DK3615023T3 - Lipoyl-glu-ala til behandlingen af neurodegenerativ skade forårsaget af traumatisk hjerneskade - Google Patents

Lipoyl-glu-ala til behandlingen af neurodegenerativ skade forårsaget af traumatisk hjerneskade Download PDF

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Publication number
DK3615023T3
DK3615023T3 DK18724073.4T DK18724073T DK3615023T3 DK 3615023 T3 DK3615023 T3 DK 3615023T3 DK 18724073 T DK18724073 T DK 18724073T DK 3615023 T3 DK3615023 T3 DK 3615023T3
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DK
Denmark
Prior art keywords
neurodegenerated
lipoyl
glu
ala
treatment
Prior art date
Application number
DK18724073.4T
Other languages
Danish (da)
English (en)
Inventor
Alexander Baguisi
Reinier Beeuwkes
Ralph Casale
David A Dewahl Jr
Steven A Kates
Alan S Lader
Original Assignee
Ischemix Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Ischemix Llc filed Critical Ischemix Llc
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Publication of DK3615023T3 publication Critical patent/DK3615023T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK18724073.4T 2017-04-25 2018-04-25 Lipoyl-glu-ala til behandlingen af neurodegenerativ skade forårsaget af traumatisk hjerneskade DK3615023T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762489735P 2017-04-25 2017-04-25
PCT/US2018/029372 WO2018200680A1 (en) 2017-04-25 2018-04-25 Compositions and methods for treating traumatic brain injury

Publications (1)

Publication Number Publication Date
DK3615023T3 true DK3615023T3 (da) 2023-09-25

Family

ID=62148517

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18724073.4T DK3615023T3 (da) 2017-04-25 2018-04-25 Lipoyl-glu-ala til behandlingen af neurodegenerativ skade forårsaget af traumatisk hjerneskade

Country Status (9)

Country Link
US (3) US10744115B2 (enExample)
EP (2) EP4282411A1 (enExample)
JP (2) JP7203756B2 (enExample)
CN (1) CN110913851B (enExample)
AU (2) AU2018258158A1 (enExample)
CA (1) CA3061203A1 (enExample)
DK (1) DK3615023T3 (enExample)
ES (1) ES2952834T3 (enExample)
WO (1) WO2018200680A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4282411A1 (en) * 2017-04-25 2023-11-29 Ischemix LLC Lipoyl-glu-ala for the treatment of neurodegenerative damage caused by traumatic brain injury
US20240124520A1 (en) * 2019-10-16 2024-04-18 The Board Of Trustees Of The Leland Stanford Junior University N-acylated histidine dipeptides as anticancer agents
CN116199666B (zh) * 2023-03-07 2025-02-28 中国药科大学 两亲性化合物及其药物组合物

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Also Published As

Publication number Publication date
CA3061203A1 (en) 2018-11-01
US11213509B2 (en) 2022-01-04
US20200352904A1 (en) 2020-11-12
AU2024202147A1 (en) 2024-05-02
US20220280477A1 (en) 2022-09-08
CN110913851A (zh) 2020-03-24
EP3615023B1 (en) 2023-06-21
JP7203756B2 (ja) 2023-01-13
EP3615023A1 (en) 2020-03-04
AU2018258158A1 (en) 2019-11-21
US10744115B2 (en) 2020-08-18
US20180303796A1 (en) 2018-10-25
EP4282411A1 (en) 2023-11-29
ES2952834T3 (es) 2023-11-06
CN110913851B (zh) 2023-08-25
WO2018200680A1 (en) 2018-11-01
JP2020517731A (ja) 2020-06-18
JP2023030158A (ja) 2023-03-07

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