DK3357919T3 - Aromatiske heterocykliske forbindelser som antiinflammatoriske forbindelser - Google Patents

Aromatiske heterocykliske forbindelser som antiinflammatoriske forbindelser Download PDF

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Publication number
DK3357919T3
DK3357919T3 DK18161869.5T DK18161869T DK3357919T3 DK 3357919 T3 DK3357919 T3 DK 3357919T3 DK 18161869 T DK18161869 T DK 18161869T DK 3357919 T3 DK3357919 T3 DK 3357919T3
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compounds
aromatic heterocyclic
inflammatory
heterocyclic compounds
inflammatory compounds
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DK18161869.5T
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Danish (da)
English (en)
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Alistair Ian Longshaw
Euan Alexander Fraser Fordyce
Stuart Thomas Onions
John King-Underwood
Jennifer Diane Venable
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Respivert Ltd
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
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    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Diabetes (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
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  • Transplantation (AREA)
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  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK18161869.5T 2014-02-14 2015-02-13 Aromatiske heterocykliske forbindelser som antiinflammatoriske forbindelser DK3357919T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461940282P 2014-02-14 2014-02-14
US201461941064P 2014-02-18 2014-02-18
EP15705797.7A EP3105222B1 (en) 2014-02-14 2015-02-13 Aromatic heterocyclic compounds as antiinflammatory compounds

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DK3357919T3 true DK3357919T3 (da) 2020-02-17

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DK18161869.5T DK3357919T3 (da) 2014-02-14 2015-02-13 Aromatiske heterocykliske forbindelser som antiinflammatoriske forbindelser
DK15705797.7T DK3105222T3 (en) 2014-02-14 2015-02-13 AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY COMPOUNDS

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DK15705797.7T DK3105222T3 (en) 2014-02-14 2015-02-13 AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY COMPOUNDS

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US (8) US9884845B2 (https=)
EP (4) EP3357919B1 (https=)
JP (4) JP6630280B2 (https=)
KR (1) KR102413704B1 (https=)
CN (4) CN110522731B (https=)
AU (3) AU2015216957B2 (https=)
BR (1) BR112016015838B1 (https=)
CA (1) CA2938924C (https=)
DK (2) DK3357919T3 (https=)
EA (1) EA034927B1 (https=)
ES (2) ES2677595T3 (https=)
JO (1) JO3392B1 (https=)
MX (2) MX371353B (https=)
PL (2) PL3357919T3 (https=)
PT (2) PT3357919T (https=)
SG (1) SG11201607058PA (https=)
TR (1) TR201809072T4 (https=)
TW (2) TWI751099B (https=)
UY (1) UY35998A (https=)
WO (2) WO2015121444A1 (https=)

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AU2014246866B2 (en) 2013-04-02 2018-05-10 Oxular Acquisitions Limited Kinase inhibitor
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CA2934199A1 (en) 2013-12-20 2015-06-25 Respivert Limited Urea derivatives useful as kinase inhibitors
PT3357919T (pt) 2014-02-14 2020-02-20 Respivert Ltd Compostos heterocíclicos aromáticos como compostos antiinflamatórios
MA40774A (fr) 2014-10-01 2017-08-08 Respivert Ltd Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38
CN105801486A (zh) * 2016-03-31 2016-07-27 常州大学 一种1-(2,4二溴苯基)-3-吡唑醇的合成方法
EA201892213A1 (ru) 2016-04-06 2019-05-31 Топайверт Фарма Лимитед Ингибиторы киназ
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