DE602006017675D1 - Herstellung von 2-substituierten 4-chlor-5-formylimidazolen durch vilsmeier-reaktion des kondensationsprodukts von glycin und einem imidoester mit einem formamid in gegenwart eines triflat- (trifluormethansulfonat-) katalysators - Google Patents

Herstellung von 2-substituierten 4-chlor-5-formylimidazolen durch vilsmeier-reaktion des kondensationsprodukts von glycin und einem imidoester mit einem formamid in gegenwart eines triflat- (trifluormethansulfonat-) katalysators

Info

Publication number
DE602006017675D1
DE602006017675D1 DE602006017675T DE602006017675T DE602006017675D1 DE 602006017675 D1 DE602006017675 D1 DE 602006017675D1 DE 602006017675 T DE602006017675 T DE 602006017675T DE 602006017675 T DE602006017675 T DE 602006017675T DE 602006017675 D1 DE602006017675 D1 DE 602006017675D1
Authority
DE
Germany
Prior art keywords
substituted
chloro
catalyst
formylimidazolenes
triflated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006017675T
Other languages
English (en)
Inventor
Vyas Janmejay Rajnikant
Varma Nidadavolu Venkata Satya
Singh Anand Prakash
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dishman Carbogen Amcis Ltd
Original Assignee
Dishman Pharmaceuticals and Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dishman Pharmaceuticals and Chemicals Ltd filed Critical Dishman Pharmaceuticals and Chemicals Ltd
Publication of DE602006017675D1 publication Critical patent/DE602006017675D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Saccharide Compounds (AREA)
DE602006017675T 2005-04-15 2006-04-07 Herstellung von 2-substituierten 4-chlor-5-formylimidazolen durch vilsmeier-reaktion des kondensationsprodukts von glycin und einem imidoester mit einem formamid in gegenwart eines triflat- (trifluormethansulfonat-) katalysators Active DE602006017675D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67147105P 2005-04-15 2005-04-15
EP05103014 2005-04-15
PCT/NL2006/050077 WO2006110037A2 (en) 2005-04-15 2006-04-07 Preparation of 2-substituted 4-chl0r0-5-f0rmylimidaz0les by vilsmeier reaction of the condensation product of glycine and an imido ester with a formamide in the presence of a triflate (trifluormethanξsulphonate) catalyst

Publications (1)

Publication Number Publication Date
DE602006017675D1 true DE602006017675D1 (de) 2010-12-02

Family

ID=34939316

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006017675T Active DE602006017675D1 (de) 2005-04-15 2006-04-07 Herstellung von 2-substituierten 4-chlor-5-formylimidazolen durch vilsmeier-reaktion des kondensationsprodukts von glycin und einem imidoester mit einem formamid in gegenwart eines triflat- (trifluormethansulfonat-) katalysators

Country Status (6)

Country Link
US (1) US20080200690A1 (de)
EP (1) EP1871745B1 (de)
JP (1) JP2008535911A (de)
AT (1) ATE485278T1 (de)
DE (1) DE602006017675D1 (de)
WO (1) WO2006110037A2 (de)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54148788A (en) * 1978-05-15 1979-11-21 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative and its preparation
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
RU2103262C1 (ru) * 1992-07-16 1998-01-27 Лонца АГ Гампель/Валлис Способ получения 2-замещенных 5-хлоримидазол-4-карбальдегидов
US5336779A (en) * 1992-10-08 1994-08-09 Nippon Gohsei Kagaku Kogyo Kabushiki Kaisha Method of producing formylimidazoles
US5484939A (en) * 1993-03-12 1996-01-16 Lonza Ltd. 2-substituted 5-chlorimidazoles
US5442075A (en) * 1993-03-12 1995-08-15 Lonza Ltd. Process for the production of 2-substituted 5-chlorimidazole-4-carbaldehydes
CA2135541C (en) * 1993-11-15 2006-01-10 Gareth Griffiths Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes
JP4103149B2 (ja) * 1996-01-05 2008-06-18 ロンザ リミテッド ２−置換５−クロロイミダゾール−４−カルブアルデヒドの製造方法
KR100567183B1 (ko) * 1997-11-14 2006-06-13 론자 아게 포르밀이미다졸의제조방법

Also Published As

Publication number Publication date
ATE485278T1 (de) 2010-11-15
WO2006110037A3 (en) 2007-04-05
JP2008535911A (ja) 2008-09-04
US20080200690A1 (en) 2008-08-21
WO2006110037A2 (en) 2006-10-19
EP1871745B1 (de) 2010-10-20
EP1871745A2 (de) 2008-01-02

Similar Documents

Publication Publication Date Title
EA200900793A1 (ru) Способ получения эзетимиба и его производных
EA200702614A1 (ru) Способы получения 4-(бифенилил)азетидин-2-оналкилфосфиновых кислот
EA200701588A1 (ru) Способы получения замещённых фенилпиразолмочевин
EA200601141A1 (ru) Сульфонамидные производные для лечения заболеваний
WO2006027705A3 (en) Synthesis of triethylenetetramines
DE602005022099D1 (de) Fluorisierungsverfahren zur synthese von 2-ä18fü fluoro-2-deoxy-d-glukose
CY1109428T1 (el) Μεθοδοι για το διαχωρισμο της μοδαφινιλης
EA200701738A1 (ru) Способ получения транс-1-((1r,3s)-6-хлор-3-фенилиндан-1-ил)-3,3-диметилпиперазина
EA200600605A1 (ru) Перегруппированные пентанолы, способ их получения и их применение в качестве противовоспалительных средств
ATE438617T1 (de) Substituierte cyclohexyl-1,4-diamin-derivate
ATE545636T1 (de) Synthese von cyclenderivaten
CR9885A (es) Metodos para preparar derivados de acido glutamico
EA201001870A1 (ru) Новые кристаллические формы рабепразола натрия
EA201201666A1 (ru) Промежуточные соединения агомелатина и способ их получения
EA201990237A1 (ru) Новые способы получения стимуляторов растворимой гуанилатциклазы
EA201170736A1 (ru) Синтез и новые солевые формы (r)-3-((e)-2-(пирролидин-3-ил)винил)-5-(тетрагидропиран-4-илокси) пиридина
DK2152667T3 (da) Fremgangsmåder til fremstilling af N-isobutyl-n-(2-hydroxy-3-amin-4-phenylbutyl)-p-nitrobenzenesulfonylamid-derivater
ATE388154T1 (de) Kristalline form von cefdinir-ammoniumsalz als zwischenprodukt für die herstellung von reinem cefdinir
DE602006017675D1 (de) Herstellung von 2-substituierten 4-chlor-5-formylimidazolen durch vilsmeier-reaktion des kondensationsprodukts von glycin und einem imidoester mit einem formamid in gegenwart eines triflat- (trifluormethansulfonat-) katalysators
WO2008059513A3 (en) Compounds suitable as modulators of hdl
DE602006020760D1 (de) Verfahren zur herstellung von perindoprilerbumin
WO2006122072A3 (en) Processes for preparing biaryl ureas and analogs thereof
JP5338072B2 (ja) ４−ハロカテコール化合物の製法
EA200700191A1 (ru) Композиции, содержащие никорандил, способ получения и применение
ATE502007T1 (de) Synthese von optisch reinem (r)-5-(2-aminopropyl)-2-methoxybenzolsulphonami