DK3727460T3 - Bicykliske peptidligander, der er specifikke for epha2 - Google Patents
Bicykliske peptidligander, der er specifikke for epha2 Download PDFInfo
- Publication number
- DK3727460T3 DK3727460T3 DK18829437.5T DK18829437T DK3727460T3 DK 3727460 T3 DK3727460 T3 DK 3727460T3 DK 18829437 T DK18829437 T DK 18829437T DK 3727460 T3 DK3727460 T3 DK 3727460T3
- Authority
- DK
- Denmark
- Prior art keywords
- epha2
- peptide ligands
- ligands specific
- bicyclic peptide
- bicyclic
- Prior art date
Links
- 101150076616 EPHA2 gene Proteins 0.000 title 1
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1721259.8A GB201721259D0 (en) | 2017-12-19 | 2017-12-19 | Bicyclic peptide ligands specific for EphA2 |
| GBGB1804102.0A GB201804102D0 (en) | 2018-03-14 | 2018-03-14 | Bicycle peptide ligands specific for EphA2 |
| GBGB1818603.1A GB201818603D0 (en) | 2018-11-14 | 2018-11-14 | Bicyclic peptide ligands specific for epha2 |
| PCT/GB2018/053675 WO2019122860A1 (en) | 2017-12-19 | 2018-12-19 | Bicyclic peptide ligands specific for epha2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3727460T3 true DK3727460T3 (da) | 2022-07-11 |
Family
ID=64902125
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18829437.5T DK3727460T3 (da) | 2017-12-19 | 2018-12-19 | Bicykliske peptidligander, der er specifikke for epha2 |
| DK22161978.6T DK4053145T3 (da) | 2017-12-19 | 2018-12-19 | Bicykliske peptidligander, der er specifikke for EphA2 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK22161978.6T DK4053145T3 (da) | 2017-12-19 | 2018-12-19 | Bicykliske peptidligander, der er specifikke for EphA2 |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US11484602B2 (da) |
| EP (3) | EP4053145B1 (da) |
| JP (3) | JP7404241B2 (da) |
| KR (2) | KR20200105839A (da) |
| CN (3) | CN118598945A (da) |
| AU (3) | AU2018387418B2 (da) |
| BR (2) | BR112020012246A2 (da) |
| CA (2) | CA3086257A1 (da) |
| DK (2) | DK3727460T3 (da) |
| ES (1) | ES2922632T3 (da) |
| FI (1) | FI4053145T3 (da) |
| HR (1) | HRP20220871T1 (da) |
| HU (1) | HUE059126T2 (da) |
| IL (2) | IL275440B2 (da) |
| LT (1) | LT3727460T (da) |
| MX (2) | MX2020006474A (da) |
| PH (1) | PH12020550929A1 (da) |
| PL (1) | PL3727460T3 (da) |
| PT (2) | PT4053145T (da) |
| SA (1) | SA520412268B1 (da) |
| SG (2) | SG11202005495UA (da) |
| SI (1) | SI3727460T1 (da) |
| TW (1) | TWI825046B (da) |
| WO (2) | WO2019122863A1 (da) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201607827D0 (en) | 2016-05-04 | 2016-06-15 | Bicycle Therapeutics Ltd | Bicyclic peptide-toxin conjugates specific for MT1-MMP |
| US11730819B2 (en) | 2016-12-23 | 2023-08-22 | Bicycletx Limited | Peptide derivatives having novel linkage structures |
| CN111032678A (zh) | 2017-06-26 | 2020-04-17 | 拜西克尔德有限公司 | 具有可检测部分的双环肽配体和其用途 |
| EP3661948B1 (en) | 2017-08-04 | 2022-06-01 | BicycleTx Limited | Bicyclic peptide ligands specific for cd137 |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
| WO2019193328A1 (en) | 2018-04-04 | 2019-10-10 | Bicycletx Limited | Heterotandem bicyclic peptide complexes |
| GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
| EP3946462A1 (en) * | 2019-04-02 | 2022-02-09 | BicycleTX Limited | Bicycle toxin conjugates and uses thereof |
| SG11202111606TA (en) | 2019-05-09 | 2021-11-29 | Bicycletx Ltd | Bicyclic peptide ligands specific for ox40 |
