DK3354734T3 - Oligonukleotid-baserede hæmmere omfattende låst nukleinsyremønster - Google Patents

Oligonukleotid-baserede hæmmere omfattende låst nukleinsyremønster Download PDF

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Publication number
DK3354734T3
DK3354734T3 DK18154472.7T DK18154472T DK3354734T3 DK 3354734 T3 DK3354734 T3 DK 3354734T3 DK 18154472 T DK18154472 T DK 18154472T DK 3354734 T3 DK3354734 T3 DK 3354734T3
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oligonucleotide
comprehensive
nucleic acid
locked nucleic
based inhibitors
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DK18154472.7T
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Danish (da)
English (en)
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Rooij Eva Van
Christina Dalby
Rusty Montgomery
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Miragen Therapeutics Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • C—CHEMISTRY; METALLURGY
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK18154472.7T 2012-06-21 2013-06-21 Oligonukleotid-baserede hæmmere omfattende låst nukleinsyremønster DK3354734T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261662746P 2012-06-21 2012-06-21
US201361801533P 2013-03-15 2013-03-15
EP13807536.1A EP2864482A4 (en) 2012-06-21 2013-06-21 OLIGONUCLEOTIDE INHIBITORS COMPRISING A BLOCKED NUCLEIC ACID PATTERN

Publications (1)

Publication Number Publication Date
DK3354734T3 true DK3354734T3 (da) 2020-06-29

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Country Link
US (3) US9388408B2 (https=)
EP (2) EP2864482A4 (https=)
JP (2) JP6208228B2 (https=)
KR (1) KR101928418B1 (https=)
CN (2) CN107236735B (https=)
AU (1) AU2013278011B2 (https=)
CA (1) CA2876180C (https=)
DK (1) DK3354734T3 (https=)
ES (1) ES2801875T3 (https=)
HK (2) HK1209781A1 (https=)
MX (1) MX355408B (https=)
WO (1) WO2013192576A2 (https=)

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US10337005B2 (en) 2019-07-02
EP3354734A1 (en) 2018-08-01
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WO2013192576A2 (en) 2013-12-27
AU2013278011A1 (en) 2015-01-15
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