AU2018258158A1 - Compositions and methods for treating traumatic brain injury - Google Patents

Compositions and methods for treating traumatic brain injury Download PDF

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Publication number
AU2018258158A1
AU2018258158A1 AU2018258158A AU2018258158A AU2018258158A1 AU 2018258158 A1 AU2018258158 A1 AU 2018258158A1 AU 2018258158 A AU2018258158 A AU 2018258158A AU 2018258158 A AU2018258158 A AU 2018258158A AU 2018258158 A1 AU2018258158 A1 AU 2018258158A1
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AU
Australia
Prior art keywords
alkyl
compound
structural formula
aryl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2018258158A
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English (en)
Inventor
Alexander Baguisi
Reinier Beeuwkes
Ralph Casale
David A. Dewahl Jr.
Steven A. Kates
Alan S. Lader
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ischemix LLC
Original Assignee
Ischemix LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ischemix LLC filed Critical Ischemix LLC
Publication of AU2018258158A1 publication Critical patent/AU2018258158A1/en
Priority to AU2024202147A priority Critical patent/AU2024202147A1/en
Abandoned legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/661Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/662Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2018258158A 2017-04-25 2018-04-25 Compositions and methods for treating traumatic brain injury Abandoned AU2018258158A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024202147A AU2024202147A1 (en) 2017-04-25 2024-04-03 Compositions and methods for treating traumatic brain injury

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762489735P 2017-04-25 2017-04-25
US62/489,735 2017-04-25
PCT/US2018/029372 WO2018200680A1 (en) 2017-04-25 2018-04-25 Compositions and methods for treating traumatic brain injury

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2024202147A Division AU2024202147A1 (en) 2017-04-25 2024-04-03 Compositions and methods for treating traumatic brain injury

Publications (1)

Publication Number Publication Date
AU2018258158A1 true AU2018258158A1 (en) 2019-11-21

Family

ID=62148517

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2018258158A Abandoned AU2018258158A1 (en) 2017-04-25 2018-04-25 Compositions and methods for treating traumatic brain injury
AU2024202147A Abandoned AU2024202147A1 (en) 2017-04-25 2024-04-03 Compositions and methods for treating traumatic brain injury

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2024202147A Abandoned AU2024202147A1 (en) 2017-04-25 2024-04-03 Compositions and methods for treating traumatic brain injury

Country Status (9)

Country Link
US (3) US10744115B2 (enExample)
EP (2) EP4282411A1 (enExample)
JP (2) JP7203756B2 (enExample)
CN (1) CN110913851B (enExample)
AU (2) AU2018258158A1 (enExample)
CA (1) CA3061203A1 (enExample)
DK (1) DK3615023T3 (enExample)
ES (1) ES2952834T3 (enExample)
WO (1) WO2018200680A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4282411A1 (en) * 2017-04-25 2023-11-29 Ischemix LLC Lipoyl-glu-ala for the treatment of neurodegenerative damage caused by traumatic brain injury
US20240124520A1 (en) * 2019-10-16 2024-04-18 The Board Of Trustees Of The Leland Stanford Junior University N-acylated histidine dipeptides as anticancer agents
CN116199666B (zh) * 2023-03-07 2025-02-28 中国药科大学 两亲性化合物及其药物组合物

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Also Published As

Publication number Publication date
CA3061203A1 (en) 2018-11-01
US11213509B2 (en) 2022-01-04
US20200352904A1 (en) 2020-11-12
AU2024202147A1 (en) 2024-05-02
US20220280477A1 (en) 2022-09-08
CN110913851A (zh) 2020-03-24
EP3615023B1 (en) 2023-06-21
DK3615023T3 (da) 2023-09-25
JP7203756B2 (ja) 2023-01-13
EP3615023A1 (en) 2020-03-04
US10744115B2 (en) 2020-08-18
US20180303796A1 (en) 2018-10-25
EP4282411A1 (en) 2023-11-29
ES2952834T3 (es) 2023-11-06
CN110913851B (zh) 2023-08-25
WO2018200680A1 (en) 2018-11-01
JP2020517731A (ja) 2020-06-18
JP2023030158A (ja) 2023-03-07

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MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted