AR071069A1 (es) * | 2008-03-26 | 2010-05-26 | Takeda Pharmaceutical | Derivados sustituidos de pirazol y su uso para la prevencion o el tratamiento de cancer |
SG157299A1 (en) | 2008-05-09 | 2009-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
MX2011002899A (es) | 2008-09-18 | 2011-04-11 | Pfizer Ltd | Compuestos de amida utiles en terapia. |
US20150272622A1 (en) * | 2011-12-22 | 2015-10-01 | Previvo Genetics, Llc | Recovery and processing of human embryos formed in vivo |
ES2701400T3 (es) | 2012-05-31 | 2019-02-22 | Repros Therapeutics Inc | Formulaciones para la administración vaginal de antiprogestinas |
CA2888377C (en) | 2012-11-02 | 2021-02-02 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
EP2929883A1 (en) | 2014-04-08 | 2015-10-14 | Institut Pasteur | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors |
WO2015171392A1 (en) * | 2014-05-06 | 2015-11-12 | E. I. Du Pont De Nemours And Company | Fungicidal pyrazoles |
WO2016081383A1 (en) | 2014-11-17 | 2016-05-26 | Arno Therapeutics, Inc. | Onapristone extended-release compositions and methods |
US10308676B2 (en) | 2015-09-25 | 2019-06-04 | Context Biopharma Inc. | Methods of making onapristone intermediates |
JP2019503353A (ja) | 2015-12-15 | 2019-02-07 | コンテキスト・バイオファーマ・インコーポレイテッド | 非晶質オナプリストン組成物およびそれを作製する方法 |
WO2018102369A1 (en) | 2016-11-30 | 2018-06-07 | Arno Therapeutics, Inc. | Methods for onapristone synthesis dehydration and deprotection |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3621024C2 (de) * | 1986-06-20 | 1999-10-28 | Schering Ag | 11beta-Phenylestradiene, deren Herstellung und diese enthaltende pharmazeutische Präparate |
PT1762567E (pt) * | 2001-04-10 | 2012-07-16 | Pfizer | Derivados de pirazole para tratamento do vih |
US6933312B2 (en) * | 2002-10-07 | 2005-08-23 | Agouron Pharmaceuticals, Inc. | Pyrazole derivatives |
-
2006
- 2006-04-10 WO PCT/IB2006/001096 patent/WO2006111856A1/en not_active Application Discontinuation
- 2006-04-10 CA CA002604218A patent/CA2604218A1/en not_active Abandoned
- 2006-04-10 JP JP2008507193A patent/JP2008536910A/ja active Pending
- 2006-04-10 EP EP06744619A patent/EP1874732A1/en not_active Withdrawn
- 2006-04-11 DO DO2006000088A patent/DOP2006000088A/es unknown
- 2006-04-18 US US11/408,286 patent/US7482375B2/en not_active Expired - Fee Related
- 2006-04-18 AR ARP060101529A patent/AR053587A1/es unknown
- 2006-04-19 GT GT200600155A patent/GT200600155A/es unknown
- 2006-04-19 UY UY29486A patent/UY29486A1/es not_active Application Discontinuation
- 2006-04-19 PE PE2006000409A patent/PE20061316A1/es not_active Application Discontinuation
- 2006-04-19 NL NL1031626A patent/NL1031626C2/nl not_active IP Right Cessation
- 2006-04-19 TW TW095113963A patent/TW200716609A/zh unknown
-
2008
- 2008-12-12 US US12/333,533 patent/US20090099209A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20060241125A1 (en) | 2006-10-26 |
TW200716609A (en) | 2007-05-01 |
GT200600155A (es) | 2007-04-18 |
WO2006111856A1 (en) | 2006-10-26 |
JP2008536910A (ja) | 2008-09-11 |
PE20061316A1 (es) | 2007-01-13 |
AR053587A1 (es) | 2007-05-09 |
NL1031626A1 (nl) | 2006-10-23 |
NL1031626C2 (nl) | 2007-03-19 |
UY29486A1 (es) | 2006-11-30 |
US20090099209A1 (en) | 2009-04-16 |
US7482375B2 (en) | 2009-01-27 |
EP1874732A1 (en) | 2008-01-09 |
CA2604218A1 (en) | 2006-10-26 |
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