DK3126383T3 - Modificeret j-kæde - Google Patents
Modificeret j-kæde Download PDFInfo
- Publication number
- DK3126383T3 DK3126383T3 DK15718304.7T DK15718304T DK3126383T3 DK 3126383 T3 DK3126383 T3 DK 3126383T3 DK 15718304 T DK15718304 T DK 15718304T DK 3126383 T3 DK3126383 T3 DK 3126383T3
- Authority
- DK
- Denmark
- Prior art keywords
- igm
- igg
- iga
- chain
- antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (18)
1. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof, der omfatter en modificeret J-kæde, hvor den modificerede J-kæde omfatter en fremmed bindingsdel, der er indført i en nativ J-kædesekvens, og hvor IgG/IgM- eller IgG/IgA-antistoffet er et hybridantistof, der indeholder et IgM-eller IgA-halestykke i den tunge IgG-kæde og har evnen til at inkorporere og danne polymerer med den modificerede J-kæde.
2. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge krav 1, hvor den native J-kædesekvens er den native humane J-kædesekvens ifølge SEQ ID NO: 1 eller et funktionelt fragment deraf.
3. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge krav 1 eller krav 2, hvor den fremmede bindingsdel er et polypeptid, der er indført i den native humane J-kædesekvens ifølge SEQ ID NO: 1 ved hjælp af direkte eller indirekte fusion, og hvor den fremmede bindingsdel eventuelt er indført ved hjælp af indirekte fusion via en peptidlinker i eller omkring en C-og/eller N-terminal af den fremmede bindingsdel, eventuelt inden for ca. 10 rester af C- og/eller N-terminalen, og hvor peptidlinkeren er ca. 10 til ca. 20 aminosyrer lang.
4. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge et hvilket som helst af kravene 1 til 3, hvor den fremmede bindingsdel er indført i den native humane J-kædesekvens mellem cysteinresterne 92 og 101 i SEQ ID NO: 1 ved hjælp af indirekte fusion via en peptidlinker.
5. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge et hvilket som helst af kravene 1 til 3, hvor den fremmede bindingsdel er indført i den native humane J-kædesekvens ifølge SEQ ID NO: 1 i eller tæt på et glycosyleringssted ved hjælp af indirekte fusion via en peptidlinker.
6. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge krav 1, hvor den fremmede bindingsdel er indført i den native humane J-kædesekvens ifølge SEQ ID NO: 1 ved hjælp af kemisk eller kemo-enzymatisk derivatisering, eventuelt ved hjælp af en spaltbar eller ikke-spaltbar kemisk linker, hvor den spaltbare linker eventuelt er en kemisk labil linker eller en enzymlabil linker, og hvor den spaltbare eller ikke-spaltbare linker eventuelt er valgt fra gruppen, der består af N-succinimidyl-3-(2-pyridyldithio)-propionat (SPDP), succinimidyl-4-(N-maleimidomethyl)-cyclohexan-l-carboxylat (SMCC), N-succinimidyl-4-(2-pyridylthio)-pentanoat (SPP), iminothiolan (IT), bifunktionelle derivater af imidoestere, aktive estere, aldehyder, bis-azidoforbindelser, bis-diazoniumderivater, diisocyanater og bis-aktive fluorforbindelser.
7. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge krav 6, hvor den modificerede J-kæde er modificeret ved insertion af et enzymgenkendelsessted og ved posttranslationel binding af en fremmed bindingsdel i enzymgenkendelsesstedet via en peptid- eller ikke-peptidlinker.
8. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge et hvilket som helst af kravene 1 til 7, hvor den fremmede bindingsdel er valgt fra gruppen, der består af antistoffer, antigenbindende fragmenter af antistoffer, antistof- lægemiddel-konjugater, antistoflignende molekyler, antigenbindende fragmenter af antistoflignende molekyler, opløselige og membranbundne proteiner, ligander, receptorer, viruslignende partikler, proteintoksiner, enzymer og alternative skeletstrukturer, hvor den alternative skeletstruktur eventuelt er valgt fra gruppen, der består af: darpiner, fibronectin-domæner, adnectiner og knottiner, og hvor den fremmede bindingsdel eventuelt er et antigenbindende fragment valgt fra gruppen, der består af: F(ab')2, F(ab)2, Fab', Fab, Fv, scFv og enkeltdomæneantistof.
9. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge et hvilket som helst af kravene 1 til 8, hvor den fremmede bindingsdel binder til en effektorcelle, hvor effektorcellen er valgt fra gruppen, der består af: T-celler, naturlige dræber (NK)-celler, makrofager og neutrofiler.
10. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge krav 9, hvor eff ektorcellen er en T-celle, og hvor den fremmede bindingsdel binder til et CD3s-polypeptid på T-cellen.
11. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge krav 9, hvor eff ektorcellen er en NK-celle, og hvor den fremmede bindingsdel binder til et mål valgt fra gruppen, der består af CD16, CD64 og NKG2D på NK-cellen.
12. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge et hvilket som helst af kravene 1 til 11, der omfatter en flerhed af fremmede bindingsdele.
13. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge et hvilket som helst af kravene 1 til 12, hvor recipientantistoffet for den modificerede J-kæde er monospecifikt, bispecifikt eller multispecifikt.
14. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge et hvilket som helst af kravene 1 til 13, der binder til en hæmatologisk cancercelle eller en fast tumorcelle, hvor antistoffet binder til en eller flere af CDIM, CD19, CD20, CD22, CD33, CD70, CD56, CD138.
15. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge krav 14, hvor antistoffet binder til CD20, og den fremmede bindingsdel på den modificerede J-kæde binder til CD3s.
16. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge et hvilket som helst af kravene 1 til 13, der binder til et viralt antigen, hvor det virale antigen er et HBV-PreSl-antigen eller et HIV-gpl20-antigen.
17. Sammensætning, der omfatter IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistoffet ifølge et hvilket som helst af kravene 1 til 16, som eventuelt er en farmaceutisk sammensætning, der yderligere omfatter et farmaceutisk acceptabelt bæremateriale.
18. IgM-, IgA-, IgG/IgM- eller IgG/IgA-antistof ifølge et hvilket som helst af kravene 1 til 16 eller sammensætning ifølge krav 17 til anvendelse til behandling af en cancer eller virussygdom.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461974738P | 2014-04-03 | 2014-04-03 | |
PCT/US2015/024149 WO2015153912A1 (en) | 2014-04-03 | 2015-04-02 | Modified j-chain |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3126383T3 true DK3126383T3 (da) | 2019-04-01 |
Family
ID=52998235
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK19165016.7T DK3560954T3 (da) | 2014-04-03 | 2015-04-02 | Modificeret j-kæde |
DK15718304.7T DK3126383T3 (da) | 2014-04-03 | 2015-04-02 | Modificeret j-kæde |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK19165016.7T DK3560954T3 (da) | 2014-04-03 | 2015-04-02 | Modificeret j-kæde |
Country Status (21)
Country | Link |
---|---|
US (5) | US10400038B2 (da) |
EP (3) | EP3126383B8 (da) |
JP (2) | JP6744822B2 (da) |
KR (3) | KR102380402B1 (da) |
CN (2) | CN112759650A (da) |
AU (3) | AU2015240595B2 (da) |
BR (1) | BR112016022841B1 (da) |
CA (1) | CA2944647A1 (da) |
DK (2) | DK3560954T3 (da) |
ES (2) | ES2887299T3 (da) |
HU (2) | HUE042829T2 (da) |
IL (3) | IL292311A (da) |
MX (2) | MX2019008359A (da) |
NZ (1) | NZ725568A (da) |
PL (2) | PL3560954T3 (da) |
PT (2) | PT3560954T (da) |
RU (2) | RU2761118C2 (da) |
SG (2) | SG11201608194VA (da) |
SI (2) | SI3126383T1 (da) |
WO (1) | WO2015153912A1 (da) |
ZA (1) | ZA201606906B (da) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3041862B1 (en) | 2013-09-05 | 2020-05-06 | IGM Biosciences, Inc. | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
TR201802728T4 (tr) | 2013-10-25 | 2018-03-21 | Psioxus Therapeutics Ltd | Heterolog genlerle donatılmış onkolitik adenovirüsler. |
WO2015120474A1 (en) | 2014-02-10 | 2015-08-13 | Igm Biosciences, Inc. | Iga multi-specific binding molecules |
SG11201608194VA (en) | 2014-04-03 | 2016-10-28 | Igm Biosciences Inc | Modified j-chain |
SG10202001779UA (en) | 2015-01-20 | 2020-04-29 | Igm Biosciences Inc | Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof |
SG11201707144VA (en) * | 2015-03-04 | 2017-09-28 | Igm Biosciences Inc | Cd20 binding molecules and uses thereof |
AU2016238246B2 (en) * | 2015-03-25 | 2021-05-13 | Igm Biosciences, Inc. | Multi-valent hepatitis B virus antigen binding molecules and uses thereof |
CN107847591B (zh) * | 2015-04-17 | 2023-07-28 | Igm生物科学股份有限公司 | 多价人免疫缺陷病毒抗原结合分子及其应用 |
EP3355913A1 (en) * | 2015-09-30 | 2018-08-08 | IGM Biosciences A/S | Binding molecules with modified j-chain |
