DK478980A - Fremgangsmaade til fremstilling af imidazol-5-eddikesyrederivater - Google Patents

Fremgangsmaade til fremstilling af imidazol-5-eddikesyrederivater

Info

Publication number
DK478980A
DK478980A DK478980A DK478980A DK478980A DK 478980 A DK478980 A DK 478980A DK 478980 A DK478980 A DK 478980A DK 478980 A DK478980 A DK 478980A DK 478980 A DK478980 A DK 478980A
Authority
DK
Denmark
Prior art keywords
acetic acid
acid derivatives
preparing imidazole
imidazole
preparing
Prior art date
Application number
DK478980A
Other languages
English (en)
Inventor
Y Furukawa
S Kishimoto
K Nishikawa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DK478980A publication Critical patent/DK478980A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK478980A 1979-11-12 1980-11-11 Fremgangsmaade til fremstilling af imidazol-5-eddikesyrederivater DK478980A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14672879A JPS5671074A (en) 1979-11-12 1979-11-12 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative

Publications (1)

Publication Number Publication Date
DK478980A true DK478980A (da) 1981-05-13

Family

ID=15414223

Family Applications (1)

Application Number Title Priority Date Filing Date
DK478980A DK478980A (da) 1979-11-12 1980-11-11 Fremgangsmaade til fremstilling af imidazol-5-eddikesyrederivater

Country Status (19)

Country Link
US (1) US4355040A (da)
EP (1) EP0028834B1 (da)
JP (1) JPS5671074A (da)
AR (1) AR228957A1 (da)
AT (1) ATE5880T1 (da)
AU (1) AU6412280A (da)
CA (1) CA1152516A (da)
DE (1) DE3066205D1 (da)
DK (1) DK478980A (da)
ES (1) ES8204724A1 (da)
FI (1) FI803508L (da)
GR (1) GR72124B (da)
HU (1) HU185389B (da)
IL (1) IL61359A0 (da)
NO (1) NO151966C (da)
NZ (1) NZ195517A (da)
PT (1) PT72049B (da)
SU (1) SU999966A3 (da)
ZA (1) ZA806832B (da)

