CA3061203A1 - Compositions and methods for treating traumatic brain injury - Google Patents

Compositions and methods for treating traumatic brain injury Download PDF

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Publication number
CA3061203A1
CA3061203A1 CA3061203A CA3061203A CA3061203A1 CA 3061203 A1 CA3061203 A1 CA 3061203A1 CA 3061203 A CA3061203 A CA 3061203A CA 3061203 A CA3061203 A CA 3061203A CA 3061203 A1 CA3061203 A1 CA 3061203A1
Authority
CA
Canada
Prior art keywords
compound
tbi
alkyl
cmx
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3061203A
Other languages
English (en)
French (fr)
Inventor
Alexander Baguisi
Reinier Beeuwkes
Ralph Casale
David A. Dewahl, Jr.
Steven A. Kates
Alan S. Lader
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ischemix LLC
Original Assignee
Ischemix LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ischemix LLC filed Critical Ischemix LLC
Publication of CA3061203A1 publication Critical patent/CA3061203A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA3061203A 2017-04-25 2018-04-25 Compositions and methods for treating traumatic brain injury Pending CA3061203A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762489735P 2017-04-25 2017-04-25
US62/489,735 2017-04-25
PCT/US2018/029372 WO2018200680A1 (en) 2017-04-25 2018-04-25 Compositions and methods for treating traumatic brain injury

Publications (1)

Publication Number Publication Date
CA3061203A1 true CA3061203A1 (en) 2018-11-01

Family

ID=62148517

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3061203A Pending CA3061203A1 (en) 2017-04-25 2018-04-25 Compositions and methods for treating traumatic brain injury

Country Status (9)

Country Link
US (3) US10744115B2 (enExample)
EP (2) EP3615023B1 (enExample)
JP (2) JP7203756B2 (enExample)
CN (1) CN110913851B (enExample)
AU (2) AU2018258158A1 (enExample)
CA (1) CA3061203A1 (enExample)
DK (1) DK3615023T3 (enExample)
ES (1) ES2952834T3 (enExample)
WO (1) WO2018200680A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3615023B1 (en) * 2017-04-25 2023-06-21 Ischemix LLC Lipoyl-glu-ala for the treatment of neurodegenerative damage caused by traumatic brain injury
US20240124520A1 (en) * 2019-10-16 2024-04-18 The Board Of Trustees Of The Leland Stanford Junior University N-acylated histidine dipeptides as anticancer agents
CN116199666B (zh) * 2023-03-07 2025-02-28 中国药科大学 两亲性化合物及其药物组合物

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Also Published As

Publication number Publication date
CN110913851A (zh) 2020-03-24
US11213509B2 (en) 2022-01-04
JP2023030158A (ja) 2023-03-07
AU2024202147A1 (en) 2024-05-02
ES2952834T3 (es) 2023-11-06
CN110913851B (zh) 2023-08-25
JP7203756B2 (ja) 2023-01-13
US20220280477A1 (en) 2022-09-08
US20180303796A1 (en) 2018-10-25
US10744115B2 (en) 2020-08-18
AU2018258158A1 (en) 2019-11-21
JP2020517731A (ja) 2020-06-18
US20200352904A1 (en) 2020-11-12
EP3615023A1 (en) 2020-03-04
DK3615023T3 (da) 2023-09-25
EP4282411A1 (en) 2023-11-29
WO2018200680A1 (en) 2018-11-01
EP3615023B1 (en) 2023-06-21

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