DK3241850T3 - Fusionspolypeptid for glp og en hybrid immunoglobulin fc og anvendelsen deraf - Google Patents
Fusionspolypeptid for glp og en hybrid immunoglobulin fc og anvendelsen deraf Download PDFInfo
- Publication number
- DK3241850T3 DK3241850T3 DK15875748T DK15875748T DK3241850T3 DK 3241850 T3 DK3241850 T3 DK 3241850T3 DK 15875748 T DK15875748 T DK 15875748T DK 15875748 T DK15875748 T DK 15875748T DK 3241850 T3 DK3241850 T3 DK 3241850T3
- Authority
- DK
- Denmark
- Prior art keywords
- polypeptime
- glp
- fusion
- hybrid immunoglobulin
- immunoglobulin
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 230000004927 fusion Effects 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20140195793 | 2014-12-31 | ||
| PCT/KR2015/014542 WO2016108654A1 (ko) | 2014-12-31 | 2015-12-31 | Glp 및 면역글로불린 하이브리드 fc 융합 폴리펩타이드 및 이의 용도 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3241850T3 true DK3241850T3 (da) | 2019-11-04 |
Family
ID=56284700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15875748T DK3241850T3 (da) | 2014-12-31 | 2015-12-31 | Fusionspolypeptid for glp og en hybrid immunoglobulin fc og anvendelsen deraf |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10538569B2 (da) |
| EP (1) | EP3241850B1 (da) |
| JP (1) | JP6379300B2 (da) |
| KR (2) | KR101825048B1 (da) |
| CN (1) | CN107207618B (da) |
| DK (1) | DK3241850T3 (da) |
| ES (1) | ES2757812T3 (da) |
| HK (1) | HK1246321A1 (da) |
| PL (1) | PL3241850T3 (da) |
| TW (2) | TWI685506B (da) |
| WO (1) | WO2016108654A1 (da) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110204617B (zh) * | 2014-12-31 | 2023-06-16 | 天境生物科技(上海)有限公司 | 含胰高血糖素样肽-1和免疫球蛋白杂合Fc的融合多肽及其用途 |
| JP2020531002A (ja) * | 2017-08-15 | 2020-11-05 | キンドレッド バイオサイエンシズ インコーポレイテッド | 獣医学用ｉｇｇ ｆｃ変異体 |
| US20200199192A1 (en) * | 2017-08-22 | 2020-06-25 | Shire-Nps Pharmaceuticals, Inc. | Glp-2 fusion polypeptides and uses for treating and preventing gastrointestinal conditions |
| BR112020008936A2 (pt) * | 2017-11-06 | 2020-10-20 | Shire-Nps Pharmaceuticals, Inc. | análogos e pepticorpos de glp-2 para administração antes, durante ou após a cirurgia |
| WO2019125003A1 (ko) * | 2017-12-22 | 2019-06-27 | 케이비바이오메드 주식회사 | 경구용 유전자 전달체 및 이의 용도 |
| WO2019125031A1 (ko) * | 2017-12-22 | 2019-06-27 | 케이비바이오메드 주식회사 | 경구용 유전자 전달체 및 이의 용도 |
| KR102177339B1 (ko) * | 2017-12-22 | 2020-11-12 | 케이비바이오메드 주식회사 | 경구용 유전자 전달체 및 이의 용도 |
| JP7128291B2 (ja) * | 2018-01-08 | 2022-08-30 | ジーアイ・イノベイション・インコーポレイテッド | ＩｇＥ Ｆｃ受容体のアルファサブユニットの細胞外ドメイン、その物を含む医薬組成物、およびその物を製造する方法 |
| KR20190093165A (ko) | 2018-01-31 | 2019-08-08 | 주식회사 제넥신 | GLP-1 및 면역글로불린 하이브리드 Fc 융합 폴리펩타이드의 안정성 증진용 조성물 |
| AU2019365212A1 (en) * | 2018-10-24 | 2021-04-29 | Shire-Nps Pharmaceuticals, Inc. | GLP-2 fusion polypeptides and uses for treating and preventing gastrointestinal conditions |
| CN113573739A (zh) * | 2019-03-08 | 2021-10-29 | 格纳西尼有限公司 | Glp-1融合蛋白及其用途 |
| CA3140561A1 (en) * | 2019-05-14 | 2020-11-19 | Progen Co., Ltd. | A novel modified immunoglobulin fc fusion protein and use thereof |
| WO2021182928A1 (ko) * | 2020-03-12 | 2021-09-16 | 주식회사 에스엘메타젠 | 신규 이중 특이성 단백질 및 그의 용도 |
| KR102349717B1 (ko) * | 2020-03-12 | 2022-01-11 | 주식회사 에스엘메타젠 | 신규 대사증후군 및 그와 관련된 질환 치료용 약학 조성물 |
| AU2021248766A1 (en) * | 2020-04-03 | 2022-12-01 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition for preventing or treating mucositis induced by radiotherapy, chemotherapy, or combination thereof, comprising GLP-2 derivatives or long-acting conjugate of same |
| KR20210141406A (ko) * | 2020-05-14 | 2021-11-23 | 주식회사 프로젠 | 신규 재조합 융합단백질 및 그의 용도 |
| WO2022015039A1 (ko) * | 2020-07-14 | 2022-01-20 | (주)지아이이노베이션 | 글루카곤-유사 펩타이드-1 및 글루카곤-유사 펩타이드-2를 포함하는 융합 단백질 및 이의 용도 |
| US11610835B2 (en) | 2020-10-30 | 2023-03-21 | Taiwan Semiconductor Manufacturing Company Limited | Organic interposer including intra-die structural reinforcement structures and methods of forming the same |
| CN114213524A (zh) * | 2021-11-08 | 2022-03-22 | 苏州博领干细胞再生医学有限公司 | 用于胰高血糖素样肽-2抗体检测的包被抗原及纯化方法、重组工程菌及培养方法 |
| WO2023204556A1 (ko) * | 2022-04-18 | 2023-10-26 | 한미약품 주식회사 | 장질환의 예방 또는 치료를 위한 GLP-2와, 인슐린 분비 펩타이드, TNFα 억제제, 또는 이 둘 모두의 병용 요법 |
| KR20230156889A (ko) * | 2022-05-04 | 2023-11-15 | 이뮤노포지 주식회사 | GLP-1, 면역글로불린 Fc, 및 IGF-1을 포함하는 융합단백질 및 이의 용도 |
| WO2024141054A1 (zh) * | 2022-12-30 | 2024-07-04 | 苏州康宁杰瑞生物科技有限公司 | 包含融合蛋白的药物组合物及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277819B1 (en) * | 1996-08-30 | 2001-08-21 | Eli Lilly And Company | Use of GLP-1 or analogs in treatment of myocardial infarction |
| US6006753A (en) | 1996-08-30 | 1999-12-28 | Eli Lilly And Company | Use of GLP-1 or analogs to abolish catabolic changes after surgery |
| UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| SE9802080D0 (sv) | 1998-06-11 | 1998-06-11 | Hellstroem | Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein |
| EP1306091A3 (en) | 1998-07-31 | 2003-05-21 | Novo Nordisk A/S | Stimulation of beta cell proliferation |
| MY155270A (en) | 1998-09-24 | 2015-09-30 | Lilly Co Eli | Use of glp-1 or analogs in treatment of stroke |
| JP4629047B2 (ja) * | 2003-06-12 | 2011-02-09 | イーライ リリー アンド カンパニー | Ｇｌｐ−１アナログ複合タンパク質 |
| CN101277722A (zh) * | 2005-08-06 | 2008-10-01 | 王庆华 | 用于预防和治疗ⅰ型糖尿病的组合物及方法 |
| CN1935846A (zh) * | 2005-09-14 | 2007-03-28 | 王庆华 | 一种用于治疗糖尿病的融合蛋白及其制备方法和应用 |
| BRPI0617515A2 (pt) * | 2005-10-24 | 2011-07-26 | Centocor Inc | mimeticorpos, polipeptÍdeos, composiÇÕes, mÉtodos e usos de glp-2 |
| EP3173484B1 (en) * | 2007-05-30 | 2018-09-26 | Postech Academy-Industry- Foundation | Immunoglobulin fusion proteins |
| EP2214700A4 (en) | 2007-11-02 | 2012-08-22 | Janssen Biotech Inc | HALF-SYNTHETIC GLP-1 PEPTIDE FUSION CONSTRUCTS, METHOD AND USES |
| KR101333958B1 (ko) * | 2010-10-20 | 2013-11-27 | 주식회사 한독 | 인간 인터루킨-1 수용체 길항제-하이브리드 Ｆｃ 융합단백질 |
| KR101895047B1 (ko) | 2011-12-30 | 2018-09-06 | 한미사이언스 주식회사 | 면역글로불린 단편을 이용한 위치 특이적 글루카곤 유사 펩타이드-2 약물 결합체 |
-
2015
- 2015-12-30 KR KR1020150189957A patent/KR101825048B1/ko active IP Right Grant
- 2015-12-31 CN CN201580071643.8A patent/CN107207618B/zh active Active
- 2015-12-31 EP EP15875748.4A patent/EP3241850B1/en active Active
- 2015-12-31 US US15/538,784 patent/US10538569B2/en active Active
- 2015-12-31 TW TW104144638A patent/TWI685506B/zh active
- 2015-12-31 ES ES15875748T patent/ES2757812T3/es active Active
- 2015-12-31 TW TW106124909A patent/TWI691513B/zh active
- 2015-12-31 DK DK15875748T patent/DK3241850T3/da active
- 2015-12-31 JP JP2017535812A patent/JP6379300B2/ja active Active
- 2015-12-31 WO PCT/KR2015/014542 patent/WO2016108654A1/ko active Application Filing
- 2015-12-31 PL PL15875748T patent/PL3241850T3/pl unknown
-
2017
- 2017-09-05 KR KR1020170113402A patent/KR101825049B1/ko active IP Right Grant
-
2018
- 2018-05-07 HK HK18105836.7A patent/HK1246321A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018504111A (ja) | 2018-02-15 |
| TWI691513B (zh) | 2020-04-21 |
| EP3241850A4 (en) | 2018-06-20 |
| US10538569B2 (en) | 2020-01-21 |
| HK1246321A1 (zh) | 2018-09-07 |
| KR20170106258A (ko) | 2017-09-20 |
| US20170362293A1 (en) | 2017-12-21 |
| TWI685506B (zh) | 2020-02-21 |
| EP3241850A1 (en) | 2017-11-08 |
| CN107207618B (zh) | 2020-10-30 |
| CN107207618A (zh) | 2017-09-26 |
| JP6379300B2 (ja) | 2018-08-22 |
| PL3241850T3 (pl) | 2020-01-31 |
| TW201738278A (zh) | 2017-11-01 |
| EP3241850B1 (en) | 2019-09-04 |
| WO2016108654A1 (ko) | 2016-07-07 |
| KR101825048B1 (ko) | 2018-02-05 |
| TW201636375A (zh) | 2016-10-16 |
| KR101825049B1 (ko) | 2018-02-05 |
| ES2757812T3 (es) | 2020-04-30 |
| KR20160083810A (ko) | 2016-07-12 |
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