DOP2006000245A - Compuestos útiles en terapia - Google Patents
Compuestos útiles en terapiaInfo
- Publication number
- DOP2006000245A DOP2006000245A DO2006000245A DO2006000245A DOP2006000245A DO P2006000245 A DOP2006000245 A DO P2006000245A DO 2006000245 A DO2006000245 A DO 2006000245A DO 2006000245 A DO2006000245 A DO 2006000245A DO P2006000245 A DOP2006000245 A DO P2006000245A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- alkyl
- halogen
- independently represent
- therapy
- pelvic pain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos de fórmula (I), o uno de sus derivados farmacéuticamente aceptables, en donde R1 y R3 representan, de modo independiente, H, alquilo C1-6, cicloalquilo C3-8 o halógeno; R2 representa alquilo C1-6, CF3 o arilo; a representa 1 ó 2; R4, R5, R7 y R8 representan, de modo independiente, H, alquilo C1-6, alquil C1-6oxi, CN o halógeno, o R4 y R5, o R7 y R8, junto con el anillo al que están unidos, forman un arilo o sistema de anillos heterocíclicos fusionados; m representa C o N; Y representa CH2 u O; R6 representa H, CN o halo, pero cuando X representa N, entonces R6 no está presente; pueden ser de utilidad para tratar endometriosis, fibroides uterinos (leiomiomas), menorragia, adenomiosis, dismenorrea primaria y secundaria (incluyendo los síntomas de dispareunia, disquexia y dolor pélvico crónico), o síndrome de dolor pélvico crónico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73509105P | 2005-11-08 | 2005-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2006000245A true DOP2006000245A (es) | 2007-06-30 |
Family
ID=37909834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2006000245A DOP2006000245A (es) | 2005-11-08 | 2006-11-08 | Compuestos útiles en terapia |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US7309712B2 (es) |
| EP (1) | EP1948615B1 (es) |
| JP (1) | JP4234786B1 (es) |
| KR (1) | KR100997595B1 (es) |
| CN (1) | CN101304974A (es) |
| AP (1) | AP2008004463A0 (es) |
| AR (1) | AR056780A1 (es) |
| AT (1) | ATE537150T1 (es) |
| AU (1) | AU2006313478A1 (es) |
| BR (1) | BRPI0618630A2 (es) |
| CA (1) | CA2628844C (es) |
| CR (1) | CR9959A (es) |
| CY (1) | CY1112286T1 (es) |
| DK (1) | DK1948615T3 (es) |
| DO (1) | DOP2006000245A (es) |
| EA (1) | EA014693B1 (es) |
| EC (1) | ECSP088431A (es) |
| ES (1) | ES2376252T3 (es) |
| GT (1) | GT200600478A (es) |
| HN (1) | HN2006037713A (es) |
| IL (1) | IL190806A0 (es) |
| MA (1) | MA29940B1 (es) |
| NL (1) | NL2000299C2 (es) |
| NO (1) | NO20082504L (es) |
| PE (1) | PE20070642A1 (es) |
| PL (1) | PL1948615T3 (es) |
| PT (1) | PT1948615E (es) |
| RS (1) | RS20080191A (es) |
| SI (1) | SI1948615T1 (es) |
| TN (1) | TNSN08202A1 (es) |
| TW (1) | TWI321563B (es) |
| UA (1) | UA90763C2 (es) |
| UY (1) | UY29904A1 (es) |
| WO (1) | WO2007054770A2 (es) |
| ZA (1) | ZA200803670B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE41920E1 (en) | 1996-07-24 | 2010-11-09 | Warner-Lambert Company Llc | Isobutylgaba and its derivatives for the treatment of pain |
| KR100997595B1 (ko) * | 2005-11-08 | 2010-11-30 | 화이자 리미티드 | 피라졸 유도체 및 이의 의약 용도 |
| EP2081905B1 (en) | 2006-07-28 | 2012-09-12 | Boehringer Ingelheim International GmbH | Sulfonyl compounds which modulate the cb2 receptor |
| CN101516839A (zh) | 2006-09-25 | 2009-08-26 | 贝林格尔.英格海姆国际有限公司 | 调节cb2受体的化合物 |
| WO2008135824A1 (en) * | 2007-05-02 | 2008-11-13 | Pfizer Limited | Oxyalkylpyrazole compounds useful in therapy |
| JP5492092B2 (ja) | 2007-11-07 | 2014-05-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節する化合物 |
| EP2116618A1 (en) | 2008-05-09 | 2009-11-11 | Agency for Science, Technology And Research | Diagnosis and treatment of Kawasaki disease |
| EP2418207A1 (en) * | 2008-05-13 | 2012-02-15 | Boehringer Ingelheim International GmbH | Sulfone compounds which modulate the CB2 receptor |
| JP5749162B2 (ja) | 2008-07-10 | 2015-07-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節するスルホン化合物 |
| BRPI0919172A2 (pt) | 2008-09-25 | 2015-12-15 | Boehringer Ingelheim Int | compostos os quais modulam seletivamente o receptor de cb2 |
| US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| EP2443107B1 (en) | 2009-06-16 | 2018-08-08 | Boehringer Ingelheim International GmbH | Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor |
| WO2011037795A1 (en) | 2009-09-22 | 2011-03-31 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the cb2 receptor |
| US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
