DK2925776T3 - TARGETED THERAPEUTIC LYSOSOMAL ENZYMUS FUSION PROTEINS AND APPLICATIONS THEREOF - Google Patents

TARGETED THERAPEUTIC LYSOSOMAL ENZYMUS FUSION PROTEINS AND APPLICATIONS THEREOF Download PDF

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Publication number
DK2925776T3
DK2925776T3 DK13802834.5T DK13802834T DK2925776T3 DK 2925776 T3 DK2925776 T3 DK 2925776T3 DK 13802834 T DK13802834 T DK 13802834T DK 2925776 T3 DK2925776 T3 DK 2925776T3
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Denmark
Prior art keywords
gly
gly gly
ser
ala
pro
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DK13802834.5T
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Danish (da)
English (en)
Inventor
Mika Aoyagi-Scharber
Teresa Margaret Christianson
Daniel J Wendt
Shinong Long
Jonathan Lebowitz
Daniel Solomon Gold
Melita Dvorak-Ewell
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Biomarin Pharm Inc
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Publication of DK2925776T3 publication Critical patent/DK2925776T3/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/65Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0105Alpha-N-acetylglucosaminidase (3.2.1.50)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/06Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
DK13802834.5T 2012-11-27 2013-11-27 TARGETED THERAPEUTIC LYSOSOMAL ENZYMUS FUSION PROTEINS AND APPLICATIONS THEREOF DK2925776T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261730378P 2012-11-27 2012-11-27
US201361788968P 2013-03-15 2013-03-15
PCT/US2013/072287 WO2014085621A1 (en) 2012-11-27 2013-11-27 Targeted therapeutic lysosomal enzyme fusion proteins and uses thereof

Publications (1)

Publication Number Publication Date
DK2925776T3 true DK2925776T3 (en) 2018-09-03

Family

ID=49753532

Family Applications (2)

Application Number Title Priority Date Filing Date
DK13802834.5T DK2925776T3 (en) 2012-11-27 2013-11-27 TARGETED THERAPEUTIC LYSOSOMAL ENZYMUS FUSION PROTEINS AND APPLICATIONS THEREOF
DK16182420.6T DK3115372T3 (da) 2012-11-27 2013-11-27 Målrettede terapeutiske lysosomale enzymfusionsproteiner og anvendelser deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK16182420.6T DK3115372T3 (da) 2012-11-27 2013-11-27 Målrettede terapeutiske lysosomale enzymfusionsproteiner og anvendelser deraf

Country Status (26)

Country Link
US (9) US9376480B2 (enExample)
EP (2) EP2925776B1 (enExample)
JP (2) JP6831176B2 (enExample)
KR (4) KR20230054482A (enExample)
CN (1) CN104822701B (enExample)
AR (1) AR093626A1 (enExample)
AU (1) AU2013352184B2 (enExample)
BR (1) BR112015012152B1 (enExample)
CA (1) CA2892146A1 (enExample)
CL (1) CL2015001371A1 (enExample)
CY (1) CY1122555T1 (enExample)
DK (2) DK2925776T3 (enExample)
ES (2) ES2679374T3 (enExample)
HR (2) HRP20181351T1 (enExample)
HU (2) HUE039334T2 (enExample)
IL (3) IL238824B (enExample)
LT (1) LT3115372T (enExample)
MX (2) MX377150B (enExample)
PL (2) PL2925776T3 (enExample)
PT (2) PT3115372T (enExample)
RS (1) RS58916B1 (enExample)
RU (1) RU2680581C2 (enExample)
SI (1) SI3115372T1 (enExample)
TW (2) TWI711632B (enExample)
WO (1) WO2014085621A1 (enExample)
ZA (1) ZA201503509B (enExample)

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Also Published As

Publication number Publication date
DK3115372T3 (da) 2019-06-11
HUE043679T2 (hu) 2019-09-30
US20190225666A1 (en) 2019-07-25
US11254725B2 (en) 2022-02-22
KR102385392B1 (ko) 2022-04-11
AU2013352184A1 (en) 2015-06-04
MX2019009191A (es) 2019-10-09
LT3115372T (lt) 2019-06-25
CL2015001371A1 (es) 2015-10-09
HRP20190918T1 (hr) 2019-09-20
RS58916B1 (sr) 2019-08-30
US20140161788A1 (en) 2014-06-12
US9834587B2 (en) 2017-12-05
US20250388644A1 (en) 2025-12-25
EP3115372B1 (en) 2019-03-06
HRP20181351T1 (hr) 2018-11-02
SI3115372T1 (sl) 2019-08-30
KR20210070389A (ko) 2021-06-14
RU2015125491A (ru) 2017-01-10
AR093626A1 (es) 2015-06-17
MX2015006644A (es) 2015-08-10
IL238824B (en) 2018-11-29
EP2925776B1 (en) 2018-05-30
CN104822701B (zh) 2018-09-21
PT2925776T (pt) 2018-07-30
US20160039900A1 (en) 2016-02-11
JP2019206556A (ja) 2019-12-05
KR20220047892A (ko) 2022-04-19
ES2679374T3 (es) 2018-08-24
US9834588B2 (en) 2017-12-05
KR20150088317A (ko) 2015-07-31
PL3115372T3 (pl) 2019-09-30
PT3115372T (pt) 2019-06-12
ZA201503509B (en) 2016-11-30
US9376480B2 (en) 2016-06-28
EP2925776A1 (en) 2015-10-07
MX367024B (es) 2019-08-02
IL272854A (en) 2020-04-30
US20160031965A1 (en) 2016-02-04
KR20230054482A (ko) 2023-04-24
TW201827468A (zh) 2018-08-01
CN104822701A (zh) 2015-08-05
AU2013352184B2 (en) 2018-05-31
JP2016505539A (ja) 2016-02-25
TW201431884A (zh) 2014-08-16
IL272854B (en) 2021-07-29
ES2729997T3 (es) 2019-11-07
TWI626250B (zh) 2018-06-11
BR112015012152A2 (pt) 2017-08-15
JP6913719B2 (ja) 2021-08-04
IL262976A (en) 2018-12-31
IL238824A0 (en) 2015-06-30
EP3115372A1 (en) 2017-01-11
US20220127326A1 (en) 2022-04-28
US20170355744A1 (en) 2017-12-14
HUE039334T2 (hu) 2018-12-28
IL262976B (en) 2020-02-27
RU2680581C2 (ru) 2019-02-22
JP6831176B2 (ja) 2021-02-17
PL2925776T3 (pl) 2018-11-30
US10301369B2 (en) 2019-05-28
WO2014085621A1 (en) 2014-06-05
MX377150B (es) 2025-03-07
BR112015012152B1 (pt) 2023-04-25
US20160031964A1 (en) 2016-02-04
HK1216026A1 (en) 2016-10-07
US9845346B2 (en) 2017-12-19
US9771408B2 (en) 2017-09-26
TWI711632B (zh) 2020-12-01
CY1122555T1 (el) 2021-01-27
US20160031963A1 (en) 2016-02-04
KR102262882B1 (ko) 2021-06-10
CA2892146A1 (en) 2014-06-05
KR102521039B1 (ko) 2023-04-12

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