ATE472552T1 - Fluorisierungsverfahren zur synthese von 2-ä18fü fluoro-2-deoxy-d-glukose - Google Patents
Fluorisierungsverfahren zur synthese von 2-ä18fü fluoro-2-deoxy-d-glukoseInfo
- Publication number
- ATE472552T1 ATE472552T1 AT05813632T AT05813632T ATE472552T1 AT E472552 T1 ATE472552 T1 AT E472552T1 AT 05813632 T AT05813632 T AT 05813632T AT 05813632 T AT05813632 T AT 05813632T AT E472552 T1 ATE472552 T1 AT E472552T1
- Authority
- AT
- Austria
- Prior art keywords
- ä18fü
- fluorization
- deoxy
- fluoro
- glucose
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- CEGXZKXILQSJHO-KODRXGBYSA-N (3r,4s,5r)-3,4,5,6-tetrahydroxyhexanoyl fluoride Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)CC(F)=O CEGXZKXILQSJHO-KODRXGBYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 238000004334 fluoridation Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/02—Monosaccharides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0425501.4A GB0425501D0 (en) | 2004-11-19 | 2004-11-19 | Fluoridation process |
| PCT/GB2005/004451 WO2006054098A2 (en) | 2004-11-19 | 2005-11-18 | Fluoridation process for the synthesis of 2- [18f] fluoro-2-deoxy-d-glucose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE472552T1 true ATE472552T1 (de) | 2010-07-15 |
Family
ID=33548541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05813632T ATE472552T1 (de) | 2004-11-19 | 2005-11-18 | Fluorisierungsverfahren zur synthese von 2-ä18fü fluoro-2-deoxy-d-glukose |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20090076259A1 (de) |
| EP (1) | EP1817320B1 (de) |
| JP (1) | JP5318416B2 (de) |
| KR (1) | KR101267122B1 (de) |
| CN (1) | CN101061130B (de) |
| AT (1) | ATE472552T1 (de) |
| AU (1) | AU2005305624B2 (de) |
| BR (1) | BRPI0518316A2 (de) |
| CA (1) | CA2584649C (de) |
| DE (1) | DE602005022099D1 (de) |
| ES (1) | ES2347165T3 (de) |
| GB (1) | GB0425501D0 (de) |
| HK (1) | HK1107353A1 (de) |
| IL (1) | IL182740A0 (de) |
| MX (1) | MX2007006052A (de) |
| NO (1) | NO20073037L (de) |
| NZ (1) | NZ554613A (de) |
| PL (1) | PL1817320T3 (de) |
| PT (1) | PT1817320E (de) |
| RU (1) | RU2394040C2 (de) |
| WO (1) | WO2006054098A2 (de) |
| ZA (1) | ZA200705015B (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007031647A (ja) * | 2005-07-29 | 2007-02-08 | Japan Health Science Foundation | 固相合成を利用した超短半減期核種を含む化合物の製造方法およびそれに用いる化合物 |
| AU2006322673A1 (en) * | 2005-12-06 | 2007-06-14 | Nihon Medi-Physics Co., Ltd. | Process for production of compound labeled with radioactive fluorine |
| EP2070937A4 (de) * | 2006-09-06 | 2014-01-01 | Nihon Mediphysics Co Ltd | Verfahren zur herstellung einer mit radioaktivem fluor markierten organischen verbindung und entsprechender syntheseapparat und programm |
| CN101678308B (zh) * | 2006-12-21 | 2014-01-29 | 哈默史密斯网上成像有限公司 | 采用微组配装置的亲核放射氟化 |
| KR101768926B1 (ko) | 2010-02-12 | 2017-08-17 | 도오쿄 인스티튜드 오브 테크놀로지 | 18ｆ 표지 화합물의 제조 방법 및 그 방법에 사용하는 고분자 화합물 |
| JP6245981B2 (ja) * | 2010-04-08 | 2017-12-13 | シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッドＳｉｅｍｅｎｓ Ｍｅｄｉｃａｌ Ｓｏｌｕｔｉｏｎｓ ＵＳＡ，Ｉｎｃ． | 含水有機溶媒中の１８ｆ−標識化トレーサーの合成 |
| EP2658831B1 (de) * | 2010-12-29 | 2017-02-15 | GE Healthcare Limited | Eluierungslösung |
| US9101895B2 (en) | 2011-04-15 | 2015-08-11 | General Electric Company | System for mixing and dispersing microbubble pharmaceuticals |
| EP2760577A2 (de) * | 2011-09-30 | 2014-08-06 | GE Healthcare UK Limited | Reaktor für mehrstufige radiochemie |
| JP6758065B2 (ja) * | 2016-03-30 | 2020-09-23 | 日本メジフィジックス株式会社 | 放射性標識化合物の製造装置及び製造方法 |
| CN113801173B (zh) * | 2021-09-24 | 2024-03-12 | 上海安迪科正电子技术有限公司 | 一种氟-18标记的脱氧葡糖注射液的制备方法及应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2581558B1 (fr) * | 1985-05-10 | 1987-06-26 | Elf France | Procede de traitement d'un carburant compose d'un melange d'hydrocarbures et d'alcools, et produit d'adsorption selective d'eau |
| GB0115927D0 (en) * | 2001-06-29 | 2001-08-22 | Nycomed Amersham Plc | Solid-phase nucleophilic fluorination |
-
2004
- 2004-11-19 GB GBGB0425501.4A patent/GB0425501D0/en not_active Ceased
-
2005
- 2005-11-18 PT PT05813632T patent/PT1817320E/pt unknown
- 2005-11-18 MX MX2007006052A patent/MX2007006052A/es active IP Right Grant
- 2005-11-18 AU AU2005305624A patent/AU2005305624B2/en not_active Ceased
- 2005-11-18 EP EP05813632A patent/EP1817320B1/de not_active Not-in-force
- 2005-11-18 AT AT05813632T patent/ATE472552T1/de not_active IP Right Cessation
- 2005-11-18 BR BRPI0518316-2A patent/BRPI0518316A2/pt not_active Application Discontinuation
- 2005-11-18 JP JP2007542100A patent/JP5318416B2/ja active Active
- 2005-11-18 ES ES05813632T patent/ES2347165T3/es active Active
- 2005-11-18 CA CA2584649A patent/CA2584649C/en not_active Expired - Fee Related
- 2005-11-18 RU RU2007115903/04A patent/RU2394040C2/ru active IP Right Revival
- 2005-11-18 PL PL05813632T patent/PL1817320T3/pl unknown
- 2005-11-18 KR KR1020077011340A patent/KR101267122B1/ko active IP Right Grant
- 2005-11-18 CN CN2005800394892A patent/CN101061130B/zh not_active Expired - Fee Related
- 2005-11-18 US US11/719,601 patent/US20090076259A1/en not_active Abandoned
- 2005-11-18 NZ NZ554613A patent/NZ554613A/en not_active IP Right Cessation
- 2005-11-18 WO PCT/GB2005/004451 patent/WO2006054098A2/en active Application Filing
- 2005-11-18 DE DE602005022099T patent/DE602005022099D1/de active Active
-
2007
- 2007-04-23 IL IL182740A patent/IL182740A0/en not_active IP Right Cessation
- 2007-06-04 ZA ZA200705015A patent/ZA200705015B/xx unknown
- 2007-06-14 NO NO20073037A patent/NO20073037L/no not_active Application Discontinuation
-
2008
- 2008-01-28 HK HK08101069.6A patent/HK1107353A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT1817320E (pt) | 2010-09-13 |
| IL182740A0 (en) | 2007-07-24 |
| AU2005305624A1 (en) | 2006-05-26 |
| ES2347165T3 (es) | 2010-10-26 |
| WO2006054098A2 (en) | 2006-05-26 |
| RU2394040C2 (ru) | 2010-07-10 |
| MX2007006052A (es) | 2007-07-10 |
| CN101061130A (zh) | 2007-10-24 |
| JP5318416B2 (ja) | 2013-10-16 |
| KR20070084361A (ko) | 2007-08-24 |
| JP2008520636A (ja) | 2008-06-19 |
| CN101061130B (zh) | 2012-08-15 |
| PL1817320T3 (pl) | 2010-11-30 |
| CA2584649C (en) | 2013-09-24 |
| AU2005305624B2 (en) | 2012-05-10 |
| EP1817320A2 (de) | 2007-08-15 |
| KR101267122B1 (ko) | 2013-05-24 |
| NZ554613A (en) | 2011-01-28 |
| CA2584649A1 (en) | 2006-05-26 |
| WO2006054098A3 (en) | 2006-08-03 |
| RU2007115903A (ru) | 2008-12-27 |
| HK1107353A1 (en) | 2008-04-03 |
| GB0425501D0 (en) | 2004-12-22 |
| US20090076259A1 (en) | 2009-03-19 |
| BRPI0518316A2 (pt) | 2008-11-11 |
| ZA200705015B (en) | 2008-09-25 |
| DE602005022099D1 (de) | 2010-08-12 |
| EP1817320B1 (de) | 2010-06-30 |
| NO20073037L (no) | 2007-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |