SG11201500499TA - Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors - Google Patents

Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors

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Publication number
SG11201500499TA
SG11201500499TA SG11201500499TA SG11201500499TA SG11201500499TA SG 11201500499T A SG11201500499T A SG 11201500499TA SG 11201500499T A SG11201500499T A SG 11201500499TA SG 11201500499T A SG11201500499T A SG 11201500499TA SG 11201500499T A SG11201500499T A SG 11201500499TA
Authority
SG
Singapore
Prior art keywords
bruton
btk
inhibitors
tyrosine kinase
heteroaromatic compounds
Prior art date
Application number
SG11201500499TA
Inventor
Joerg Martin Bentzien
Angela Kay Berry
Todd Bosanac
Michael Jason Burke
Darren Todd Disalvo
Joshua Courtney Horan
Shuang Liang
Can Mao
Wang Mao
Yue Shen
Fariba Soleymanzadeh
Renee M Zindell
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49029216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201500499T(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of SG11201500499TA publication Critical patent/SG11201500499TA/en

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
SG11201500499TA 2012-08-10 2013-08-08 Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors SG11201500499TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261681684P 2012-08-10 2012-08-10
PCT/US2013/054096 WO2014025976A1 (en) 2012-08-10 2013-08-08 Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors

Publications (1)

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SG11201500499TA true SG11201500499TA (en) 2015-03-30

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ID=49029216

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SG11201500499TA SG11201500499TA (en) 2012-08-10 2013-08-08 Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors

Country Status (25)

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US (5) US20140045813A1 (en)
EP (1) EP2882741B1 (en)
JP (1) JP6348492B2 (en)
KR (1) KR20150040292A (en)
CN (1) CN104603124B (en)
AP (1) AP2015008203A0 (en)
AU (1) AU2013299557B2 (en)
BR (1) BR112015002590A2 (en)
CA (1) CA2881519A1 (en)
CL (1) CL2015000256A1 (en)
EA (1) EA029210B1 (en)
EC (1) ECSP15008851A (en)
GE (1) GEP201706748B (en)
HK (1) HK1210161A1 (en)
IL (1) IL236495A0 (en)
IN (1) IN2015DN00524A (en)
MA (1) MA37830B1 (en)
MX (1) MX2015001802A (en)
NZ (1) NZ703607A (en)
PE (1) PE20150756A1 (en)
PH (1) PH12015500294A1 (en)
SA (1) SA515360007B1 (en)
SG (1) SG11201500499TA (en)
TN (1) TN2015000029A1 (en)
WO (1) WO2014025976A1 (en)

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EA201500393A1 (en) * 2012-11-02 2016-05-31 Пфайзер Инк. BLUTON TYROSINKINASE INHIBITORS
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JP6403751B2 (en) 2013-03-14 2018-10-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 5-thiazole carboxamine derivatives and their use as BTK inhibitors
CN105026400A (en) * 2013-03-15 2015-11-04 詹森药业有限公司 Processes and intermediates for preparing a medicament
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KR102200032B1 (en) * 2019-03-13 2021-01-08 전남대학교산학협력단 Novel compound and composition for the prevention or treatment of respiratory diseases comprising the same
CA3129665A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
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