EP3356401B1 (en) | 2015-09-30 | 2020-06-24 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
BR112018012180A2 (pt) | 2015-12-17 | 2018-12-04 | Psioxus Therapeutics Ltd | vírus de codificação de um anticorpo ou fragmento de complexo anti-tcr |
KR102343742B1 (ko) * | 2016-05-09 | 2021-12-24 | 아이쥐엠 바이오사이언스 인코포레이티드 | 항-pd-l1 항체 |
GB201713765D0 (en) | 2017-08-28 | 2017-10-11 | Psioxus Therapeutics Ltd | Modified adenovirus |
WO2018148445A1 (en) | 2017-02-08 | 2018-08-16 | Adimab, Llc | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
KR20240060739A (ko) | 2017-02-20 | 2024-05-08 | 드래곤플라이 쎄라퓨틱스, 인크. | Her2, nkg2d 및 cd16에 결합하는 단백질 |
EP3607091A4 (en) | 2017-04-07 | 2021-01-20 | IGM Biosciences, Inc. | MODIFIED HUMAN CONSTANT IGM REGIONS FOR THE MODULATION OF COMPLEMENT-DEPENDENT CYTOLYSIS EFFECTOR FUNCTION |
CA3237846A1 (en) | 2018-02-08 | 2019-08-15 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the nkg2d receptor |
KR20200128391A (ko) * | 2018-03-01 | 2020-11-12 | 아이쥐엠 바이오사이언스 인코포레이티드 | IgM 혈청 반감기에 영향을 미치는 IgM Fc 및 J-쇄 돌연변이 |
MX2022001934A (es) * | 2019-08-15 | 2022-03-11 | Igm Biosciences Inc | Moleculas de union multimericas inmunoestimuladoras. |
CN114616031A (zh) * | 2019-09-19 | 2022-06-10 | Igm生物科学股份有限公司 | 对靶标密度高的细胞的选择性增强的多聚体抗体 |
CN115052884A (zh) * | 2019-09-27 | 2022-09-13 | 北京烁星生物医药科技有限公司 | 单特异性和多特异性抗体 |
WO2021216756A2 (en) | 2020-04-22 | 2021-10-28 | Igm Biosciences, Inc. | Pd-1 agonist multimeric binding molecules |
CN116635064A (zh) | 2020-12-18 | 2023-08-22 | 世纪治疗股份有限公司 | 具有适应性受体特异性的嵌合抗原受体系统 |
WO2022256740A1 (en) | 2021-06-04 | 2022-12-08 | Curia Ip Holdings, Llc | Polymeric fusion proteins and compositions for inducing an immune response against infection |
WO2023196995A1 (en) | 2022-04-07 | 2023-10-12 | Repertoire Immune Medicines, Inc. | T cell receptor multimers and uses thereof |
Family Cites Families (147)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
GB8719963D0 (en) | 1987-08-24 | 1987-09-30 | Cattaneo A | Recombinant dna products |
US5831034A (en) | 1987-11-13 | 1998-11-03 | Hermann Katinger | Human monoclonal anti-HIV-I-antibodies |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
EP0438803B1 (en) | 1990-01-26 | 1997-03-12 | Immunomedics, Inc. | Vaccines against cancer and infectious diseases |
DE69333950T2 (de) | 1992-05-18 | 2006-08-17 | Genentech, Inc., South San Francisco | Aktivierung von Rezeptoren fähig zur Oligomerisierung durch Verwendung von fusionierten Rezeptor Liganden |
US6476198B1 (en) | 1993-07-13 | 2002-11-05 | The Scripps Research Institute | Multispecific and multivalent antigen-binding polypeptide molecules |
UA40577C2 (uk) | 1993-08-02 | 2001-08-15 | Мерк Патент Гмбх | Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин |
AU697387C (en) | 1994-09-16 | 2006-03-02 | Austin Research Institute Cancer and Anti-inflammatory Syndicate No 1 | Polypeptides with Fc binding ability |
US5874540A (en) | 1994-10-05 | 1999-02-23 | Immunomedics, Inc. | CDR-grafted type III anti-CEA humanized mouse monoclonal antibodies |
IL111196A0 (en) | 1994-10-07 | 1994-12-29 | Yeda Res & Dev | Peptides and pharmaceutical compositions comprising them |
US6808709B1 (en) | 1994-12-30 | 2004-10-26 | The Regents Of The University Of California | Immunoglobulins containing protection proteins and their use |
US6165463A (en) | 1997-10-16 | 2000-12-26 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
EP0822941B1 (en) | 1995-04-19 | 2002-06-12 | Polymun Scientific Immunbiologische Forschung GmbH | Monoclonal antibodies against hiv-1 and vaccines made thereof |
US20050003431A1 (en) | 1996-08-16 | 2005-01-06 | Wucherpfennig Kai W. | Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor |
US8212004B2 (en) | 1999-03-02 | 2012-07-03 | Human Genome Sciences, Inc. | Neutrokine-alpha fusion proteins |