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1181082A (en) * 1981-11-20 1985-01-15 Toni Dockner Substituted benzylimidazolium salts and microbicides containing these compounds
JPS58157768A (ja) * 1982-03-16 1983-09-19 Takeda Chem Ind Ltd ４−クロロ−２−フエニルイミダゾ−ル−５−酢酸誘導体
EP0113570B1 (en) * 1982-12-20 1987-02-25 Merck & Co. Inc. 5-(amino or substituted amino) imidazoles
US4602093A (en) * 1984-02-08 1986-07-22 Merck & Co., Inc. Novel substituted imidazoles, their preparation and use
US5182264A (en) * 1986-03-07 1993-01-26 Schering Corporation Angiotensin II receptor blockers as antiglaucoma agents
US5036048A (en) * 1986-03-07 1991-07-30 Schering Corporation Angiotensin II receptor blockers as antiglaucoma agents
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
NZ221427A (en) * 1986-08-18 1990-12-21 Smithkline Beckman Corp 2-mercaptoimidazole derivatives and pharmaceutical compositions
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US5315013A (en) * 1988-01-07 1994-05-24 E. I. Du Pont De Nemours And Company Substituted pyrazole angiotensin II antagonists
EP0733366B1 (en) * 1988-01-07 1998-04-01 E.I. Du Pont De Nemours And Company Pharmaceutical compositions comprising angiotensin II receptor blocking imidazoles and diuretics
CA1338238C (en) 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US5189048A (en) * 1988-01-07 1993-02-23 E. I. Du Pont De Nemours And Company Substituted 1,2,3 triazole angiotensin II antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5210079A (en) * 1988-01-07 1993-05-11 E. I. Du Pont De Nemours And Company Treatment of chronic renal failure with imidazole angiotensin-II receptor antagonists
US5081127A (en) * 1988-01-07 1992-01-14 E. I. Du Pont De Nemours And Company Substituted 1,2,3-triazole angiotensin II antagonists
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
JPH029507A (ja) * 1988-06-24 1990-01-12 Teikku Ag 迅速交換形タップホルダ
US5354867A (en) * 1988-12-06 1994-10-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US4916129A (en) * 1989-01-19 1990-04-10 E. I. Du Pont De Nemours And Company Combination β-blocking/angiotensin II blocking antihypertensives
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
US5418250A (en) * 1989-06-14 1995-05-23 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
US5185351A (en) * 1989-06-14 1993-02-09 Smithkline Beecham Corporation Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists
DE10075018I2 (de) * 1989-06-14 2001-08-09 Smithkline Beecham Corp Imidazoalkensäure.
EP0403158A3 (en) * 1989-06-14 1991-12-18 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
US5312828A (en) * 1989-06-14 1994-05-17 Finkelstein Joseph A Substituted imidazoles having angiotensin II receptor blocking activity
SG50669A1 (en) * 1989-06-30 1998-07-20 Du Pont Fused-ring aryl subtituted imidazoles
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
EP0411507B1 (en) * 1989-08-02 1994-10-26 Takeda Chemical Industries, Ltd. Pyrazole derivatives, their production and use
IL95975A (en) * 1989-10-24 1997-06-10 Takeda Chemical Industries Ltd N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
US5250554A (en) * 1989-10-24 1993-10-05 Takeda Chemical Industries, Ltd. Benzimidazole derivatives useful as angiotensin II inhibitors
US5177096A (en) * 1989-10-25 1993-01-05 Smithkline Beecham Corporation Substituted 5-((tetrazolyl)alkenyl)imidazoles and pharmaceutical methods of use thereof
US5248689A (en) * 1989-11-06 1993-09-28 Smithkline Beecham Corporation Substituted N-(imidazolyl)alkyl alanine derivatives
CA2028925A1 (en) * 1989-11-06 1991-05-07 Gerald R. Girard Substituted n-(imidazolyl)alkyl alanine derivatives
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
WO1991010140A2 (en) * 1989-12-29 1991-07-11 University Technologies International Inc. Methods for modelling tertiary structures of biologically active ligands including agonists and antagonists thereto and novel synthetic antagonists based on angiotensin
ZA9010460B (en) * 1989-12-29 1992-11-25 Univ Technologies Int Methods for modelling tertiary structures of biologically active ligands including agonists and antagonists thereto and novel synthetic antagonists based on angiotensin
US5234917A (en) * 1989-12-29 1993-08-10 Finkelstein Joseph A Substituted 5-(alkyl)carboxamide imidazoles
JPH0396182U (da) * 1990-01-19 1991-10-01
US5011851A (en) * 1990-02-13 1991-04-30 Bristol-Myers Squibb Co. Imidazole carboxylic acids and esters and inhibition of blood platelet aggregation therewith
