CN111718424A - 单链trail受体激动剂蛋白 - Google Patents
单链trail受体激动剂蛋白 Download PDFInfo
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- CN111718424A CN111718424A CN202010767219.XA CN202010767219A CN111718424A CN 111718424 A CN111718424 A CN 111718424A CN 202010767219 A CN202010767219 A CN 202010767219A CN 111718424 A CN111718424 A CN 111718424A
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| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
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| ES2560871T3 (es) | 2007-07-10 | 2016-02-23 | Apogenix Gmbh | Proteínas de fusión de colectina de la superfamilia de TNF |
| CA2726087A1 (en) | 2008-06-03 | 2009-12-10 | Tariq Ghayur | Dual variable domain immunoglobulins and uses thereof |
| ES2538122T3 (es) | 2008-07-21 | 2015-06-17 | Apogenix Gmbh | Moléculas de una sola cadena de TNFSF |
| WO2010033315A1 (en) | 2008-09-22 | 2010-03-25 | Amgen Inc. | Method of treatment |
| US8664366B2 (en) | 2009-01-09 | 2014-03-04 | Apogenix Gmbh | Fusion proteins forming trimers |
| JP2012515556A (ja) * | 2009-01-23 | 2012-07-12 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 低下したエフェクタ機能を有する安定化Ｆｃポリペプチドおよび使用方法 |
| BR112012017164A2 (pt) | 2009-12-22 | 2019-09-24 | Novartis Ag | proteína de fusão de região constante de anticorpo-cd47 tetravalente |
| WO2011130324A1 (en) * | 2010-04-13 | 2011-10-20 | Medimmune, Llc | Fibronectin type iii domain-based multimeric scaffolds |
| EP2793947B1 (en) * | 2011-12-23 | 2021-02-03 | Innate Pharma | Enzymatic conjugation of polypeptides |
| EP3409686B1 (en) * | 2012-07-18 | 2022-04-13 | Apogenix AG | Composition comprising a mixture of cd95-fc isoforms |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102317314A (zh) * | 2008-10-10 | 2012-01-11 | 阿纳福公司 | 结合trail-r1和trail-r2的多肽 |
Non-Patent Citations (2)
| Title |
|---|
| EUNAH CHOI ET AL.: "The combination of TRAIL treatment and cancer cell selective expression of TRAIL-death receptor DR4 induces cell death in TRAIL-resistant cancer cells", 《YONSEI MED J》, pages 55 - 62 * |
| 梁文昌等: "高糖对THP-1细胞及平滑肌细胞肿瘤坏死因子相关凋亡诱导配体受体4表达的影响", 《中国病理生理杂志》, pages 852 - 855 * |
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