US6045774A (en) * | 1997-01-10 | 2000-04-04 | Epicyte Pharmaceutical Inc. | J chain polypeptide targeting molecule linked to an imaging agent |
EP1015493A1 (en) | 1997-01-10 | 2000-07-05 | EPIcyte Pharmaceutical, Inc. | Novel epithelial tissue targeting agent |
US20040009166A1 (en) | 1997-04-30 | 2004-01-15 | Filpula David R. | Single chain antigen-binding polypeptides for polymer conjugation |
WO1999054484A1 (en) | 1998-04-20 | 1999-10-28 | The Regents Of The University Of California | Modified immunoglobulin molecules and methods for use thereof |
KR100699524B1 (ko) | 1999-01-07 | 2007-03-23 | 지모제넥틱스, 인코포레이티드 | 가용성 수용체 br43×2 및 이용 방법 |
JP2002544123A (ja) | 1999-04-14 | 2002-12-24 | スミスクライン・ビーチャム・コーポレイション | エリトロポイエチン受容体抗体 |
AU782160B2 (en) | 1999-06-09 | 2005-07-07 | Immunomedics Inc. | Immunotherapy of autoimmune disorders using antibodies which target B-cells |
WO2001012820A1 (en) | 1999-08-17 | 2001-02-22 | Health Research Institute | Genetic system and self-cleaving inteins derived therefrom, bioseparations and protein purification employing same, and methods for determining critical, generalizable amino acid residues for varying intein activity |
ES2282133T3 (es) | 1999-08-24 | 2007-10-16 | Medarex, Inc. | Anticuerpos frente a la ctla-4 humano y sus usos. |
US20050287153A1 (en) | 2002-06-28 | 2005-12-29 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
PL357939A1 (en) | 2000-04-11 | 2004-08-09 | Genentech, Inc. | Multivalent antibodies and uses therefor |
US20020168367A1 (en) * | 2000-04-28 | 2002-11-14 | Planet Biotechnology Incorporated | Novel immunoadhesins for treating and preventing viral and bacterial diseases |
US7951378B2 (en) | 2000-04-28 | 2011-05-31 | Planet Biotechnology Inc. | Immunoadhesin comprising a chimeric ICAM-1 molecule produced in a plant |
US7947275B2 (en) | 2000-05-10 | 2011-05-24 | Signe Biopharma, Inc. | Compositions and methods for demonstrating secretory immune system regulation of steroid hormone responsive cancer cell growth |
JP2004502450A (ja) | 2000-07-10 | 2004-01-29 | ノバルティス アクチエンゲゼルシャフト | ターゲッティング遺伝子送達のための二官能性分子およびそれと複合化されたベクター |
AU8886601A (en) | 2000-09-07 | 2002-03-22 | John R Schreiber | Human antibodies against pseudomonas aeruginosa lps derived from transgenic xenomouse |
AU2004297218B2 (en) | 2000-09-07 | 2012-03-01 | Amgen, Inc. | Human anti-Pseudomonas-aeruginosa antibodies derived from transgenic Xenomouse |
US7138496B2 (en) | 2002-02-08 | 2006-11-21 | Genetastix Corporation | Human monoclonal antibodies against human CXCR4 |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
DK1366067T3 (da) * | 2001-03-07 | 2012-10-22 | Merck Patent Gmbh | Ekspressionsteknologi for proteiner indeholdende en hybrid isotype-antistof-enhed |
US7402312B2 (en) | 2001-04-13 | 2008-07-22 | Human Genome Sciences, Inc. | Antibodies to vascular endothelial growth factor 2 (VEGF-2) |
US20050129616A1 (en) | 2001-05-25 | 2005-06-16 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
NZ513418A (en) | 2001-08-07 | 2004-04-30 | Univ Massey | Vaccine comprising proteins from mycobacterium paratuberculosis |
AU2002356844C1 (en) | 2001-10-23 | 2010-03-04 | Amgen Fremont Inc. | PSMA antibodies and protein multimers |
EP2295468B1 (en) | 2002-02-14 | 2015-07-08 | Immunomedics, Inc. | Anti-CD20 antibodies and fusion proteins thereof and methods of use |
ATE477276T1 (de) | 2002-03-01 | 2010-08-15 | Immunomedics Inc | Internalisierung von anti cd74 monoklonalen antikörpern und deren verwendungen |
KR101002443B1 (ko) | 2002-03-01 | 2010-12-17 | 이뮤노메딕스, 인코오포레이티드 | Rs7 항체 |
JP2005529873A (ja) | 2002-04-12 | 2005-10-06 | メダレックス インコーポレイテッド | Ctla−4抗体を使用した治療の方法 |
AU2003277087B2 (en) | 2002-06-14 | 2008-07-31 | Immunomedics, Inc. | Humanized monoclonal antiboby hPAM4 |
US7601351B1 (en) | 2002-06-26 | 2009-10-13 | Human Genome Sciences, Inc. | Antibodies against protective antigen |
