DK3134430T3 - Single-chain TRAIL receptor agonist proteins - Google Patents

Single-chain TRAIL receptor agonist proteins Download PDF

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Publication number
DK3134430T3
DK3134430T3 DK15721089.9T DK15721089T DK3134430T3 DK 3134430 T3 DK3134430 T3 DK 3134430T3 DK 15721089 T DK15721089 T DK 15721089T DK 3134430 T3 DK3134430 T3 DK 3134430T3
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DK
Denmark
Prior art keywords
trail
receptor agonist
trail receptor
agonist protein
seq
Prior art date
Application number
DK15721089.9T
Other languages
Danish (da)
English (en)
Inventor
Oliver Hill
Meinolf Thiemann
Fritz G Buchanan
Darren C Phillips
Susan E Lappe
Christian Gieffers
Original Assignee
Abbvie Inc
Apogenix Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc, Apogenix Ag filed Critical Abbvie Inc
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Publication of DK3134430T3 publication Critical patent/DK3134430T3/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
DK15721089.9T 2014-04-23 2015-04-23 Single-chain TRAIL receptor agonist proteins DK3134430T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461983152P 2014-04-23 2014-04-23
PCT/US2015/027270 WO2015164588A1 (en) 2014-04-23 2015-04-23 Single-chain trail-receptor agonist proteins

Publications (1)

Publication Number Publication Date
DK3134430T3 true DK3134430T3 (en) 2018-05-22

Family

ID=53055121

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15721089.9T DK3134430T3 (en) 2014-04-23 2015-04-23 Single-chain TRAIL receptor agonist proteins

Country Status (38)

Country Link
US (5) US9908927B2 (https=)
EP (2) EP3366699A1 (https=)
JP (2) JP6523331B2 (https=)
KR (2) KR102079919B1 (https=)
CN (2) CN111718424A (https=)
AR (1) AR100168A1 (https=)
AU (3) AU2015249649B2 (https=)
BR (1) BR112016024515B1 (https=)
CA (2) CA3184067A1 (https=)
CL (1) CL2016002683A1 (https=)
CR (1) CR20160516A (https=)
CY (1) CY1120281T1 (https=)
DK (1) DK3134430T3 (https=)
DO (1) DOP2016000284A (https=)
EC (1) ECSP16089579A (https=)
ES (1) ES2672368T3 (https=)
HR (1) HRP20180950T1 (https=)
HU (1) HUE038914T2 (https=)
IL (2) IL248244B (https=)
LT (1) LT3134430T (https=)
MA (2) MA39770A (https=)
MX (2) MX2016013858A (https=)
MY (1) MY181986A (https=)
NO (1) NO2776305T3 (https=)
PE (1) PE20170299A1 (https=)
PH (2) PH12020500377A1 (https=)
PL (1) PL3134430T3 (https=)
PT (1) PT3134430T (https=)
RS (1) RS57153B1 (https=)
RU (1) RU2699285C2 (https=)
SG (3) SG10201806465TA (https=)
SI (1) SI3134430T1 (https=)
SM (1) SMT201800286T1 (https=)
TR (1) TR201806912T4 (https=)
TW (2) TWI683825B (https=)
UA (1) UA118286C2 (https=)
UY (1) UY36095A (https=)
WO (1) WO2015164588A1 (https=)

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WO2016177771A1 (en) * 2015-05-04 2016-11-10 Apogenix Ag Single-chain cd40-receptor agonist proteins
CN108430492B (zh) 2015-10-23 2022-05-03 阿珀吉科吉尼科斯股份公司 单链cd27受体激动剂蛋白
AU2016342420B2 (en) * 2015-10-23 2020-10-01 Apogenix Ag Single-chain LIGHT receptor agonist proteins
CA3002741A1 (en) * 2015-10-23 2017-04-27 Apogenix Ag Single-chain gitr-receptor agonist proteins
WO2017102010A1 (en) * 2015-12-17 2017-06-22 Biontech Rna Pharmaceuticals Gmbh Novel cytokine fusion proteins
EP3423480A1 (en) 2016-03-01 2019-01-09 The Board of Trustees of the University of Illinois L-asparaginase variants and fusion proteins with reduced l-glutaminase activity and enhanced stability
CN108884142A (zh) * 2016-03-16 2018-11-23 梅里麦克制药股份有限公司 用于癌症治疗的工程化trail
US10501744B2 (en) 2016-05-04 2019-12-10 Indiana University Research And Technology Corporation Presentation of bioactive proteins
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
AU2017283487A1 (en) * 2016-06-13 2018-11-22 Merrimack Pharmaceuticals, Inc. Methods for selecting and treating patients with a trail-based therapeutic or death receptor agonist
EP3360898A1 (en) 2017-02-14 2018-08-15 Boehringer Ingelheim International GmbH Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer
EP3664832B1 (en) * 2017-08-11 2023-10-18 The Board of Trustees of the University of Illinois Truncated guinea pig l-asparaginase variants and methods of use
WO2019178433A1 (en) * 2018-03-15 2019-09-19 Abbvie Inc. Abbv-621 in combination with anti-cancer agents for the treatment of pancreatic cancer
WO2019178438A1 (en) * 2018-03-15 2019-09-19 Abbvie Inc. Abbv-621 in combination with anti-cancer agents for the treatment of cancer
EP4149964A2 (en) 2020-05-15 2023-03-22 Apogenix AG Multi-specific immune modulators
US20240294673A1 (en) 2021-05-28 2024-09-05 Julius-Maximilians-Universitaet Wuerzburg Recombinant proteinaceous binding molecules
WO2023088876A1 (en) 2021-11-16 2023-05-25 Apogenix Ag Multi-specific immune modulators

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AU7645700A (en) 1999-10-07 2001-05-10 Maxygen Aps Single-chain antagonist polypeptides
DE19963859A1 (de) 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
CA2314199A1 (en) 2000-07-21 2002-01-21 Robert Simoneau C-chip
BR0116024A (pt) 2000-12-07 2005-12-13 Lilly Co Eli Proteìna de fusão heteróloga e uso da mesma
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
WO2003091447A2 (en) 2002-04-26 2003-11-06 California Institute Of Technology D1-1 nucleic acids, polypeptides and related methods
DE102004014983A1 (de) 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
US20060188498A1 (en) * 2005-02-18 2006-08-24 Genentech, Inc. Methods of using death receptor agonists and EGFR inhibitors
CA2597789A1 (en) 2005-04-15 2006-10-19 Rappaport Family Institute For Research In The Medical Sciences Molecules and methods of using same for treating mcp-1/ccr2 associated diseases
WO2006116260A2 (en) 2005-04-26 2006-11-02 Medimmune, Inc. Modulation of antibody effector function by hinge domain engineering
EP1894940A1 (en) 2006-08-28 2008-03-05 Apogenix GmbH TNF superfamily fusion proteins
EP2176288B1 (en) 2007-07-10 2015-11-04 Apogenix GmbH Tnf superfamily collectin fusion proteins
PE20100092A1 (es) 2008-06-03 2010-03-12 Abbott Lab Inmunoglobulina con dominio variable dual y usos de la misma
DK2604693T3 (en) * 2008-07-21 2016-05-30 Apogenix Gmbh Single-chain TNFSF molecules
EP2350641B1 (en) 2008-09-22 2014-09-24 Amgen Inc. A combination of a tnf alpha inhibitor, an iap inhibitor and a trail receptor agonist for use in treating cancer
CA2739663A1 (en) * 2008-10-10 2010-05-15 Anaphore, Inc. Polypeptides that bind trail-r1 and trail-r2
JP5844158B2 (ja) 2009-01-09 2016-01-13 アポゲニクス ゲゼルシャフト ミット ベシュレンクテル ハフツングApogenix GmbH 三量体形成融合タンパク質
EP2389192A4 (en) * 2009-01-23 2013-01-16 Biogen Idec Inc STABILIZED FC POLYPEPTIDES WITH REDUCED EFFECTOR FUNCTION AND METHOD OF USE
AU2010334974A1 (en) 2009-12-22 2012-07-12 Novartis Ag Tetravalent CD47-antibody constant region fusion protein for use in therapy
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Also Published As

Publication number Publication date
PT3134430T (pt) 2018-04-20
MX2019013587A (es) 2020-01-13
EP3134430A1 (en) 2017-03-01
PE20170299A1 (es) 2017-05-06
MA39770A (fr) 2015-10-29
CY1120281T1 (el) 2019-07-10
CL2016002683A1 (es) 2017-07-07
RU2016145608A (ru) 2018-05-28
RU2699285C2 (ru) 2019-09-04
KR20170012257A (ko) 2017-02-02
HRP20180950T1 (hr) 2018-08-10
RS57153B1 (sr) 2018-07-31
DOP2016000284A (es) 2017-02-15
CA3184067A1 (en) 2015-10-29
CN106459221A (zh) 2017-02-22
ES2672368T3 (es) 2018-06-14
CR20160516A (es) 2017-05-10
SMT201800286T1 (it) 2018-07-17
BR112016024515A2 (pt) 2017-10-10
US20240174731A1 (en) 2024-05-30
US9908927B2 (en) 2018-03-06
AU2015249649B2 (en) 2018-10-04
US20250145688A1 (en) 2025-05-08
AU2020202247A1 (en) 2020-04-23
PH12016502079A1 (en) 2016-12-19
TR201806912T4 (tr) 2018-06-21
PH12016502079B1 (en) 2016-12-19
TWI747178B (zh) 2021-11-21
JP2019162114A (ja) 2019-09-26
TWI683825B (zh) 2020-02-01
AU2018271369B2 (en) 2020-01-02
CN111718424A (zh) 2020-09-29
UA118286C2 (uk) 2018-12-26
UY36095A (es) 2015-10-30
MX2016013858A (es) 2017-08-02
JP2017513503A (ja) 2017-06-01
TW201620928A (zh) 2016-06-16
JP6523331B2 (ja) 2019-05-29
IL248244A0 (en) 2016-11-30
PH12020500377A1 (en) 2022-11-14
KR20190135546A (ko) 2019-12-06
IL248244B (en) 2020-03-31
NZ725476A (en) 2023-09-29
US20150337027A1 (en) 2015-11-26
CA2946402C (en) 2023-02-28
SG11201608767XA (en) 2016-11-29
US20180222962A1 (en) 2018-08-09
TW202024123A (zh) 2020-07-01
SI3134430T1 (en) 2018-05-31
SG10201806465TA (en) 2018-08-30
AU2018271369A1 (en) 2018-12-20
SG10202111785VA (en) 2021-12-30
BR112016024515B1 (pt) 2020-03-31
JP6714751B2 (ja) 2020-06-24
NO2776305T3 (https=) 2018-01-27
CA2946402A1 (en) 2015-10-29
MA45069A (fr) 2019-04-03
IL272612A (en) 2020-03-31
PL3134430T3 (pl) 2018-08-31
KR102079919B1 (ko) 2020-02-24
MY181986A (en) 2021-01-18
LT3134430T (lt) 2018-05-10
RU2016145608A3 (https=) 2018-12-26
CN106459221B (zh) 2020-09-01
AU2015249649A1 (en) 2016-11-10
WO2015164588A1 (en) 2015-10-29
EP3134430B1 (en) 2018-03-21
AR100168A1 (es) 2016-09-14
ECSP16089579A (es) 2018-05-31
EP3366699A1 (en) 2018-08-29
HUE038914T2 (hu) 2018-12-28
US20210040178A1 (en) 2021-02-11

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