EP0442448A3 (en) 1990-02-13 1992-08-12 Bristol-Myers Squibb Company Heterocyclic carboxylic acids and esters
US5162326A (en) * 1990-02-15 1992-11-10 Takeda Chemical Industries, Ltd. Pyrimidinedione derivatives, their production and use
DE122007000050I1 (de) * 1990-02-19 2007-11-08 Novartis Ag Acylverbindungen
CA2037630C (en) * 1990-03-07 2001-07-03 Akira Morimoto Nitrogen-containing heterocylic compounds, their production and use
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
FR2665702B1 (fr) * 1990-08-08 1994-02-25 Sanofi Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5703110A (en) * 1990-04-27 1997-12-30 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
ZA912983B (en) 1990-04-27 1992-01-29 Takeda Chemical Industries Ltd Benzimidazole derivatives,their production and use
US6004989A (en) 1990-04-27 1999-12-21 Takeda Chemical Industries, Ltd. Benzimidazole derivatives, their production and use
ES2097208T3 (es) 1990-05-11 1997-04-01 Pfizer Composiciones y procedimientos terapeuticos y sinergicos.
US5821232A (en) * 1990-05-11 1998-10-13 Pfizer Inc. Synergistic therapeutic compositions and methods
NZ238688A (en) * 1990-06-28 1992-05-26 Smithkline Beecham Corp Substituted histidines: pharmaceutical compositions, preparation and uses thereof
NZ239161A (en) * 1990-07-31 1994-01-26 Smithkline Beecham Corp Substituted [1h-imidazol-5-yl] alkanoic acid derivatives; medicaments,
US5126342A (en) * 1990-10-01 1992-06-30 Merck & Co., Inc. Imidazole angiotensin ii antagonists incorporating acidic functional groups
AU636066B2 (en) * 1990-10-30 1993-04-08 Takeda Chemical Industries Ltd. Thienoimidazole derivatives, their production and use
US5374615A (en) * 1990-10-31 1994-12-20 E. R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives
DE4036706A1 (de) * 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
TW197428B (da) 1991-01-04 1993-01-01 Hoechst Ag
CA2058198A1 (en) * 1991-01-04 1992-07-05 Adalbert Wagner Azole derivatives, process for their preparation, and their use
US5153347A (en) * 1991-01-31 1992-10-06 E. R. Squibb & Sons, Inc. Phosphonate, phosphinate derivatives useful as antihypertensive agents
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
CA2229000C (en) 1991-02-21 2002-04-09 Sankyo Company, Limited 1-biphenylimidazole derivatives, their preparation and their therapeutic use
US5104877A (en) * 1991-02-25 1992-04-14 Abbott Laboratories Psoriasis treatment
US5191086A (en) * 1991-03-19 1993-03-02 E.R. Squibb & Sons, Inc. Imidazole and benzimidazole derivatives
US5177074A (en) 1991-03-26 1993-01-05 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted thiophene or furan
TW274551B (da) * 1991-04-16 1996-04-21 Takeda Pharm Industry Co Ltd
US5190942A (en) * 1991-04-22 1993-03-02 E. R. Squibb & Sons, Inc. Benzoxazole and related heterocyclic substituted imidazole and benzimidazole derivatives
GB9110636D0 (en) * 1991-05-16 1991-07-03 Glaxo Group Ltd Chemical compounds
GB9110635D0 (en) * 1991-05-16 1991-07-03 Glaxo Group Ltd Chemical compounds
US5332820A (en) * 1991-05-20 1994-07-26 E. I. Du Pont De Nemours And Company Dibenzobicyclo(2.2.2) octane angiotensin II antagonists
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
US5177097A (en) * 1991-07-24 1993-01-05 E. R. Squibb & Sons, Inc. Acyl amidine and acyl, guanidine substituted biphenyl derivatives
US5389661A (en) * 1991-12-05 1995-02-14 Warner-Lambert Company Imidazole and 1,2,4-triazole derivatives with angiotensin II antagonist properties
US5322950A (en) * 1991-12-05 1994-06-21 Warner-Lambert Company Imidazole with angiotensin II antagonist properties
US5212177A (en) * 1991-12-16 1993-05-18 E. R. Squibb & Sons, Inc. Indole and benzimidazole-substituted dihydropyrimidine derivatives
TW215434B (da) * 1992-03-07 1993-11-01 Hoechst Ag
US5208234A (en) * 1992-03-10 1993-05-04 E. R. Squibb & Sons, Inc. Substituted imidazole phosphonic and phosphinic acid derivatives
DE4208051A1 (de) * 1992-03-13 1993-09-16 Bayer Ag Substituierte phenylessigsaeureamide
DE4208052A1 (de) * 1992-03-13 1993-09-16 Bayer Ag Imidazolyl substituierte phenylessigsaeureamide
US5616591A (en) * 1992-03-27 1997-04-01 E.R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted quinoline derivatives
DE4212796A1 (de) * 1992-04-16 1993-10-21 Bayer Ag Propenoyl-imidazolderivate
US5294722A (en) * 1992-04-16 1994-03-15 E. R. Squibb & Sons, Inc. Process for the preparation of imidazoles useful in angiotensin II antagonism