| US20110136815A1 (en) | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
| WO2011088015A1 (en) | 2010-01-15 | 2011-07-21 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
| US8329735B2 (en) | 2010-03-05 | 2012-12-11 | Boehringer Ingelheim International Gmbh | Tetrazole compounds which selectively modulate the CB2 receptor |
| US20110263606A1 (en) * | 2010-04-26 | 2011-10-27 | Horst Zerbe | Solid oral dosage forms comprising tadalafil |
| EP2595959B1 (en) | 2010-07-22 | 2015-11-04 | Boehringer Ingelheim International GmbH | Sulfonyl compounds which modulate the cb2 receptor |
| EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
| AU2019362242A1 (en) * | 2018-10-18 | 2021-05-27 | Nanjing Sanhome Pharmaceutical Co., Ltd. | Compound as TGF-β R1 inhibitor and application thereof |
| RU2711615C1 (ru) * | 2019-09-12 | 2020-01-17 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт акушерства, гинекологии и репродуктологии имени Д.О. Отта" | Способ лечения эндометриоза на основании экспериментальной модели у крыс |
| CN111269097B (zh) * | 2020-04-02 | 2023-02-17 | 苏州爱玛特生物科技有限公司 | 一种多元环双取代的1,3-丙二酮类化合物的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6281638A (ja) * | 1985-10-07 | 1987-04-15 | Fuji Photo Film Co Ltd | ハロゲン化銀カラ−写真感光材料 |
| JPS63313784A (ja) * | 1987-03-12 | 1988-12-21 | Zeria Shinyaku Kogyo Kk | 新規ピラゾール誘導体およびその製造法ならびにこれを有効成分とする抗潰瘍剤 |
| DE4414792A1 (de) * | 1993-08-11 | 1995-02-16 | Bayer Ag | Arzneimittel enthaltend 1-Thiocarbamoyl-5-hydroxypyrazolen und deren Verwendung als Mittel zur Bekämpfung des septischen Schocks |
| DE60219292T2 (de) | 2001-04-10 | 2008-04-10 | Pfizer Inc. | Pyrazolderivate zur behandlung von hiv |
| GB0229618D0 (en) * | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
| KR100997595B1 (ko) * | 2005-11-08 | 2010-11-30 | 화이자 리미티드 | 피라졸 유도체 및 이의 의약 용도 |
-
2006
- 2006-10-26 KR KR1020087010982A patent/KR100997595B1/ko not_active IP Right Cessation
- 2006-10-26 RS RSP-2008/0191A patent/RS20080191A/sr unknown
- 2006-10-26 EP EP06809167A patent/EP1948615B1/en active Active
- 2006-10-26 PL PL06809167T patent/PL1948615T3/pl unknown
- 2006-10-26 PT PT06809167T patent/PT1948615E/pt unknown
- 2006-10-26 SI SI200631237T patent/SI1948615T1/sl unknown
- 2006-10-26 CA CA2628844A patent/CA2628844C/en not_active Expired - Fee Related
- 2006-10-26 AT AT06809167T patent/ATE537150T1/de active
- 2006-10-26 WO PCT/IB2006/003080 patent/WO2007054770A2/en active Application Filing
- 2006-10-26 AP AP2008004463A patent/AP2008004463A0/xx unknown
- 2006-10-26 AU AU2006313478A patent/AU2006313478A1/en not_active Abandoned
- 2006-10-26 DK DK06809167.7T patent/DK1948615T3/da active
- 2006-10-26 CN CNA2006800416684A patent/CN101304974A/zh active Pending
- 2006-10-26 JP JP2008539519A patent/JP4234786B1/ja not_active Expired - Fee Related
- 2006-10-26 BR BRPI0618630-0A patent/BRPI0618630A2/pt not_active IP Right Cessation
- 2006-10-26 EA EA200801053A patent/EA014693B1/ru not_active IP Right Cessation
- 2006-10-26 ES ES06809167T patent/ES2376252T3/es active Active
- 2006-10-26 UA UAA200805973A patent/UA90763C2/ru unknown
- 2006-11-02 NL NL2000299A patent/NL2000299C2/nl not_active IP Right Cessation
- 2006-11-03 US US11/592,574 patent/US7309712B2/en not_active Expired - Fee Related
- 2006-11-06 PE PE2006001366A patent/PE20070642A1/es not_active Application Discontinuation
- 2006-11-07 GT GT200600478A patent/GT200600478A/es unknown
- 2006-11-07 AR ARP060104881A patent/AR056780A1/es unknown
- 2006-11-07 TW TW095141158A patent/TWI321563B/zh active
- 2006-11-07 HN HN2006037713A patent/HN2006037713A/es unknown
- 2006-11-08 UY UY29904A patent/UY29904A1/es not_active Application Discontinuation
- 2006-11-08 DO DO2006000245A patent/DOP2006000245A/es unknown
-
2007
- 2007-10-11 US US11/870,451 patent/US7425569B2/en not_active Expired - Fee Related
-
2008
- 2008-04-10 IL IL190806A patent/IL190806A0/en unknown
- 2008-04-25 ZA ZA200803670A patent/ZA200803670B/xx unknown
- 2008-05-06 EC EC2008008431A patent/ECSP088431A/es unknown
- 2008-05-07 TN TNP2008000202A patent/TNSN08202A1/fr unknown
- 2008-05-08 MA MA30910A patent/MA29940B1/fr unknown
- 2008-05-08 CR CR9959A patent/CR9959A/es not_active Application Discontinuation
- 2008-06-05 NO NO20082504A patent/NO20082504L/no not_active Application Discontinuation
-
2012
- 2012-01-27 CY CY20121100096T patent/CY1112286T1/el unknown
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