DK339782A - 1,4-dihydropyridiner, isomere, isomerblandinger, racemater, og optiske antipoder samt salte deraf, deres fremstilling med positiv inotrop virkning - Google Patents

1,4-dihydropyridiner, isomere, isomerblandinger, racemater, og optiske antipoder samt salte deraf, deres fremstilling med positiv inotrop virkning Download PDF

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Publication number
DK339782A
DK339782A DK339782A DK339782A DK339782A DK 339782 A DK339782 A DK 339782A DK 339782 A DK339782 A DK 339782A DK 339782 A DK339782 A DK 339782A DK 339782 A DK339782 A DK 339782A
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Prior art keywords
dihydropyridines
racemates
isomers
salts
preparing
Prior art date
Application number
DK339782A
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Danish (da)
English (en)
Inventor
Gerhard Franckowiak
Horst Boeshagen
Friedrich Bossert
Siegfried Goldmann
Horst Meyer
Egbert Wehinger
Juergen Stoltefuss
Matthias Schramm
Guenter Thomas
Robertson Towart
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25794943&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK339782(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19813130041 external-priority patent/DE3130041A1/de
Priority claimed from DE19823206671 external-priority patent/DE3206671A1/de
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK339782A publication Critical patent/DK339782A/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
DK339782A 1981-07-30 1982-07-29 1,4-dihydropyridiner, isomere, isomerblandinger, racemater, og optiske antipoder samt salte deraf, deres fremstilling med positiv inotrop virkning DK339782A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19813130041 DE3130041A1 (de) 1981-07-30 1981-07-30 Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung
DE19823206671 DE3206671A1 (de) 1982-02-25 1982-02-25 Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DK339782A true DK339782A (da) 1983-01-31

Family

ID=25794943

Family Applications (1)

Application Number Title Priority Date Filing Date
DK339782A DK339782A (da) 1981-07-30 1982-07-29 1,4-dihydropyridiner, isomere, isomerblandinger, racemater, og optiske antipoder samt salte deraf, deres fremstilling med positiv inotrop virkning

Country Status (21)

Country Link
US (1) US4532248A (fr)
EP (1) EP0071819B2 (fr)
JP (2) JPH066535B2 (fr)
KR (2) KR890001567B1 (fr)
AU (1) AU566502B2 (fr)
CA (1) CA1212672A (fr)
CH (1) CH656530A5 (fr)
DE (1) DE3276112D1 (fr)
DK (1) DK339782A (fr)
ES (1) ES8305716A1 (fr)
FI (1) FI822643L (fr)
FR (1) FR2511247B1 (fr)
GB (1) GB2105989B (fr)
HK (1) HK19389A (fr)
IE (1) IE54259B1 (fr)
IL (1) IL66405A (fr)
IT (1) IT1190929B (fr)
NL (1) NL8202958A (fr)
NZ (1) NZ201395A (fr)
PH (1) PH23086A (fr)
SG (1) SG52988G (fr)

Families Citing this family (142)

* Cited by examiner, † Cited by third party
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GB2111978B (en) * 1981-10-19 1985-05-01 Maruko Pharmaceutical Co 1 4-dihydropyridine compounds
EP0080220B1 (fr) * 1981-11-17 1986-02-19 FISONS plc Dihydropyridines, leur procédé de préparation, leurs compositions et leur application comme médicaments
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
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DE3235221A1 (de) * 1982-09-23 1984-03-29 Bayer Ag, 5090 Leverkusen Ringverbrueckte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS5970666A (ja) * 1982-10-15 1984-04-21 Kyowa Hakko Kogyo Co Ltd １，４−ジヒドロピリジン誘導体
DE3382204D1 (de) * 1982-10-15 1991-04-18 Kyowa Hakko Kogyo Kk 1,4-dihydropyridin-derivate.
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
EP0111453A1 (fr) * 1982-12-10 1984-06-20 Ciba-Geigy Ag Dérivés d'amides
EP0111455A3 (fr) * 1982-12-10 1984-07-25 Ciba-Geigy Ag Lactones non-saturés
GR79111B (fr) * 1982-12-20 1984-10-02 Lepetit Spa
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EP0125803A3 (fr) * 1983-04-27 1987-01-21 FISONS plc Dihydropyridines pharmaceutiquement actives
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US5137889A (en) * 1983-12-02 1992-08-11 Otsuka Pharmaceutical Co., Ltd. Dihydropyridine derivatives and process for preparing the same
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US4678796A (en) * 1984-11-30 1987-07-07 Warner-Lambert Company 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
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DE3517473A1 (de) * 1985-05-15 1986-11-20 Bayer Ag, 5090 Leverkusen Pyrimidinyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
US4728652A (en) * 1985-05-20 1988-03-01 E. R. Squibb & Sons, Inc. 2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-dihydropyrimidines, composition containing them, and method of using them to reduce blood pressure
CA1267416A (fr) * 1985-06-17 1990-04-03 Ila Sircar Derives de la 1,4-dihydropyridine utiles pour le traitement de desordres cardiovasculaires
DE3521761A1 (de) * 1985-06-19 1987-01-02 Bayer Ag Neue 1,4-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
DK224786A (da) * 1985-06-21 1986-12-22 Hoffmann La Roche Dihydropyridinderivater
JPS6210087A (ja) * 1985-07-03 1987-01-19 Shionogi & Co Ltd ４，７−ジヒドロチエノ〔２，３−ｂ〕ピリジン誘導体，その製造法および循環器系疾患治療剤
IT1215298B (it) * 1985-08-06 1990-01-31 Boehringer Biochemia Srl 2-(eteroalchil)-1,4-diidropiridine ed un processo per la loro produzione.
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IT1190929B (it) 1988-02-24
FI822643L (fi) 1983-02-01
KR840000494A (ko) 1984-02-22
IT8222620A1 (it) 1984-01-28
CH656530A5 (de) 1986-07-15
GB2105989A (en) 1983-04-07
SG52988G (en) 1993-02-19
JPH05271078A (ja) 1993-10-19
IE54259B1 (en) 1989-08-02
IL66405A (en) 1987-12-31
FI822643A0 (fi) 1982-07-28
FR2511247B1 (fr) 1986-03-07
CA1212672A (fr) 1986-10-14
GB2105989B (en) 1986-01-08
HK19389A (en) 1989-03-17
US4532248A (en) 1985-07-30
NL8202958A (nl) 1983-02-16
EP0071819A1 (fr) 1983-02-16
IT8222620A0 (it) 1982-07-28
AU566502B2 (en) 1987-10-22
JPH066535B2 (ja) 1994-01-26
IE821827L (en) 1983-01-30
EP0071819B2 (fr) 1992-06-10
NZ201395A (en) 1987-02-20
IL66405A0 (en) 1982-11-30
PH23086A (en) 1989-04-10
EP0071819B1 (fr) 1987-04-22
ES514525A0 (es) 1983-04-16
JPS5826872A (ja) 1983-02-17
DE3276112D1 (en) 1987-05-27
ES8305716A1 (es) 1983-04-16
KR890001567B1 (ko) 1989-05-08
AU8594582A (en) 1983-02-03
KR890001566B1 (ko) 1989-05-08
FR2511247A1 (fr) 1983-02-18

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