| TW202118770A (zh) | 2019-07-30 | 2021-05-16 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| EP4013501A1 (en) * | 2019-08-13 | 2022-06-22 | BicycleTX Limited | Modified multimeric bicyclic peptide ligands |
| WO2021064428A1 (en) * | 2019-10-03 | 2021-04-08 | Bicycletx Limited | Heterotandem bicyclic peptide complexes |
| MX2022006001A (es) * | 2019-11-27 | 2022-10-27 | Bicycletx Ltd | Ligandos de peptidos biciclicos especificos para el receptor 2 tipo a de efrina (epha2) y usos de los mismos. |
| CN115697417A (zh) * | 2020-05-20 | 2023-02-03 | 拜斯科技术开发有限公司 | Nectin-4特异性的双环肽配体及其用途 |
| WO2021250418A1 (en) | 2020-06-12 | 2021-12-16 | Bicycletx Limited | Treatment of diseases characterized by overexpression of erythropoietin-producing hepatocellular receptor a2 (epha2) |
| MX2023001466A (es) * | 2020-08-03 | 2023-03-03 | Bicycletx Ltd | Enlazadores de base peptidica. |
| US20240197897A1 (en) | 2021-01-08 | 2024-06-20 | Bicycle TX Limited | Heterotandem bicyclic peptide complexes |
| US20240325554A1 (en) | 2021-01-11 | 2024-10-03 | Bicycle TX Limited | Methods for treating cancer |
| US20240245722A1 (en) | 2021-05-25 | 2024-07-25 | Vaxcell-Bio | Monobody-based chimeric antigen receptor and immune cell including same |
| CN117881430A (zh) * | 2021-08-17 | 2024-04-12 | 南京明德新药研发有限公司 | 具有新颖结构的多肽药物偶联物及其应用 |
| AU2022365991A1 (en) * | 2021-10-14 | 2024-05-30 | Xizang Haisco Pharmaceutical Co., Ltd. | Epha2 bicyclic peptide ligand and conjugate thereof |
| KR20230140746A (ko) * | 2022-03-30 | 2023-10-10 | 연세대학교 산학협력단 | 암전이의 검출용 신규 바이오마커 |
| WO2024184661A1 (en) | 2023-03-09 | 2024-09-12 | Bicycletx Limited | Synthesis of bicycle toxin conjugates, and intermediates thereof |
Family Cites Families (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4709016A (en) | 1982-02-01 | 1987-11-24 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
| US4650750A (en) | 1982-02-01 | 1987-03-17 | Giese Roger W | Method of chemical analysis employing molecular release tag compounds |
| US5650270A (en) | 1982-02-01 | 1997-07-22 | Northeastern University | Molecular analytical release tags and their use in chemical analysis |
| US5516931A (en) | 1982-02-01 | 1996-05-14 | Northeastern University | Release tag compounds producing ketone signal groups |
| US20020164788A1 (en) | 1994-12-02 | 2002-11-07 | The Wellcome Foundation Limited | Humanized antibodies to CD38 |
| US6326144B1 (en) | 1998-09-18 | 2001-12-04 | Massachusetts Institute Of Technology | Biological applications of quantum dots |
| AU3468500A (en) | 1998-09-24 | 2000-06-05 | Advanced Research And Technology Institute, Inc. | Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and methods of use |
| US6927203B1 (en) | 1999-08-17 | 2005-08-09 | Purdue Research Foundation | Treatment of metastatic disease |
| DE60007552T2 (de) | 1999-12-10 | 2004-09-23 | Pfizer Products Inc., Groton | PYRROLO[2,3-d]PYRIMIDIN-VERBINDUNGEN ALS PROTEIN KINASEN HEMMER |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| CA2477163C (en) | 2002-02-21 | 2010-07-27 | Institute Of Virology | Soluble form of carbonic anhydrase ix (s-ca-ix), assays to detect s-ca ix, and ca ix's coexpression with her-2/neu/c-erbb-2, and ca ix-specific monoclonal antibodies to non-immunodominant epitopes |
| ATE419865T1 (de) | 2002-08-14 | 2009-01-15 | Silence Therapeutics Ag | Verwendung von protein-kinase-n-beta |