US5380719A (en) * 1992-04-28 1995-01-10 E. R. Squibb & Sons, Inc. Quinoxaline biphenyl angiotensin II inhibitors
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US5401851A (en) * 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
DE4221009A1 (de) * 1992-06-26 1994-01-05 Bayer Ag Imidazolyl-substituierte Cyclohexanderivate
DE4220983A1 (de) * 1992-06-26 1994-01-05 Bayer Ag Imidazolyl-substituierte Phenylpropion- und -zimtsäurederivate
RU2103262C1 (ru) * 1992-07-16 1998-01-27 Лонца АГ Гампель/Валлис Способ получения 2-замещенных 5-хлоримидазол-4-карбальдегидов
JP3501484B2 (ja) * 1992-12-17 2004-03-02 三共株式会社 ビフェニル誘導体
TW240224B (da) * 1993-02-15 1995-02-11 Shikoku Kakoki Co Ltd
DE59403903D1 (de) * 1993-03-12 1997-10-09 Lonza Ag Verfahren zur Herstellung von gegebenfalls 2-substituierten 5-Chlorimidazolen
EP0614889A1 (de) * 1993-03-12 1994-09-14 Lonza Ag Verfahren zur Herstellung von gegebenenfalls 2-substituierten 5-Chlorimidazol-4-carbaldehyden
US5484939A (en) * 1993-03-12 1996-01-16 Lonza Ltd. 2-substituted 5-chlorimidazoles
US5442075A (en) * 1993-03-12 1995-08-15 Lonza Ltd. Process for the production of 2-substituted 5-chlorimidazole-4-carbaldehydes
US5721264A (en) * 1993-04-07 1998-02-24 Nissan Chemical Industries, Ltd. Pyrazole derivatives
CA2135541C (en) * 1993-11-15 2006-01-10 Gareth Griffiths Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes
US5395847A (en) * 1993-12-02 1995-03-07 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
PL185858B1 (pl) * 1994-05-20 2003-08-29 Smithkline Beecham Corp Związek addycyjny kwasu 4-[(2-n-butylo-5-formylo-1Związek addycyjny kwasu 4-[(2-n-butylo-5-formylo-1H-imidazol-1-ilo)metylo]benzoesowego z wodorosiarcH-imidazol-1-ilo)metylo]benzoesowego z wodorosiarczynem i sposób jego wytwarzaniazynem i sposób jego wytwarzania
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
EP0709377B1 (en) 1994-10-27 1999-09-29 Asahi Glass Company Ltd. Process for producing quinolin-2-yl benzoic acid compounds
CA2175420C (en) * 1995-05-17 2007-04-10 Gareth Griffiths Process for the preparation of optionally 2-substituted 5-chloroimidazole-4-carbaldehydes
JP4103149B2 (ja) * 1996-01-05 2008-06-18 ロンザ リミテッド ２−置換５−クロロイミダゾール−４−カルブアルデヒドの製造方法
JPH09202774A (ja) 1996-01-25 1997-08-05 Green Cross Corp:The ２−アリールキノリン類およびその製造方法
JP3890453B2 (ja) 1996-09-18 2007-03-07 リードケミカル株式会社 新規２，４−ジオキソピロリジンおよび２，４−ジオキソテトラヒドロフラン誘導体及び該化合物を有効成分とする医薬
IT1295405B1 (it) 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
CA2318446C (en) 1998-03-04 2008-09-23 Takeda Chemical Industries, Ltd. Sustained-release preparation for aii antagonist, production and use thereof
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US7812044B2 (en) 2001-11-13 2010-10-12 Takeda Pharmaceutical Company Limited Anticancer agents
ATE321039T1 (de) * 2002-04-29 2006-04-15 Teva Pharma Verfahren zur herstellung von losartan und losartan-kaliumsalz
DE10335027A1 (de) 2003-07-31 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Angiotensin II Rezeptor Antagonisten
DE10306179A1 (de) 2003-02-13 2004-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Dipyridamol in Kombination mit Acetylsalicylsäure und einem Angiotensin II-Antagonisten zur Schlaganfall-Prophylaxe
EP1844019B1 (de) * 2005-02-03 2009-09-02 Ratiopharm GmbH Verfahren zur herstellung von losartan
WO2006110037A2 (en) * 2005-04-15 2006-10-19 Dishman Pharmaceuticals And Chemicals Ltd. Preparation of 2-substituted 4-chl0r0-5-f0rmylimidaz0les by vilsmeier reaction of the condensation product of glycine and an imido ester with a formamide in the presence of a triflate (trifluormethanξsulphonate) catalyst
EP1908469A1 (en) 2006-10-06 2008-04-09 Boehringer Ingelheim Vetmedica Gmbh Angiotensin II receptor antagonist for the treatment of systemic diseases in cats
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA3089569C (en) 2007-06-04 2023-12-05 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20090299177A1 (en) * 2008-06-03 2009-12-03 Mallinckrodt Inc. Risk Stratification of Patients with Chronic Myocardial Infarction
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN102584628B (zh) * 2011-12-30 2015-04-22 浙江外国语学院 一种n-羧甲基戊脒的合成方法
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
RS65632B1 (sr) 2013-06-05 2024-07-31 Bausch Health Ireland Ltd Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe
DK3648761T3 (da) 2017-07-07 2024-06-24 Boehringer Ingelheim Vetmedica Gmbh Telmisartan til forebyggelsen eller behandlingen af hypertension i katte

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH510394A (de) * 1969-07-04 1971-07-31 Ciba Geigy Ag Akarizides Mittel
CA1066709A (en) 1975-03-10 1979-11-20 Walter A.M. Helsen Preparation of loweralkyl imidazole carboxylates
JPS54148788A (en) * 1978-05-15 1979-11-21 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative and its preparation
JPS611022A (ja) * 1985-06-03 1986-01-07 Hitachi Ltd 半導体集積回路装置

Also Published As

Publication number Publication date
PT72049B (pt) 1981-09-24
EP0028834B1 (en) 1984-01-18
ZA806832B (en) 1981-10-28
NO803388L (no) 1981-05-13
IL61359A0 (en) 1980-12-31
ES496709A0 (es) 1982-05-01
AU6412280A (en) 1981-05-21
FI803508L (fi) 1981-05-13
NO151966B (no) 1985-04-01
US4355040A (en) 1982-10-19
CA1152516A (en) 1983-08-23
AR228957A1 (es) 1983-05-13
GR72124B (da) 1983-09-16
SU999966A3 (ru) 1983-02-23
NO151966C (no) 1985-07-10
JPS6364428B2 (da) 1988-12-12
JPS5671074A (en) 1981-06-13
ES8204724A1 (es) 1982-05-01
PT72049A (en) 1980-12-01
DE3066205D1 (en) 1984-02-23
ATE5880T1 (de) 1984-02-15
EP0028834A1 (en) 1981-05-20
HU185389B (en) 1985-01-28
NZ195517A (en) 1982-12-07

Similar Documents

Publication Publication Date Title
DK478980A (da) Fremgangsmaade til fremstilling af imidazol-5-eddikesyrederivater
DK540080A (da) Fremgangsmaade til fremstilling af 2-amino-4-hydroxyquinazolinderivater
DK42480A (da) Fremgangsmaade til fremstilling af 1-aryl-2-acylamido-3-fluor-1-propanoler
DK470583D0 (da) Fremgangsmade til fremstilling af 1-phenyl-2-piperidinopropanolderivater
DK492783D0 (da) Fremgangsmade til fremstilling af 3-aryl-5-pyrazol-derivater
DK95483D0 (da) Fremgangsmade til fremstilling af tetrahydropyranderivater
DK157009C (da) Fremgangsmaade til fremstilling af 1-(3-mercapto-2s-methylpropionyl)-pyrrolidin-2s-carboxylsyre
DK158669C (da) Fremgangsmaade til fremstilling af 6beta-halogensubstituerede penicillansyrederivater.
DK396880A (da) Fremgangsmaade til fremstilling af cyclohexancarboxylsyrederivater
DK99980A (da) Fremgangsmaade til fremstilling af mercaptoacyldihydropyrazolcarboxylsyrederivater
DK289580A (da) Fremgangsmaade til fremstilling af heterocycliske phenoxyaminer
DK154554C (da) Fremgangsmaade til fremstilling af alfa-methyl-carbazol-2-eddikesyrederivater
DK188881A (da) Fremgangsmaade til fremstilling af 2-guanidinthiazol-derivater
DK157677C (da) Fremgangsmaade til fremstilling af cyclopropancarboxylsyreesterderivater
DK158312C (da) Fremgangsmaade til fremstilling af diacetoneketogulonsyre
DK154085C (da) Fremgangsmaade til fremstilling af 1,1-dioxopenicillansyrederivater
DK444279A (da) Fremgangsmaade til fremstilling af 6-hydroxymethyl-2-(beta-aminoethylthio)-1-carbadethiapen-2-em-3-carboxylsyre
DK57381A (da) Fremgansmaade til fremstilling af bifenyloxypropionsyrederivater
DK163667C (da) Fremgangsmaade til fremstilling af 7-amino-3-chlor-3-cephem-4-carboxylsyreestere
DK145741C (da) Fremgangsmaade til fremstilling af 6-chlor-alfa-methyl-carbazol-2-eddikesyre
DK149962C (da) Fremgangsmaade til fremstilling af 2,5-diketogluconsyre
DK157613C (da) Fremgangsmaade til fremstilling af cyclopropancarboxylsyreesterderivater
DK228583D0 (da) Fremgangsmade til fremstilling af 5-oxo-2-pyrrolidinpropansyrederivater
DK287480A (da) Fremgangsmaade til fremstilling af 2-isopropylaminopyrimidin
DK159446C (da) Fremgangsmaade til fremstilling af oxazolinoazetidinylhydroxymethylbutensyrederivater

Legal Events

Date Code Title Description
ATS Application withdrawn