ATE485278T1 - Herstellung von 2-substituierten 4-chlor-5- formylimidazolen durch vilsmeier-reaktion des kondensationsprodukts von glycin und einem imidoester mit einem formamid in gegenwart eines triflat- (trifluormethansulfonat-) katalysators - Google Patents

Herstellung von 2-substituierten 4-chlor-5- formylimidazolen durch vilsmeier-reaktion des kondensationsprodukts von glycin und einem imidoester mit einem formamid in gegenwart eines triflat- (trifluormethansulfonat-) katalysators

Info

Publication number
ATE485278T1
ATE485278T1 AT06733056T AT06733056T ATE485278T1 AT E485278 T1 ATE485278 T1 AT E485278T1 AT 06733056 T AT06733056 T AT 06733056T AT 06733056 T AT06733056 T AT 06733056T AT E485278 T1 ATE485278 T1 AT E485278T1
Authority
AT
Austria
Prior art keywords
substituted
formylimidazoles
triflate
catalyst
imidoester
Prior art date
Application number
AT06733056T
Other languages
English (en)
Inventor
Vyas Janmejay Rajnikant
Varma Nidadavolu Venkata Satya
Singh Anand Prakash
Original Assignee
Dishman Pharmaceuticals And Ch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dishman Pharmaceuticals And Ch filed Critical Dishman Pharmaceuticals And Ch
Application granted granted Critical
Publication of ATE485278T1 publication Critical patent/ATE485278T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
AT06733056T 2005-04-15 2006-04-07 Herstellung von 2-substituierten 4-chlor-5- formylimidazolen durch vilsmeier-reaktion des kondensationsprodukts von glycin und einem imidoester mit einem formamid in gegenwart eines triflat- (trifluormethansulfonat-) katalysators ATE485278T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67147105P 2005-04-15 2005-04-15
EP05103014 2005-04-15
PCT/NL2006/050077 WO2006110037A2 (en) 2005-04-15 2006-04-07 Preparation of 2-substituted 4-chl0r0-5-f0rmylimidaz0les by vilsmeier reaction of the condensation product of glycine and an imido ester with a formamide in the presence of a triflate (trifluormethanξsulphonate) catalyst

Publications (1)

Publication Number Publication Date
ATE485278T1 true ATE485278T1 (de) 2010-11-15

Family

ID=34939316

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06733056T ATE485278T1 (de) 2005-04-15 2006-04-07 Herstellung von 2-substituierten 4-chlor-5- formylimidazolen durch vilsmeier-reaktion des kondensationsprodukts von glycin und einem imidoester mit einem formamid in gegenwart eines triflat- (trifluormethansulfonat-) katalysators

Country Status (6)

Country Link
US (1) US20080200690A1 (de)
EP (1) EP1871745B1 (de)
JP (1) JP2008535911A (de)
AT (1) ATE485278T1 (de)
DE (1) DE602006017675D1 (de)
WO (1) WO2006110037A2 (de)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54148788A (en) * 1978-05-15 1979-11-21 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative and its preparation
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
RU2103262C1 (ru) * 1992-07-16 1998-01-27 Лонца АГ Гампель/Валлис Способ получения 2-замещенных 5-хлоримидазол-4-карбальдегидов
US5336779A (en) * 1992-10-08 1994-08-09 Nippon Gohsei Kagaku Kogyo Kabushiki Kaisha Method of producing formylimidazoles
US5442075A (en) * 1993-03-12 1995-08-15 Lonza Ltd. Process for the production of 2-substituted 5-chlorimidazole-4-carbaldehydes
US5484939A (en) * 1993-03-12 1996-01-16 Lonza Ltd. 2-substituted 5-chlorimidazoles
CA2135541C (en) * 1993-11-15 2006-01-10 Gareth Griffiths Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes
JP4103149B2 (ja) * 1996-01-05 2008-06-18 ロンザ リミテッド ２−置換５−クロロイミダゾール−４−カルブアルデヒドの製造方法
KR100567183B1 (ko) * 1997-11-14 2006-06-13 론자 아게 포르밀이미다졸의제조방법

Also Published As

Publication number Publication date
JP2008535911A (ja) 2008-09-04
WO2006110037A3 (en) 2007-04-05
EP1871745B1 (de) 2010-10-20
US20080200690A1 (en) 2008-08-21
DE602006017675D1 (de) 2010-12-02
WO2006110037A2 (en) 2006-10-19
EP1871745A2 (de) 2008-01-02

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