JP4836451B2 (ja) | 2002-07-18 | 2011-12-14 | メルス ベー ヴェー | 抗体混合物の組換え生産 |
KR101115797B1 (ko) | 2002-08-01 | 2012-07-27 | 이뮤노메딕스, 인코오포레이티드 | 알파 태아 단백질 Immu31 항체 및 융합단백질, 및이들의 이용 방법 |
US20040156826A1 (en) | 2002-09-27 | 2004-08-12 | Fernando Dangond | Treatment of patients with multiple sclerosis based on gene expression changes in central nervous system tissues |
US7541440B2 (en) | 2002-09-30 | 2009-06-02 | Immunomedics, Inc. | Chimeric, human and humanized anti-granulocyte antibodies and methods of use |
US20050014932A1 (en) | 2003-05-15 | 2005-01-20 | Iogenetics, Llc | Targeted biocides |
AR044388A1 (es) | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
AU2004240782B2 (en) | 2003-05-23 | 2011-04-21 | Crucell Holland B.V. | Production of recombinant IGM in per.C6 cells |
EP2204190A1 (en) | 2003-07-15 | 2010-07-07 | Chugai Seiyaku Kabushiki Kaisha | IgM production by transformed cells and methods for quantifying said IgM production |
JP4733635B2 (ja) | 2003-07-31 | 2011-07-27 | イミューノメディクス、インコーポレイテッド | 抗cd19抗体 |
US8147832B2 (en) | 2003-08-14 | 2012-04-03 | Merck Patent Gmbh | CD20-binding polypeptide compositions and methods |
JP4671864B2 (ja) | 2003-10-09 | 2011-04-20 | 中外製薬株式会社 | タンパク質溶液の安定化方法 |
KR20120125634A (ko) | 2003-10-16 | 2012-11-16 | 마이크로메트 에이지 | 다중특이적 탈면역화된 cd3-바인더 |
FR2861255B1 (fr) | 2003-10-24 | 2006-02-17 | Centre Nat Rech Scient | Mammifere non-humain transgenique pour la region constante de la chaine lourde des immunoglobulines humaines de classe a et ses applications. |
EP1697520A2 (en) | 2003-12-22 | 2006-09-06 | Xencor, Inc. | Fc polypeptides with novel fc ligand binding sites |
EP1740946B1 (en) | 2004-04-20 | 2013-11-06 | Genmab A/S | Human monoclonal antibodies against cd20 |
AU2005304973A1 (en) | 2004-11-05 | 2006-05-18 | Palingen, Inc. | Antibody induced cell membrane wounding |
US7251164B2 (en) | 2004-11-10 | 2007-07-31 | Innovative Silicon S.A. | Circuitry for and method of improving statistical distribution of integrated circuits |
WO2006063067A2 (en) | 2004-12-09 | 2006-06-15 | La Jolla Institute For Allergy And Immunology | Novel tnf receptor regulatory domain |
AU2006218454B2 (en) | 2005-03-03 | 2011-11-17 | Immunomedics, Inc. | Humanized L243 antibodies |
US8349332B2 (en) | 2005-04-06 | 2013-01-08 | Ibc Pharmaceuticals, Inc. | Multiple signaling pathways induced by hexavalent, monospecific and bispecific antibodies for enhanced toxicity to B-cell lymphomas and other diseases |
AU2006252733A1 (en) | 2005-06-02 | 2006-12-07 | Astrazeneca Ab | Antibodies directed to CD20 and uses thereof |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
TW200732350A (en) | 2005-10-21 | 2007-09-01 | Amgen Inc | Methods for generating monovalent IgG |
KR20080090441A (ko) | 2005-12-21 | 2008-10-08 | 메디뮨 엘엘씨 | Epha2 bite 분자 및 이의 용도 |
CN101506358B (zh) | 2006-05-15 | 2013-07-17 | 免疫医学股份有限公司 | 使用偶合的抗体或抗体片段治疗人免疫缺陷病毒感染的方法和组合物 |
AU2007252295B2 (en) | 2006-05-19 | 2013-07-25 | Central Adelaide Local Health Network Incorporated | Selective modulation of receptor signalling |
KR101571027B1 (ko) | 2006-06-12 | 2015-11-23 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | 효과기 기능을 갖는 단일쇄 다가 결합 단백질 |
MX349810B (es) | 2006-09-08 | 2017-08-14 | Abbvie Bahamas Ltd | Proteinas de enlace de interleucina-13. |
US9382327B2 (en) | 2006-10-10 | 2016-07-05 | Vaccinex, Inc. | Anti-CD20 antibodies and methods of use |
CA2668208C (en) | 2006-11-02 | 2017-09-12 | Daniel J. Capon | Hybrid immunoglobulins with moving parts |
US20080145420A1 (en) | 2006-12-13 | 2008-06-19 | Simon Michael R | HUMAN SECRETORY IgA FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASES |
EP2087111A2 (en) | 2007-03-19 | 2009-08-12 | Medimmune Limited | Polypeptide variants |
US20100298223A1 (en) | 2007-05-02 | 2010-11-25 | Dietmar Rudolf Fries | Fibrinogen for treatment of bleeding in trauma and platelet disorders |