| EP1852441B1 (en) * | 2002-09-24 | 2012-03-28 | The Burnham Institute | Agents that modulate EPH receptor activity |
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| NZ542475A (en) | 2003-04-03 | 2009-04-30 | Semafore Pharmaceuticals Inc | PI-3 kinase inhibitor prodrugs |
| EP1692153A4 (en) | 2003-07-03 | 2007-03-21 | Univ Pennsylvania | INHIBITION OF EXPRESSION OF SYK-KINASE |
| KR20130126747A (ko) | 2004-02-06 | 2013-11-20 | 모르포시스 아게 | 항-ｃｄ３８ 인간 항체 및 그의 용도 |
| US7151047B2 (en) | 2004-04-28 | 2006-12-19 | Warren Chan | Stable, water-soluble quantum dot, method of preparation and conjugates thereof |
| PT3153514T (pt) | 2004-05-13 | 2021-06-25 | Icos Corp | Quinazolinonas como inibidoras da fosfatidilinositol 3-quinase delta humana |
| MX2007007189A (es) | 2005-01-19 | 2010-09-28 | Rigel Pharmaceuticals Inc | Prodrogas de compuestos de 2,4-pirimidindiamina y sus usos. |
| NZ560504A (en) | 2005-01-24 | 2009-07-31 | Pepscan Systems Bv | Binding compounds, immunogenic compounds and peptidomimetics |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| US7402325B2 (en) | 2005-07-28 | 2008-07-22 | Phoenix Biotechnology, Inc. | Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander |
| AU2006302179C1 (en) | 2005-10-07 | 2013-06-20 | Exelixis, Inc. | N- (3-amino-quinoxalin-2-yl) -sulfonamide derivatives and their use as phosphatidylinositol 3-kinase inhibitors |
| NZ567851A (en) | 2005-11-01 | 2011-09-30 | Targegen Inc | Bi-aryl meta-pyrimidine inhibitors of kinases |
| SI2348023T1 (sl) | 2005-12-13 | 2015-10-30 | Incyte Corporation | S heteroarilom substituirani pirolo (2,3-b)piridini in pirolo (2,3-b)pirimidini kot zaviralci janus kinaze |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| ES2347187T3 (es) | 2006-04-26 | 2010-10-26 | F. Hoffmann-La Roche Ag | Derivado de tieno(3,2-d)pirimidina, util como un inhibidor de pi3k. |
| JP5622390B2 (ja) * | 2006-07-18 | 2014-11-12 | サノフイ | 癌治療用対ｅｐｈａ２アンタゴニスト抗体 |
| WO2008033561A2 (en) | 2006-09-15 | 2008-03-20 | Siemens Medical Solutions Usa, Inc. | Click chemistry-derived cyclopeptide derivatives as imaging agents for integrins |
| PT2526933E (pt) | 2006-09-22 | 2015-06-23 | Pharmacyclics Inc | Inibidores da tirosina-quinase de bruton |
| MX2009009792A (es) | 2007-03-12 | 2009-09-23 | Cytopia Res Pty Ltd | Compuestos de fenil amino pirimidina y usos de los mismos. |
| PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| CA2690449A1 (en) | 2007-06-18 | 2008-12-24 | Medimmune, Llc | Synergistic treatment of cells that express epha2 and erbb2 |
| ATE555200T1 (de) | 2008-02-05 | 2012-05-15 | Medical Res Council | Verfahren und zusammensetzungen |
| BRPI0909040B8 (pt) | 2008-03-11 | 2021-05-25 | Incyte Holdings Corp | derivados de azetidina e ciclobutano, seus usos, e composição |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| GB0913775D0 (en) | 2009-08-06 | 2009-09-16 | Medical Res Council | Multispecific peptides |
| GB0914110D0 (en) | 2009-08-12 | 2009-09-16 | Medical Res Council | Peptide libraries |
| WO2012057624A1 (en) | 2010-10-25 | 2012-05-03 | Pepscan Systems B.V. | Novel bicyclic peptide mimetics |
| PT2764140T (pt) | 2011-10-07 | 2017-12-07 | Bicycle Therapeutics Ltd | Modulação da especificidade do polipéptida estruturado |
| GB201117428D0 (en) | 2011-10-07 | 2011-11-23 | Bicycle Therapeutics Ltd | Structured polypeptides with sarcosine linkers |
| AU2014249107C1 (en) | 2013-03-12 | 2018-07-19 | Molecular Templates, Inc. | CD20-binding immunotoxins for inducing cellular internalization and methods using same |
| US20140274759A1 (en) | 2013-03-15 | 2014-09-18 | Bicycle Therapeutics Limited | Modification of polypeptides |
| GB201306623D0 (en) | 2013-04-11 | 2013-05-29 | Bicycle Therapeutics Ltd | Modulation of structured polypeptide specificity |
| ES2705068T3 (es) | 2013-05-23 | 2019-03-21 | Ohio State Innovation Foundation | Síntesis química y cribado de bibliotecas de péptidos bicíclicos |
| US10294274B2 (en) | 2013-10-28 | 2019-05-21 | Bicyclerd Limited | Polypeptide ligands specific for plasma kallikrein |
| EP3140653B1 (en) | 2014-05-08 | 2022-05-11 | Novodiax, Inc. | Direct immunohistochemistry assay |
| WO2015179691A2 (en) | 2014-05-21 | 2015-11-26 | Ohio State Innovation Foundation | Cell penetrating peptides and methods of making and using thereof |
| RU2708459C2 (ru) | 2014-10-29 | 2019-12-09 | БайсиклРД Лимитед | Бициклические пептидные лиганды, специфичные для мт1-ммр |
| WO2016171242A1 (ja) | 2015-04-24 | 2016-10-27 | 第一三共株式会社 | Ｅｐｈａ２の検出 |
| WO2016174103A1 (en) * | 2015-04-28 | 2016-11-03 | Ecole polytechnique fédérale de Lausanne (EPFL) | Novel inhibitors of the enzyme activated factor xii (fxiia) |
| KR20180121905A (ko) | 2016-03-16 | 2018-11-09 | 메리맥 파마슈티컬즈, 인크. | 에프린 수용체 a2(epha2)의 나노리포솜 표적화 및 관련된 진단 |
| MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
| KR102426765B1 (ko) | 2016-04-22 | 2022-07-29 | 엘리게이터 바이오사이언스 에이비 | Cd137에 대한 신규한 이중특이성 폴리펩타이드 |
| GB201607827D0 (en) | 2016-05-04 | 2016-06-15 | Bicycle Therapeutics Ltd | Bicyclic peptide-toxin conjugates specific for MT1-MMP |
| EP3544621A1 (en) | 2016-11-27 | 2019-10-02 | BicycleRD Limited | Methods for treating cancer |
| US11730819B2 (en) | 2016-12-23 | 2023-08-22 | Bicycletx Limited | Peptide derivatives having novel linkage structures |
| MX2019007367A (es) | 2016-12-23 | 2020-01-27 | Bicycletx Ltd | Ligandos de peptido para enlace a mt1-mmp. |
| US10624968B2 (en) | 2017-01-06 | 2020-04-21 | Bicyclerd Limited | Compounds for treating cancer |
| BR112019017628A2 (pt) | 2017-02-24 | 2020-07-07 | Macrogenics, Inc. | molécula de ligação a cd137 x ta, composições farmacêuticas, uso da molécula de ligação a cd137 x ta, molécula de ligação a cd137, uso da molécula de ligação a cd137, molécula de ligação a her2/neu, uso da molécula de ligação a her2/neu, e uso de uma composição |
| GB201706477D0 (en) | 2017-04-24 | 2017-06-07 | Bicycle Therapeutics Ltd | Modification of polypeptides |
| WO2018197893A1 (en) | 2017-04-27 | 2018-11-01 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| CN111032678A (zh) | 2017-06-26 | 2020-04-17 | 拜西克尔德有限公司 | 具有可检测部分的双环肽配体和其用途 |
| EP3661948B1 (en) | 2017-08-04 | 2022-06-01 | BicycleTx Limited | Bicyclic peptide ligands specific for cd137 |
| EP3668887A1 (en) | 2017-08-14 | 2020-06-24 | Bicyclerd Limited | Bicyclic peptide ligand sting conjugates and uses thereof |
| EP3668550A1 (en) | 2017-08-14 | 2020-06-24 | Bicyclerd Limited | Bicyclic peptide ligand prr-a conjugates and uses thereof |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
| US11572370B2 (en) | 2018-01-08 | 2023-02-07 | Biohaven Therapeutics Ltd. | CD16A binding agents and uses thereof |
| SG11202007678QA (en) | 2018-02-23 | 2020-09-29 | Bicycletx Ltd | Multimeric bicyclic peptide ligands |
| WO2019193328A1 (en) | 2018-04-04 | 2019-10-10 | Bicycletx Limited | Heterotandem bicyclic peptide complexes |
