DK3370828T3 - Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren - Google Patents

Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren Download PDF

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Publication number
DK3370828T3
DK3370828T3 DK16793975.0T DK16793975T DK3370828T3 DK 3370828 T3 DK3370828 T3 DK 3370828T3 DK 16793975 T DK16793975 T DK 16793975T DK 3370828 T3 DK3370828 T3 DK 3370828T3
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Prior art keywords
muscarin
agonists
receptor
oxim
compound
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DK16793975.0T
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Danish (da)
English (en)
Inventor
Giles Albert Brown
Benjamin Gerald Tehan
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Heptares Therapeutics Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK16793975.0T 2015-11-02 2016-11-02 Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren DK3370828T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1519352.7A GB201519352D0 (en) 2015-11-02 2015-11-02 Pharmaceutical compounds
PCT/GB2016/053396 WO2017077292A1 (en) 2015-11-02 2016-11-02 Oxime compounds as agonists of the muscarinic m1 and/or m4 receptor

Publications (1)

Publication Number Publication Date
DK3370828T3 true DK3370828T3 (da) 2020-07-13

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DK16793975.0T DK3370828T3 (da) 2015-11-02 2016-11-02 Oximforbindelse som agonister af muscarin m1- og/eller m4- receptoren

Country Status (10)

Country Link
US (2) US11208396B2 (https=)
EP (2) EP3797778A1 (https=)
JP (1) JP6799596B2 (https=)
CN (1) CN108290055B (https=)
AU (1) AU2016348847B2 (https=)
CA (1) CA3003669C (https=)
DK (1) DK3370828T3 (https=)
ES (1) ES2804774T3 (https=)
GB (1) GB201519352D0 (https=)
WO (1) WO2017077292A1 (https=)

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Publication number Publication date
EP3370828A1 (en) 2018-09-12
US20220298133A1 (en) 2022-09-22
EP3370828B1 (en) 2020-04-15
CA3003669C (en) 2024-04-09
AU2016348847A1 (en) 2018-06-07
WO2017077292A1 (en) 2017-05-11
US11208396B2 (en) 2021-12-28
AU2016348847B2 (en) 2021-07-08
CN108290055B (zh) 2021-05-14
HK1253036A1 (en) 2019-06-06
JP6799596B2 (ja) 2020-12-23
JP2018536653A (ja) 2018-12-13
US12291512B2 (en) 2025-05-06
ES2804774T3 (es) 2021-02-09
EP3797778A1 (en) 2021-03-31
CA3003669A1 (en) 2017-05-11
GB201519352D0 (en) 2015-12-16
CN108290055A (zh) 2018-07-17
US20200165220A1 (en) 2020-05-28

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