WO2009013620A2 (en) | 2007-06-11 | 2009-01-29 | Erasmus University Medical Center Rotterdam | Homologous recombination |
WO2009030285A1 (en) | 2007-09-07 | 2009-03-12 | Ablynx N.V. | Binding molecules with multiple binding sites, compositions comprising the same and uses thereof |
US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
US7960145B2 (en) | 2007-11-08 | 2011-06-14 | Cytimmune Sciences, Inc. | Compositions and methods for generating antibodies |
EP2254592B1 (en) | 2008-02-28 | 2019-06-05 | Dako Denmark A/S | Mhc multimers in borrelia diagnostics and disease |
ITTO20080313A1 (it) | 2008-04-22 | 2009-10-23 | Marco Colombatti | Anticorpo monoclonale isolato o suo frammento legante l'antigene specifico di membrana della prostata, suoi coniugati e suoi usi |
BRPI0915512A2 (pt) | 2008-07-11 | 2017-06-20 | Sea Lane Biotechnologies Llc | construtos e bibliotecas compreendendo sequências substitutas de cadeia leve kappa de anticorpo |
US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
WO2010054010A1 (en) | 2008-11-07 | 2010-05-14 | Fabrus Llc | Anti-dll4 antibodies and uses thereof |
US20120269830A1 (en) | 2009-12-07 | 2012-10-25 | Lawrence Horowitz | Conjugates with improved pharmacokinetic properties |
EP3112382A1 (en) | 2009-12-29 | 2017-01-04 | Emergent Product Development Seattle, LLC | Heterodimer binding proteins and uses thereof |
MX341687B (es) | 2010-02-10 | 2016-08-30 | Immunogen Inc | "anticuerpos cd20 y su utilización". |
WO2011100538A1 (en) | 2010-02-11 | 2011-08-18 | Alexion Pharmaceuticals, Inc. | Therapeutic methods using an ti-cd200 antibodies |
CA2815046C (en) | 2010-10-19 | 2019-05-14 | Mayo Foundation For Medical Education And Research | Human antibodies and diagnostic and therapeutic uses thereof for the treatment of neurological disease |
WO2012088290A2 (en) | 2010-12-22 | 2012-06-28 | Abbott Laboratories | Tri-variable domain binding proteins and uses thereof |
EP2771361A1 (en) | 2011-10-24 | 2014-09-03 | AbbVie Inc. | Bispecific immunobinders directed against tnf and il-17 |
US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
US9573996B2 (en) | 2011-12-16 | 2017-02-21 | Synthon Biopharmaceuticals B.V. | Monoclonal antibodies to human proinflammatory cytokines and methods for treating inflammatory diseases |
CA2863714C (en) | 2012-02-08 | 2022-07-05 | Igm Biosciences, Inc. | Cdim binding proteins and uses thereof |
EP3427747A1 (en) | 2012-04-05 | 2019-01-16 | Gottfried Himmler | Secretory immunoglobulin complex |
EP2838562B1 (en) * | 2012-04-17 | 2017-08-30 | Mayo Foundation for Medical Education and Research | Human antibodies and specific binding sequences thereof for use in stroke and ischemia or ischemic conditions |
US20150175678A1 (en) | 2012-06-15 | 2015-06-25 | Beth Israel Deaconess Medical Center, Inc. | IgA CD4i ANTIBODIES AND METHODS OF TREATMENT USING SAME |
CN103570821A (zh) * | 2012-07-27 | 2014-02-12 | 北京智飞绿竹生物制药有限公司 | 粘蛋白-1抗原性多肽及其作为肿瘤疫苗的用途 |
JP2015524821A (ja) | 2012-08-02 | 2015-08-27 | ジェイエヌ バイオサイエンシーズ エルエルシー | システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質 |
JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
WO2014124457A1 (en) | 2013-02-11 | 2014-08-14 | University Of Louisville Research Foundation, Inc. | Methods for producing antibodies |
US9487773B2 (en) | 2013-03-01 | 2016-11-08 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Cell-based methods for coupling protein interactions and binding molecule selection |
EP2968587A2 (en) | 2013-03-13 | 2016-01-20 | Bristol-Myers Squibb Company | Fibronectin based scaffold domains linked to serum albumin or a moiety binding thereto |
GB201311487D0 (en) | 2013-06-27 | 2013-08-14 | Alligator Bioscience Ab | Bispecific molecules |
US20150038682A1 (en) | 2013-08-02 | 2015-02-05 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via homomultimerizing peptide |