| EP3797120A1 (en) | 2018-05-21 | 2021-03-31 | Compass Therapeutics LLC | Compositions and methods for enhancing the killing of target cells by nk cells |
| US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
| GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| WO2020084305A1 (en) | 2018-10-23 | 2020-04-30 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
| EP3894010A1 (en) | 2018-12-13 | 2021-10-20 | BicycleTX Limited | Bicyclic peptide ligands specific for mt1-mmp |
| EP3897851A2 (en) | 2018-12-17 | 2021-10-27 | Revitope Limited | Twin immune cell engager |
| US20220306689A9 (en) | 2018-12-21 | 2022-09-29 | Bicycletx Limited | Bicyclic peptide ligands specific for pd-l1 |
| EP3946462A1 (en) | 2019-04-02 | 2022-02-09 | BicycleTX Limited | Bicycle toxin conjugates and uses thereof |
| SG11202111606TA (en) | 2019-05-09 | 2021-11-29 | Bicycletx Ltd | Bicyclic peptide ligands specific for ox40 |
| TW202118770A (zh) | 2019-07-30 | 2021-05-16 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| EP4013501A1 (en) | 2019-08-13 | 2022-06-22 | BicycleTX Limited | Modified multimeric bicyclic peptide ligands |
| WO2021064428A1 (en) | 2019-10-03 | 2021-04-08 | Bicycletx Limited | Heterotandem bicyclic peptide complexes |
| MX2022006001A (es) | 2019-11-27 | 2022-10-27 | Bicycletx Ltd | Ligandos de peptidos biciclicos especificos para el receptor 2 tipo a de efrina (epha2) y usos de los mismos. |
| WO2021250418A1 (en) | 2020-06-12 | 2021-12-16 | Bicycletx Limited | Treatment of diseases characterized by overexpression of erythropoietin-producing hepatocellular receptor a2 (epha2) |
| KR20230074721A (ko) | 2020-08-17 | 2023-05-31 | 바이사이클티엑스 리미티드 | Nectin-4에 특이적인 이환 콘쥬게이트 및 이의 용도 |
| US20240197897A1 (en) | 2021-01-08 | 2024-06-20 | Bicycle TX Limited | Heterotandem bicyclic peptide complexes |
| US20240325554A1 (en) | 2021-01-11 | 2024-10-03 | Bicycle TX Limited | Methods for treating cancer |
-
2018
- 2018-12-11 TW TW107144453A patent/TWI825046B/zh active
- 2018-12-14 US US16/220,685 patent/US11484602B2/en active Active
- 2018-12-19 EP EP22161978.6A patent/EP4053145B1/en active Active
- 2018-12-19 MX MX2020006474A patent/MX2020006474A/es unknown
- 2018-12-19 SG SG11202005495UA patent/SG11202005495UA/en unknown
- 2018-12-19 ES ES18829437T patent/ES2922632T3/es active Active
- 2018-12-19 PL PL18829437.5T patent/PL3727460T3/pl unknown
- 2018-12-19 DK DK18829437.5T patent/DK3727460T3/da active
- 2018-12-19 KR KR1020207019675A patent/KR20200105839A/ko active Search and Examination
- 2018-12-19 PT PT221619786T patent/PT4053145T/pt unknown
- 2018-12-19 US US16/771,186 patent/US11696956B2/en active Active
- 2018-12-19 JP JP2020534361A patent/JP7404241B2/ja active Active
- 2018-12-19 WO PCT/GB2018/053678 patent/WO2019122863A1/en active Application Filing
- 2018-12-19 LT LTEPPCT/GB2018/053675T patent/LT3727460T/lt unknown
- 2018-12-19 HU HUE18829437A patent/HUE059126T2/hu unknown
- 2018-12-19 PT PT188294375T patent/PT3727460T/pt unknown
- 2018-12-19 CA CA3086257A patent/CA3086257A1/en active Pending
- 2018-12-19 EP EP18829437.5A patent/EP3727460B1/en active Active
- 2018-12-19 DK DK22161978.6T patent/DK4053145T3/da active
- 2018-12-19 BR BR112020012246-7A patent/BR112020012246A2/pt unknown
- 2018-12-19 KR KR1020207019676A patent/KR20200105840A/ko not_active Application Discontinuation