EP3041862B1 (en) | 2013-09-05 | 2020-05-06 | IGM Biosciences, Inc. | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
WO2015037000A1 (en) | 2013-09-11 | 2015-03-19 | Compugen Ltd | Vstm5 polypeptides and uses thereof as a drug for treatment of cancer, infectious diseases and immune related diseases |
CN106459182B (zh) | 2013-12-30 | 2021-09-03 | 岸迈生物科技有限公司 | 串联fab免疫球蛋白及其用途 |
WO2015107126A1 (en) | 2014-01-16 | 2015-07-23 | Mondelli Mario Umberto Francesco | Neutralizing human monoclonal antibodies against hepatitis b virus surface antigen |
WO2015120474A1 (en) | 2014-02-10 | 2015-08-13 | Igm Biosciences, Inc. | Iga multi-specific binding molecules |
TWI777174B (zh) | 2014-03-14 | 2022-09-11 | 瑞士商諾華公司 | 針對lag-3之抗體分子及其用途 |
SG11201608194VA (en) | 2014-04-03 | 2016-10-28 | Igm Biosciences Inc | Modified j-chain |
SG10202001779UA (en) | 2015-01-20 | 2020-04-29 | Igm Biosciences Inc | Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof |
SG11201707144VA (en) | 2015-03-04 | 2017-09-28 | Igm Biosciences Inc | Cd20 binding molecules and uses thereof |
AU2016238246B2 (en) | 2015-03-25 | 2021-05-13 | Igm Biosciences, Inc. | Multi-valent hepatitis B virus antigen binding molecules and uses thereof |
CN107847591B (zh) | 2015-04-17 | 2023-07-28 | Igm生物科学股份有限公司 | 多价人免疫缺陷病毒抗原结合分子及其应用 |
EP3319936A4 (en) | 2015-07-12 | 2019-02-06 | Suzhou M-conj Biotech Co., Ltd. | PLACES OF CONDUCT FOR THE CONJUGATION OF CELL BINDING MOLECULES |
EP3355913A1 (en) | 2015-09-30 | 2018-08-08 | IGM Biosciences A/S | Binding molecules with modified j-chain |
EP3356401B1 (en) | 2015-09-30 | 2020-06-24 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
KR102343742B1 (ko) | 2016-05-09 | 2021-12-24 | 아이쥐엠 바이오사이언스 인코포레이티드 | 항-pd-l1 항체 |
WO2018017888A1 (en) | 2016-07-20 | 2018-01-25 | Igm Biosciences, Inc. | Multimeric ox40 binding molecules and uses thereof |
US20190338040A1 (en) | 2016-07-20 | 2019-11-07 | Igm Biosciences, Inc. | Multimeric cd137/4-1bb binding molecules and uses thereof |
CA3030640A1 (en) | 2016-07-20 | 2018-01-25 | Igm Biosciences, Inc. | Multimeric cd40 binding molecules and uses thereof |
WO2018017889A1 (en) | 2016-07-20 | 2018-01-25 | Igm Biosciences, Inc. | Multimeric gitr binding molecules and uses thereof |
EP3607091A4 (en) | 2017-04-07 | 2021-01-20 | IGM Biosciences, Inc. | MODIFIED HUMAN CONSTANT IGM REGIONS FOR THE MODULATION OF COMPLEMENT-DEPENDENT CYTOLYSIS EFFECTOR FUNCTION |
CN111757941A (zh) | 2018-02-26 | 2020-10-09 | Igm生物科学股份有限公司 | 多聚体抗dr5结合分子与化学治疗剂联合用于治疗癌症的用途 |
KR20200128391A (ko) | 2018-03-01 | 2020-11-12 | 아이쥐엠 바이오사이언스 인코포레이티드 | IgM 혈청 반감기에 영향을 미치는 IgM Fc 및 J-쇄 돌연변이 |
KR20210083260A (ko) | 2018-10-23 | 2021-07-06 | 아이쥐엠 바이오사이언스 인코포레이티드 | 다가 IgM- 및 IgA-Fc 기반 결합 분자 |
WO2020163646A1 (en) | 2019-02-08 | 2020-08-13 | Igm Biosciences, Inc. | Anti-gitr antigen-binding domains and uses thereof |
MX2022001934A (es) | 2019-08-15 | 2022-03-11 | Igm Biosciences Inc | Moleculas de union multimericas inmunoestimuladoras. |
EP4013796A4 (en) | 2019-08-17 | 2023-08-02 | IGM Biosciences Inc. | MULTIMERIC BISPECIFIC ANTI-CD123 BINDING MOLECULES AND USES THEREOF |
CA3149350A1 (en) | 2019-08-23 | 2021-03-04 | Igm Biosciences, Inc. | Igm glycovariants |
CN114616031A (zh) | 2019-09-19 | 2022-06-10 | Igm生物科学股份有限公司 | 对靶标密度高的细胞的选择性增强的多聚体抗体 |
KR20220122699A (ko) | 2020-01-06 | 2022-09-02 | 아이쥐엠 바이오사이언스 인코포레이티드 | 고도로 시알릴화된 다량체 결합 분자 |
WO2021216756A2 (en) | 2020-04-22 | 2021-10-28 | Igm Biosciences, Inc. | Pd-1 agonist multimeric binding molecules |
MX2022014259A (es) | 2020-05-12 | 2022-12-07 | Igm Biosciences Inc | Uso de una molecula de union anti-dr5 multimerica en combinacion con una terapia contra el cancer para tratar el cancer. |
CA3187008A1 (en) | 2020-07-27 | 2022-02-03 | Paul R. Hinton | Multimeric coronavirus binding molecules and uses thereof |
WO2022109023A1 (en) | 2020-11-17 | 2022-05-27 | Igm Biosciences, Inc. | Uses of effector cell engaging molecules with moieties of differing potencies |
US20240076392A1 (en) | 2021-02-17 | 2024-03-07 | Igm Biosciences, Inc. | Anti-cd123 binding molecules and uses thereof |
US20220267415A1 (en) | 2021-02-17 | 2022-08-25 | The Board Of Regents Of The University Of Texas System | Multimeric sars-cov-2 binding molecules and uses thereof |
-
2015
- 2015-04-02 SG SG11201608194VA patent/SG11201608194VA/en unknown
- 2015-04-02 CN CN202110059477.7A patent/CN112759650A/zh active Pending
- 2015-04-02 PT PT191650167T patent/PT3560954T/pt unknown
- 2015-04-02 PL PL19165016T patent/PL3560954T3/pl unknown
- 2015-04-02 HU HUE15718304A patent/HUE042829T2/hu unknown
- 2015-04-02 CA CA2944647A patent/CA2944647A1/en active Pending
- 2015-04-02 WO PCT/US2015/024149 patent/WO2015153912A1/en active Application Filing
- 2015-04-02 EP EP15718304.7A patent/EP3126383B8/en active Active
- 2015-04-02 IL IL292311A patent/IL292311A/en unknown
- 2015-04-02 DK DK19165016.7T patent/DK3560954T3/da active
- 2015-04-02 SG SG10201909716R patent/SG10201909716RA/en unknown
- 2015-04-02 BR BR112016022841-3A patent/BR112016022841B1/pt active IP Right Grant
- 2015-04-02 PL PL15718304T patent/PL3126383T3/pl unknown
- 2015-04-02 MX MX2019008359A patent/MX2019008359A/es unknown
- 2015-04-02 KR KR1020167030462A patent/KR102380402B1/ko active IP Right Grant
- 2015-04-02 DK DK15718304.7T patent/DK3126383T3/da active
- 2015-04-02 IL IL278350A patent/IL278350B/en unknown
- 2015-04-02 EP EP19165016.7A patent/EP3560954B1/en active Active
- 2015-04-02 KR KR1020237037174A patent/KR20230155600A/ko active Application Filing
- 2015-04-02 ES ES19165016T patent/ES2887299T3/es active Active
- 2015-04-02 HU HUE19165016A patent/HUE055693T2/hu unknown
- 2015-04-02 ES ES15718304T patent/ES2717704T3/es active Active
- 2015-04-02 US US15/301,366 patent/US10400038B2/en active Active
- 2015-04-02 JP JP2016560487A patent/JP6744822B2/ja active Active
- 2015-04-02 AU AU2015240595A patent/AU2015240595B2/en active Active
- 2015-04-02 MX MX2016012880A patent/MX366588B/es active IP Right Grant
- 2015-04-02 KR KR1020227010016A patent/KR20220044377A/ko not_active Application Discontinuation
- 2015-04-02 CN CN201580018643.1A patent/CN106459213B/zh active Active
- 2015-04-02 EP EP21189059.5A patent/EP4011910A1/en active Pending
- 2015-04-02 RU RU2016141579A patent/RU2761118C2/ru active
- 2015-04-02 RU RU2021134101A patent/RU2021134101A/ru unknown
- 2015-04-02 PT PT15718304T patent/PT3126383T/pt unknown
- 2015-04-02 SI SI201530652T patent/SI3126383T1/sl unknown
- 2015-04-02 NZ NZ725568A patent/NZ725568A/en unknown
- 2015-04-02 SI SI201531717T patent/SI3560954T1/sl unknown
-
2016
- 2016-09-29 IL IL248151A patent/IL248151A0/en active IP Right Grant
- 2016-10-07 ZA ZA2016/06906A patent/ZA201606906B/en unknown
-
2017
- 2017-03-07 US US15/452,616 patent/US9951134B2/en active Active
-
2018
- 2018-09-19 US US16/136,049 patent/US11555075B2/en active Active
-
2020
- 2020-02-25 AU AU2020201347A patent/AU2020201347B2/en active Active
- 2020-02-27 US US16/803,745 patent/US10975147B2/en active Active
- 2020-03-11 JP JP2020041558A patent/JP7062025B2/ja active Active
-
2022
- 2022-03-08 AU AU2022201585A patent/AU2022201585A1/en active Pending
- 2022-11-03 US US18/052,388 patent/US20230279111A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10975147B2 (en) | Modified J-chain | |
CN112040979A (zh) | 针对信号调控蛋白α的抗体和使用方法 | |
JP6205363B2 (ja) | ハイブリッド定常領域 | |
TWI802633B (zh) | 針對pd-1之單域抗體及其變異體 | |
EP3356401A1 (en) | Binding molecules with modified j-chain | |
JP2024036342A (ja) | Cd3を標的とする抗体、二重特異性抗体及びその使用 | |
JP2015524821A (ja) | システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質 | |
CN113508134A (zh) | 白蛋白结合抗体及其用途 | |
WO2024108032A2 (en) | Anti-cd3 antibodies |