- 2018-12-19 AU AU2018387418A patent/AU2018387418B2/en active Active
- 2018-12-19 SG SG11202005494QA patent/SG11202005494QA/en unknown
- 2018-12-19 CN CN202410627078.XA patent/CN118598945A/zh active Pending
- 2018-12-19 IL IL275440A patent/IL275440B2/en unknown
- 2018-12-19 AU AU2018387417A patent/AU2018387417C9/en active Active
- 2018-12-19 SI SI201830718T patent/SI3727460T1/sl unknown
- 2018-12-19 FI FIEP22161978.6T patent/FI4053145T3/fi active
- 2018-12-19 CN CN201880089757.9A patent/CN111741771B/zh active Active
- 2018-12-19 EP EP18829926.7A patent/EP3727461A1/en active Pending
- 2018-12-19 BR BR112020012349-8A patent/BR112020012349A2/pt unknown
- 2018-12-19 JP JP2020534623A patent/JP7293231B2/ja active Active
- 2018-12-19 CN CN201880089662.7A patent/CN111787955B/zh active Active
- 2018-12-19 MX MX2020006482A patent/MX2020006482A/es unknown
- 2018-12-19 WO PCT/GB2018/053675 patent/WO2019122860A1/en unknown
- 2018-12-19 CA CA3085253A patent/CA3085253A1/en active Pending
- 2018-12-19 HR HRP20220871TT patent/HRP20220871T1/hr unknown
-
2020
- 2020-06-17 PH PH12020550929A patent/PH12020550929A1/en unknown
- 2020-06-17 IL IL275437A patent/IL275437A/en unknown
- 2020-06-18 SA SA520412268A patent/SA520412268B1/ar unknown
-
2022
- 2022-09-23 US US17/934,896 patent/US11833211B2/en active Active
-
2023
- 2023-05-08 US US18/313,983 patent/US20240000957A1/en active Pending
- 2023-06-07 JP JP2023093890A patent/JP7503689B2/ja active Active
- 2023-11-01 US US18/499,739 patent/US20240189436A1/en active Pending
-
2024
- 2024-04-22 AU AU2024202618A patent/AU2024202618A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK4053145T3 (da) | Bicykliske peptidligander, der er specifikke for EphA2 | |
| ZA202100442B (en) | Bicyclic peptide ligands specific for nectin-4 | |
| DK3215518T3 (da) | Bicykliske peptidligander, der er specifikke for mt1-mmp | |
| GB201721265D0 (en) | Bicyclic peptide ligands specific for EphA2 | |
| DK3556260T3 (da) | Bæreanordning til børn | |
| MA43302A (fr) | Polypeptides inhibant le ligand cd40l | |
| GB201820320D0 (en) | Bicyclic peptide ligands specific for FAPalpha | |
| GB201721259D0 (en) | Bicyclic peptide ligands specific for EphA2 | |
| GB201707734D0 (en) | Bicyclic peptide ligands specific for EphA2 | |
| GB201818603D0 (en) | Bicyclic peptide ligands specific for epha2 | |
| GB201720934D0 (en) | Bicyclic peptide ligands specific for FAPalpha | |
| GB201720941D0 (en) | Bicyclic peptide ligands specific for EPHA3 | |
| GB201712693D0 (en) | Bicyclic peptide ligands specific for nectin-4 | |
| GB201720939D0 (en) | Bicyclic peptide ligands specific for VEGF | |
| GB201720928D0 (en) | Bicyclic peptide ligands specific for IL-6 | |
| GB201810321D0 (en) | Peptide ligands for bindingto EphA2 | |
| GB201720940D0 (en) | Bicyclic peptide ligands specific for PSMA | |
| GB201818499D0 (en) | Bicyclic peptide ligands specific for nectin-4 | |
| GB201621574D0 (en) | Bicyclic peptide ligands specific for fapalpha | |
| GB201715621D0 (en) | Bicycle peptide ligands specific for EphA2 | |
| GB201815684D0 (en) | Bicyclic peptide ligands specific for nectin-4 | |
| GB201720938D0 (en) | Bicyclic peptide ligands specific for TNFalpha | |
| GB201820326D0 (en) | Bicyclic peptide ligands specific for epha3 | |
| GB201621994D0 (en) | Bicyclic peptide ligands specific for PSMA | |
| GB201712589D0 (en) | Bicyclic peptide ligands specific for CD137 |